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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for GPR161 |
 Gene summary |
| Gene information | Gene symbol | GPR161 | Gene ID | 23432 |
| Gene name | G protein-coupled receptor 161 | |
| Synonyms | RE2 | |
| Cytomap | 1q24.2 | |
| Type of gene | protein-coding | |
| Description | G-protein coupled receptor 161G-protein coupled receptor RE2 | |
| Modification date | 20200313 | |
| UniProtAcc | A0A0A0MQW8, Q8N6U8, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for GPR161 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000143147
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000367838.5 | GPR161-204:protein_coding:GPR161 | 4.062128e+00 | 2.603755e+00 | 5.280427e-05 | 4.307402e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for GPR161 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_218446 | chr1 | 168090564:168090668:168096508:168097232:168104477:168104894 | 168096508:168097232 |
| exon_skip_222468 | chr1 | 168104477:168104894:168114456:168114549:168137165:168137583 | 168114456:168114549 |
| exon_skip_234189 | chr1 | 168104477:168104894:168134906:168135036:168137165:168137667 | 168134906:168135036 |
| exon_skip_253672 | chr1 | 168104477:168104894:168114456:168114549:168133876:168133921 | 168114456:168114549 |
| exon_skip_28907 | chr1 | 168104477:168104894:168134906:168135036:168137165:168137583 | 168134906:168135036 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for GPR161 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000367835 | 168114456 | 168114549 | 3UTR-3UTR |
| ENST00000367838 | 168114456 | 168114549 | 3UTR-3UTR |
| ENST00000367835 | 168096508 | 168097232 | Frame-shift |
| ENST00000367838 | 168096508 | 168097232 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000367835 | 168114456 | 168114549 | 3UTR-3UTR |
| ENST00000367838 | 168114456 | 168114549 | 3UTR-3UTR |
| ENST00000367835 | 168096508 | 168097232 | Frame-shift |
| ENST00000367838 | 168096508 | 168097232 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for GPR161 |
p-ENSG00000143147_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in GPR161 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000367838 | 168114456 | 168114549 | hsa-miR-3620-3p | chr1:168114538-168114545 | 8mer-1a | chr1:168114523-168114547 | 154.00 | -18.02 |
| Mayo | ENST00000367838 | 168114456 | 168114549 | hsa-miR-6742-3p | chr1:168114502-168114509 | 8mer-1a | chr1:168114496-168114516 | 155.00 | -25.02 |
| Mayo | ENST00000367838 | 168114456 | 168114549 | hsa-miR-6747-3p | chr1:168114483-168114490 | 8mer-1a | chr1:168114472-168114492 | 153.00 | -25.04 |
| Mayo | ENST00000367838 | 168114456 | 168114549 | hsa-miR-6511a-5p | chr1:168114525-168114532 | 8mer-1a | chr1:168114523-168114547 | 154.00 | -18.02 |
| Mayo | ENST00000367838 | 168114456 | 168114549 | hsa-miR-6862-3p | chr1:168114540-168114547 | 8mer-1a | chr1:168114523-168114547 | 154.00 | -18.02 |
| Mayo | ENST00000367838 | 168114456 | 168114549 | hsa-miR-1910-3p | chr1:168114525-168114532 | 8mer-1a | chr1:168114523-168114547 | 154.00 | -18.02 |
| Mayo | ENST00000367838 | 168114456 | 168114549 | hsa-miR-6784-3p | chr1:168114540-168114547 | 8mer-1a | chr1:168114523-168114547 | 154.00 | -18.02 |
| Mayo | ENST00000367838 | 168114456 | 168114549 | hsa-miR-4634 | chr1:168114517-168114524 | 8mer-1a | chr1:168114503-168114524 | 150.00 | -31.78 |
| Mayo | ENST00000367838 | 168114456 | 168114549 | hsa-miR-4638-5p | chr1:168114509-168114516 | 8mer-1a | chr1:168114503-168114524 | 150.00 | -31.78 |
| ROSMAP | ENST00000367838 | 168114456 | 168114549 | hsa-miR-3620-3p | chr1:168114538-168114545 | 8mer-1a | chr1:168114523-168114547 | 154.00 | -18.02 |
| ROSMAP | ENST00000367838 | 168114456 | 168114549 | hsa-miR-6742-3p | chr1:168114502-168114509 | 8mer-1a | chr1:168114496-168114516 | 155.00 | -25.02 |
| ROSMAP | ENST00000367838 | 168114456 | 168114549 | hsa-miR-6747-3p | chr1:168114483-168114490 | 8mer-1a | chr1:168114472-168114492 | 153.00 | -25.04 |
| ROSMAP | ENST00000367838 | 168114456 | 168114549 | hsa-miR-6511a-5p | chr1:168114525-168114532 | 8mer-1a | chr1:168114523-168114547 | 154.00 | -18.02 |
| ROSMAP | ENST00000367838 | 168114456 | 168114549 | hsa-miR-6862-3p | chr1:168114540-168114547 | 8mer-1a | chr1:168114523-168114547 | 154.00 | -18.02 |
| ROSMAP | ENST00000367838 | 168114456 | 168114549 | hsa-miR-1910-3p | chr1:168114525-168114532 | 8mer-1a | chr1:168114523-168114547 | 154.00 | -18.02 |
| ROSMAP | ENST00000367838 | 168114456 | 168114549 | hsa-miR-6784-3p | chr1:168114540-168114547 | 8mer-1a | chr1:168114523-168114547 | 154.00 | -18.02 |
| ROSMAP | ENST00000367838 | 168114456 | 168114549 | hsa-miR-4634 | chr1:168114517-168114524 | 8mer-1a | chr1:168114503-168114524 | 150.00 | -31.78 |
| ROSMAP | ENST00000367838 | 168114456 | 168114549 | hsa-miR-4638-5p | chr1:168114509-168114516 | 8mer-1a | chr1:168114503-168114524 | 150.00 | -31.78 |
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SNVs in the skipped exons for GPR161 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for GPR161 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for GPR161 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for GPR161 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for GPR161 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GPR161 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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