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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for FLI1 |
Gene summary |
Gene information | Gene symbol | FLI1 | Gene ID | 2313 |
Gene name | Fli-1 proto-oncogene, ETS transcription factor | |
Synonyms | BDPLT21|EWSR2|SIC-1 | |
Cytomap | 11q24.3 | |
Type of gene | protein-coding | |
Description | Friend leukemia integration 1 transcription factorEwing sarcoma breakpoint region 2Friend leukemia virus integration 1transcription factor ERGB | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
FLI1 | GO:0045893 | positive regulation of transcription, DNA-templated | 26316623 |
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Gene structures and expression levels for FLI1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PG | UP | ENST00000528790.1 | FLI1-206:retained_intron:FLI1 | 2.663921e+01 | 8.193698e-01 | 2.013885e-08 | 4.235195e-06 |
PG | UP | ENST00000608303.5 | FLI1-209:nonsense_mediated_decay:FLI1 | 1.369346e+01 | 1.855017e+00 | 5.324792e-03 | 4.774892e-02 |
TC | UP | ENST00000527767.7 | FLI1-204:protein_coding:FLI1 | 1.091138e+01 | 1.010821e+00 | 8.145989e-07 | 3.411049e-05 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FLI1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_116235 | chr11 | 128781958:128782023:128805366:128805431:128807180:128807239 | 128805366:128805431 |
exon_skip_129329 | chr11 | 128758115:128758326:128764651:128764821:128768118:128768272 | 128764651:128764821 |
exon_skip_167083 | chr11 | 128805366:128805431:128807180:128807239:128809157:128809204 | 128807180:128807239 |
exon_skip_176062 | chr11 | 128694092:128694276:128748237:128748290:128758115:128758326 | 128748237:128748290 |
exon_skip_71190 | chr11 | 128758118:128758326:128764651:128764821:128768118:128768272 | 128764651:128764821 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for FLI1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000527786 | 128807180 | 128807239 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000527786 | 128807180 | 128807239 | In-frame |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000527786 | 128805366 | 128805431 | In-frame |
ENST00000527786 | 128807180 | 128807239 | In-frame |
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Infer the effects of exon skipping event on protein functional features for FLI1 |
p-ENSG00000151702_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000527786 | 4144 | 452 | 128807180 | 128807239 | 1212 | 1270 | 241 | 260 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000527786 | 4144 | 452 | 128807180 | 128807239 | 1212 | 1270 | 241 | 260 |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000527786 | 4144 | 452 | 128805366 | 128805431 | 1146 | 1210 | 219 | 240 |
ENST00000527786 | 4144 | 452 | 128807180 | 128807239 | 1212 | 1270 | 241 | 260 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q01543 | 241 | 260 | 1 | 452 | Chain | ID=PRO_0000204124;Note=Friend leukemia integration 1 transcription factor |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q01543 | 241 | 260 | 1 | 452 | Chain | ID=PRO_0000204124;Note=Friend leukemia integration 1 transcription factor |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q01543 | 219 | 240 | 1 | 452 | Chain | ID=PRO_0000204124;Note=Friend leukemia integration 1 transcription factor |
Q01543 | 241 | 260 | 1 | 452 | Chain | ID=PRO_0000204124;Note=Friend leukemia integration 1 transcription factor |
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3'-UTR located exon skipping events that lost miRNA binding sites in FLI1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for FLI1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for FLI1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FLI1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for FLI1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for FLI1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FLI1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |