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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for ACSL6 |
Gene summary |
Gene information | Gene symbol | ACSL6 | Gene ID | 23305 |
Gene name | acyl-CoA synthetase long chain family member 6 | |
Synonyms | ACS2|FACL6|LACS 6|LACS2|LACS5 | |
Cytomap | 5q31.1 | |
Type of gene | protein-coding | |
Description | long-chain-fatty-acid--CoA ligase 6arachidonate--CoA ligasefatty-acid-Coenzyme A ligase, long-chain 6long fatty acyl-CoA synthetase 2 | |
Modification date | 20200313 | |
UniProtAcc | A0A494BZW8, A0A494C005, A0A494C046, A0A494C0A5, A0A494C0B6, A0A494C0D5, A0A494C0J9, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
ACSL6 | GO:0001676 | long-chain fatty acid metabolic process | 24269233 |
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Gene structures and expression levels for ACSL6 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PCC | DOWN | ENST00000379246.5 | ACSL6-205:protein_coding:ACSL6 | 3.285176e+01 | -9.184190e-01 | 2.297477e-03 | 4.252902e-02 |
PG | UP | ENST00000357096.5 | ACSL6-202:protein_coding:ACSL6 | 8.823286e+01 | 1.595387e+00 | 2.364284e-03 | 2.691125e-02 |
PG | UP | ENST00000416557.5 | ACSL6-208:protein_coding:ACSL6 | 1.819953e+00 | 3.837526e+00 | 2.761393e-03 | 3.003651e-02 |
CB | DOWN | ENST00000357096.5 | ACSL6-202:protein_coding:ACSL6 | 1.048099e+03 | -1.374932e+00 | 2.324360e-10 | 1.287683e-08 |
CB | UP | ENST00000652493.1 | ACSL6-234:nonsense_mediated_decay:ACSL6 | 1.168763e+01 | 9.305598e-01 | 2.748504e-03 | 1.200179e-02 |
CB | UP | ENST00000650912.1 | ACSL6-222:nonsense_mediated_decay:ACSL6 | 3.681097e+01 | 1.704237e+00 | 8.905920e-03 | 3.162071e-02 |
TC | DOWN | ENST00000357096.5 | ACSL6-202:protein_coding:ACSL6 | 4.265032e+02 | -1.054348e+00 | 3.261426e-04 | 4.100436e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ACSL6 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_166270 | chr5 | 131974893:131974970:131976184:131976240:131976648:131976721 | 131976184:131976240 |
exon_skip_223367 | chr5 | 131988048:131988226:131988556:131988600:131988805:131988904 | 131988556:131988600 |
exon_skip_265563 | chr5 | 131990853:131990967:131991745:131991813:131994031:131994251 | 131991745:131991813 |
exon_skip_85076 | chr5 | 131971550:131971645:131971747:131971759:131972724:131972858 | 131971747:131971759 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ACSL6 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for ACSL6 |
p-ENSG00000164398_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ACSL6 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ACSL6 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ACSL6 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ACSL6 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ACSL6 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ACSL6 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ACSL6 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |