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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CLASP2 |
 Gene summary |
| Gene information | Gene symbol | CLASP2 | Gene ID | 23122 |
| Gene name | cytoplasmic linker associated protein 2 | |
| Synonyms | - | |
| Cytomap | 3p22.3 | |
| Type of gene | protein-coding | |
| Description | CLIP-associating protein 2CLIP-associating protein CLASP2multiple asters (Mast)-like homolog 2protein Orbit homolog 2 | |
| Modification date | 20200313 | |
| UniProtAcc | A0A024R2J1, A0A024R2L7, A0A024R2S6, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for CLASP2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000163539
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000461133.8 | CLASP2-205:protein_coding:CLASP2 | 8.549757e+02 | 2.083312e+00 | 1.077401e-10 | 6.710406e-09 |
| CB | UP | ENST00000491045.1 | CLASP2-220:retained_intron:CLASP2 | 2.368948e+01 | 8.831808e-01 | 2.055887e-07 | 3.906295e-06 |
| CB | UP | ENST00000482896.5 | CLASP2-215:lncRNA:CLASP2 | 1.704346e+00 | 1.206088e+00 | 1.342842e-05 | 1.351436e-04 |
| CB | UP | ENST00000476251.1 | CLASP2-211:nonsense_mediated_decay:CLASP2 | 4.257470e+01 | 1.025978e+00 | 5.075746e-05 | 4.165424e-04 |
| CB | UP | ENST00000480013.6 | CLASP2-213:protein_coding:CLASP2 | 2.067701e+03 | 1.196052e+00 | 5.501413e-05 | 4.461400e-04 |
| CB | UP | ENST00000498331.1 | CLASP2-224:lncRNA:CLASP2 | 2.239641e+00 | 8.907684e-01 | 4.305683e-04 | 2.538029e-03 |
| CB | UP | ENST00000496954.2 | CLASP2-223:protein_coding:CLASP2 | 1.556022e+01 | 8.180758e-01 | 2.399972e-03 | 1.071845e-02 |
| CB | UP | ENST00000485378.6 | CLASP2-216:protein_coding:CLASP2 | 4.949991e+01 | 1.259038e+00 | 3.053320e-03 | 1.309225e-02 |
| CB | UP | ENST00000476433.5 | CLASP2-212:lncRNA:CLASP2 | 7.820890e-01 | 1.129783e+00 | 8.070933e-03 | 2.916514e-02 |
| CB | UP | ENST00000635664.1 | CLASP2-225:protein_coding:CLASP2 | 2.947357e+02 | 8.645936e-01 | 8.372264e-03 | 3.003601e-02 |
| TC | UP | ENST00000461133.8 | CLASP2-205:protein_coding:CLASP2 | 4.159542e+02 | 1.054598e+00 | 2.142940e-05 | 4.717897e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CLASP2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_103090 | chr3 | 33626988:33627080:33632292:33632374:33644757:33644903 | 33632292:33632374 |
| exon_skip_105751 | chr3 | 33576169:33576275:33577202:33577264:33581821:33581869 | 33577202:33577264 |
| exon_skip_105985 | chr3 | 33510558:33510764:33516023:33516151:33516981:33517174 | 33516023:33516151 |
| exon_skip_11346 | chr3 | 33689829:33689932:33696855:33696933:33717808:33718010 | 33696855:33696933 |
| exon_skip_122603 | chr3 | 33501652:33501768:33516023:33516151:33516981:33517174 | 33516023:33516151 |
| exon_skip_13030 | chr3 | 33644757:33644903:33658974:33659009:33659507:33659602 | 33658974:33659009 |
| exon_skip_134230 | chr3 | 33576169:33576275:33577202:33577264:33581821:33581928 | 33577202:33577264 |
| exon_skip_13615 | chr3 | 33498584:33498717:33501652:33501768:33510558:33510764 | 33501652:33501768 |
| exon_skip_142699 | chr3 | 33551252:33551395:33559125:33559175:33559307:33559341 | 33559125:33559175 |
| exon_skip_143190 | chr3 | 33576169:33576275:33581821:33581928:33584750:33584798 | 33581821:33581928 |
| exon_skip_146691 | chr3 | 33510558:33510764:33514580:33514679:33516023:33516151 | 33514580:33514679 |
| exon_skip_149309 | chr3 | 33516981:33517174:33535233:33535461:33538789:33538894 | 33535233:33535461 |
| exon_skip_154098 | chr3 | 33608567:33608626:33612001:33612071:33619603:33619724 | 33612001:33612071 |
| exon_skip_15964 | chr3 | 33516023:33516151:33516981:33517174:33535233:33535366 | 33516981:33517174 |
| exon_skip_16528 | chr3 | 33573170:33573354:33574473:33574496:33576169:33576275 | 33574473:33574496 |
| exon_skip_169897 | chr3 | 33588705:33588731:33592213:33592239:33592395:33592496 | 33592213:33592239 |
| exon_skip_170420 | chr3 | 33501652:33501768:33510558:33510764:33516023:33516151 | 33510558:33510764 |
| exon_skip_171208 | chr3 | 33498584:33498717:33501652:33501768:33516023:33516151 | 33501652:33501768 |
| exon_skip_182332 | chr3 | 33510558:33510764:33514580:33514679:33516023:33516124 | 33514580:33514679 |
| exon_skip_193711 | chr3 | 33516981:33517174:33535233:33535461:33538789:33538942 | 33535233:33535461 |
| exon_skip_197619 | chr3 | 33644764:33644903:33658974:33659009:33659507:33659602 | 33658974:33659009 |
| exon_skip_206243 | chr3 | 33622187:33622280:33626988:33627080:33632292:33632371 | 33626988:33627080 |
| exon_skip_208226 | chr3 | 33632292:33632371:33644757:33644903:33658974:33659009 | 33644757:33644903 |
| exon_skip_208331 | chr3 | 33560808:33560971:33563964:33563966:33570727:33570790 | 33563964:33563966 |
| exon_skip_22128 | chr3 | 33538923:33538942:33543433:33543539:33544698:33544841 | 33543433:33543539 |
| exon_skip_222028 | chr3 | 33584754:33584920:33588705:33588731:33592213:33592239 | 33588705:33588731 |
| exon_skip_229549 | chr3 | 33501652:33501768:33510558:33510764:33516023:33516104 | 33510558:33510764 |
| exon_skip_235432 | chr3 | 33501652:33501768:33510558:33510764:33516023:33516124 | 33510558:33510764 |
| exon_skip_236050 | chr3 | 33581821:33581928:33584750:33584920:33592395:33592496 | 33584750:33584920 |
| exon_skip_248733 | chr3 | 33644764:33644903:33663445:33663515:33684359:33684456 | 33663445:33663515 |
| exon_skip_249116 | chr3 | 33498584:33498717:33501652:33501768:33510558:33510597 | 33501652:33501768 |
| exon_skip_251431 | chr3 | 33501716:33501768:33510558:33510764:33516023:33516151 | 33510558:33510764 |
| exon_skip_251750 | chr3 | 33607384:33607461:33608567:33608626:33612001:33612071 | 33608567:33608626 |
| exon_skip_258203 | chr3 | 33592395:33592496:33594951:33594968:33596711:33596734 | 33594951:33594968 |
| exon_skip_258557 | chr3 | 33535373:33535461:33538789:33538942:33543433:33543539 | 33538789:33538942 |
| exon_skip_275061 | chr3 | 33626988:33627080:33632292:33632371:33644757:33644903 | 33632292:33632371 |
| exon_skip_44701 | chr3 | 33644757:33644903:33663445:33663515:33684359:33684456 | 33663445:33663515 |
| exon_skip_45631 | chr3 | 33604154:33604209:33606591:33606758:33607384:33607461 | 33606591:33606758 |
| exon_skip_5943 | chr3 | 33516981:33517174:33535233:33535461:33538789:33538922 | 33535233:33535461 |
| exon_skip_69285 | chr3 | 33560808:33560971:33570727:33570790:33573110:33573354 | 33570727:33570790 |
| exon_skip_71885 | chr3 | 33584750:33584920:33588705:33588731:33592213:33592239 | 33588705:33588731 |
| exon_skip_83672 | chr3 | 33560808:33560971:33566732:33566734:33570727:33570790 | 33566732:33566734 |
| exon_skip_88077 | chr3 | 33608567:33608626:33612001:33612071:33619603:33619738 | 33612001:33612071 |
| exon_skip_88198 | chr3 | 33592395:33592496:33594951:33594968:33596711:33596732 | 33594951:33594968 |
| exon_skip_95003 | chr3 | 33594951:33594968:33596711:33596734:33602952:33603125 | 33596711:33596734 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_16528 | ROSMAP_DLPFC | 2.720588e-01 | 3.861261e-01 | -1.140673e-01 | 4.140818e-04 |
| exon_skip_16528 | ROSMAP_PCC | 4.357143e-01 | 5.533333e-01 | -1.176190e-01 | 9.587252e-05 |
| exon_skip_110525 | ROSMAP_HCC | 2.858278e-01 | 1.764384e-01 | 1.093895e-01 | 3.154085e-02 |
| exon_skip_208331 | MSBB_STG | 6.040909e-01 | 4.808333e-01 | 1.232576e-01 | 9.978899e-03 |
| exon_skip_16528 | MSBB_STG | 4.063768e-01 | 5.425000e-01 | -1.361232e-01 | 3.173720e-03 |
| exon_skip_208331 | MSBB_PG | 6.768456e-01 | 5.190909e-01 | 1.577547e-01 | 3.279307e-06 |
| exon_skip_83672 | MSBB_PG | 3.192000e-01 | 1.911765e-01 | 1.280235e-01 | 1.853591e-05 |
| exon_skip_16528 | MSBB_PG | 2.788667e-01 | 4.631034e-01 | -1.842368e-01 | 1.493169e-07 |
| exon_skip_83672 | Mayo_TC | 4.755556e-01 | 3.683099e-01 | 1.072457e-01 | 4.121270e-02 |
| exon_skip_16528 | Mayo_TC | 1.553659e-01 | 2.643590e-01 | -1.089931e-01 | 1.771365e-03 |
| exon_skip_134230 | Mayo_TC | 3.228049e-01 | 4.375641e-01 | -1.147592e-01 | 5.080720e-04 |
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Open reading frame (ORF) annotation in the exon skipping event for CLASP2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for CLASP2 |
p-ENSG00000163539_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in CLASP2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CLASP2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CLASP2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| CDR | MSBB | IFG | exon_skip_16528 | -4.103472e-01 | 3.008994e-02 | chr3 | - | 33573170 | 33573354 | 33574473 | 33574496 | 33576169 | 33576275 |
| CDR | MSBB | STG | exon_skip_16528 | -4.613831e-01 | 3.250000e-06 | chr3 | - | 33573170 | 33573354 | 33574473 | 33574496 | 33576169 | 33576275 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CLASP2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CLASP2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | NUP42 | exon_skip_70185 | 6.992133e-01 | 1.781496e-23 |
| CB | PABPC1 | exon_skip_70185 | 4.968535e-01 | 8.651819e-11 |
| CB | TRA2A | exon_skip_16528 | -4.293748e-01 | 2.230273e-08 |
| CB | NUP42 | exon_skip_16528 | 7.296656e-01 | 3.322231e-27 |
| CB | PABPC1 | exon_skip_16528 | 4.915626e-01 | 7.214981e-11 |
| CB | SRSF9 | exon_skip_16528 | 4.162907e-01 | 6.479626e-08 |
| CB | RBM6 | exon_skip_134230 | -4.821558e-01 | 1.412859e-10 |
| CB | PCBP4 | exon_skip_134230 | 5.561000e-01 | 3.317064e-14 |
| CB | TRA2A | exon_skip_134230 | -4.358136e-01 | 1.044637e-08 |
| CB | NUP42 | exon_skip_126991 | 6.011127e-01 | 1.070730e-16 |
| FL | HNRNPL | exon_skip_16528 | 5.038112e-01 | 3.314796e-14 |
| FL | SRSF9 | exon_skip_16528 | 4.105506e-01 | 1.715471e-09 |
| FL | HNRNPK | exon_skip_105751 | 4.013452e-01 | 4.631221e-09 |
| HCC | TRA2A | exon_skip_16528 | -4.206164e-01 | 4.361551e-13 |
| HCC | PCBP4 | exon_skip_134230 | 4.662316e-01 | 5.619326e-16 |
| HCC | RBM5 | exon_skip_126991 | -6.386963e-01 | 1.832097e-32 |
| HCC | SF1 | exon_skip_126991 | -4.981409e-01 | 2.111853e-18 |
| HCC | PABPC1 | exon_skip_126991 | -4.864282e-01 | 1.674301e-17 |
| HCC | SART3 | exon_skip_126991 | -4.280790e-01 | 1.675477e-13 |
| HCC | RBM5 | exon_skip_269026 | -6.350986e-01 | 5.197004e-32 |
| HCC | PABPC1 | exon_skip_269026 | -4.724878e-01 | 1.778648e-16 |
| IFG | TRA2A | exon_skip_16528 | -4.578713e-01 | 1.428194e-02 |
| IFG | PABPC1 | exon_skip_16528 | -5.638534e-01 | 1.778781e-03 |
| IFG | PCBP4 | exon_skip_134230 | 4.992469e-01 | 6.837609e-03 |
| IFG | PABPC1 | exon_skip_247913 | -4.610484e-01 | 1.353797e-02 |
| PCC | PABPC1 | exon_skip_16528 | -5.027297e-01 | 7.522614e-15 |
| PCC | PABPC1 | exon_skip_247913 | -4.120985e-01 | 5.660451e-10 |
| PG | HNRNPL | exon_skip_16528 | 4.874605e-01 | 8.201216e-14 |
| PG | SART3 | exon_skip_16528 | 4.065021e-01 | 1.111920e-09 |
| PG | PCBP4 | exon_skip_134230 | 4.484620e-01 | 2.747050e-11 |
| PG | HNRNPK | exon_skip_126991 | 5.373340e-01 | 9.862306e-17 |
| PG | SF1 | exon_skip_126991 | 4.107538e-01 | 9.519570e-10 |
| PG | NUP42 | exon_skip_126991 | 4.786249e-01 | 3.909717e-13 |
| PG | SRSF9 | exon_skip_126991 | 4.706349e-01 | 1.073308e-12 |
| PG | SART3 | exon_skip_126991 | 5.457493e-01 | 2.623768e-17 |
| PG | NOVA1 | exon_skip_126991 | 5.650010e-01 | 1.098982e-18 |
| STG | NUP42 | exon_skip_16528 | 5.323788e-01 | 3.964991e-08 |
| STG | HNRNPL | exon_skip_16528 | 5.367469e-01 | 2.922304e-08 |
| STG | SRSF9 | exon_skip_16528 | 5.136815e-01 | 1.395756e-07 |
| TC | NUP42 | exon_skip_16528 | 6.604799e-01 | 2.067540e-21 |
| TC | PCBP4 | exon_skip_134230 | 5.917098e-01 | 1.732642e-16 |
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RelatedDrugs for CLASP2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CLASP2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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