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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for KIF13B |
 Gene summary |
| Gene information | Gene symbol | KIF13B | Gene ID | 23303 |
| Gene name | kinesin family member 13B | |
| Synonyms | GAKIN | |
| Cytomap | 8p12 | |
| Type of gene | protein-coding | |
| Description | kinesin-like protein KIF13Bguanylate kinase associated kinesinkinesin 13Bkinesin-like protein GAKIN | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context | - 24854535(Functions of the Neuron-Specific Protein ADAP1 (centaurin-α1) in Neuronal Differentiation and Neurodegenerative Diseases, With an Overview of Structural and Biochemical Properties of ADAP1) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| KIF13B | GO:0050770 | regulation of axonogenesis | 20194617 |
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Gene structures and expression levels for KIF13B |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000197892
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000523130.1 | KIF13B-204:protein_coding:KIF13B | 1.025584e+01 | 8.372021e-01 | 6.597499e-04 | 1.078228e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for KIF13B |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_115158 | chr8 | 29190997:29191057:29196187:29196199:29245346:29245439 | 29196187:29196199 |
| exon_skip_129470 | chr8 | 29071676:29072316:29075281:29075343:29092745:29092878 | 29075281:29075343 |
| exon_skip_129900 | chr8 | 29189301:29191057:29196187:29196199:29245346:29245439 | 29196187:29196199 |
| exon_skip_173717 | chr8 | 29196187:29196199:29245346:29245439:29262980:29263062 | 29245346:29245439 |
| exon_skip_192759 | chr8 | 29071620:29072316:29075281:29075343:29092745:29092878 | 29075281:29075343 |
| exon_skip_21870 | chr8 | 29150297:29150383:29155726:29155856:29160733:29160867 | 29155726:29155856 |
| exon_skip_257705 | chr8 | 29075281:29075343:29092745:29092878:29099133:29099241 | 29092745:29092878 |
| exon_skip_275905 | chr8 | 29160733:29160867:29165662:29165772:29167373:29167585 | 29165662:29165772 |
| exon_skip_283352 | chr8 | 29071620:29072316:29092745:29092878:29099133:29099241 | 29092745:29092878 |
| exon_skip_288526 | chr8 | 29109918:29110070:29113463:29113555:29116831:29117007 | 29113463:29113555 |
| exon_skip_295803 | chr8 | 29245346:29245439:29249985:29250084:29262980:29263062 | 29249985:29250084 |
| exon_skip_3923 | chr8 | 29071620:29072316:29075281:29075343:29092745:29092871 | 29075281:29075343 |
| exon_skip_65910 | chr8 | 29123366:29123492:29124024:29124123:29126482:29126511 | 29124024:29124123 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for KIF13B |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000524189 | 29092745 | 29092878 | Frame-shift |
| ENST00000524189 | 29124024 | 29124123 | Frame-shift |
| ENST00000524189 | 29196187 | 29196199 | Frame-shift |
| ENST00000524189 | 29075281 | 29075343 | In-frame |
| ENST00000524189 | 29165662 | 29165772 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000524189 | 29092745 | 29092878 | Frame-shift |
| ENST00000524189 | 29124024 | 29124123 | Frame-shift |
| ENST00000524189 | 29155726 | 29155856 | Frame-shift |
| ENST00000524189 | 29196187 | 29196199 | Frame-shift |
| ENST00000524189 | 29075281 | 29075343 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000524189 | 29092745 | 29092878 | Frame-shift |
| ENST00000524189 | 29124024 | 29124123 | Frame-shift |
| ENST00000524189 | 29155726 | 29155856 | Frame-shift |
| ENST00000524189 | 29196187 | 29196199 | Frame-shift |
| ENST00000524189 | 29075281 | 29075343 | In-frame |
| ENST00000524189 | 29113463 | 29113555 | In-frame |
| ENST00000524189 | 29165662 | 29165772 | In-frame |
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Infer the effects of exon skipping event on protein functional features for KIF13B |
p-ENSG00000197892_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000524189 | 8762 | 1826 | 29165662 | 29165772 | 1198 | 1307 | 386 | 422 |
| ENST00000524189 | 8762 | 1826 | 29075281 | 29075343 | 4498 | 4559 | 1486 | 1506 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000524189 | 8762 | 1826 | 29075281 | 29075343 | 4498 | 4559 | 1486 | 1506 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000524189 | 8762 | 1826 | 29165662 | 29165772 | 1198 | 1307 | 386 | 422 |
| ENST00000524189 | 8762 | 1826 | 29113463 | 29113555 | 3877 | 3968 | 1279 | 1309 |
| ENST00000524189 | 8762 | 1826 | 29075281 | 29075343 | 4498 | 4559 | 1486 | 1506 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NQT8 | 386 | 422 | 1 | 1460 | Alternative sequence | ID=VSP_056360;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NQT8 | 386 | 422 | 1 | 1826 | Chain | ID=PRO_0000125448;Note=Kinesin-like protein KIF13B |
| Q9NQT8 | 386 | 422 | 364 | 439 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9NQT8 | 1486 | 1506 | 1487 | 1507 | Alternative sequence | ID=VSP_056361;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NQT8 | 1486 | 1506 | 1 | 1826 | Chain | ID=PRO_0000125448;Note=Kinesin-like protein KIF13B |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NQT8 | 1486 | 1506 | 1487 | 1507 | Alternative sequence | ID=VSP_056361;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NQT8 | 1486 | 1506 | 1 | 1826 | Chain | ID=PRO_0000125448;Note=Kinesin-like protein KIF13B |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NQT8 | 386 | 422 | 1 | 1460 | Alternative sequence | ID=VSP_056360;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NQT8 | 386 | 422 | 1 | 1826 | Chain | ID=PRO_0000125448;Note=Kinesin-like protein KIF13B |
| Q9NQT8 | 386 | 422 | 364 | 439 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9NQT8 | 1279 | 1309 | 1 | 1460 | Alternative sequence | ID=VSP_056360;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NQT8 | 1279 | 1309 | 1 | 1826 | Chain | ID=PRO_0000125448;Note=Kinesin-like protein KIF13B |
| Q9NQT8 | 1486 | 1506 | 1487 | 1507 | Alternative sequence | ID=VSP_056361;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NQT8 | 1486 | 1506 | 1 | 1826 | Chain | ID=PRO_0000125448;Note=Kinesin-like protein KIF13B |
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3'-UTR located exon skipping events that lost miRNA binding sites in KIF13B |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for KIF13B |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for KIF13B |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for KIF13B |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| DLPFC | exon_skip_65910 | rs11775127 | chr8:29117527 | 2.471601e-05 | 2.499174e-03 |
| DLPFC | exon_skip_65910 | rs17527001 | chr8:29122509 | 2.471601e-05 | 2.499174e-03 |
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Correlation with RNA binding proteins (RBPs) for KIF13B |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TRA2A | exon_skip_65910 | -4.481640e-01 | 7.971330e-08 |
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RelatedDrugs for KIF13B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KIF13B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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