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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ATP10B |
 Gene summary |
| Gene information | Gene symbol | ATP10B | Gene ID | 23120 |
| Gene name | ATPase phospholipid transporting 10B (putative) | |
| Synonyms | ATPVB | |
| Cytomap | 5q34 | |
| Type of gene | protein-coding | |
| Description | probable phospholipid-transporting ATPase VBATPase, class V, type 10BP4-ATPase flippase complex alpha subunit ATP10B | |
| Modification date | 20200320 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ATP10B |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000118322
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000523758.1 | ATP10B-211:lncRNA:ATP10B | 2.162879e+00 | -1.068338e+00 | 4.163445e-04 | 2.468253e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ATP10B |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_139281 | chr5 | 160640461:160640592:160644138:160644244:160649171:160649256 | 160644138:160644244 |
| exon_skip_149905 | chr5 | 160644138:160644244:160649171:160649256:160670463:160670667 | 160649171:160649256 |
| exon_skip_17393 | chr5 | 160687800:160688094:160688760:160688943:160716909:160717034 | 160688760:160688943 |
| exon_skip_179300 | chr5 | 160591059:160591139:160598770:160598970:160602577:160602702 | 160598770:160598970 |
| exon_skip_208320 | chr5 | 160716909:160717034:160785736:160785803:160851941:160852154 | 160785736:160785803 |
| exon_skip_22552 | chr5 | 160687911:160688094:160688760:160688943:160716909:160717034 | 160688760:160688943 |
| exon_skip_239440 | chr5 | 160687800:160688094:160716909:160717034:160785736:160785803 | 160716909:160717034 |
| exon_skip_249873 | chr5 | 160687800:160688094:160716909:160717034:160785559:160785803 | 160716909:160717034 |
| exon_skip_286950 | chr5 | 160636182:160636309:160640461:160640592:160644138:160644244 | 160640461:160640592 |
| exon_skip_37326 | chr5 | 160716909:160717034:160785559:160785803:160851941:160852154 | 160785559:160785803 |
| exon_skip_66360 | chr5 | 160687911:160688094:160716909:160717034:160785559:160785803 | 160716909:160717034 |
| exon_skip_7102 | chr5 | 160687911:160688094:160716909:160717034:160785736:160785803 | 160716909:160717034 |
| exon_skip_839 | chr5 | 160589592:160589696:160591059:160591139:160598770:160598970 | 160591059:160591139 |
| exon_skip_88115 | chr5 | 160632129:160632367:160634354:160634606:160636182:160636309 | 160634354:160634606 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ATP10B |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000327245 | 160688760 | 160688943 | 3UTR-3UTR |
| ENST00000327245 | 160634354 | 160634606 | Frame-shift |
| ENST00000327245 | 160644138 | 160644244 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000327245 | 160688760 | 160688943 | 3UTR-3UTR |
| ENST00000327245 | 160785559 | 160785803 | 3UTR-3UTR |
| ENST00000327245 | 160644138 | 160644244 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000327245 | 160688760 | 160688943 | 3UTR-3UTR |
| ENST00000327245 | 160785559 | 160785803 | 3UTR-3UTR |
| ENST00000327245 | 160634354 | 160634606 | Frame-shift |
| ENST00000327245 | 160644138 | 160644244 | Frame-shift |
| ENST00000327245 | 160649171 | 160649256 | Frame-shift |
| ENST00000327245 | 160591059 | 160591139 | In-frame |
| ENST00000327245 | 160598770 | 160598970 | In-frame |
