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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for DICER1 |
 Gene summary |
| Gene information | Gene symbol | DICER1 | Gene ID | 23405 |
| Gene name | dicer 1, ribonuclease III | |
| Synonyms | DCR1|Dicer|Dicer1e|GLOW|HERNA|K12H4.8-LIKE|MNG1|RMSE2 | |
| Cytomap | 14q32.13 | |
| Type of gene | protein-coding | |
| Description | endoribonuclease DicerDicer1, Dcr-1 homologdicer 1, double-stranded RNA-specific endoribonucleasedicer 1, ribonuclease type IIIhelicase MOIhelicase with RNAse motif | |
| Modification date | 20200329 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| DICER1 | GO:0030422 | production of siRNA involved in RNA interference | 15973356|17452327|23661684 |
| DICER1 | GO:0031054 | pre-miRNA processing | 15973356|16357216|18178619|23661684|25549615 |
| DICER1 | GO:0035087 | siRNA loading onto RISC involved in RNA interference | 15973356 |
| DICER1 | GO:0035196 | production of miRNAs involved in gene silencing by miRNA | 15973356|23661684 |
| DICER1 | GO:0035280 | miRNA loading onto RISC involved in gene silencing by miRNA | 18178619 |
| DICER1 | GO:0038061 | NIK/NF-kappaB signaling | 26435691 |
| DICER1 | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic | 21753850|25549615 |
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Gene structures and expression levels for DICER1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000100697
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000661445.1 | DICER1-AS1-206:lncRNA:DICER1 | 1.062446e+02 | -8.487394e-01 | 3.209559e-12 | 3.915022e-10 |
| CB | UP | ENST00000529206.1 | DICER1-207:retained_intron:DICER1 | 2.700688e+00 | 1.165305e+00 | 3.690864e-08 | 9.119366e-07 |
| CB | UP | ENST00000556045.5 | DICER1-214:protein_coding:DICER1 | 3.162963e+00 | 1.449513e+00 | 1.859794e-04 | 1.250913e-03 |
| TC | DOWN | ENST00000661445.1 | DICER1-AS1-206:lncRNA:DICER1 | 8.820284e+01 | -8.317435e-01 | 1.650701e-09 | 1.994002e-07 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DICER1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_136815 | chr14 | 95126580:95126748:95129472:95129632:95130058:95130192 | 95129472:95129632 |
| exon_skip_138617 | chr14 | 95140659:95140759:95141683:95141748:95157230:95157270 | 95141683:95141748 |
| exon_skip_142997 | chr14 | 95133315:95133503:95134361:95134503:95140659:95140754 | 95134361:95134503 |
| exon_skip_164005 | chr14 | 95116453:95116695:95117622:95117754:95124196:95124275 | 95117622:95117754 |
| exon_skip_183541 | chr14 | 95140659:95140759:95141154:95141187:95141683:95141748 | 95141154:95141187 |
| exon_skip_196857 | chr14 | 95140659:95140759:95141154:95141187:95141683:95141718 | 95141154:95141187 |
| exon_skip_216394 | chr14 | 95130058:95130192:95131509:95131639:95132515:95132677 | 95131509:95131639 |
| exon_skip_45236 | chr14 | 95091034:95091109:95091203:95091365:95093888:95094156 | 95091203:95091365 |
| exon_skip_62021 | chr14 | 95107608:95107761:95107880:95108093:95108324:95108503 | 95107880:95108093 |
| exon_skip_94766 | chr14 | 95133315:95133503:95134361:95134503:95140659:95140759 | 95134361:95134503 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for DICER1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000343455 | 95091203 | 95091365 | Frame-shift |
| ENST00000393063 | 95091203 | 95091365 | Frame-shift |
| ENST00000526495 | 95091203 | 95091365 | Frame-shift |
| ENST00000527414 | 95091203 | 95091365 | Frame-shift |
| ENST00000343455 | 95107880 | 95108093 | Frame-shift |
| ENST00000393063 | 95107880 | 95108093 | Frame-shift |
| ENST00000526495 | 95107880 | 95108093 | Frame-shift |
| ENST00000527414 | 95107880 | 95108093 | Frame-shift |
| ENST00000343455 | 95131509 | 95131639 | Frame-shift |
| ENST00000393063 | 95131509 | 95131639 | Frame-shift |
| ENST00000526495 | 95131509 | 95131639 | Frame-shift |
| ENST00000527414 | 95131509 | 95131639 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000343455 | 95131509 | 95131639 | Frame-shift |
| ENST00000393063 | 95131509 | 95131639 | Frame-shift |
| ENST00000526495 | 95131509 | 95131639 | Frame-shift |
| ENST00000527414 | 95131509 | 95131639 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000343455 | 95091203 | 95091365 | Frame-shift |
| ENST00000393063 | 95091203 | 95091365 | Frame-shift |
| ENST00000526495 | 95091203 | 95091365 | Frame-shift |
| ENST00000527414 | 95091203 | 95091365 | Frame-shift |
| ENST00000343455 | 95117622 | 95117754 | Frame-shift |
| ENST00000393063 | 95117622 | 95117754 | Frame-shift |
| ENST00000526495 | 95117622 | 95117754 | Frame-shift |
| ENST00000527414 | 95117622 | 95117754 | Frame-shift |
| ENST00000343455 | 95129472 | 95129632 | Frame-shift |
| ENST00000393063 | 95129472 | 95129632 | Frame-shift |
| ENST00000526495 | 95129472 | 95129632 | Frame-shift |
| ENST00000527414 | 95129472 | 95129632 | Frame-shift |
| ENST00000343455 | 95131509 | 95131639 | Frame-shift |
| ENST00000393063 | 95131509 | 95131639 | Frame-shift |
| ENST00000526495 | 95131509 | 95131639 | Frame-shift |
| ENST00000527414 | 95131509 | 95131639 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for DICER1 |
p-ENSG00000100697_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in DICER1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for DICER1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for DICER1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DICER1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for DICER1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for DICER1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DICER1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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