ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for FLNA

Gene summary

Gene information	Gene symbol	FLNA
	Gene ID	2316
	Gene name	filamin A
	Synonyms	ABP-280\|ABPX\|CSBS\|CVD1\|FGS2\|FLN\|FLN-A\|FLN1\|FMD\|MNS\|NHBP\|OPD\|OPD1\|OPD2\|XLVD\|XMVD
	Cytomap	Xq28
	Type of gene	protein-coding
	Description	filamin-Aactin binding protein 280alpha-filaminendothelial actin-binding proteinepididymis secretory sperm binding proteinfilamin A, alphafilamin-1non-muscle filamin
	Modification date	20200313
	UniProtAcc	A0A087WWY3, A6NDY9, F8WE98, H0Y5C6, H0Y5F3, H7C2E7, P21333, Q2VP91, Q60FE5, Q60FE6, Q6NXF2,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
FLNA	GO:0016479	negative regulation of transcription by RNA polymerase I	22307607
FLNA	GO:0030334	regulation of cell migration	16291724
FLNA	GO:0031532	actin cytoskeleton reorganization	10051605
FLNA	GO:0034394	protein localization to cell surface	18322202
FLNA	GO:0043113	receptor clustering	10692483
FLNA	GO:0043433	negative regulation of DNA-binding transcription factor activity	15684392
FLNA	GO:0044319	wound healing, spreading of cells	16291724
FLNA	GO:0045184	establishment of protein localization	18322202
FLNA	GO:0051764	actin crosslink formation	10051605
FLNA	GO:0072659	protein localization to plasma membrane	24951510
FLNA	GO:0090307	mitotic spindle assembly	18548008
FLNA	GO:1901381	positive regulation of potassium ion transmembrane transport	24951510

Top

Gene structures and expression levels for FLNA

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000196924

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
PCC	UP	ENST00000498411.1	FLNA-216:lncRNA:FLNA	3.076727e+00	1.655778e+00	9.237406e-04	2.443589e-02
CB	DOWN	ENST00000498411.1	FLNA-216:lncRNA:FLNA	4.729137e+01	-1.332496e+00	8.827154e-06	9.498763e-05
CB	DOWN	ENST00000498491.5	FLNA-217:lncRNA:FLNA	1.682661e+02	-9.795901e-01	3.183349e-04	1.969830e-03
CB	DOWN	ENST00000610817.4	FLNA-218:protein_coding:FLNA	2.707934e+01	-4.716825e+00	2.657273e-03	1.166655e-02
TC	UP	ENST00000360319.9	FLNA-201:protein_coding:FLNA	3.346758e+02	3.151724e+00	8.809261e-09	8.091651e-07
TC	UP	ENST00000546355.4	RFLNA-205:protein_coding:RFLNA	3.636467e+01	1.114450e+00	2.079600e-05	4.616127e-04
TC	DOWN	ENST00000498411.1	FLNA-216:lncRNA:FLNA	5.145161e+01	-1.151572e+00	1.592046e-04	2.334706e-03
TC	UP	ENST00000422373.5	FLNA-206:protein_coding:FLNA	2.061855e+02	2.420509e+00	1.895804e-04	2.681742e-03
TC	UP	ENST00000324038.6	RFLNA-201:protein_coding:RFLNA	6.366164e+01	1.127081e+00	9.357819e-04	9.391935e-03

Landscape of isoform expressions across multiple brain tissues between AD and control.

Top

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FLNA

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_115340	chrX	154352276:154352447:154352553:154352675:154352772:154352924	154352553:154352675
exon_skip_132213	chrX	154350909:154351041:154351581:154351696:154351884:154351950	154351581:154351696
exon_skip_134837	chrX	154354825:154355072:154357251:154357274:154357434:154357623	154357251:154357274
exon_skip_175152	chrX	154353393:154353457:154353554:154353727:154353915:154354039	154353554:154353727
exon_skip_180828	chrX	154362242:154362332:154362418:154362578:154362661:154362784	154362418:154362578
exon_skip_239113	chrX	154354381:154354483:154354616:154354711:154354825:154354889	154354616:154354711
exon_skip_248078	chrX	154361308:154361570:154361670:154361787:154361979:154362148	154361670:154361787
exon_skip_248754	chrX	154350031:154350207:154350909:154351041:154351581:154351696	154350909:154351041
exon_skip_276548	chrX	154353393:154353457:154353554:154353727:154353915:154354043	154353554:154353727
exon_skip_291096	chrX	154361438:154361570:154361670:154361787:154361979:154362148	154361670:154361787
exon_skip_30234	chrX	154353296:154353457:154353554:154353727:154353915:154354043	154353554:154353727
exon_skip_30474	chrX	154354873:154355072:154357251:154357274:154357434:154357623	154357251:154357274
exon_skip_41167	chrX	154365349:154365486:154366024:154366224:154366308:154366470	154366024:154366224
exon_skip_52341	chrX	154353438:154353457:154353554:154353727:154353915:154354043	154353554:154353727
exon_skip_57672	chrX	154352181:154352447:154352553:154352675:154352772:154352783	154352553:154352675
exon_skip_70486	chrX	154359732:154359905:154359990:154360587:154361308:154361570	154359990:154360587
exon_skip_83010	chrX	154352181:154352447:154352553:154352675:154352772:154352924	154352553:154352675

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information	Tissue type	Avg(PSIs) in AD	Avg(PSIs) in control	Difference (PSI)	Adj. p-value
exon_skip_30474	Mayo_TC	5.836585e-01	7.403846e-01	-1.567261e-01	2.040787e-08

Top

Open reading frame (ORF) annotation in the exon skipping event for FLNA

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000369850	154350909	154351041	Frame-shift
ENST00000369850	154351581	154351696	Frame-shift
ENST00000369850	154362418	154362578	Frame-shift
ENST00000369850	154352553	154352675	In-frame
ENST00000369850	154353554	154353727	In-frame
ENST00000369850	154354616	154354711	In-frame
ENST00000369850	154357251	154357274	In-frame
ENST00000369850	154366024	154366224	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000369850	154361670	154361787	Frame-shift
ENST00000369850	154352553	154352675	In-frame
ENST00000369850	154353554	154353727	In-frame
ENST00000369850	154354616	154354711	In-frame
ENST00000369850	154357251	154357274	In-frame
ENST00000369850	154366024	154366224	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000369850	154350909	154351041	Frame-shift
ENST00000369850	154351581	154351696	Frame-shift
ENST00000369850	154359990	154360587	Frame-shift
ENST00000369850	154361670	154361787	Frame-shift
ENST00000369850	154362418	154362578	Frame-shift
ENST00000369850	154352553	154352675	In-frame
ENST00000369850	154353554	154353727	In-frame
ENST00000369850	154354616	154354711	In-frame
ENST00000369850	154357251	154357274	In-frame

Top

Infer the effects of exon skipping event on protein functional features for FLNA

p-ENSG00000196924_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000369850	8533	2647	154366024	154366224	1478	1677	409	476
ENST00000369850	8533	2647	154354616	154354711	5467	5561	1739	1770
ENST00000369850	8533	2647	154353554	154353727	5936	6108	1895	1953
ENST00000369850	8533	2647	154352553	154352675	6629	6750	2126	2167

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000369850	8533	2647	154366024	154366224	1478	1677	409	476
ENST00000369850	8533	2647	154354616	154354711	5467	5561	1739	1770
ENST00000369850	8533	2647	154353554	154353727	5936	6108	1895	1953
ENST00000369850	8533	2647	154352553	154352675	6629	6750	2126	2167

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000369850	8533	2647	154354616	154354711	5467	5561	1739	1770
ENST00000369850	8533	2647	154353554	154353727	5936	6108	1895	1953
ENST00000369850	8533	2647	154352553	154352675	6629	6750	2126	2167

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P21333	409	476	2	2647	Chain	ID=PRO_0000087296;Note=Filamin-A
P21333	409	476	429	429	Natural variant	ID=VAR_069803;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:12612583;Dbxref=dbSNP:rs36051194,PMID:12612583
P21333	409	476	376	474	Repeat	Note=Filamin 2
P21333	409	476	475	570	Repeat	Note=Filamin 3
P21333	1739	1770	2	2647	Chain	ID=PRO_0000087296;Note=Filamin-A
P21333	1739	1770	1724	1739	Natural variant	ID=VAR_064159;Note=In TOD. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:20598277;Dbxref=PMID:20598277
P21333	1739	1770	1764	1764	Natural variant	ID=VAR_012835;Note=A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11532987,ECO:0000269\|PubMed:12612583;Dbxref=dbSNP:rs57108893,PMID:11532987,PMID:12612583
P21333	1739	1770	1741	1778	Region	Note=Hinge 1
P21333	1739	1770	1649	1740	Repeat	Note=Filamin 15
P21333	1739	1770	1761	1762	Site	Note=Cleavage%3B by calpain
P21333	1895	1953	1895	1906	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2BP3
P21333	1895	1953	1909	1914	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2BP3
P21333	1895	1953	1916	1925	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2BP3
P21333	1895	1953	1930	1938	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2BP3
P21333	1895	1953	1947	1953	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2BP3
P21333	1895	1953	2	2647	Chain	ID=PRO_0000087296;Note=Filamin-A
P21333	1895	1953	1861	1950	Repeat	Note=Filamin 17
P21333	1895	1953	1951	2039	Repeat	Note=Filamin 18
P21333	2126	2167	2129	2136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2J3S
P21333	2126	2167	2139	2148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2J3S
P21333	2126	2167	2161	2165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4P3W
P21333	2126	2167	2	2647	Chain	ID=PRO_0000087296;Note=Filamin-A
P21333	2126	2167	2128	2128	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
P21333	2126	2167	2152	2152	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:18088087,ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20
P21333	2126	2167	2158	2158	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18088087,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:18088087,PMID:23186163,PMID:24275569
P21333	2126	2167	2163	2163	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
P21333	2126	2167	2042	2131	Repeat	Note=Filamin 19
P21333	2126	2167	2132	2230	Repeat	Note=Filamin 20

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P21333	409	476	2	2647	Chain	ID=PRO_0000087296;Note=Filamin-A
P21333	409	476	429	429	Natural variant	ID=VAR_069803;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:12612583;Dbxref=dbSNP:rs36051194,PMID:12612583
P21333	409	476	376	474	Repeat	Note=Filamin 2
P21333	409	476	475	570	Repeat	Note=Filamin 3
P21333	1739	1770	2	2647	Chain	ID=PRO_0000087296;Note=Filamin-A
P21333	1739	1770	1724	1739	Natural variant	ID=VAR_064159;Note=In TOD. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:20598277;Dbxref=PMID:20598277
P21333	1739	1770	1764	1764	Natural variant	ID=VAR_012835;Note=A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11532987,ECO:0000269\|PubMed:12612583;Dbxref=dbSNP:rs57108893,PMID:11532987,PMID:12612583
P21333	1739	1770	1741	1778	Region	Note=Hinge 1
P21333	1739	1770	1649	1740	Repeat	Note=Filamin 15
P21333	1739	1770	1761	1762	Site	Note=Cleavage%3B by calpain
P21333	1895	1953	1895	1906	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2BP3
P21333	1895	1953	1909	1914	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2BP3
P21333	1895	1953	1916	1925	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2BP3
P21333	1895	1953	1930	1938	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2BP3
P21333	1895	1953	1947	1953	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2BP3
P21333	1895	1953	2	2647	Chain	ID=PRO_0000087296;Note=Filamin-A
P21333	1895	1953	1861	1950	Repeat	Note=Filamin 17
P21333	1895	1953	1951	2039	Repeat	Note=Filamin 18
P21333	2126	2167	2129	2136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2J3S
P21333	2126	2167	2139	2148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2J3S
P21333	2126	2167	2161	2165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4P3W
P21333	2126	2167	2	2647	Chain	ID=PRO_0000087296;Note=Filamin-A
P21333	2126	2167	2128	2128	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
P21333	2126	2167	2152	2152	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:18088087,ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20
P21333	2126	2167	2158	2158	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18088087,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:18088087,PMID:23186163,PMID:24275569
P21333	2126	2167	2163	2163	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
P21333	2126	2167	2042	2131	Repeat	Note=Filamin 19
P21333	2126	2167	2132	2230	Repeat	Note=Filamin 20

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P21333	1739	1770	2	2647	Chain	ID=PRO_0000087296;Note=Filamin-A
P21333	1739	1770	1724	1739	Natural variant	ID=VAR_064159;Note=In TOD. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:20598277;Dbxref=PMID:20598277
P21333	1739	1770	1764	1764	Natural variant	ID=VAR_012835;Note=A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11532987,ECO:0000269\|PubMed:12612583;Dbxref=dbSNP:rs57108893,PMID:11532987,PMID:12612583
P21333	1739	1770	1741	1778	Region	Note=Hinge 1
P21333	1739	1770	1649	1740	Repeat	Note=Filamin 15
P21333	1739	1770	1761	1762	Site	Note=Cleavage%3B by calpain
P21333	1895	1953	1895	1906	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2BP3
P21333	1895	1953	1909	1914	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2BP3
P21333	1895	1953	1916	1925	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2BP3
P21333	1895	1953	1930	1938	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2BP3
P21333	1895	1953	1947	1953	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2BP3
P21333	1895	1953	2	2647	Chain	ID=PRO_0000087296;Note=Filamin-A
P21333	1895	1953	1861	1950	Repeat	Note=Filamin 17
P21333	1895	1953	1951	2039	Repeat	Note=Filamin 18
P21333	2126	2167	2129	2136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2J3S
P21333	2126	2167	2139	2148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2J3S
P21333	2126	2167	2161	2165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4P3W
P21333	2126	2167	2	2647	Chain	ID=PRO_0000087296;Note=Filamin-A
P21333	2126	2167	2128	2128	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
P21333	2126	2167	2152	2152	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:18088087,ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20
P21333	2126	2167	2158	2158	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18088087,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:18088087,PMID:23186163,PMID:24275569
P21333	2126	2167	2163	2163	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
P21333	2126	2167	2042	2131	Repeat	Note=Filamin 19
P21333	2126	2167	2132	2230	Repeat	Note=Filamin 20

Top

3'-UTR located exon skipping events that lost miRNA binding sites in FLNA

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

Top

SNVs in the skipped exons for FLNA

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

Top

AD stage-associated exon skippint events for FLNA

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

Top

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FLNA

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

Top

Correlation with RNA binding proteins (RBPs) for FLNA

Correlated RBP and related information.

Tissue type

RBP name

Exon skip ID

Correlation coeifficient

P-value

Top

RelatedDrugs for FLNA

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for FLNA

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

Home

Download

Statistics

Landscape

Help

Contact

Gene summary for FLNA

Gene structures and expression levels for FLNA

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FLNA

Open reading frame (ORF) annotation in the exon skipping event for FLNA

Infer the effects of exon skipping event on protein functional features for FLNA

3'-UTR located exon skipping events that lost miRNA binding sites in FLNA

SNVs in the skipped exons for FLNA

AD stage-associated exon skippint events for FLNA

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FLNA

Correlation with RNA binding proteins (RBPs) for FLNA

RelatedDrugs for FLNA

RelatedDiseases for FLNA