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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for NUP160 |
Gene summary |
Gene information | Gene symbol | NUP160 | Gene ID | 23279 |
Gene name | nucleoporin 160 | |
Synonyms | NPHS19 | |
Cytomap | 11p11.2 | |
Type of gene | protein-coding | |
Description | nuclear pore complex protein Nup160160 kDa nucleoporinnucleoporin 160kDnucleoporin 160kDanucleoporin Nup160 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context | - 27215977(miRNA-dependent target regulation: functional characterization of single-nucleotide polymorphisms identified in genome-wide association studies of Alzheimer's disease) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
NUP160 | GO:0006406 | mRNA export from nucleus | 11684705 |
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Gene structures and expression levels for NUP160 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | UP | ENST00000528071.5 | NUP160-206:protein_coding:NUP160 | 6.107446e+01 | 9.139750e-01 | 1.640884e-11 | 1.460526e-09 |
CB | UP | ENST00000528501.5 | NUP160-207:nonsense_mediated_decay:NUP160 | 5.761823e+00 | 9.025747e-01 | 7.644087e-05 | 5.905840e-04 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NUP160 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_104050 | chr11 | 47798368:47798463:47801811:47801930:47803438:47803536 | 47801811:47801930 |
exon_skip_120226 | chr11 | 47806153:47806312:47807070:47807140:47808396:47808529 | 47807070:47807140 |
exon_skip_121400 | chr11 | 47778087:47779194:47780343:47780447:47783073:47783198 | 47780343:47780447 |
exon_skip_22069 | chr11 | 47815946:47816029:47818056:47818124:47819374:47819458 | 47818056:47818124 |
exon_skip_270835 | chr11 | 47788501:47788611:47791930:47791990:47792786:47792946 | 47791930:47791990 |
exon_skip_44405 | chr11 | 47797978:47798074:47798168:47798262:47798368:47798463 | 47798168:47798262 |
exon_skip_47920 | chr11 | 47839946:47840065:47840378:47840588:47847848:47847959 | 47840378:47840588 |
exon_skip_66787 | chr11 | 47822087:47822164:47827075:47827194:47835651:47835809 | 47827075:47827194 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for NUP160 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for NUP160 |
p-ENSG00000030066_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in NUP160 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for NUP160 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for NUP160 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NUP160 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for NUP160 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | TARDBP | exon_skip_270835 | -5.266524e-01 | 2.289096e-12 |
CB | RBM6 | exon_skip_270835 | -4.122891e-01 | 1.078724e-07 |
CB | CNOT4 | exon_skip_270835 | -5.518441e-01 | 1.189421e-13 |
CB | PCBP1 | exon_skip_270835 | -4.563520e-01 | 2.711828e-09 |
CB | SNRPA | exon_skip_270835 | -4.071980e-01 | 1.597471e-07 |
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RelatedDrugs for NUP160 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NUP160 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |