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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for CIC |
Gene summary |
Gene information | Gene symbol | CIC | Gene ID | 23152 |
Gene name | capicua transcriptional repressor | |
Synonyms | MRD45 | |
Cytomap | 19q13.2 | |
Type of gene | protein-coding | |
Description | protein capicua homolog | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for CIC |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
STG | UP | ENST00000575354.6 | CIC-207:protein_coding:CIC | 4.670351e+02 | 9.876462e-01 | 7.572034e-08 | 6.733214e-05 |
STG | UP | ENST00000573349.5 | CIC-205:protein_coding:CIC | 1.471100e+01 | 1.080213e+00 | 5.556152e-04 | 2.836766e-02 |
CB | DOWN | ENST00000576505.6 | CIC-209:protein_coding:CIC | 7.329395e+01 | -2.298577e+00 | 4.817828e-09 | 1.630770e-07 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CIC |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_114875 | chr19 | 42289328:42289406:42289848:42289951:42290233:42290884 | 42289848:42289951 |
exon_skip_119079 | chr19 | 42292086:42292207:42292300:42292466:42292569:42292597 | 42292300:42292466 |
exon_skip_1507 | chr19 | 42289181:42289406:42289848:42289951:42290233:42290709 | 42289848:42289951 |
exon_skip_162887 | chr19 | 42292959:42293281:42293592:42293836:42293938:42294089 | 42293592:42293836 |
exon_skip_176487 | chr19 | 42289328:42289406:42289848:42289951:42290233:42291466 | 42289848:42289951 |
exon_skip_215999 | chr19 | 42292086:42292207:42292300:42292466:42292566:42292859 | 42292300:42292466 |
exon_skip_225457 | chr19 | 42291442:42291466:42291558:42291745:42292086:42292207 | 42291558:42291745 |
exon_skip_23746 | chr19 | 42292086:42292207:42292300:42292466:42292569:42292859 | 42292300:42292466 |
exon_skip_251133 | chr19 | 42291274:42291466:42291558:42291745:42292086:42292207 | 42291558:42291745 |
exon_skip_267559 | chr19 | 42287545:42287727:42287810:42287975:42288888:42289086 | 42287810:42287975 |
exon_skip_62990 | chr19 | 42287810:42287975:42288888:42289090:42289181:42289406 | 42288888:42289090 |
exon_skip_77356 | chr19 | 42289181:42289406:42289848:42289951:42290233:42290617 | 42289848:42289951 |
exon_skip_77700 | chr19 | 42289181:42289406:42289848:42289951:42290233:42291466 | 42289848:42289951 |
exon_skip_88999 | chr19 | 42292086:42292207:42292300:42292466:42292566:42292597 | 42292300:42292466 |
exon_skip_90909 | chr19 | 42289181:42289406:42289848:42289951:42290233:42290884 | 42289848:42289951 |
exon_skip_92269 | chr19 | 42287810:42287975:42288888:42289090:42289181:42289227 | 42288888:42289090 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CIC |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000575354 | 42288888 | 42289090 | Frame-shift |
ENST00000575354 | 42289848 | 42289951 | Frame-shift |
ENST00000575354 | 42291558 | 42291745 | Frame-shift |
ENST00000575354 | 42292300 | 42292466 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000575354 | 42288888 | 42289090 | Frame-shift |
ENST00000575354 | 42289848 | 42289951 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000575354 | 42287810 | 42287975 | Frame-shift |
ENST00000575354 | 42288888 | 42289090 | Frame-shift |
ENST00000575354 | 42289848 | 42289951 | Frame-shift |
ENST00000575354 | 42291558 | 42291745 | Frame-shift |
ENST00000575354 | 42292300 | 42292466 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for CIC |
p-ENSG00000079432_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in CIC |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CIC |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CIC |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CIC |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CIC |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CIC |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CIC |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |