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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for EXOC7 |
 Gene summary |
| Gene information | Gene symbol | EXOC7 | Gene ID | 23265 |
| Gene name | exocyst complex component 7 | |
| Synonyms | 2-5-3p|BLOM4|EX070|EXO70|EXOC1|Exo70p|YJL085W | |
| Cytomap | 17q25.1 | |
| Type of gene | protein-coding | |
| Description | exocyst complex component 7exocyst complex component Exo70 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for EXOC7 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000182473
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | DOWN | ENST00000467929.6 | EXOC7-213:protein_coding:EXOC7 | 5.939820e+01 | -1.113991e+00 | 3.753298e-03 | 3.745228e-02 |
| CB | DOWN | ENST00000591724.1 | EXOC7-218:lncRNA:EXOC7 | 3.574741e+00 | -2.179834e+00 | 1.302129e-05 | 1.316904e-04 |
| TC | DOWN | ENST00000591724.1 | EXOC7-218:lncRNA:EXOC7 | 7.034116e+00 | -3.062594e+00 | 7.958835e-11 | 1.584349e-08 |
| TC | DOWN | ENST00000465252.5 | EXOC7-211:retained_intron:EXOC7 | 4.740226e+01 | -9.045253e-01 | 3.635449e-05 | 7.197436e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for EXOC7 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_112787 | chr17 | 76090329:76090397:76091143:76091235:76094414:76094489 | 76091143:76091235 |
| exon_skip_118705 | chr17 | 76086080:76086145:76086854:76086892:76087654:76087699 | 76086854:76086892 |
| exon_skip_122716 | chr17 | 76085677:76085797:76086080:76086145:76087654:76087708 | 76086080:76086145 |
| exon_skip_155931 | chr17 | 76089175:76089320:76091143:76091235:76094414:76094489 | 76091143:76091235 |
| exon_skip_16247 | chr17 | 76089175:76089320:76090329:76090397:76094414:76094581 | 76090329:76090397 |
| exon_skip_191633 | chr17 | 76084006:76084139:76084248:76084289:76084517:76084580 | 76084248:76084289 |
| exon_skip_193650 | chr17 | 76088780:76088923:76089175:76089320:76094414:76094489 | 76089175:76089320 |
| exon_skip_21069 | chr17 | 76101271:76101376:76101679:76101863:76103361:76103426 | 76101679:76101863 |
| exon_skip_244261 | chr17 | 76088771:76088923:76089175:76089320:76094414:76094489 | 76089175:76089320 |
| exon_skip_274135 | chr17 | 76090329:76090397:76091143:76091235:76094414:76094581 | 76091143:76091235 |
| exon_skip_28373 | chr17 | 76089175:76089320:76090329:76090397:76094414:76094489 | 76090329:76090397 |
| exon_skip_286281 | chr17 | 76083648:76083750:76084006:76084139:76084248:76084289 | 76084006:76084139 |
| exon_skip_31493 | chr17 | 76086080:76086145:76086854:76086892:76087654:76087702 | 76086854:76086892 |
| exon_skip_38254 | chr17 | 76086080:76086145:76086854:76086892:76087654:76087708 | 76086854:76086892 |
| exon_skip_45786 | chr17 | 76085677:76085797:76086080:76086145:76087654:76087720 | 76086080:76086145 |
| exon_skip_81409 | chr17 | 76089175:76089320:76090329:76090397:76091143:76091235 | 76090329:76090397 |
| exon_skip_82729 | chr17 | 76087654:76087720:76088060:76088122:76088464:76088562 | 76088060:76088122 |
| exon_skip_91999 | chr17 | 76088861:76088923:76089175:76089320:76094414:76094489 | 76089175:76089320 |
| exon_skip_94006 | chr17 | 76084006:76084139:76084248:76084289:76084517:76084570 | 76084248:76084289 |
| exon_skip_98286 | chr17 | 76089175:76089320:76090329:76090481:76091143:76091235 | 76090329:76090481 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_38254 | MSBB_PG | 4.379508e-01 | 6.101887e-01 | -1.722379e-01 | 6.807114e-03 |
| exon_skip_155931 | MSBB_PG | 6.821429e-01 | 8.178846e-01 | -1.357418e-01 | 4.570190e-04 |
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Open reading frame (ORF) annotation in the exon skipping event for EXOC7 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000589210 | 76084248 | 76084289 | In-frame |
| ENST00000589210 | 76086080 | 76086145 | In-frame |
| ENST00000589210 | 76088060 | 76088122 | In-frame |
| ENST00000589210 | 76091143 | 76091235 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000589210 | 76088060 | 76088122 | In-frame |
| ENST00000589210 | 76091143 | 76091235 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000589210 | 76084006 | 76084139 | Frame-shift |
| ENST00000589210 | 76101679 | 76101863 | Frame-shift |
| ENST00000589210 | 76084248 | 76084289 | In-frame |
| ENST00000589210 | 76088060 | 76088122 | In-frame |
| ENST00000589210 | 76091143 | 76091235 | In-frame |
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Infer the effects of exon skipping event on protein functional features for EXOC7 |
p-ENSG00000182473_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in EXOC7 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for EXOC7 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for EXOC7 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | ROSMAP | PCC | exon_skip_155931 | -3.106561e-01 | 3.420000e-06 | chr17 | - | 76089175 | 76089320 | 76091143 | 76091235 | 76094414 | 76094489 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for EXOC7 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for EXOC7 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | HNRNPDL | exon_skip_38254 | 4.054183e-01 | 1.150291e-07 |
| CB | RALYL | exon_skip_38254 | 6.482566e-01 | 2.529568e-20 |
| CB | NUP42 | exon_skip_165280 | 4.163463e-01 | 8.662953e-08 |
| CB | NUP42 | exon_skip_234561 | 4.428283e-01 | 9.940865e-09 |
| CB | TIA1 | exon_skip_44715 | 4.639766e-01 | 1.970983e-09 |
| CB | RBM3 | exon_skip_44715 | 4.200424e-01 | 7.911584e-08 |
| CB | UNK | exon_skip_44715 | 4.494018e-01 | 7.112590e-09 |
| CB | HNRNPA1 | exon_skip_44715 | 4.202146e-01 | 7.805718e-08 |
| CB | FUBP3 | exon_skip_44715 | 4.190879e-01 | 8.523908e-08 |
| CB | RBM45 | exon_skip_44715 | 4.426188e-01 | 1.266564e-08 |
| CB | NUP42 | exon_skip_44715 | 5.248681e-01 | 4.578958e-12 |
| CB | NUP42 | exon_skip_155931 | 4.924232e-01 | 4.317316e-11 |
| CB | NUP42 | exon_skip_153754 | 4.052197e-01 | 1.543003e-07 |
| DLPFC | CNOT4 | exon_skip_38254 | 6.165030e-01 | 9.981290e-27 |
| DLPFC | HNRNPDL | exon_skip_38254 | 6.935882e-01 | 4.807929e-36 |
| DLPFC | RALYL | exon_skip_38254 | 7.991135e-01 | 5.873176e-55 |
| DLPFC | HNRNPL | exon_skip_38254 | 7.048730e-01 | 1.163009e-37 |
| FL | RALYL | exon_skip_38254 | 6.624537e-01 | 7.042164e-26 |
| FL | HNRNPL | exon_skip_38254 | 4.785064e-01 | 1.704235e-12 |
