ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for SYNE1

Gene summary

Gene information	Gene symbol	SYNE1
	Gene ID	23345
	Gene name	spectrin repeat containing nuclear envelope protein 1
	Synonyms	8B\|AMCM\|ARCA1\|C6orf98\|CPG2\|EDMD4\|KASH1\|MYNE1\|Nesp1\|SCAR8\|dJ45H2.2
	Cytomap	6q25.2
	Type of gene	protein-coding
	Description	nesprin-1CPG2 full lengthKASH domain-containing protein 1enaptinmyocyte nuclear envelope protein 1nesprin 1spectrin repeat containing, nuclear envelope 1synaptic nuclear envelope protein 1synaptic nuclei expressed gene 1
	Modification date	20200320
	UniProtAcc	A0A087WYJ5, A0A0C4DG40, A0A0C4DH48, A0A1Z2R910, A0A5F9ZH00, A0A5F9ZH86, A0A5F9ZH87, A0A5F9ZHB2, A0A5F9ZHD7, A0A5F9ZHE1, A0A5F9ZHI3, A0A5F9ZHR3, A0A5F9ZI52, A7E2D5, E7ENN3, E9PEL9, F5GXQ8, F5GYQ7, F5GZ83, F5H422, F5H4Q0, F5H6R8, F8WAI0, H0Y325, H0Y326, H0YFT4, H0YGD3, I6WNA2, I6WZ08, I6WZ14, I6XKI8, I6XKJ3, I6XTI3, Q5BKU8, Q5JV20, Q7RTM4, Q8NF91,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
SYNE1	GO:0007030	Golgi organization	12808039
SYNE1	GO:0042692	muscle cell differentiation	11792814
SYNE1	GO:0090286	cytoskeletal anchoring at nuclear membrane	18396275
SYNE1	GO:0090292	nuclear matrix anchoring at nuclear membrane	11801724

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Gene structures and expression levels for SYNE1

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000131018

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
STG	DOWN	ENST00000495090.6	SYNE1-230:protein_coding:SYNE1	4.442679e+01	-1.286700e+00	7.592883e-04	3.333014e-02
PG	DOWN	ENST00000481502.5	SYNE1-225:lncRNA:SYNE1	5.903141e+00	-9.362670e-01	8.344239e-04	1.277532e-02
PG	UP	ENST00000466159.6	SYNE1-217:protein_coding:SYNE1	2.108497e+00	3.652550e+00	2.931702e-03	3.131327e-02
PG	DOWN	ENST00000498751.1	SYNE1-231:lncRNA:SYNE1	3.836979e+00	-8.428121e-01	3.754647e-03	3.745817e-02
CB	UP	ENST00000423061.6	SYNE1-212:protein_coding:SYNE1	9.072147e+02	1.101678e+00	6.991221e-08	1.568768e-06
CB	DOWN	ENST00000539504.5	SYNE1-237:protein_coding:SYNE1	1.432464e+02	-3.431278e+00	1.460910e-07	2.925086e-06
CB	UP	ENST00000540663.5	SYNE1-238:protein_coding:SYNE1	6.317077e+01	1.913389e+00	2.541885e-07	4.671064e-06
CB	UP	ENST00000673281.1	SYNE1-247:protein_coding:SYNE1	2.367429e+01	1.086487e+00	2.743460e-06	3.536518e-05
CB	UP	ENST00000673163.1	SYNE1-245:nonsense_mediated_decay:SYNE1	1.369022e+01	8.925354e-01	8.450898e-06	9.170479e-05
CB	UP	ENST00000672122.1	SYNE1-242:protein_coding:SYNE1	3.006672e+02	1.467052e+00	2.290971e-04	1.493922e-03
CB	DOWN	ENST00000673173.1	SYNE1-246:protein_coding:SYNE1	9.393827e+02	-1.499406e+00	7.047020e-04	3.849189e-03
TC	DOWN	ENST00000474655.6	SYNE1-222:nonsense_mediated_decay:SYNE1	3.877275e+01	-1.540043e+00	1.323203e-04	2.019690e-03
TC	UP	ENST00000540663.5	SYNE1-238:protein_coding:SYNE1	5.924473e+00	1.305006e+00	9.690642e-04	9.667170e-03
TC	DOWN	ENST00000481502.5	SYNE1-225:lncRNA:SYNE1	5.308645e+00	-1.209250e+00	1.236229e-03	1.162740e-02
TC	DOWN	ENST00000539504.5	SYNE1-237:protein_coding:SYNE1	6.815766e+01	-2.340756e+00	1.823581e-03	1.564747e-02

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SYNE1

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_100196	chr6	152318863:152319015:152319899:152320216:152321238:152321390	152319899:152320216
exon_skip_103928	chr6	152293960:152294127:152300641:152300781:152301869:152302063	152300641:152300781
exon_skip_104382	chr6	152344081:152344227:152347059:152347235:152350168:152350335	152347059:152347235
exon_skip_117927	chr6	152143623:152143765:152145487:152145555:152148045:152148231	152145487:152145555
exon_skip_125960	chr6	152358373:152358537:152359315:152359458:152362170:152362214	152359315:152359458
exon_skip_136049	chr6	152430580:152430709:152433795:152433945:152435941:152436101	152433795:152433945
exon_skip_136118	chr6	152164163:152164325:152176394:152176560:152180136:152180294	152176394:152176560
exon_skip_143054	chr6	152326313:152326633:152329730:152331890:152334008:152334147	152329730:152331890
exon_skip_143513	chr6	152231391:152231567:152232116:152232265:152233781:152233963	152232116:152232265
exon_skip_14619	chr6	152281807:152281980:152283978:152284184:152293588:152293749	152283978:152284184
exon_skip_158925	chr6	152310688:152310873:152316849:152316986:152318081:152318263	152316849:152316986
exon_skip_165035	chr6	152428205:152428392:152430112:152430210:152430482:152430709	152430112:152430210
exon_skip_167823	chr6	152416387:152417015:152419569:152419722:152425381:152425468	152419569:152419722
exon_skip_167933	chr6	152510193:152510371:152511011:152511103:152520459:152520542	152511011:152511103
exon_skip_17270	chr6	152347059:152347235:152350168:152350335:152350618:152350770	152350168:152350335
exon_skip_180499	chr6	152143623:152143765:152145487:152145555:152148045:152148264	152145487:152145555
exon_skip_191971	chr6	152242240:152242440:152244537:152244656:152249161:152249262	152244537:152244656
exon_skip_19755	chr6	152135104:152135232:152136273:152136314:152136618:152136818	152136273:152136314
exon_skip_197766	chr6	152207972:152208206:152211494:152211588:152213612:152213759	152211494:152211588
exon_skip_200836	chr6	152139950:152140161:152141203:152141329:152143623:152143765	152141203:152141329
exon_skip_203912	chr6	152244537:152244656:152249161:152249262:152254880:152254958	152249161:152249262
exon_skip_208536	chr6	152224494:152224664:152225721:152225876:152230547:152230702	152225721:152225876
exon_skip_211227	chr6	152176399:152176560:152180136:152180294:152189252:152189407	152180136:152180294
exon_skip_211855	chr6	152310396:152310518:152310688:152310873:152316849:152316986	152310688:152310873
exon_skip_220745	chr6	152316849:152316986:152318081:152318263:152318863:152319015	152318081:152318263
exon_skip_249395	chr6	152135104:152135232:152136273:152136314:152136618:152136759	152136273:152136314
exon_skip_252799	chr6	152135104:152135232:152136273:152136314:152136618:152136815	152136273:152136314
exon_skip_253300	chr6	152180136:152180294:152189252:152189407:152201824:152201949	152189252:152189407
exon_skip_254772	chr6	152628265:152628554:152636638:152636805:152637189:152637362	152636638:152636805
exon_skip_261645	chr6	152155910:152156097:152164163:152164325:152176394:152176560	152164163:152164325
exon_skip_27590	chr6	152281807:152281980:152283978:152284172:152293588:152293749	152283978:152284172
exon_skip_278104	chr6	152122605:152122676:152130720:152130778:152132122:152132214	152130720:152130778
exon_skip_278529	chr6	152213612:152213759:152214906:152215060:152218257:152218385	152214906:152215060
exon_skip_290056	chr6	152488396:152488503:152498742:152498792:152502633:152502742	152498742:152498792
exon_skip_31492	chr6	152367218:152367382:152368972:152369127:152369471:152369614	152368972:152369127
exon_skip_31884	chr6	152539960:152540021:152628265:152628554:152636638:152636683	152628265:152628554
exon_skip_32493	chr6	152293960:152294127:152300641:152300781:152301869:152302060	152300641:152300781
exon_skip_36392	chr6	152176394:152176560:152180136:152180294:152189252:152189407	152180136:152180294
exon_skip_39872	chr6	152244537:152244656:152249161:152249262:152254880:152255089	152249161:152249262
exon_skip_45659	chr6	152526080:152526175:152539960:152540021:152628265:152628331	152539960:152540021
exon_skip_47969	chr6	152539960:152540021:152542160:152542240:152628265:152628554	152542160:152542240
exon_skip_50931	chr6	152141203:152141329:152143623:152143765:152148045:152148264	152143623:152143765
exon_skip_5358	chr6	152435941:152436101:152441130:152441270:152442075:152442245	152441130:152441270
exon_skip_5458	chr6	152409068:152409226:152409559:152409709:152413352:152413531	152409559:152409709
exon_skip_58738	chr6	152220842:152221046:152221426:152221559:152224494:152224664	152221426:152221559
exon_skip_66253	chr6	152511011:152511103:152511571:152511591:152520459:152520542	152511571:152511591
exon_skip_67761	chr6	152318863:152319015:152319899:152320216:152321238:152321377	152319899:152320216
exon_skip_73739	chr6	152455426:152455590:152455886:152456044:152458757:152458780	152455886:152456044
exon_skip_75604	chr6	152135104:152135232:152136273:152136314:152136618:152136809	152136273:152136314
exon_skip_86771	chr6	152294103:152294127:152300641:152300781:152301869:152302063	152300641:152300781
exon_skip_95184	chr6	152236817:152236948:152239533:152239706:152242240:152242440	152239533:152239706

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information	Tissue type	Avg(PSIs) in AD	Avg(PSIs) in control	Difference (PSI)	Adj. p-value
exon_skip_180499	MSBB_PG	3.638211e-01	2.288889e-01	1.349322e-01	1.706321e-06
exon_skip_103928	MSBB_PG	7.753543e-01	8.934545e-01	-1.181002e-01	1.970639e-04
exon_skip_290056	MSBB_PG	6.622535e-01	5.541071e-01	1.081464e-01	1.160061e-05
exon_skip_103928	Mayo_CB	6.770732e-01	7.801299e-01	-1.030567e-01	6.885113e-06

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Open reading frame (ORF) annotation in the exon skipping event for SYNE1

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000367255	152628265	152628554	3UTR-3CDS
ENST00000367255	152636638	152636805	3UTR-3UTR
ENST00000367255	152130720	152130778	Frame-shift
ENST00000367255	152214906	152215060	Frame-shift
ENST00000367255	152409559	152409709	Frame-shift
ENST00000367255	152180136	152180294	In-frame
ENST00000367255	152189252	152189407	In-frame
ENST00000367255	152225721	152225876	In-frame
ENST00000367255	152239533	152239706	In-frame
ENST00000367255	152244537	152244656	In-frame
ENST00000367255	152249161	152249262	In-frame
ENST00000367255	152283978	152284172	In-frame
ENST00000367255	152300641	152300781	In-frame
ENST00000367255	152318081	152318263	In-frame
ENST00000367255	152350168	152350335	In-frame
ENST00000367255	152359315	152359458	In-frame
ENST00000367255	152368972	152369127	In-frame
ENST00000367255	152430112	152430210	In-frame
ENST00000367255	152441130	152441270	In-frame
ENST00000367255	152455886	152456044	In-frame
ENST00000367255	152498742	152498792	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000367255	152628265	152628554	3UTR-3CDS
ENST00000367255	152636638	152636805	3UTR-3UTR
ENST00000367255	152130720	152130778	Frame-shift
ENST00000367255	152214906	152215060	Frame-shift
ENST00000367255	152409559	152409709	Frame-shift
ENST00000367255	152180136	152180294	In-frame
ENST00000367255	152225721	152225876	In-frame
ENST00000367255	152239533	152239706	In-frame
ENST00000367255	152244537	152244656	In-frame
ENST00000367255	152249161	152249262	In-frame
ENST00000367255	152300641	152300781	In-frame
ENST00000367255	152347059	152347235	In-frame
ENST00000367255	152368972	152369127	In-frame
ENST00000367255	152455886	152456044	In-frame
ENST00000367255	152498742	152498792	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000367255	152636638	152636805	3UTR-3UTR
ENST00000367255	152130720	152130778	Frame-shift
ENST00000367255	152141203	152141329	Frame-shift
ENST00000367255	152143623	152143765	Frame-shift
ENST00000367255	152164163	152164325	Frame-shift
ENST00000367255	152176394	152176560	Frame-shift
ENST00000367255	152211494	152211588	Frame-shift
ENST00000367255	152214906	152215060	Frame-shift
ENST00000367255	152221426	152221559	Frame-shift
ENST00000367255	152329730	152331890	Frame-shift
ENST00000367255	152409559	152409709	Frame-shift
ENST00000367255	152419569	152419722	Frame-shift
ENST00000367255	152433795	152433945	Frame-shift
ENST00000367255	152539960	152540021	Frame-shift
ENST00000367255	152180136	152180294	In-frame
ENST00000367255	152189252	152189407	In-frame
ENST00000367255	152225721	152225876	In-frame
ENST00000367255	152232116	152232265	In-frame
ENST00000367255	152239533	152239706	In-frame
ENST00000367255	152244537	152244656	In-frame
ENST00000367255	152249161	152249262	In-frame
ENST00000367255	152283978	152284172	In-frame
ENST00000367255	152300641	152300781	In-frame
ENST00000367255	152310688	152310873	In-frame
ENST00000367255	152316849	152316986	In-frame
ENST00000367255	152318081	152318263	In-frame
ENST00000367255	152359315	152359458	In-frame
ENST00000367255	152368972	152369127	In-frame
ENST00000367255	152430112	152430210	In-frame
ENST00000367255	152455886	152456044	In-frame
ENST00000367255	152498742	152498792	In-frame
ENST00000367255	152511011	152511103	In-frame

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Infer the effects of exon skipping event on protein functional features for SYNE1

p-ENSG00000131018_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000367255	27765	8797	152498742	152498792	1491	1540	296	312
ENST00000367255	27765	8797	152455886	152456044	3171	3328	856	908
ENST00000367255	27765	8797	152441130	152441270	4611	4750	1336	1382
ENST00000367255	27765	8797	152430112	152430210	5292	5389	1563	1595
ENST00000367255	27765	8797	152368972	152369127	10254	10408	3217	3268
ENST00000367255	27765	8797	152359315	152359458	10902	11044	3433	3480
ENST00000367255	27765	8797	152350168	152350335	12336	12502	3911	3966
ENST00000367255	27765	8797	152318081	152318263	16992	17173	5463	5523
ENST00000367255	27765	8797	152300641	152300781	18144	18283	5847	5893
ENST00000367255	27765	8797	152283978	152284172	18615	18808	6004	6068
ENST00000367255	27765	8797	152249161	152249262	20073	20173	6490	6523
ENST00000367255	27765	8797	152244537	152244656	20175	20293	6524	6563
ENST00000367255	27765	8797	152239533	152239706	20496	20668	6631	6688
ENST00000367255	27765	8797	152225721	152225876	21798	21952	7065	7116
ENST00000367255	27765	8797	152189252	152189407	23748	23902	7715	7766
ENST00000367255	27765	8797	152180136	152180294	23904	24061	7767	7819

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000367255	27765	8797	152498742	152498792	1491	1540	296	312
ENST00000367255	27765	8797	152455886	152456044	3171	3328	856	908
ENST00000367255	27765	8797	152368972	152369127	10254	10408	3217	3268
ENST00000367255	27765	8797	152347059	152347235	12504	12679	3967	4025
ENST00000367255	27765	8797	152300641	152300781	18144	18283	5847	5893
ENST00000367255	27765	8797	152249161	152249262	20073	20173	6490	6523
ENST00000367255	27765	8797	152244537	152244656	20175	20293	6524	6563
ENST00000367255	27765	8797	152239533	152239706	20496	20668	6631	6688
ENST00000367255	27765	8797	152225721	152225876	21798	21952	7065	7116
ENST00000367255	27765	8797	152180136	152180294	23904	24061	7767	7819

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000367255	27765	8797	152511011	152511103	912	1003	103	133
ENST00000367255	27765	8797	152498742	152498792	1491	1540	296	312
ENST00000367255	27765	8797	152455886	152456044	3171	3328	856	908
ENST00000367255	27765	8797	152430112	152430210	5292	5389	1563	1595
ENST00000367255	27765	8797	152368972	152369127	10254	10408	3217	3268
ENST00000367255	27765	8797	152359315	152359458	10902	11044	3433	3480
ENST00000367255	27765	8797	152318081	152318263	16992	17173	5463	5523
ENST00000367255	27765	8797	152316849	152316986	17175	17311	5524	5569
ENST00000367255	27765	8797	152310688	152310873	17313	17497	5570	5631
ENST00000367255	27765	8797	152300641	152300781	18144	18283	5847	5893
ENST00000367255	27765	8797	152283978	152284172	18615	18808	6004	6068
ENST00000367255	27765	8797	152249161	152249262	20073	20173	6490	6523
ENST00000367255	27765	8797	152244537	152244656	20175	20293	6524	6563
ENST00000367255	27765	8797	152239533	152239706	20496	20668	6631	6688
ENST00000367255	27765	8797	152232116	152232265	21315	21463	6904	6953
ENST00000367255	27765	8797	152225721	152225876	21798	21952	7065	7116
ENST00000367255	27765	8797	152189252	152189407	23748	23902	7715	7766
ENST00000367255	27765	8797	152180136	152180294	23904	24061	7767	7819

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q8NF91	296	312	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	296	312	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	296	312	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	296	312	1	5585	Alternative sequence	ID=VSP_007131;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	296	312	1	5476	Alternative sequence	ID=VSP_007130;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	296	312	1	2918	Alternative sequence	ID=VSP_057477;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	296	312	297	313	Alternative sequence	ID=VSP_057478;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	296	312	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	296	312	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	856	908	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	856	908	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	856	908	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	856	908	1	5585	Alternative sequence	ID=VSP_007131;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	856	908	1	5476	Alternative sequence	ID=VSP_007130;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	856	908	1	2918	Alternative sequence	ID=VSP_057477;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	856	908	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	856	908	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	856	908	885	885	Natural variant	ID=VAR_056212;Note=L->V;Dbxref=dbSNP:rs17082709
Q8NF91	856	908	816	923	Repeat	Note=Spectrin 6
Q8NF91	856	908	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	1336	1382	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	1336	1382	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	1336	1382	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	1336	1382	1	5585	Alternative sequence	ID=VSP_007131;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	1336	1382	1	5476	Alternative sequence	ID=VSP_007130;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	1336	1382	1	2918	Alternative sequence	ID=VSP_057477;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	1336	1382	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	1336	1382	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	1336	1382	1336	1444	Repeat	Note=Spectrin 11
Q8NF91	1336	1382	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	1563	1595	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	1563	1595	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	1563	1595	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	1563	1595	1	5585	Alternative sequence	ID=VSP_007131;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	1563	1595	1	5476	Alternative sequence	ID=VSP_007130;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	1563	1595	1	2918	Alternative sequence	ID=VSP_057477;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	1563	1595	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	1563	1595	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	1563	1595	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	1563	1595	1551	1653	Repeat	Note=Spectrin 13
Q8NF91	1563	1595	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	3217	3268	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	3217	3268	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	3217	3268	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	3217	3268	1	5585	Alternative sequence	ID=VSP_007131;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	3217	3268	1	5476	Alternative sequence	ID=VSP_007130;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	3217	3268	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	3217	3268	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	3217	3268	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	3217	3268	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	3217	3268	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	3217	3268	3172	3275	Repeat	Note=Spectrin 28
Q8NF91	3217	3268	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	3433	3480	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	3433	3480	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	3433	3480	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	3433	3480	1	5585	Alternative sequence	ID=VSP_007131;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	3433	3480	1	5476	Alternative sequence	ID=VSP_007130;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	3433	3480	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	3433	3480	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	3433	3480	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	3433	3480	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	3433	3480	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	3433	3480	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	3433	3480	3388	3490	Repeat	Note=Spectrin 30
Q8NF91	3433	3480	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	3911	3966	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	3911	3966	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	3911	3966	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	3911	3966	1	5585	Alternative sequence	ID=VSP_007131;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	3911	3966	1	5476	Alternative sequence	ID=VSP_007130;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	3911	3966	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	3911	3966	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	3911	3966	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	3911	3966	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	3911	3966	3912	3967	Alternative sequence	ID=VSP_007140;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15093733;Dbxref=PMID:15093733
Q8NF91	3911	3966	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	3911	3966	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	3911	3966	3954	3954	Natural variant	ID=VAR_056217;Note=S->T;Dbxref=dbSNP:rs7775119
Q8NF91	3911	3966	3815	3920	Repeat	Note=Spectrin 34
Q8NF91	3911	3966	3921	4028	Repeat	Note=Spectrin 35
Q8NF91	3911	3966	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	5463	5523	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	5463	5523	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	5463	5523	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	5463	5523	1	5585	Alternative sequence	ID=VSP_007131;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	5463	5523	1	5476	Alternative sequence	ID=VSP_007130;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	5463	5523	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	5463	5523	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	5463	5523	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	5463	5523	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	5463	5523	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	5463	5523	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	5463	5523	5507	5507	Natural variant	ID=VAR_036253;Note=In a colorectal cancer sample%3B somatic mutation. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q8NF91	5463	5523	5425	5522	Repeat	Note=Spectrin 49
Q8NF91	5463	5523	5523	5630	Repeat	Note=Spectrin 50
Q8NF91	5463	5523	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	5847	5893	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	5847	5893	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	5847	5893	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	5847	5893	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	5847	5893	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	5847	5893	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	5847	5893	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	5847	5893	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	5847	5893	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	5847	5893	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	5847	5893	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	6004	6068	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	6004	6068	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	6004	6068	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	6004	6068	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	6004	6068	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	6004	6068	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	6004	6068	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	6004	6068	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	6004	6068	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	6004	6068	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	6004	6068	5962	6071	Repeat	Note=Spectrin 53
Q8NF91	6004	6068	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	6490	6523	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	6490	6523	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	6490	6523	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	6490	6523	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	6490	6523	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	6490	6523	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	6490	6523	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	6490	6523	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	6490	6523	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	6490	6523	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	6490	6523	6486	6581	Repeat	Note=Spectrin 56
Q8NF91	6490	6523	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	6524	6563	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	6524	6563	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	6524	6563	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	6524	6563	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	6524	6563	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	6524	6563	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	6524	6563	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	6524	6563	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	6524	6563	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	6524	6563	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	6524	6563	6486	6581	Repeat	Note=Spectrin 56
Q8NF91	6524	6563	6549	6549	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6524	6563	6549	6549	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6524	6563	6549	6549	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6524	6563	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	6631	6688	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	6631	6688	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	6631	6688	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	6631	6688	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	6631	6688	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	6631	6688	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	6631	6688	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	6631	6688	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	6631	6688	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	6631	6688	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	6631	6688	6664	6664	Natural variant	ID=VAR_056229;Note=T->I;Dbxref=dbSNP:rs35079654
Q8NF91	6631	6688	6582	6691	Repeat	Note=Spectrin 57
Q8NF91	6631	6688	6645	6645	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6631	6688	6645	6645	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6631	6688	6645	6645	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6631	6688	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	7065	7116	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	7065	7116	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	7065	7116	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	7065	7116	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	7065	7116	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	7065	7116	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	7065	7116	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	7065	7116	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	7065	7116	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	7065	7116	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	7065	7116	7021	7128	Repeat	Note=Spectrin 61
Q8NF91	7065	7116	7075	7075	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	7065	7116	7075	7075	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	7065	7116	7075	7075	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	7065	7116	7091	7091	Sequence conflict	Note=N->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	7065	7116	7091	7091	Sequence conflict	Note=N->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	7065	7116	7091	7091	Sequence conflict	Note=N->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	7065	7116	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	7715	7766	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	7715	7766	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	7715	7766	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	7715	7766	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	7715	7766	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	7715	7766	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	7715	7766	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	7715	7766	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	7715	7766	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	7715	7766	7672	7783	Repeat	Note=Spectrin 67
Q8NF91	7715	7766	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	7767	7819	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	7767	7819	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	7767	7819	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	7767	7819	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	7767	7819	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	7767	7819	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	7767	7819	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	7767	7819	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	7767	7819	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	7767	7819	7672	7783	Repeat	Note=Spectrin 67
Q8NF91	7767	7819	7784	7883	Repeat	Note=Spectrin 68
Q8NF91	7767	7819	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q8NF91	296	312	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	296	312	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	296	312	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	296	312	1	5585	Alternative sequence	ID=VSP_007131;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	296	312	1	5476	Alternative sequence	ID=VSP_007130;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	296	312	1	2918	Alternative sequence	ID=VSP_057477;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	296	312	297	313	Alternative sequence	ID=VSP_057478;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	296	312	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	296	312	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	856	908	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	856	908	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	856	908	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	856	908	1	5585	Alternative sequence	ID=VSP_007131;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	856	908	1	5476	Alternative sequence	ID=VSP_007130;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	856	908	1	2918	Alternative sequence	ID=VSP_057477;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	856	908	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	856	908	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	856	908	885	885	Natural variant	ID=VAR_056212;Note=L->V;Dbxref=dbSNP:rs17082709
Q8NF91	856	908	816	923	Repeat	Note=Spectrin 6
Q8NF91	856	908	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	3217	3268	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	3217	3268	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	3217	3268	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	3217	3268	1	5585	Alternative sequence	ID=VSP_007131;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	3217	3268	1	5476	Alternative sequence	ID=VSP_007130;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	3217	3268	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	3217	3268	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	3217	3268	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	3217	3268	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	3217	3268	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	3217	3268	3172	3275	Repeat	Note=Spectrin 28
Q8NF91	3217	3268	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	3967	4025	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	3967	4025	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	3967	4025	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	3967	4025	1	5585	Alternative sequence	ID=VSP_007131;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	3967	4025	1	5476	Alternative sequence	ID=VSP_007130;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	3967	4025	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	3967	4025	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	3967	4025	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	3967	4025	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	3967	4025	3912	3967	Alternative sequence	ID=VSP_007140;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15093733;Dbxref=PMID:15093733
Q8NF91	3967	4025	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	3967	4025	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	3967	4025	3921	4028	Repeat	Note=Spectrin 35
Q8NF91	3967	4025	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	5847	5893	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	5847	5893	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	5847	5893	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	5847	5893	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	5847	5893	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	5847	5893	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	5847	5893	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	5847	5893	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	5847	5893	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	5847	5893	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	5847	5893	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	6490	6523	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	6490	6523	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	6490	6523	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	6490	6523	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	6490	6523	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	6490	6523	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	6490	6523	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	6490	6523	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	6490	6523	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	6490	6523	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	6490	6523	6486	6581	Repeat	Note=Spectrin 56
Q8NF91	6490	6523	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	6524	6563	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	6524	6563	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	6524	6563	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	6524	6563	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	6524	6563	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	6524	6563	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	6524	6563	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	6524	6563	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	6524	6563	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	6524	6563	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	6524	6563	6486	6581	Repeat	Note=Spectrin 56
Q8NF91	6524	6563	6549	6549	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6524	6563	6549	6549	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6524	6563	6549	6549	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6524	6563	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	6631	6688	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	6631	6688	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	6631	6688	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	6631	6688	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	6631	6688	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	6631	6688	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	6631	6688	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	6631	6688	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	6631	6688	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	6631	6688	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	6631	6688	6664	6664	Natural variant	ID=VAR_056229;Note=T->I;Dbxref=dbSNP:rs35079654
Q8NF91	6631	6688	6582	6691	Repeat	Note=Spectrin 57
Q8NF91	6631	6688	6645	6645	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6631	6688	6645	6645	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6631	6688	6645	6645	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6631	6688	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	7065	7116	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	7065	7116	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	7065	7116	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	7065	7116	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	7065	7116	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	7065	7116	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	7065	7116	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	7065	7116	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	7065	7116	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	7065	7116	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	7065	7116	7021	7128	Repeat	Note=Spectrin 61
Q8NF91	7065	7116	7075	7075	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	7065	7116	7075	7075	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	7065	7116	7075	7075	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	7065	7116	7091	7091	Sequence conflict	Note=N->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	7065	7116	7091	7091	Sequence conflict	Note=N->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	7065	7116	7091	7091	Sequence conflict	Note=N->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	7065	7116	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	7767	7819	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	7767	7819	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	7767	7819	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	7767	7819	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	7767	7819	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	7767	7819	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	7767	7819	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	7767	7819	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	7767	7819	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	7767	7819	7672	7783	Repeat	Note=Spectrin 67
Q8NF91	7767	7819	7784	7883	Repeat	Note=Spectrin 68
Q8NF91	7767	7819	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q8NF91	103	133	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	103	133	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	103	133	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	103	133	1	5585	Alternative sequence	ID=VSP_007131;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	103	133	1	5476	Alternative sequence	ID=VSP_007130;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	103	133	1	2918	Alternative sequence	ID=VSP_057477;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	103	133	103	103	Alternative sequence	ID=VSP_007134;Note=In isoform 4. K->KSMHRGSP;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15093733;Dbxref=PMID:15093733
Q8NF91	103	133	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	103	133	27	134	Domain	Note=Calponin-homology (CH) 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00044
Q8NF91	103	133	1	289	Region	Note=Actin-binding
Q8NF91	103	133	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	296	312	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	296	312	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	296	312	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	296	312	1	5585	Alternative sequence	ID=VSP_007131;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	296	312	1	5476	Alternative sequence	ID=VSP_007130;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	296	312	1	2918	Alternative sequence	ID=VSP_057477;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	296	312	297	313	Alternative sequence	ID=VSP_057478;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	296	312	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	296	312	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	856	908	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	856	908	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	856	908	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	856	908	1	5585	Alternative sequence	ID=VSP_007131;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	856	908	1	5476	Alternative sequence	ID=VSP_007130;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	856	908	1	2918	Alternative sequence	ID=VSP_057477;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	856	908	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	856	908	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	856	908	885	885	Natural variant	ID=VAR_056212;Note=L->V;Dbxref=dbSNP:rs17082709
Q8NF91	856	908	816	923	Repeat	Note=Spectrin 6
Q8NF91	856	908	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	1563	1595	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	1563	1595	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	1563	1595	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	1563	1595	1	5585	Alternative sequence	ID=VSP_007131;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	1563	1595	1	5476	Alternative sequence	ID=VSP_007130;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	1563	1595	1	2918	Alternative sequence	ID=VSP_057477;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	1563	1595	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	1563	1595	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	1563	1595	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	1563	1595	1551	1653	Repeat	Note=Spectrin 13
Q8NF91	1563	1595	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	3217	3268	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	3217	3268	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	3217	3268	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	3217	3268	1	5585	Alternative sequence	ID=VSP_007131;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	3217	3268	1	5476	Alternative sequence	ID=VSP_007130;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	3217	3268	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	3217	3268	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	3217	3268	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	3217	3268	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	3217	3268	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	3217	3268	3172	3275	Repeat	Note=Spectrin 28
Q8NF91	3217	3268	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	3433	3480	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	3433	3480	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	3433	3480	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	3433	3480	1	5585	Alternative sequence	ID=VSP_007131;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	3433	3480	1	5476	Alternative sequence	ID=VSP_007130;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	3433	3480	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	3433	3480	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	3433	3480	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	3433	3480	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	3433	3480	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	3433	3480	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	3433	3480	3388	3490	Repeat	Note=Spectrin 30
Q8NF91	3433	3480	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	5463	5523	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	5463	5523	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	5463	5523	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	5463	5523	1	5585	Alternative sequence	ID=VSP_007131;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	5463	5523	1	5476	Alternative sequence	ID=VSP_007130;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	5463	5523	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	5463	5523	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	5463	5523	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	5463	5523	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	5463	5523	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	5463	5523	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	5463	5523	5507	5507	Natural variant	ID=VAR_036253;Note=In a colorectal cancer sample%3B somatic mutation. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q8NF91	5463	5523	5425	5522	Repeat	Note=Spectrin 49
Q8NF91	5463	5523	5523	5630	Repeat	Note=Spectrin 50
Q8NF91	5463	5523	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	5524	5569	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	5524	5569	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	5524	5569	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	5524	5569	1	5585	Alternative sequence	ID=VSP_007131;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	5524	5569	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	5524	5569	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	5524	5569	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	5524	5569	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	5524	5569	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	5524	5569	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	5524	5569	5523	5630	Repeat	Note=Spectrin 50
Q8NF91	5524	5569	5526	5526	Sequence conflict	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	5524	5569	5564	5564	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	5524	5569	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	5570	5631	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	5570	5631	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	5570	5631	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	5570	5631	1	5585	Alternative sequence	ID=VSP_007131;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	5570	5631	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	5570	5631	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	5570	5631	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	5570	5631	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	5570	5631	5571	5580	Alternative sequence	ID=VSP_007141;Note=In isoform 7. TLLEESKEID->VTLGKIIFKK;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	5570	5631	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	5570	5631	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	5570	5631	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	5570	5631	5523	5630	Repeat	Note=Spectrin 50
Q8NF91	5570	5631	5631	5736	Repeat	Note=Spectrin 51
Q8NF91	5570	5631	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	5847	5893	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	5847	5893	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	5847	5893	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	5847	5893	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	5847	5893	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	5847	5893	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	5847	5893	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	5847	5893	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	5847	5893	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	5847	5893	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	5847	5893	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	6004	6068	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	6004	6068	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	6004	6068	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	6004	6068	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	6004	6068	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	6004	6068	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	6004	6068	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	6004	6068	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	6004	6068	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	6004	6068	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	6004	6068	5962	6071	Repeat	Note=Spectrin 53
Q8NF91	6004	6068	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	6490	6523	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	6490	6523	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	6490	6523	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	6490	6523	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	6490	6523	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	6490	6523	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	6490	6523	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	6490	6523	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	6490	6523	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	6490	6523	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	6490	6523	6486	6581	Repeat	Note=Spectrin 56
Q8NF91	6490	6523	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	6524	6563	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	6524	6563	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	6524	6563	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	6524	6563	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	6524	6563	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	6524	6563	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	6524	6563	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	6524	6563	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	6524	6563	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	6524	6563	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	6524	6563	6486	6581	Repeat	Note=Spectrin 56
Q8NF91	6524	6563	6549	6549	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6524	6563	6549	6549	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6524	6563	6549	6549	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6524	6563	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	6631	6688	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	6631	6688	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	6631	6688	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	6631	6688	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	6631	6688	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	6631	6688	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	6631	6688	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	6631	6688	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	6631	6688	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	6631	6688	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	6631	6688	6664	6664	Natural variant	ID=VAR_056229;Note=T->I;Dbxref=dbSNP:rs35079654
Q8NF91	6631	6688	6582	6691	Repeat	Note=Spectrin 57
Q8NF91	6631	6688	6645	6645	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6631	6688	6645	6645	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6631	6688	6645	6645	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6631	6688	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	6904	6953	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	6904	6953	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	6904	6953	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	6904	6953	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	6904	6953	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	6904	6953	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	6904	6953	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	6904	6953	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	6904	6953	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	6904	6953	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	6904	6953	6951	6951	Natural variant	ID=VAR_056230;Note=Q->H;Dbxref=dbSNP:rs3945783
Q8NF91	6904	6953	6903	7020	Repeat	Note=Spectrin 60
Q8NF91	6904	6953	6923	6923	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6904	6953	6923	6923	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6904	6953	6923	6923	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6904	6953	6929	6929	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6904	6953	6929	6929	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6904	6953	6929	6929	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	6904	6953	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	7065	7116	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	7065	7116	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	7065	7116	1	7658	Alternative sequence	ID=VSP_057476;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11801724;Dbxref=PMID:11801724
Q8NF91	7065	7116	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	7065	7116	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	7065	7116	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	7065	7116	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	7065	7116	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	7065	7116	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	7065	7116	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	7065	7116	7021	7128	Repeat	Note=Spectrin 61
Q8NF91	7065	7116	7075	7075	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	7065	7116	7075	7075	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	7065	7116	7075	7075	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	7065	7116	7091	7091	Sequence conflict	Note=N->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	7065	7116	7091	7091	Sequence conflict	Note=N->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	7065	7116	7091	7091	Sequence conflict	Note=N->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NF91	7065	7116	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	7715	7766	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	7715	7766	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	7715	7766	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	7715	7766	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	7715	7766	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	7715	7766	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	7715	7766	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	7715	7766	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	7715	7766	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	7715	7766	7672	7783	Repeat	Note=Spectrin 67
Q8NF91	7715	7766	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385
Q8NF91	7767	7819	1	7843	Alternative sequence	ID=VSP_007133;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q8NF91	7767	7819	1	7838	Alternative sequence	ID=VSP_007132;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11792814;Dbxref=PMID:11792814
Q8NF91	7767	7819	1444	8797	Alternative sequence	ID=VSP_007136;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11214970;Dbxref=PMID:11214970
Q8NF91	7767	7819	1726	8797	Alternative sequence	ID=VSP_007138;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q8NF91	7767	7819	3050	8797	Alternative sequence	ID=VSP_057480;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18709643;Dbxref=PMID:18709643
Q8NF91	7767	7819	3395	8797	Alternative sequence	ID=VSP_057482;Note=In isoform GSRP-56. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NF91	7767	7819	5581	8797	Alternative sequence	ID=VSP_007142;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10574462;Dbxref=PMID:10574462
Q8NF91	7767	7819	1	8797	Chain	ID=PRO_0000163591;Note=Nesprin-1
Q8NF91	7767	7819	314	8666	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NF91	7767	7819	7672	7783	Repeat	Note=Spectrin 67
Q8NF91	7767	7819	7784	7883	Repeat	Note=Spectrin 68
Q8NF91	7767	7819	1	8746	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00385

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3'-UTR located exon skipping events that lost miRNA binding sites in SYNE1

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type	ENST	Exon skip start	Exon skip end	microRNA	Binding site by TargetScan	Binding type by TargetScan	Bdinding site by miRanda	Score of miRanda	Energy by miRanda
Mayo	ENST00000367255	152636638	152636805	hsa-miR-10392-5p	chr6:152636676-152636683	8mer-1a	chr6:152636663-152636683	158.00	-25.36
Mayo	ENST00000367255	152636638	152636805	hsa-miR-5587-3p	chr6:152636728-152636735	8mer-1a	chr6:152636718-152636739	151.00	-31.80
MSBB	ENST00000367255	152636638	152636805	hsa-miR-10392-5p	chr6:152636676-152636683	8mer-1a	chr6:152636663-152636683	158.00	-25.36
MSBB	ENST00000367255	152636638	152636805	hsa-miR-5587-3p	chr6:152636728-152636735	8mer-1a	chr6:152636718-152636739	151.00	-31.80
ROSMAP	ENST00000367255	152636638	152636805	hsa-miR-10392-5p	chr6:152636676-152636683	8mer-1a	chr6:152636663-152636683	158.00	-25.36
ROSMAP	ENST00000367255	152636638	152636805	hsa-miR-5587-3p	chr6:152636728-152636735	8mer-1a	chr6:152636718-152636739	151.00	-31.80

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SNVs in the skipped exons for SYNE1

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for SYNE1

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info	Cohort	Tissue	SE id	Coefficient	P-value	Chromosome	Strand	E1 start	E1 end	Skipped start	Skipped end	E2 start	E2 end
ADstage	MSBB	IFG	exon_skip_208536	-3.903781e-01	3.999415e-02	chr6	-	152224494	152224664	152225721	152225876	152230547	152230702
CDR	MSBB	IFG	exon_skip_19755	-4.350765e-01	2.067533e-02	chr6	-	152135104	152135232	152136273	152136314	152136618	152136818
CDR	MSBB	IFG	exon_skip_103928	-4.289807e-01	2.273457e-02	chr6	-	152293960	152294127	152300641	152300781	152301869	152302063
CDR	MSBB	IFG	exon_skip_290056	4.145801e-01	2.826995e-02	chr6	-	152488396	152488503	152498742	152498792	152502633	152502742

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SYNE1

sQTL information located at the skipped exons.

Tissue type	Exon skip ID	SNP id	Location	P-value	FDR
CB	exon_skip_66253	rs2038615	chr6:152606132	4.961945e-05	9.790031e-03

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Correlation with RNA binding proteins (RBPs) for SYNE1

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	RBM6	exon_skip_278104	-4.689040e-01	4.550623e-10
CB	PCBP1	exon_skip_117927	-4.658988e-01	6.071083e-10
CB	KHSRP	exon_skip_117927	-4.159524e-01	4.960845e-08
CB	PUM1	exon_skip_117927	-4.432652e-01	4.877147e-09
CB	RBM4B	exon_skip_117927	-4.086149e-01	8.939145e-08
CB	RBM6	exon_skip_19381	-5.423159e-01	3.219929e-10
CB	RBM3	exon_skip_19381	5.030742e-01	8.649128e-09
CB	PCBP4	exon_skip_19381	6.884623e-01	1.341863e-17
CB	RBM6	exon_skip_191971	-4.765969e-01	2.147890e-10
CB	PCBP4	exon_skip_191971	5.475654e-01	8.077538e-14
CB	CNOT4	exon_skip_103928	-4.966223e-01	2.781488e-11
CB	PCBP1	exon_skip_103928	-4.123577e-01	6.631467e-08
CB	PCBP4	exon_skip_103928	5.978140e-01	8.836379e-17
CB	HNRNPA2B1	exon_skip_103928	-4.924135e-01	4.321677e-11
CB	SRSF9	exon_skip_66253	4.058308e-01	1.946131e-07
FL	SRSF2	exon_skip_103928	5.318583e-01	7.455307e-16
FL	ILF2	exon_skip_103928	4.791416e-01	9.272677e-13
FL	HNRNPH2	exon_skip_103928	5.624783e-01	6.490291e-18
FL	RALYL	exon_skip_290056	-4.774619e-01	1.301945e-12
FL	KHDRBS2	exon_skip_66253	4.270459e-01	5.889564e-10
FL	SRSF9	exon_skip_66253	4.483476e-01	6.210436e-11
HCC	RBMS2	exon_skip_117927	6.145820e-01	1.539617e-29
HCC	SFPQ	exon_skip_117927	5.977361e-01	1.217543e-27
HCC	RBM6	exon_skip_117927	6.476373e-01	1.291742e-33
HCC	IGF2BP2	exon_skip_117927	4.407783e-01	2.614569e-14
HCC	RBM47	exon_skip_117927	4.483786e-01	8.283942e-15
HCC	FUBP3	exon_skip_117927	5.003186e-01	1.424466e-18
HCC	FUBP1	exon_skip_117927	4.344240e-01	6.687698e-14
HCC	PABPC1	exon_skip_117927	4.400168e-01	2.929052e-14
HCC	PABPC4	exon_skip_117927	4.363227e-01	5.061607e-14
HCC	RBM4B	exon_skip_117927	5.686409e-01	1.295039e-24
HCC	RBM5	exon_skip_32493	-5.449243e-01	5.667589e-22
HCC	RC3H1	exon_skip_32493	-4.019087e-01	9.523811e-12
HCC	SF1	exon_skip_32493	-4.335125e-01	1.297341e-13
HCC	ENOX1	exon_skip_32493	-4.015638e-01	9.956611e-12
HCC	HNRNPA2B1	exon_skip_32493	-4.832582e-01	5.676411e-17
HCC	HNRNPF	exon_skip_32493	-6.076483e-01	3.067042e-28
HCC	KHDRBS2	exon_skip_66253	4.678666e-01	4.119585e-15
IFG	RBM5	exon_skip_103928	-4.490099e-01	1.653810e-02
IFG	LIN28A	exon_skip_103928	4.971265e-01	7.116199e-03
IFG	RBM47	exon_skip_290056	4.163697e-01	2.752782e-02
PCC	RBMS2	exon_skip_117927	7.368399e-01	2.188514e-37
PCC	SFPQ	exon_skip_117927	4.746525e-01	2.971056e-13
PCC	RBM6	exon_skip_117927	5.772579e-01	3.816564e-20
PCC	IGF2BP2	exon_skip_117927	4.027959e-01	1.235857e-09
PCC	FUBP3	exon_skip_117927	5.196494e-01	5.435934e-16
PCC	PUM1	exon_skip_117927	-4.456135e-01	1.092236e-11
PCC	PABPC1	exon_skip_117927	5.647015e-01	3.602351e-19
PCC	PABPC4	exon_skip_117927	4.144181e-01	3.654078e-10
PCC	RBM4B	exon_skip_117927	4.083243e-01	6.962675e-10
PCC	ESRP2	exon_skip_103928	-4.133642e-01	2.305011e-09
PCC	HNRNPF	exon_skip_103928	-5.028004e-01	9.242801e-14
PCC	RALYL	exon_skip_290056	-4.006725e-01	9.273515e-09
PG	SRSF2	exon_skip_103928	4.648658e-01	3.815531e-11
PG	RBM25	exon_skip_103928	4.146439e-01	5.905477e-09
PG	IGF2BP2	exon_skip_103928	-4.162932e-01	5.068582e-09
PG	ILF2	exon_skip_103928	5.220339e-01	4.109395e-14
PG	HNRNPH2	exon_skip_103928	6.227466e-01	6.240937e-21
PG	RALYL	exon_skip_290056	-5.368127e-01	3.574214e-16
PG	KHDRBS2	exon_skip_66253	6.093223e-01	2.271381e-19
PG	SRSF9	exon_skip_66253	4.390176e-01	9.804469e-10
STG	IGF2BP2	exon_skip_117927	4.233256e-01	3.576138e-05
STG	HNRNPH2	exon_skip_103928	5.676003e-01	5.421319e-09
STG	ESRP2	exon_skip_103928	-4.164904e-01	4.444158e-05
STG	RALYL	exon_skip_290056	-4.581779e-01	9.166206e-06
STG	KHDRBS2	exon_skip_66253	4.483508e-01	1.183248e-05
TC	NOVA1	exon_skip_278104	-4.621452e-01	8.668479e-10
TC	CNOT4	exon_skip_117927	-4.703660e-01	5.104919e-10
TC	PCBP1	exon_skip_117927	-4.559024e-01	1.972106e-09
TC	PUM1	exon_skip_117927	-7.286818e-01	2.875127e-27
TC	NUP42	exon_skip_117927	-7.353735e-01	5.549927e-28
TC	SART3	exon_skip_117927	-4.010706e-01	1.935143e-07
TC	SRSF2	exon_skip_86771	4.182916e-01	7.435476e-08
TC	HNRNPH2	exon_skip_86771	5.198993e-01	5.702527e-12
TC	ESRP1	exon_skip_86771	4.450161e-01	8.243063e-09
TC	RALYL	exon_skip_290056	-6.790327e-01	9.224811e-19

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RelatedDrugs for SYNE1

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SYNE1

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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