|
||||||
|
 | |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| 3'-UTR located exon skipping events lost miRNA binding sites |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| |
| |
|
Gene summary for WDR7 |
 Gene summary |
| Gene information | Gene symbol | WDR7 | Gene ID | 23335 |
| Gene name | WD repeat domain 7 | |
| Synonyms | TRAG | |
| Cytomap | 18q21.31 | |
| Type of gene | protein-coding | |
| Description | WD repeat-containing protein 7TGF-beta resistance associatedTGF-beta resistance-associated protein TRAGrabconnectin-3 beta | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
Gene structures and expression levels for WDR7 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
ENSG00000091157
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| TC | UP | ENST00000591524.1 | WDR7-211:retained_intron:WDR7 | 9.234722e-01 | 8.902302e-01 | 1.499398e-03 | 1.345058e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
 |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for WDR7 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_102377 | chr18 | 56779431:56779549:56781533:56781656:56816031:56816144 | 56781533:56781656 |
| exon_skip_14546 | chr18 | 56717964:56718159:56731383:56731597:56756583:56756698 | 56731383:56731597 |
| exon_skip_149476 | chr18 | 56758865:56758953:56776782:56776880:56779431:56779549 | 56776782:56776880 |
| exon_skip_153617 | chr18 | 56816031:56816144:56879944:56880165:56923922:56924108 | 56879944:56880165 |
| exon_skip_155932 | chr18 | 56694647:56694760:56694950:56695198:56696242:56696462 | 56694950:56695198 |
| exon_skip_196734 | chr18 | 56935844:56935905:56938533:56938682:56939311:56939393 | 56938533:56938682 |
| exon_skip_217047 | chr18 | 56757325:56757352:56758865:56758953:56779431:56779549 | 56758865:56758953 |
| exon_skip_247693 | chr18 | 56781639:56781656:56816031:56816144:56879944:56880165 | 56816031:56816144 |
| exon_skip_27086 | chr18 | 56681313:56681391:56682679:56682853:56685956:56686032 | 56682679:56682853 |
| exon_skip_276373 | chr18 | 56781533:56781656:56816031:56816144:56879944:56880165 | 56816031:56816144 |
| exon_skip_279305 | chr18 | 56758874:56758953:56776782:56776880:56779431:56779549 | 56776782:56776880 |
| exon_skip_279776 | chr18 | 56816031:56816144:56879944:56880165:56923922:56924000 | 56879944:56880165 |
| exon_skip_281670 | chr18 | 56879944:56880165:56923922:56924108:56935788:56935905 | 56923922:56924108 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
 |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_149476 | MSBB_PG | 7.152027e-01 | 8.320000e-01 | -1.167973e-01 | 1.525726e-07 |
| exon_skip_279305 | Mayo_TC | 3.225000e-01 | 4.583607e-01 | -1.358607e-01 | 6.690127e-05 |
Top |
Open reading frame (ORF) annotation in the exon skipping event for WDR7 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000254442 | 56682679 | 56682853 | Frame-shift |
| ENST00000254442 | 56731383 | 56731597 | Frame-shift |
| ENST00000254442 | 56776782 | 56776880 | In-frame |
| ENST00000254442 | 56816031 | 56816144 | In-frame |
| ENST00000254442 | 56879944 | 56880165 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000254442 | 56731383 | 56731597 | Frame-shift |
| ENST00000254442 | 56776782 | 56776880 | In-frame |
| ENST00000254442 | 56816031 | 56816144 | In-frame |
| ENST00000254442 | 56879944 | 56880165 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000254442 | 56781533 | 56781656 | Frame-shift |
| ENST00000254442 | 56923922 | 56924108 | Frame-shift |
| ENST00000254442 | 56694950 | 56695198 | In-frame |
| ENST00000254442 | 56776782 | 56776880 | In-frame |
| ENST00000254442 | 56816031 | 56816144 | In-frame |
| ENST00000254442 | 56879944 | 56880165 | In-frame |
| ENST00000254442 | 56938533 | 56938682 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for WDR7 |
p-ENSG00000091157_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000254442 | 14100 | 1490 | 56776782 | 56776880 | 3061 | 3158 | 950 | 982 |
| ENST00000254442 | 14100 | 1490 | 56816031 | 56816144 | 3403 | 3515 | 1064 | 1101 |
| ENST00000254442 | 14100 | 1490 | 56879944 | 56880165 | 3517 | 3737 | 1102 | 1175 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000254442 | 14100 | 1490 | 56776782 | 56776880 | 3061 | 3158 | 950 | 982 |
| ENST00000254442 | 14100 | 1490 | 56816031 | 56816144 | 3403 | 3515 | 1064 | 1101 |
| ENST00000254442 | 14100 | 1490 | 56879944 | 56880165 | 3517 | 3737 | 1102 | 1175 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000254442 | 14100 | 1490 | 56694950 | 56695198 | 1321 | 1568 | 370 | 452 |
| ENST00000254442 | 14100 | 1490 | 56776782 | 56776880 | 3061 | 3158 | 950 | 982 |
| ENST00000254442 | 14100 | 1490 | 56816031 | 56816144 | 3403 | 3515 | 1064 | 1101 |
| ENST00000254442 | 14100 | 1490 | 56879944 | 56880165 | 3517 | 3737 | 1102 | 1175 |
| ENST00000254442 | 14100 | 1490 | 56938533 | 56938682 | 4044 | 4192 | 1277 | 1327 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y4E6 | 950 | 982 | 950 | 982 | Alternative sequence | ID=VSP_015274;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| Q9Y4E6 | 950 | 982 | 1 | 1490 | Chain | ID=PRO_0000051353;Note=WD repeat-containing protein 7 |
| Q9Y4E6 | 1064 | 1101 | 1 | 1490 | Chain | ID=PRO_0000051353;Note=WD repeat-containing protein 7 |
| Q9Y4E6 | 1102 | 1175 | 1 | 1490 | Chain | ID=PRO_0000051353;Note=WD repeat-containing protein 7 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y4E6 | 950 | 982 | 950 | 982 | Alternative sequence | ID=VSP_015274;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| Q9Y4E6 | 950 | 982 | 1 | 1490 | Chain | ID=PRO_0000051353;Note=WD repeat-containing protein 7 |
| Q9Y4E6 | 1064 | 1101 | 1 | 1490 | Chain | ID=PRO_0000051353;Note=WD repeat-containing protein 7 |
| Q9Y4E6 | 1102 | 1175 | 1 | 1490 | Chain | ID=PRO_0000051353;Note=WD repeat-containing protein 7 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y4E6 | 370 | 452 | 1 | 1490 | Chain | ID=PRO_0000051353;Note=WD repeat-containing protein 7 |
| Q9Y4E6 | 370 | 452 | 404 | 443 | Repeat | Note=WD 5 |
| Q9Y4E6 | 950 | 982 | 950 | 982 | Alternative sequence | ID=VSP_015274;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| Q9Y4E6 | 950 | 982 | 1 | 1490 | Chain | ID=PRO_0000051353;Note=WD repeat-containing protein 7 |
| Q9Y4E6 | 1064 | 1101 | 1 | 1490 | Chain | ID=PRO_0000051353;Note=WD repeat-containing protein 7 |
| Q9Y4E6 | 1102 | 1175 | 1 | 1490 | Chain | ID=PRO_0000051353;Note=WD repeat-containing protein 7 |
| Q9Y4E6 | 1277 | 1327 | 1 | 1490 | Chain | ID=PRO_0000051353;Note=WD repeat-containing protein 7 |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in WDR7 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for WDR7 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for WDR7 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | MSBB | IFG | exon_skip_149476 | -3.991752e-01 | 3.535159e-02 | chr18 | + | 56758865 | 56758953 | 56776782 | 56776880 | 56779431 | 56779549 |
| CDR | MSBB | IFG | exon_skip_149476 | -4.770063e-01 | 1.027068e-02 | chr18 | + | 56758865 | 56758953 | 56776782 | 56776880 | 56779431 | 56779549 |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for WDR7 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for WDR7 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | PCBP4 | exon_skip_149476 | 4.116952e-01 | 8.513935e-07 |
| CB | NUP42 | exon_skip_149476 | 5.129407e-01 | 2.745626e-10 |
| CB | RALYL | exon_skip_149476 | 4.446098e-01 | 8.259635e-08 |
| FL | MSI1 | exon_skip_149476 | -4.632673e-01 | 6.305894e-12 |
| FL | RALYL | exon_skip_149476 | 4.865900e-01 | 3.643592e-13 |
| HCC | RBMS3 | exon_skip_91645 | -4.303589e-01 | 3.800104e-13 |
| HCC | PCBP4 | exon_skip_91645 | -5.304393e-01 | 2.860336e-20 |
| HCC | UNK | exon_skip_91645 | -4.202536e-01 | 1.505358e-12 |
| HCC | DAZAP1 | exon_skip_149476 | -5.816353e-01 | 4.094281e-25 |
| HCC | RBMS3 | exon_skip_149476 | -4.148467e-01 | 2.545576e-12 |
| HCC | MSI1 | exon_skip_149476 | -6.510247e-01 | 5.616791e-33 |
| HCC | IGF2BP2 | exon_skip_149476 | -4.114790e-01 | 3.968549e-12 |
| HCC | PCBP1 | exon_skip_149476 | -4.035981e-01 | 1.100469e-11 |
| HCC | PCBP4 | exon_skip_149476 | -4.229256e-01 | 8.595831e-13 |
| HCC | UNK | exon_skip_149476 | -5.327946e-01 | 1.295170e-20 |
| IFG | RALYL | exon_skip_91645 | 5.719210e-01 | 2.817446e-03 |
| IFG | IGF2BP2 | exon_skip_149476 | -4.240672e-01 | 2.451376e-02 |
| IFG | RALYL | exon_skip_149476 | 4.710425e-01 | 1.140445e-02 |
| PCC | MSI1 | exon_skip_279305 | -4.969332e-01 | 1.707416e-13 |
| PCC | RALYL | exon_skip_279305 | 4.888783e-01 | 4.747681e-13 |
| PG | MSI1 | exon_skip_149476 | -4.032183e-01 | 2.451336e-09 |
| PG | IGF2BP2 | exon_skip_149476 | -4.250623e-01 | 2.596124e-10 |
| PG | PCBP1 | exon_skip_149476 | 4.402788e-01 | 4.927537e-11 |
| PG | RALYL | exon_skip_149476 | 4.789308e-01 | 4.901866e-13 |
| STG | MSI1 | exon_skip_149476 | -4.648316e-01 | 3.453204e-06 |
| STG | IGF2BP2 | exon_skip_149476 | -4.298009e-01 | 2.121735e-05 |
| STG | RALYL | exon_skip_149476 | 5.333299e-01 | 5.241671e-08 |
| TC | MSI1 | exon_skip_279305 | -4.789853e-01 | 1.875392e-09 |
| TC | NUP42 | exon_skip_279305 | 6.932794e-01 | 1.624619e-21 |
| TC | RALYL | exon_skip_279305 | 8.578527e-01 | 5.090443e-42 |
Top |
RelatedDrugs for WDR7 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for WDR7 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|