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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TAB2 |
 Gene summary |
| Gene information | Gene symbol | TAB2 | Gene ID | 23118 |
| Gene name | TGF-beta activated kinase 1 (MAP3K7) binding protein 2 | |
| Synonyms | CHTD2|MAP3K7IP2|TAB-2 | |
| Cytomap | 6q25.1 | |
| Type of gene | protein-coding | |
| Description | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2TAK1-binding protein 2mitogen-activated protein kinase kinase kinase 7-interacting protein 2 | |
| Modification date | 20200315 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TAB2 | GO:0032496 | response to lipopolysaccharide | 19193853 |
| TAB2 | GO:0045860 | positive regulation of protein kinase activity | 11460167 |
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Gene structures and expression levels for TAB2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000228408
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| PG | UP | 3.717293e+02 | 1.323802e+00 | 2.891785e-14 | 3.022657e-11 |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PCC | UP | ENST00000637865.1 | TAB2-AS1-202:lncRNA:TAB2 | 1.587926e+00 | 1.230472e+00 | 5.629763e-06 | 8.515204e-04 |
| PG | UP | ENST00000637865.1 | TAB2-AS1-202:lncRNA:TAB2 | 3.019671e+00 | 1.108238e+00 | 1.558224e-05 | 6.988689e-04 |
| PG | UP | ENST00000424421.2 | TAB2-AS1-201:lncRNA:TAB2 | 3.674919e+00 | 1.009560e+00 | 5.471495e-05 | 1.756038e-03 |
| PG | UP | ENST00000606202.1 | TAB2-206:protein_coding:TAB2 | 1.070292e+01 | 1.311761e+00 | 2.675993e-03 | 2.939332e-02 |
| CB | UP | ENST00000470466.5 | TAB2-203:nonsense_mediated_decay:TAB2 | 1.728256e+02 | 1.279630e+00 | 5.600228e-13 | 9.230886e-11 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TAB2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_10182 | chr6 | 149378672:149379518:149379934:149380143:149397604:149397764 | 149379934:149380143 |
| exon_skip_11063 | chr6 | 149317712:149318015:149369909:149370099:149378018:149378059 | 149369909:149370099 |
| exon_skip_115368 | chr6 | 149379411:149379518:149379934:149380143:149397604:149397764 | 149379934:149380143 |
| exon_skip_127994 | chr6 | 149378672:149379518:149397604:149397764:149397969:149398062 | 149397604:149397764 |
| exon_skip_193231 | chr6 | 149397604:149397764:149397969:149398062:149399104:149399184 | 149397969:149398062 |
| exon_skip_198576 | chr6 | 149342813:149342833:149369909:149370099:149378018:149378529 | 149369909:149370099 |
| exon_skip_203763 | chr6 | 149369909:149370099:149378018:149379518:149397604:149397764 | 149378018:149379518 |
| exon_skip_58561 | chr6 | 149317712:149318015:149369909:149370099:149378018:149378529 | 149369909:149370099 |
| exon_skip_6912 | chr6 | 149317972:149318015:149369909:149370099:149378018:149378529 | 149369909:149370099 |
| exon_skip_71163 | chr6 | 149342685:149342833:149346478:149346596:149347171:149347225 | 149346478:149346596 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TAB2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000367456 | 149369909 | 149370099 | 5CDS-5UTR |
| ENST00000538427 | 149369909 | 149370099 | 5CDS-5UTR |
| ENST00000637181 | 149369909 | 149370099 | 5CDS-5UTR |
| ENST00000367456 | 149378018 | 149379518 | Frame-shift |
| ENST00000538427 | 149378018 | 149379518 | Frame-shift |
| ENST00000637181 | 149378018 | 149379518 | Frame-shift |
| ENST00000367456 | 149397604 | 149397764 | Frame-shift |
| ENST00000538427 | 149397604 | 149397764 | Frame-shift |
| ENST00000637181 | 149397604 | 149397764 | Frame-shift |
| ENST00000367456 | 149397969 | 149398062 | Frame-shift |
| ENST00000538427 | 149397969 | 149398062 | Frame-shift |
| ENST00000637181 | 149397969 | 149398062 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000637181 | 149369909 | 149370099 | 5CDS-5UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000367456 | 149369909 | 149370099 | 5CDS-5UTR |
| ENST00000538427 | 149369909 | 149370099 | 5CDS-5UTR |
| ENST00000637181 | 149369909 | 149370099 | 5CDS-5UTR |
| ENST00000367456 | 149378018 | 149379518 | Frame-shift |
| ENST00000538427 | 149378018 | 149379518 | Frame-shift |
| ENST00000637181 | 149378018 | 149379518 | Frame-shift |
| ENST00000367456 | 149397969 | 149398062 | Frame-shift |
| ENST00000538427 | 149397969 | 149398062 | Frame-shift |
| ENST00000637181 | 149397969 | 149398062 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for TAB2 |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in TAB2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TAB2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TAB2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TAB2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TAB2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for TAB2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAB2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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