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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ADGRL3 |
 Gene summary |
| Gene information | Gene symbol | ADGRL3 | Gene ID | 23284 |
| Gene name | adhesion G protein-coupled receptor L3 | |
| Synonyms | CIRL3|CL3|LEC3|LPHN3 | |
| Cytomap | 4q13.1 | |
| Type of gene | protein-coding | |
| Description | adhesion G protein-coupled receptor L3CIRL-3calcium-independent alpha-latrotoxin receptor 3latrophilin homolog 3 (cow)latrophilin-3lectomedin 3 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ADGRL3 | GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 26235030 |
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Gene structures and expression levels for ADGRL3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000150471
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ADGRL3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_110522 | chr4 | 61948100:61948276:61979563:61979772:61983383:61983603 | 61979563:61979772 |
| exon_skip_110798 | chr4 | 61946914:61947122:61948100:61948276:61979563:61979772 | 61948100:61948276 |
| exon_skip_14640 | chr4 | 61909560:61909745:61912719:61912757:61934840:61935023 | 61912719:61912757 |
| exon_skip_184843 | chr4 | 62044453:62044549:62068166:62068217:62070109:62070993 | 62068166:62068217 |
| exon_skip_184961 | chr4 | 61497294:61497348:61587227:61587440:61676826:61676935 | 61587227:61587440 |
| exon_skip_19712 | chr4 | 61497294:61497348:61517315:61517518:61587227:61587440 | 61517315:61517518 |
| exon_skip_199759 | chr4 | 62037731:62037856:62044453:62044549:62068166:62068183 | 62044453:62044549 |
| exon_skip_228978 | chr4 | 62044453:62044549:62063505:62063633:62070109:62070993 | 62063505:62063633 |
| exon_skip_237141 | chr4 | 61732754:61733554:61813809:61813889:61892656:61892958 | 61813809:61813889 |
| exon_skip_242391 | chr4 | 61676826:61676935:61730622:61730636:61732754:61733302 | 61730622:61730636 |
| exon_skip_253627 | chr4 | 61998174:61998265:62028855:62028881:62031442:62031576 | 62028855:62028881 |
| exon_skip_254126 | chr4 | 61998174:61998265:62028855:62028881:62031442:62031528 | 62028855:62028881 |
| exon_skip_274093 | chr4 | 61587368:61587440:61676826:61676935:61730622:61730636 | 61676826:61676935 |
| exon_skip_279587 | chr4 | 61676826:61676935:61730622:61730636:61732754:61733282 | 61730622:61730636 |
| exon_skip_283265 | chr4 | 61733336:61733554:61813809:61813889:61892656:61892958 | 61813809:61813889 |
| exon_skip_46561 | chr4 | 61676826:61676935:61730622:61730636:61732754:61733554 | 61730622:61730636 |
| exon_skip_58622 | chr4 | 62044453:62044549:62063505:62063633:62068166:62068183 | 62063505:62063633 |
| exon_skip_60323 | chr4 | 62063505:62063633:62068166:62068217:62070109:62070993 | 62068166:62068217 |
| exon_skip_92195 | chr4 | 61998174:61998265:62028855:62028881:62031442:62031610 | 62028855:62028881 |
| exon_skip_93303 | chr4 | 62037731:62037856:62044453:62044549:62070109:62070993 | 62044453:62044549 |
| exon_skip_9730 | chr4 | 61998174:61998265:62031442:62031610:62037731:62037856 | 62031442:62031610 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_184843 | MSBB_STG | 3.354687e-01 | 4.491667e-01 | -1.136979e-01 | 3.809247e-02 |
| exon_skip_253627 | MSBB_PG | 4.000676e-01 | 5.036842e-01 | -1.036166e-01 | 3.198577e-05 |
| exon_skip_184843 | MSBB_PG | 2.363971e-01 | 3.618182e-01 | -1.254211e-01 | 8.110063e-04 |
| exon_skip_14640 | Mayo_TC | 5.892683e-01 | 6.907576e-01 | -1.014893e-01 | 3.879974e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for ADGRL3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for ADGRL3 |
p-ENSG00000150471_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ADGRL3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ADGRL3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ADGRL3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | MSBB | IFG | exon_skip_92195 | -4.311375e-01 | 2.198763e-02 | chr4 | + | 61998174 | 61998265 | 62028855 | 62028881 | 62031442 | 62031610 |
| ADstage | MSBB | IFG | exon_skip_228978 | -4.187829e-01 | 2.655220e-02 | chr4 | + | 62044453 | 62044549 | 62063505 | 62063633 | 62070109 | 62070993 |
| ADstage | MSBB | IFG | exon_skip_46561 | -3.812144e-01 | 4.533472e-02 | chr4 | + | 61676826 | 61676935 | 61730622 | 61730636 | 61732754 | 61733554 |
| CDR | MSBB | IFG | exon_skip_92195 | -5.189933e-01 | 4.656592e-03 | chr4 | + | 61998174 | 61998265 | 62028855 | 62028881 | 62031442 | 62031610 |
| CDR | MSBB | IFG | exon_skip_184843 | -4.473285e-01 | 1.699776e-02 | chr4 | + | 62044453 | 62044549 | 62068166 | 62068217 | 62070109 | 62070993 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ADGRL3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| HCC | exon_skip_19712 | rs335314 | chr4:61520399 | 2.211427e-04 | 1.762339e-02 |
| HCC | exon_skip_19712 | rs335315 | chr4:61520913 | 2.211427e-04 | 1.762339e-02 |
| HCC | exon_skip_19712 | rs335317 | chr4:61521422 | 2.211427e-04 | 1.762339e-02 |
| HCC | exon_skip_19712 | rs335302 | chr4:61530685 | 5.950523e-04 | 3.885226e-02 |
| DLPFC | exon_skip_184843 | rs997407 | chr4:62012598 | 5.217174e-04 | 3.337772e-02 |
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Correlation with RNA binding proteins (RBPs) for ADGRL3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | G3BP2 | exon_skip_92195 | 4.688002e-01 | 2.116349e-09 |
| CB | SRSF9 | exon_skip_92195 | 5.040085e-01 | 7.626262e-11 |
| CB | NOVA1 | exon_skip_92195 | 4.062369e-01 | 3.304253e-07 |
| CB | SRSF11 | exon_skip_184843 | 4.229238e-01 | 6.308467e-08 |
| CB | RBM3 | exon_skip_184843 | 5.163186e-01 | 1.155253e-11 |
| CB | NUP42 | exon_skip_184843 | 7.248150e-01 | 6.937301e-26 |
| CB | NOVA1 | exon_skip_184843 | 4.397772e-01 | 1.606913e-08 |
| DLPFC | RC3H1 | exon_skip_184843 | 4.480222e-01 | 8.989957e-16 |
| FL | RBM24 | exon_skip_46561 | 4.128134e-01 | 1.505847e-09 |
| FL | G3BP2 | exon_skip_92195 | 6.850588e-01 | 8.950631e-29 |
| FL | SRSF9 | exon_skip_92195 | 4.956485e-01 | 1.134360e-13 |
| FL | NOVA1 | exon_skip_92195 | 5.118065e-01 | 1.296635e-14 |
| FL | RBM3 | exon_skip_184843 | 4.563763e-01 | 2.876021e-11 |
| FL | NOVA1 | exon_skip_184843 | 4.254910e-01 | 7.642425e-10 |
| HCC | G3BP2 | exon_skip_254126 | 4.379283e-01 | 4.959457e-14 |
| HCC | SRSF11 | exon_skip_184843 | -5.169365e-01 | 6.421274e-20 |
| HCC | CNOT4 | exon_skip_184843 | -4.459877e-01 | 1.192897e-14 |
| IFG | SRSF11 | exon_skip_19712 | 4.359665e-01 | 2.038792e-02 |
| IFG | RBM5 | exon_skip_19712 | 4.373392e-01 | 1.995104e-02 |
| IFG | EIF4G2 | exon_skip_19712 | 5.087191e-01 | 5.702816e-03 |
| IFG | SRSF4 | exon_skip_19712 | 4.572937e-01 | 1.442078e-02 |
| IFG | G3BP2 | exon_skip_92195 | 6.431023e-01 | 2.232777e-04 |
| IFG | RBMS2 | exon_skip_58622 | 5.117573e-01 | 7.531213e-03 |
| IFG | RBM3 | exon_skip_114601 | 5.623604e-01 | 1.840682e-03 |
| IFG | RBM3 | exon_skip_184843 | 4.825984e-01 | 9.294807e-03 |
| PCC | G3BP2 | exon_skip_92195 | 7.016953e-01 | 5.191464e-32 |
| PCC | SRSF11 | exon_skip_184843 | -4.040008e-01 | 9.962357e-10 |
| PG | RBM3 | exon_skip_114601 | 4.331731e-01 | 1.010825e-09 |
| PG | SRSF11 | exon_skip_184843 | 4.229167e-01 | 1.095214e-09 |
| PG | RBM3 | exon_skip_184843 | 5.268123e-01 | 4.944828e-15 |
| PG | IGF2BP2 | exon_skip_184843 | -4.136075e-01 | 2.729132e-09 |
| PG | NUP42 | exon_skip_184843 | 4.183132e-01 | 1.726231e-09 |
| PG | NOVA1 | exon_skip_184843 | 4.941785e-01 | 3.726109e-13 |
| STG | NUP42 | exon_skip_14640 | 4.068738e-01 | 6.273729e-05 |
| STG | G3BP2 | exon_skip_92195 | 5.931437e-01 | 4.660840e-10 |
| STG | SRSF9 | exon_skip_92195 | 4.200567e-01 | 3.066241e-05 |
| STG | NOVA1 | exon_skip_92195 | 4.481642e-01 | 7.469680e-06 |
| STG | RBFOX2 | exon_skip_58622 | 4.278991e-01 | 3.385506e-04 |
| STG | ILF2 | exon_skip_58622 | 4.390339e-01 | 2.262906e-04 |
| STG | SRSF11 | exon_skip_184843 | 4.658410e-01 | 4.791346e-06 |
| STG | RBM3 | exon_skip_184843 | 5.716501e-01 | 5.988251e-09 |
| STG | IGF2BP2 | exon_skip_184843 | -4.870683e-01 | 1.492707e-06 |
| STG | NUP42 | exon_skip_184843 | 5.010285e-01 | 6.635577e-07 |
| STG | NOVA1 | exon_skip_184843 | 5.552541e-01 | 1.971296e-08 |
| TC | G3BP2 | exon_skip_92195 | 6.963254e-01 | 1.643374e-23 |
| TC | NOVA1 | exon_skip_92195 | 7.265135e-01 | 2.202804e-26 |
| TC | RBM3 | exon_skip_184843 | 4.886254e-01 | 1.116914e-10 |
| TC | NUP42 | exon_skip_184843 | 7.183571e-01 | 6.887964e-26 |
| TC | NOVA1 | exon_skip_184843 | 7.352068e-01 | 1.267251e-27 |
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RelatedDrugs for ADGRL3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ADGRL3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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