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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for NUP210 |
 Gene summary |
| Gene information | Gene symbol | NUP210 | Gene ID | 23225 |
| Gene name | nucleoporin 210 | |
| Synonyms | GP210|POM210 | |
| Cytomap | 3p25.1 | |
| Type of gene | protein-coding | |
| Description | nuclear pore membrane glycoprotein 210nuclear envelope pore membrane protein POM 210nuclear pore protein gp210nucleoporin 210kDanucleoporin Nup210pore membrane protein of 210 kDa | |
| Modification date | 20200320 | |
| UniProtAcc | Q8TEM1, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for NUP210 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000132182
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NUP210 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_101087 | chr3 | 13332293:13332384:13335454:13335612:13336787:13336918 | 13335454:13335612 |
| exon_skip_193859 | chr3 | 13376291:13376431:13377456:13377562:13378912:13378980 | 13377456:13377562 |
| exon_skip_204373 | chr3 | 13328771:13328946:13330460:13330634:13332293:13332384 | 13330460:13330634 |
| exon_skip_21017 | chr3 | 13365946:13366091:13371834:13372032:13373718:13373873 | 13371834:13372032 |
| exon_skip_72261 | chr3 | 13339854:13340033:13340236:13340298:13341748:13341883 | 13340236:13340298 |
| exon_skip_74924 | chr3 | 13360270:13360491:13365946:13366091:13371834:13372032 | 13365946:13366091 |
| exon_skip_9096 | chr3 | 13340236:13340298:13341748:13341883:13341996:13342123 | 13341748:13341883 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for NUP210 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000254508 | 13341748 | 13341883 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000254508 | 13371834 | 13372032 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000254508 | 13330460 | 13330634 | Frame-shift |
| ENST00000254508 | 13341748 | 13341883 | Frame-shift |
| ENST00000254508 | 13365946 | 13366091 | Frame-shift |
| ENST00000254508 | 13377456 | 13377562 | Frame-shift |
| ENST00000254508 | 13335454 | 13335612 | In-frame |
| ENST00000254508 | 13340236 | 13340298 | In-frame |
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Infer the effects of exon skipping event on protein functional features for NUP210 |
p-ENSG00000132182_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000254508 | 7210 | 1887 | 13340236 | 13340298 | 3312 | 3373 | 1076 | 1096 |
| ENST00000254508 | 7210 | 1887 | 13335454 | 13335612 | 3768 | 3925 | 1228 | 1280 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8TEM1 | 1076 | 1096 | 968 | 1887 | Alternative sequence | ID=VSP_018568;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q8TEM1 | 1076 | 1096 | 27 | 1887 | Chain | ID=PRO_0000236046;Note=Nuclear pore membrane glycoprotein 210 |
| Q8TEM1 | 1076 | 1096 | 1078 | 1151 | Domain | Note=BIG2;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8TEM1 | 1076 | 1096 | 1096 | 1096 | Natural variant | ID=VAR_028152;Note=M->I;Dbxref=dbSNP:rs2271505 |
| Q8TEM1 | 1076 | 1096 | 27 | 1808 | Topological domain | Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q8TEM1 | 1228 | 1280 | 968 | 1887 | Alternative sequence | ID=VSP_018568;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q8TEM1 | 1228 | 1280 | 27 | 1887 | Chain | ID=PRO_0000236046;Note=Nuclear pore membrane glycoprotein 210 |
| Q8TEM1 | 1228 | 1280 | 27 | 1808 | Topological domain | Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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3'-UTR located exon skipping events that lost miRNA binding sites in NUP210 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for NUP210 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for NUP210 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NUP210 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for NUP210 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TARDBP | exon_skip_9096 | -4.173383e-01 | 7.260622e-08 |
| CB | SAMD4A | exon_skip_9096 | -5.206840e-01 | 4.453266e-12 |
| CB | CNOT4 | exon_skip_9096 | -4.699434e-01 | 7.801068e-10 |
| CB | PCBP1 | exon_skip_9096 | -4.442785e-01 | 7.842670e-09 |
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RelatedDrugs for NUP210 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NUP210 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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