| ENST00000327245 | 160640461 | 160640592 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ATP10B |
p-ENSG00000118322_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000327245 | 7583 | 1461 | 160640461 | 160640592 | 1716 | 1846 | 289 | 333 |
| ENST00000327245 | 7583 | 1461 | 160598770 | 160598970 | 4211 | 4410 | 1121 | 1187 |
| ENST00000327245 | 7583 | 1461 | 160591059 | 160591139 | 4412 | 4491 | 1188 | 1214 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O94823 | 289 | 333 | 1 | 1461 | Chain | ID=PRO_0000046381;Note=Probable phospholipid-transporting ATPase VB |
| O94823 | 289 | 333 | 133 | 316 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O94823 | 289 | 333 | 317 | 338 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O94823 | 1121 | 1187 | 530 | 1461 | Alternative sequence | ID=VSP_007307;Note=In isoform B and isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| O94823 | 1121 | 1187 | 1 | 1461 | Chain | ID=PRO_0000046381;Note=Probable phospholipid-transporting ATPase VB |
| O94823 | 1121 | 1187 | 1133 | 1144 | Topological domain | Note=Exoplasmic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O94823 | 1121 | 1187 | 1165 | 1194 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O94823 | 1121 | 1187 | 1112 | 1132 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O94823 | 1121 | 1187 | 1145 | 1164 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O94823 | 1188 | 1214 | 530 | 1461 | Alternative sequence | ID=VSP_007307;Note=In isoform B and isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| O94823 | 1188 | 1214 | 1 | 1461 | Chain | ID=PRO_0000046381;Note=Probable phospholipid-transporting ATPase VB |
| O94823 | 1188 | 1214 | 1165 | 1194 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O94823 | 1188 | 1214 | 1195 | 1216 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ATP10B |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000327245 | 160688760 | 160688943 | hsa-miR-26a-2-3p | chr5:160688793-160688800 | 8mer-1a | chr5:160688777-160688800 | 156.00 | -14.65 |
| Mayo | ENST00000327245 | 160688760 | 160688943 | hsa-miR-2116-3p | chr5:160688800-160688807 | 8mer-1a | chr5:160688793-160688815 | 155.00 | -14.25 |
| Mayo | ENST00000327245 | 160785559 | 160785803 | hsa-miR-324-3p | chr5:160785675-160785682 | 8mer-1a | chr5:160785661-160785682 | 154.00 | -21.48 |
| Mayo | ENST00000327245 | 160688760 | 160688943 | hsa-miR-6793-3p | chr5:160688894-160688901 | 8mer-1a | chr5:160688882-160688901 | 159.00 | -25.58 |
| Mayo | ENST00000327245 | 160688760 | 160688943 | hsa-miR-5571-3p | chr5:160688816-160688823 | 8mer-1a | chr5:160688804-160688823 | 156.00 | -25.37 |
| Mayo | ENST00000327245 | 160785559 | 160785803 | hsa-miR-466 | chr5:160785645-160785652 | 8mer-1a | chr5:160785630-160785652 | 160.00 | -14.17 |
| Mayo | ENST00000327245 | 160688760 | 160688943 | hsa-miR-26a-1-3p | chr5:160688793-160688800 | 8mer-1a | chr5:160688777-160688800 | 156.00 | -14.65 |
| Mayo | ENST00000327245 | 160688760 | 160688943 | hsa-miR-4639-3p | chr5:160688780-160688787 | 8mer-1a | chr5:160688777-160688800 | 156.00 | -14.65 |
| Mayo | ENST00000327245 | 160785559 | 160785803 | hsa-miR-4643 | chr5:160785644-160785651 | 8mer-1a | chr5:160785630-160785651 | 160.00 | -15.04 |
| Mayo | ENST00000327245 | 160785559 | 160785803 | hsa-miR-12123 | chr5:160785711-160785718 | 8mer-1a | chr5:160785697-160785721 | 153.00 | -14.10 |
| Mayo | ENST00000327245 | 160688760 | 160688943 | hsa-miR-384 | chr5:160688817-160688824 | 8mer-1a | chr5:160688805-160688824 | 147.00 | -10.17 |
| MSBB | ENST00000327245 | 160688760 | 160688943 | hsa-miR-26a-2-3p | chr5:160688793-160688800 | 8mer-1a | chr5:160688777-160688800 | 156.00 | -14.65 |
| MSBB | ENST00000327245 | 160688760 | 160688943 | hsa-miR-2116-3p | chr5:160688800-160688807 | 8mer-1a | chr5:160688793-160688815 | 155.00 | -14.25 |
| MSBB | ENST00000327245 | 160785559 | 160785803 | hsa-miR-324-3p | chr5:160785675-160785682 | 8mer-1a | chr5:160785661-160785682 | 154.00 | -21.48 |
| MSBB | ENST00000327245 | 160688760 | 160688943 | hsa-miR-6793-3p | chr5:160688894-160688901 | 8mer-1a | chr5:160688882-160688901 | 159.00 | -25.58 |
| MSBB | ENST00000327245 | 160688760 | 160688943 | hsa-miR-5571-3p | chr5:160688816-160688823 | 8mer-1a | chr5:160688804-160688823 | 156.00 | -25.37 |
| MSBB | ENST00000327245 | 160785559 | 160785803 | hsa-miR-466 | chr5:160785645-160785652 | 8mer-1a | chr5:160785630-160785652 | 160.00 | -14.17 |
| MSBB | ENST00000327245 | 160688760 | 160688943 | hsa-miR-26a-1-3p | chr5:160688793-160688800 | 8mer-1a | chr5:160688777-160688800 | 156.00 | -14.65 |
| MSBB | ENST00000327245 | 160688760 | 160688943 | hsa-miR-4639-3p | chr5:160688780-160688787 | 8mer-1a | chr5:160688777-160688800 | 156.00 | -14.65 |
| MSBB | ENST00000327245 | 160785559 | 160785803 | hsa-miR-4643 | chr5:160785644-160785651 | 8mer-1a | chr5:160785630-160785651 | 160.00 | -15.04 |
| MSBB | ENST00000327245 | 160785559 | 160785803 | hsa-miR-12123 | chr5:160785711-160785718 | 8mer-1a | chr5:160785697-160785721 | 153.00 | -14.10 |
| MSBB | ENST00000327245 | 160688760 | 160688943 | hsa-miR-384 | chr5:160688817-160688824 | 8mer-1a | chr5:160688805-160688824 | 147.00 | -10.17 |
| ROSMAP | ENST00000327245 | 160688760 | 160688943 | hsa-miR-26a-2-3p | chr5:160688793-160688800 | 8mer-1a | chr5:160688777-160688800 | 156.00 | -14.65 |
| ROSMAP | ENST00000327245 | 160688760 | 160688943 | hsa-miR-2116-3p | chr5:160688800-160688807 | 8mer-1a | chr5:160688793-160688815 | 155.00 | -14.25 |
| ROSMAP | ENST00000327245 | 160688760 | 160688943 | hsa-miR-6793-3p | chr5:160688894-160688901 | 8mer-1a | chr5:160688882-160688901 | 159.00 | -25.58 |
| ROSMAP | ENST00000327245 | 160688760 | 160688943 | hsa-miR-5571-3p | chr5:160688816-160688823 | 8mer-1a | chr5:160688804-160688823 | 156.00 | -25.37 |
| ROSMAP | ENST00000327245 | 160688760 | 160688943 | hsa-miR-26a-1-3p | chr5:160688793-160688800 | 8mer-1a | chr5:160688777-160688800 | 156.00 | -14.65 |
| ROSMAP | ENST00000327245 | 160688760 | 160688943 | hsa-miR-4639-3p | chr5:160688780-160688787 | 8mer-1a | chr5:160688777-160688800 | 156.00 | -14.65 |
| ROSMAP | ENST00000327245 | 160688760 | 160688943 | hsa-miR-384 | chr5:160688817-160688824 | 8mer-1a | chr5:160688805-160688824 | 147.00 | -10.17 |
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SNVs in the skipped exons for ATP10B |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ATP10B |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ATP10B |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ATP10B |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ATP10B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATP10B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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