| FL | MSI1 | exon_skip_155931 | -4.756308e-01 | 2.115197e-12 |
| HCC | RBMS3 | exon_skip_38254 | -4.778801e-01 | 5.552579e-17 |
| HCC | RBM6 | exon_skip_38254 | -6.261167e-01 | 4.006452e-31 |
| HCC | CNOT4 | exon_skip_38254 | -4.232833e-01 | 2.709063e-13 |
| HCC | IGF2BP2 | exon_skip_38254 | -4.400932e-01 | 2.326642e-14 |
| HCC | MSI1 | exon_skip_155931 | -6.332099e-01 | 5.332651e-32 |
| HCC | RBM5 | exon_skip_155931 | -4.258201e-01 | 1.886664e-13 |
| HCC | HNRNPF | exon_skip_155931 | -5.872340e-01 | 1.066613e-26 |
| IFG | IGF2BP2 | exon_skip_38254 | -5.558923e-01 | 2.130826e-03 |
| IFG | RALYL | exon_skip_38254 | 5.191893e-01 | 4.638346e-03 |
| PCC | RBM6 | exon_skip_31493 | -4.564923e-01 | 2.060173e-12 |
| PCC | RALYL | exon_skip_31493 | 5.010938e-01 | 5.268853e-15 |
| PCC | MSI1 | exon_skip_155931 | -4.400707e-01 | 1.348154e-11 |
| PCC | HNRNPF | exon_skip_155931 | -5.937305e-01 | 7.176613e-22 |
| PG | CNOT4 | exon_skip_38254 | 4.460885e-01 | 6.135368e-10 |
| PG | IGF2BP2 | exon_skip_38254 | -4.875156e-01 | 7.797774e-12 |
| PG | HNRNPDL | exon_skip_38254 | 5.172319e-01 | 2.325051e-13 |
| PG | RALYL | exon_skip_38254 | 8.074413e-01 | 1.677394e-41 |
| PG | HNRNPL | exon_skip_38254 | 6.396027e-01 | 1.619405e-21 |
| PG | MSI1 | exon_skip_155931 | -5.106992e-01 | 3.266535e-13 |
| PG | RBM25 | exon_skip_155931 | 4.550900e-01 | 1.747704e-10 |
| PG | CNOT4 | exon_skip_155931 | 4.121334e-01 | 1.091236e-08 |
| PG | NUP42 | exon_skip_155931 | 4.680912e-01 | 4.444991e-11 |
| PG | HNRNPH2 | exon_skip_155931 | 6.393381e-01 | 7.674075e-22 |
| STG | IGF2BP2 | exon_skip_38254 | -5.232595e-01 | 3.277149e-07 |
| STG | HNRNPDL | exon_skip_38254 | 4.093351e-01 | 1.105249e-04 |
| STG | RALYL | exon_skip_38254 | 6.659914e-01 | 4.749210e-12 |
| STG | ESRP2 | exon_skip_38254 | -4.894718e-01 | 2.301418e-06 |
| STG | NUP42 | exon_skip_155931 | 4.563792e-01 | 8.883675e-06 |
| STG | HNRNPH2 | exon_skip_155931 | 4.812160e-01 | 2.379987e-06 |
| TC | CNOT4 | exon_skip_118705 | 4.570643e-01 | 1.236373e-09 |
| TC | HNRNPDL | exon_skip_118705 | 4.917005e-01 | 4.040105e-11 |
| TC | RALYL | exon_skip_118705 | 8.610039e-01 | 2.973096e-48 |
| TC | HNRNPL | exon_skip_118705 | 4.509201e-01 | 2.181784e-09 |
| TC | ELAVL4 | exon_skip_44715 | 5.328213e-01 | 1.134857e-12 |
| TC | KHDRBS2 | exon_skip_44715 | 4.780498e-01 | 3.613744e-10 |
| TC | RBM24 | exon_skip_44715 | 4.235177e-01 | 4.432767e-08 |
| TC | PUM1 | exon_skip_44715 | 4.066734e-01 | 1.662820e-07 |
| TC | NUP42 | exon_skip_44715 | 4.483482e-01 | 5.508170e-09 |
| TC | RALYL | exon_skip_44715 | 4.642423e-01 | 1.324397e-09 |
| TC | ESRP1 | exon_skip_44715 | 4.025419e-01 | 2.274711e-07 |
| TC | MSI1 | exon_skip_155931 | -4.277962e-01 | 1.676673e-08 |
| TC | NUP42 | exon_skip_155931 | 6.696170e-01 | 3.647098e-22 |
| TC | PTBP3 | exon_skip_155931 | 4.003118e-01 | 1.563759e-07 |
| TC | HNRNPH2 | exon_skip_155931 | 6.521405e-01 | 9.563323e-21 |
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RelatedDrugs for EXOC7 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EXOC7 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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