|
||||||
|
 | |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| 3'-UTR located exon skipping events lost miRNA binding sites |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| |
| |
|
Gene summary for FLT3 |
 Gene summary |
| Gene information | Gene symbol | FLT3 | Gene ID | 2322 |
| Gene name | fms related receptor tyrosine kinase 3 | |
| Synonyms | CD135|FLK-2|FLK2|STK1 | |
| Cytomap | 13q12.2 | |
| Type of gene | protein-coding | |
| Description | receptor-type tyrosine-protein kinase FLT3CD135 antigenFL cytokine receptorfetal liver kinase 2fms related tyrosine kinase 3fms-like tyrosine kinase 3growth factor receptor tyrosine kinase type IIIstem cell tyrosine kinase 1 | |
| Modification date | 20200329 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| FLT3 | GO:0030097 | hemopoiesis | 7507245 |
Top |
Gene structures and expression levels for FLT3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
ENSG00000122025
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| TC | DOWN | 5.311082e+01 | -8.311343e-01 | 5.900855e-06 | 8.615687e-05 |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
 |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FLT3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_110143 | chr13 | 28035495:28035673:28035935:28036043:28037185:28037288 | 28035935:28036043 |
| exon_skip_146232 | chr13 | 28015157:28015256:28015590:28015701:28018467:28018589 | 28015590:28015701 |
| exon_skip_166859 | chr13 | 28024861:28024943:28025284:28025415:28027088:28027241 | 28025284:28025415 |
| exon_skip_216499 | chr13 | 28015590:28015701:28018467:28018589:28023350:28023477 | 28018467:28018589 |
| exon_skip_223479 | chr13 | 28061867:28062069:28070491:28070612:28100468:28100592 | 28070491:28070612 |
| exon_skip_253013 | chr13 | 28049384:28049537:28049635:28049774:28050095:28050222 | 28049635:28049774 |
| exon_skip_262064 | chr13 | 28023350:28023477:28024861:28024943:28027088:28027241 | 28024861:28024943 |
| exon_skip_283901 | chr13 | 28035935:28036043:28037185:28037288:28048275:28048443 | 28037185:28037288 |
| exon_skip_38511 | chr13 | 28018467:28018589:28023350:28023477:28024861:28024943 | 28023350:28023477 |
| exon_skip_4381 | chr13 | 28050095:28050222:28052545:28052674:28057347:28057462 | 28052545:28052674 |
| exon_skip_62115 | chr13 | 28003947:28004174:28009306:28009490:28014452:28014512 | 28009306:28009490 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for FLT3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000241453 | 28052545 | 28052674 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000241453 | 28037185 | 28037288 | Frame-shift |
| ENST00000241453 | 28052545 | 28052674 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000241453 | 28015590 | 28015701 | Frame-shift |
| ENST00000241453 | 28023350 | 28023477 | Frame-shift |
| ENST00000241453 | 28024861 | 28024943 | Frame-shift |
| ENST00000241453 | 28035935 | 28036043 | Frame-shift |
| ENST00000241453 | 28037185 | 28037288 | Frame-shift |
| ENST00000241453 | 28049635 | 28049774 | Frame-shift |
| ENST00000241453 | 28052545 | 28052674 | Frame-shift |
| ENST00000241453 | 28018467 | 28018589 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for FLT3 |
p-ENSG00000122025_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000241453 | 3859 | 993 | 28018467 | 28018589 | 2501 | 2622 | 806 | 846 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P36888 | 806 | 846 | 811 | 811 | Active site | Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10028 |
| P36888 | 806 | 846 | 807 | 847 | Alternative sequence | ID=VSP_041796;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P36888 | 806 | 846 | 807 | 809 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJB |
| P36888 | 806 | 846 | 817 | 820 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJB |
| P36888 | 806 | 846 | 824 | 827 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJB |
| P36888 | 806 | 846 | 842 | 845 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJB |
| P36888 | 806 | 846 | 27 | 993 | Chain | ID=PRO_0000016778;Note=Receptor-type tyrosine-protein kinase FLT3 |
| P36888 | 806 | 846 | 610 | 943 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P36888 | 806 | 846 | 814 | 816 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJB |
| P36888 | 806 | 846 | 831 | 833 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJB |
| P36888 | 806 | 846 | 836 | 838 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJB |
| P36888 | 806 | 846 | 842 | 842 | Modified residue | Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16627759,ECO:0000269|PubMed:19477218,ECO:0000269|PubMed:21262971;Dbxref=PMID:16627759,PMID:19477218,PMID:21262971 |
| P36888 | 806 | 846 | 835 | 835 | Natural variant | ID=VAR_065679;Note=In acute lymphoblastic leukemia patients and acute myelogenous leukemia patients%3B somatic mutation%3B constitutively activated. D->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11290608,ECO:0000269|PubMed:1450409 |
| P36888 | 806 | 846 | 835 | 835 | Natural variant | ID=VAR_065680;Note=In acute lymphoblastic leukemia patients and in acute myelogenous leukemia patients%3B somatic mutation%3B constitutively activated. D->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11290608,ECO:0000269 |
| P36888 | 806 | 846 | 835 | 835 | Natural variant | ID=VAR_065681;Note=In acute lymphoblastic leukemia patients and in acute myelogenous leukemia patients%3B somatic mutation%3B constitutively activated. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11290608;Dbxref=dbSNP:rs121913488,PMID:11290 |
| P36888 | 806 | 846 | 835 | 835 | Natural variant | ID=VAR_065682;Note=In acute lymphoblastic leukemia patients and in acute myelogenous leukemia patients%3B somatic mutation%3B constitutively activated. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11290608;Dbxref=dbSNP:rs121909646,PMID:11290 |
| P36888 | 806 | 846 | 835 | 835 | Natural variant | ID=VAR_065683;Note=In acute lymphoblastic leukemia patients and in acute myelogenous leukemia patients%3B somatic mutation%3B constitutively activated. D->Y;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11290608,ECO:0000269 |
| P36888 | 806 | 846 | 836 | 836 | Natural variant | ID=VAR_065684;Note=In acute lymphoblastic leukemia patients%3B somatic mutation. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14504097;Dbxref=dbSNP:rs121913232,PMID:14504097 |
| P36888 | 806 | 846 | 564 | 993 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P36888 | 806 | 846 | 821 | 823 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RJB |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in FLT3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for FLT3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for FLT3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FLT3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for FLT3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TRA2A | exon_skip_166859 | -5.937928e-01 | 3.850157e-16 |
| CB | FUBP1 | exon_skip_166859 | -4.231919e-01 | 4.110363e-08 |
Top |
RelatedDrugs for FLT3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P36888 | approved|investigational | DB00398 | Sorafenib | small molecule | P36888 |
| P36888 | approved|investigational | DB01268 | Sunitinib | small molecule | P36888 |
| P36888 | approved|investigational | DB06595 | Midostaurin | small molecule | P36888 |
| P36888 | approved|investigational | DB08901 | Ponatinib | small molecule | P36888 |
| P36888 | approved | DB09079 | Nintedanib | small molecule | P36888 |
| P36888 | approved|investigational | DB12010 | Fostamatinib | small molecule | P36888 |
| P36888 | approved|investigational | DB12267 | Brigatinib | small molecule | P36888 |
Top |
RelatedDiseases for FLT3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|