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![]() | Open reading frame (ORF) annotation in the exon skipping event |
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![]() | 3'-UTR located exon skipping events lost miRNA binding sites |
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![]() | Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for FAM168A |
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Gene information | Gene symbol | FAM168A | Gene ID | 23201 |
Gene name | family with sequence similarity 168 member A | |
Synonyms | KIAA0280|TCRP1 | |
Cytomap | 11q13.4 | |
Type of gene | protein-coding | |
Description | protein FAM168Atongue cancer chemotherapy resistance-associated protein 1 | |
Modification date | 20200313 | |
UniProtAcc | Q92567, | |
Context |
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Gene | GO ID | GO term | PubMed ID |
FAM168A | GO:1905053 | positive regulation of base-excision repair | 25260657 |
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Gene structures and expression levels for FAM168A |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
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Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | UP | ENST00000356467.4 | FAM168A-202:protein_coding:FAM168A | 3.002973e+01 | 1.506641e+00 | 8.008845e-13 | 1.231183e-10 |
CB | UP | ENST00000450446.6 | FAM168A-204:protein_coding:FAM168A | 3.367533e+01 | 8.536498e-01 | 2.109132e-07 | 3.995299e-06 |
TC | UP | ENST00000356467.4 | FAM168A-202:protein_coding:FAM168A | 1.551500e+01 | 1.567286e+00 | 1.880828e-12 | 6.372394e-10 |
TC | UP | ENST00000450446.6 | FAM168A-204:protein_coding:FAM168A | 2.768581e+01 | 1.019959e+00 | 4.892314e-10 | 7.267464e-08 |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FAM168A |
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Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_12991 | chr11 | 73407513:73407643:73409487:73409661:73411394:73411536 | 73409487:73409661 |
exon_skip_142334 | chr11 | 73405983:73406744:73407513:73407643:73409487:73409661 | 73407513:73407643 |
exon_skip_184779 | chr11 | 73419874:73419999:73420890:73420901:73425022:73425048 | 73420890:73420901 |
exon_skip_20001 | chr11 | 73411394:73411536:73419874:73419999:73425022:73425048 | 73419874:73419999 |
exon_skip_227281 | chr11 | 73420890:73420901:73425022:73425048:73430690:73430770 | 73425022:73425048 |
exon_skip_228724 | chr11 | 73405983:73406744:73407513:73407643:73419874:73419999 | 73407513:73407643 |
exon_skip_235288 | chr11 | 73407535:73407643:73419874:73419999:73430690:73430770 | 73419874:73419999 |
exon_skip_244763 | chr11 | 73409487:73409661:73411394:73411536:73419874:73419999 | 73411394:73411536 |
exon_skip_4176 | chr11 | 73419874:73419999:73425022:73425048:73430690:73430770 | 73425022:73425048 |
exon_skip_4380 | chr11 | 73411394:73411536:73419874:73419999:73430690:73430770 | 73419874:73419999 |
exon_skip_69243 | chr11 | 73430690:73430770:73468405:73468492:73597923:73598097 | 73468405:73468492 |
exon_skip_74732 | chr11 | 73407535:73407643:73409487:73409661:73411394:73411536 | 73409487:73409661 |
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Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_76761 | Mayo_CB | 8.225610e-01 | 9.331507e-01 | -1.105897e-01 | 4.230621e-08 |
exon_skip_4176 | Mayo_CB | 5.828049e-01 | 7.606579e-01 | -1.778530e-01 | 5.096214e-08 |
exon_skip_4176 | Mayo_TC | 7.504878e-01 | 8.801299e-01 | -1.296421e-01 | 3.702666e-07 |
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Open reading frame (ORF) annotation in the exon skipping event for FAM168A |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000064778 | 73407513 | 73407643 | 5CDS-5UTR |
ENST00000064778 | 73409487 | 73409661 | Frame-shift |
ENST00000064778 | 73411394 | 73411536 | Frame-shift |
ENST00000064778 | 73419874 | 73419999 | In-frame |
ENST00000064778 | 73425022 | 73425048 | In-frame |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000064778 | 73419874 | 73419999 | In-frame |
ENST00000064778 | 73425022 | 73425048 | In-frame |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000064778 | 73407513 | 73407643 | 5CDS-5UTR |
ENST00000064778 | 73409487 | 73409661 | Frame-shift |
ENST00000064778 | 73411394 | 73411536 | Frame-shift |
ENST00000064778 | 73419874 | 73419999 | In-frame |
ENST00000064778 | 73425022 | 73425048 | In-frame |
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Infer the effects of exon skipping event on protein functional features for FAM168A |
p-ENSG00000054965_img4.png![]() |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000064778 | 7313 | 244 | 73419874 | 73419999 | 464 | 588 | 59 | 101 |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000064778 | 7313 | 244 | 73419874 | 73419999 | 464 | 588 | 59 | 101 |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000064778 | 7313 | 244 | 73419874 | 73419999 | 464 | 588 | 59 | 101 |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q92567 | 59 | 101 | 51 | 59 | Alternative sequence | ID=VSP_010095;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1;Dbxref=PMID:14702039,PMID:15489334 |
Q92567 | 59 | 101 | 1 | 244 | Chain | ID=PRO_0000050742;Note=Protein FAM168A |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q92567 | 59 | 101 | 51 | 59 | Alternative sequence | ID=VSP_010095;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1;Dbxref=PMID:14702039,PMID:15489334 |
Q92567 | 59 | 101 | 1 | 244 | Chain | ID=PRO_0000050742;Note=Protein FAM168A |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q92567 | 59 | 101 | 51 | 59 | Alternative sequence | ID=VSP_010095;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1;Dbxref=PMID:14702039,PMID:15489334 |
Q92567 | 59 | 101 | 1 | 244 | Chain | ID=PRO_0000050742;Note=Protein FAM168A |
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3'-UTR located exon skipping events that lost miRNA binding sites in FAM168A |
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Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for FAM168A |
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Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for FAM168A |
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AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
ADstage | MSBB | IFG | exon_skip_69243 | -4.094682e-01 | 3.047947e-02 | chr11 | - | 73430690 | 73430770 | 73468405 | 73468492 | 73597923 | 73598097 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FAM168A |
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Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for FAM168A |
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Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | RBM45 | exon_skip_4380 | 4.601241e-01 | 7.399913e-09 |
CB | RBM6 | exon_skip_76761 | -4.373028e-01 | 1.274739e-08 |
CB | PCBP1 | exon_skip_76761 | -4.670432e-01 | 9.012041e-10 |
CB | RBM45 | exon_skip_76761 | 6.966748e-01 | 7.820262e-24 |
CB | RBM23 | exon_skip_76761 | -4.366760e-01 | 1.344319e-08 |
TC | NOVA1 | exon_skip_4176 | 4.941942e-01 | 3.589229e-11 |
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RelatedDrugs for FAM168A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM168A |
![]() (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |