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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MAPK8IP3 |
 Gene summary |
| Gene information | Gene symbol | MAPK8IP3 | Gene ID | 23162 |
| Gene name | mitogen-activated protein kinase 8 interacting protein 3 | |
| Synonyms | JIP-3|JIP3|JSAP1|NEDBA|SYD2|syd | |
| Cytomap | 16p13.3 | |
| Type of gene | protein-coding | |
| Description | C-Jun-amino-terminal kinase-interacting protein 3C-jun-amino-terminal kinase interacting protein 3JNK MAP kinase scaffold protein 3JNK-interacting protein 3JNK/SAPK-associated protein-1JNK/stress-activated protein kinase-associated protein 1homolog | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for MAPK8IP3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000138834
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000567849.1 | MAPK8IP3-212:nonsense_mediated_decay:MAPK8IP3 | 4.666247e+00 | 1.519346e+00 | 3.770880e-03 | 3.756695e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MAPK8IP3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_10129 | chr16 | 1758148:1758159:1759958:1760015:1760380:1760532 | 1759958:1760015 |
| exon_skip_142066 | chr16 | 1766271:1766409:1766529:1766648:1766723:1766801 | 1766529:1766648 |
| exon_skip_16601 | chr16 | 1748602:1748720:1758148:1758159:1759958:1760015 | 1758148:1758159 |
| exon_skip_175928 | chr16 | 1767564:1767735:1767805:1768107:1768199:1768378 | 1767805:1768107 |
| exon_skip_207804 | chr16 | 1767564:1767735:1767805:1767918:1768069:1768107 | 1767805:1767918 |
| exon_skip_236143 | chr16 | 1766220:1766409:1766529:1766648:1766723:1766801 | 1766529:1766648 |
| exon_skip_252104 | chr16 | 1766633:1766648:1766723:1766803:1766904:1766971 | 1766723:1766803 |
| exon_skip_278897 | chr16 | 1767567:1767735:1767805:1767918:1768069:1768107 | 1767805:1767918 |
| exon_skip_283238 | chr16 | 1767567:1767735:1767805:1768107:1768199:1768378 | 1767805:1768107 |
| exon_skip_289292 | chr16 | 1767805:1767918:1768069:1768107:1768199:1768378 | 1768069:1768107 |
| exon_skip_295633 | chr16 | 1744039:1744189:1744978:1745103:1747029:1747067 | 1744978:1745103 |
| exon_skip_41494 | chr16 | 1724557:1724677:1729138:1729208:1729487:1729578 | 1729138:1729208 |
| exon_skip_60454 | chr16 | 1766355:1766409:1766529:1766648:1766723:1766803 | 1766529:1766648 |
| exon_skip_74234 | chr16 | 1758148:1758159:1758978:1758995:1759958:1760015 | 1758978:1758995 |
| exon_skip_87020 | chr16 | 1766529:1766648:1766723:1766803:1766904:1766971 | 1766723:1766803 |
| exon_skip_89393 | chr16 | 1748244:1748346:1748602:1748720:1758148:1758159 | 1748602:1748720 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_74234 | MSBB_PG | 5.648438e-01 | 7.086792e-01 | -1.438355e-01 | 5.265971e-04 |
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Open reading frame (ORF) annotation in the exon skipping event for MAPK8IP3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000250894 | 1729138 | 1729208 | Frame-shift |
| ENST00000250894 | 1758978 | 1758995 | In-frame |
| ENST00000250894 | 1766529 | 1766648 | In-frame |
| ENST00000250894 | 1766723 | 1766803 | In-frame |
| ENST00000250894 | 1767805 | 1767918 | In-frame |
| ENST00000250894 | 1768069 | 1768107 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000250894 | 1729138 | 1729208 | Frame-shift |
| ENST00000250894 | 1758978 | 1758995 | In-frame |
| ENST00000250894 | 1766723 | 1766803 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000250894 | 1729138 | 1729208 | Frame-shift |
| ENST00000250894 | 1748602 | 1748720 | Frame-shift |
| ENST00000250894 | 1758978 | 1758995 | In-frame |
| ENST00000250894 | 1766529 | 1766648 | In-frame |
| ENST00000250894 | 1766723 | 1766803 | In-frame |
| ENST00000250894 | 1767805 | 1767918 | In-frame |
| ENST00000250894 | 1768069 | 1768107 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MAPK8IP3 |
p-ENSG00000138834_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000250894 | 5678 | 1336 | 1766529 | 1766648 | 2975 | 3093 | 939 | 978 |
| ENST00000250894 | 5678 | 1336 | 1766723 | 1766803 | 3095 | 3174 | 979 | 1005 |
| ENST00000250894 | 5678 | 1336 | 1767805 | 1767918 | 3565 | 3677 | 1136 | 1173 |
| ENST00000250894 | 5678 | 1336 | 1768069 | 1768107 | 3679 | 3716 | 1174 | 1186 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000250894 | 5678 | 1336 | 1766723 | 1766803 | 3095 | 3174 | 979 | 1005 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000250894 | 5678 | 1336 | 1766529 | 1766648 | 2975 | 3093 | 939 | 978 |
| ENST00000250894 | 5678 | 1336 | 1766723 | 1766803 | 3095 | 3174 | 979 | 1005 |
| ENST00000250894 | 5678 | 1336 | 1767805 | 1767918 | 3565 | 3677 | 1136 | 1173 |
| ENST00000250894 | 5678 | 1336 | 1768069 | 1768107 | 3679 | 3716 | 1174 | 1186 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UPT6 | 939 | 978 | 251 | 1336 | Alternative sequence | ID=VSP_024431;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11214971;Dbxref=PMID:11214971 |
| Q9UPT6 | 939 | 978 | 1 | 1336 | Chain | ID=PRO_0000220633;Note=C-Jun-amino-terminal kinase-interacting protein 3 |
| Q9UPT6 | 979 | 1005 | 251 | 1336 | Alternative sequence | ID=VSP_024431;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11214971;Dbxref=PMID:11214971 |
| Q9UPT6 | 979 | 1005 | 1 | 1336 | Chain | ID=PRO_0000220633;Note=C-Jun-amino-terminal kinase-interacting protein 3 |
| Q9UPT6 | 1136 | 1173 | 251 | 1336 | Alternative sequence | ID=VSP_024431;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11214971;Dbxref=PMID:11214971 |
| Q9UPT6 | 1136 | 1173 | 1 | 1336 | Chain | ID=PRO_0000220633;Note=C-Jun-amino-terminal kinase-interacting protein 3 |
| Q9UPT6 | 1174 | 1186 | 251 | 1336 | Alternative sequence | ID=VSP_024431;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11214971;Dbxref=PMID:11214971 |
| Q9UPT6 | 1174 | 1186 | 1 | 1336 | Chain | ID=PRO_0000220633;Note=C-Jun-amino-terminal kinase-interacting protein 3 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UPT6 | 979 | 1005 | 251 | 1336 | Alternative sequence | ID=VSP_024431;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11214971;Dbxref=PMID:11214971 |
| Q9UPT6 | 979 | 1005 | 1 | 1336 | Chain | ID=PRO_0000220633;Note=C-Jun-amino-terminal kinase-interacting protein 3 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UPT6 | 939 | 978 | 251 | 1336 | Alternative sequence | ID=VSP_024431;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11214971;Dbxref=PMID:11214971 |
| Q9UPT6 | 939 | 978 | 1 | 1336 | Chain | ID=PRO_0000220633;Note=C-Jun-amino-terminal kinase-interacting protein 3 |
| Q9UPT6 | 979 | 1005 | 251 | 1336 | Alternative sequence | ID=VSP_024431;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11214971;Dbxref=PMID:11214971 |
| Q9UPT6 | 979 | 1005 | 1 | 1336 | Chain | ID=PRO_0000220633;Note=C-Jun-amino-terminal kinase-interacting protein 3 |
| Q9UPT6 | 1136 | 1173 | 251 | 1336 | Alternative sequence | ID=VSP_024431;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11214971;Dbxref=PMID:11214971 |
| Q9UPT6 | 1136 | 1173 | 1 | 1336 | Chain | ID=PRO_0000220633;Note=C-Jun-amino-terminal kinase-interacting protein 3 |
| Q9UPT6 | 1174 | 1186 | 251 | 1336 | Alternative sequence | ID=VSP_024431;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11214971;Dbxref=PMID:11214971 |
| Q9UPT6 | 1174 | 1186 | 1 | 1336 | Chain | ID=PRO_0000220633;Note=C-Jun-amino-terminal kinase-interacting protein 3 |
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3'-UTR located exon skipping events that lost miRNA binding sites in MAPK8IP3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MAPK8IP3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MAPK8IP3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| CDR | MSBB | IFG | exon_skip_74234 | -3.763160e-01 | 4.841283e-02 | chr16 | + | 1758148 | 1758159 | 1758978 | 1758995 | 1759958 | 1760015 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAPK8IP3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MAPK8IP3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| DLPFC | ELAVL4 | exon_skip_74234 | 4.018474e-01 | 9.632948e-15 |
| DLPFC | EIF4B | exon_skip_74234 | 4.671825e-01 | 5.351941e-20 |
| FL | ELAVL4 | exon_skip_74234 | 5.101964e-01 | 2.562077e-14 |
| FL | RALYL | exon_skip_74234 | 4.496256e-01 | 4.286172e-11 |
| HCC | TIA1 | exon_skip_74234 | -5.239279e-01 | 1.655578e-20 |
| HCC | FUBP1 | exon_skip_74234 | -4.027197e-01 | 5.461248e-12 |
| HCC | RBM4 | exon_skip_74234 | -4.190703e-01 | 5.974405e-13 |
| HCC | RBM4B | exon_skip_74234 | -5.135574e-01 | 1.222671e-19 |
| IFG | ELAVL4 | exon_skip_74234 | 4.692502e-01 | 1.176492e-02 |
| IFG | RALYL | exon_skip_74234 | 5.351484e-01 | 3.342597e-03 |
| PCC | ELAVL4 | exon_skip_74234 | 5.473437e-01 | 6.887068e-18 |
| PCC | RALYL | exon_skip_74234 | 4.551389e-01 | 3.475603e-12 |
| PG | ELAVL4 | exon_skip_74234 | 7.308093e-01 | 1.669995e-31 |
| PG | ELAVL1 | exon_skip_74234 | 4.352684e-01 | 9.158087e-10 |
| PG | RALYL | exon_skip_74234 | 6.984938e-01 | 8.241353e-28 |
| PG | RBM4 | exon_skip_74234 | 4.349270e-01 | 9.470538e-10 |
| STG | ELAVL4 | exon_skip_74234 | 6.741866e-01 | 8.207557e-13 |
| STG | RALYL | exon_skip_74234 | 5.862347e-01 | 2.434873e-09 |
| TC | ELAVL4 | exon_skip_74234 | 8.158364e-01 | 2.028315e-39 |
| TC | RALYL | exon_skip_74234 | 8.314226e-01 | 3.616903e-42 |
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RelatedDrugs for MAPK8IP3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAPK8IP3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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