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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TNRC6B |
 Gene summary |
| Gene information | Gene symbol | TNRC6B | Gene ID | 23112 |
| Gene name | trinucleotide repeat containing adaptor 6B | |
| Synonyms | - | |
| Cytomap | 22q13.1 | |
| Type of gene | protein-coding | |
| Description | trinucleotide repeat-containing gene 6B proteintrinucleotide repeat containing 6B | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TNRC6B |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000100354
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TNRC6B |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_102382 | chr22 | 40279999:40280143:40281119:40281289:40285645:40285770 | 40281119:40281289 |
| exon_skip_151665 | chr22 | 40261832:40262173:40264688:40267036:40273425:40273600 | 40264688:40267036 |
| exon_skip_186104 | chr22 | 40117055:40117128:40125772:40125862:40156115:40156182 | 40125772:40125862 |
| exon_skip_201559 | chr22 | 40044817:40044998:40117055:40117128:40125772:40125862 | 40117055:40117128 |
| exon_skip_209768 | chr22 | 40279995:40280143:40281119:40281289:40285645:40285770 | 40281119:40281289 |
| exon_skip_219898 | chr22 | 40246015:40246102:40251179:40251200:40261832:40262173 | 40251179:40251200 |
| exon_skip_256982 | chr22 | 40261832:40262173:40270122:40270280:40273425:40273600 | 40270122:40270280 |
| exon_skip_26829 | chr22 | 40265003:40267036:40273425:40273600:40277077:40277151 | 40273425:40273600 |
| exon_skip_285785 | chr22 | 40261832:40262173:40264688:40267036:40270122:40270280 | 40264688:40267036 |
| exon_skip_41127 | chr22 | 40177942:40178140:40246015:40246102:40251179:40251200 | 40246015:40246102 |
| exon_skip_60831 | chr22 | 40125772:40125862:40156115:40156182:40246015:40246102 | 40156115:40156182 |
| exon_skip_63842 | chr22 | 40265003:40267036:40270122:40270280:40273425:40273499 | 40270122:40270280 |
| exon_skip_9242 | chr22 | 40301150:40301333:40308512:40308649:40310817:40310993 | 40308512:40308649 |
| exon_skip_93265 | chr22 | 40266801:40267036:40270122:40270280:40273425:40273600 | 40270122:40270280 |
| exon_skip_93746 | chr22 | 40265003:40267036:40270122:40270280:40273425:40273600 | 40270122:40270280 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TNRC6B |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000335727 | 40251179 | 40251200 | Frame-shift |
| ENST00000335727 | 40273425 | 40273600 | Frame-shift |
| ENST00000335727 | 40264688 | 40267036 | In-frame |
| ENST00000335727 | 40308512 | 40308649 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000335727 | 40273425 | 40273600 | Frame-shift |
| ENST00000335727 | 40264688 | 40267036 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000335727 | 40246015 | 40246102 | Frame-shift |
| ENST00000335727 | 40273425 | 40273600 | Frame-shift |
| ENST00000335727 | 40264688 | 40267036 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TNRC6B |
p-ENSG00000100354_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in TNRC6B |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TNRC6B |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TNRC6B |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| CDR | MSBB | IFG | exon_skip_209768 | -4.575233e-01 | 1.436546e-02 | chr22 | + | 40279995 | 40280143 | 40281119 | 40281289 | 40285645 | 40285770 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TNRC6B |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TNRC6B |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM4B | exon_skip_93746 | -4.998492e-01 | 4.117746e-11 |
| CB | RBM6 | exon_skip_209768 | -4.777437e-01 | 5.541827e-10 |
| CB | PCBP4 | exon_skip_209768 | 4.635411e-01 | 2.049826e-09 |
| CB | RBM45 | exon_skip_209768 | 5.557767e-01 | 1.287876e-13 |
| HCC | RBM6 | exon_skip_93746 | -4.666939e-01 | 1.335420e-14 |
| HCC | G3BP2 | exon_skip_93746 | 4.984806e-01 | 9.892683e-17 |
| HCC | HNRNPF | exon_skip_93746 | -4.204161e-01 | 7.200011e-12 |
| HCC | RBM4B | exon_skip_93746 | -4.795418e-01 | 1.954666e-15 |
| HCC | RBM6 | exon_skip_209768 | -5.370118e-01 | 3.157094e-20 |
| HCC | RBM47 | exon_skip_209768 | -4.555613e-01 | 2.570840e-14 |
| HCC | PTBP1 | exon_skip_209768 | -6.019032e-01 | 3.148769e-26 |
| HCC | SNRNP70 | exon_skip_209768 | -4.340506e-01 | 5.316477e-13 |
| IFG | RBM6 | exon_skip_93746 | -6.311324e-01 | 3.168100e-04 |
| IFG | SRSF11 | exon_skip_93746 | -4.058650e-01 | 3.211915e-02 |
| IFG | CNOT4 | exon_skip_93746 | -4.010968e-01 | 3.439746e-02 |
| IFG | PCBP2 | exon_skip_93746 | -5.478218e-01 | 2.547427e-03 |
| IFG | HNRNPA2B1 | exon_skip_93746 | -5.080849e-01 | 5.773448e-03 |
| IFG | ESRP2 | exon_skip_93746 | -5.913831e-01 | 9.188546e-04 |
| IFG | RBM6 | exon_skip_209768 | -6.297474e-01 | 3.295921e-04 |
| IFG | IGF2BP3 | exon_skip_209768 | -4.267271e-01 | 2.353702e-02 |
| IFG | RBM47 | exon_skip_209768 | -4.986281e-01 | 6.917945e-03 |
| IFG | PCBP2 | exon_skip_209768 | -4.145312e-01 | 2.829046e-02 |
| IFG | PTBP1 | exon_skip_209768 | -4.765567e-01 | 1.035272e-02 |
| IFG | SNRNP70 | exon_skip_209768 | -4.937636e-01 | 7.577679e-03 |
| IFG | ESRP1 | exon_skip_209768 | 4.574972e-01 | 1.437174e-02 |
| IFG | ESRP2 | exon_skip_209768 | -5.438573e-01 | 2.776520e-03 |
| PCC | G3BP2 | exon_skip_93265 | 4.082772e-01 | 7.264307e-09 |
| PCC | ESRP2 | exon_skip_93265 | -4.046214e-01 | 1.016517e-08 |
| PCC | RBM47 | exon_skip_209768 | -4.490298e-01 | 8.141277e-11 |
| PCC | PTBP1 | exon_skip_209768 | -5.335787e-01 | 2.254529e-15 |
| PG | PTBP1 | exon_skip_209768 | -4.047099e-01 | 1.604701e-07 |
| STG | HNRNPH2 | exon_skip_93746 | 5.108869e-01 | 6.215278e-06 |
| TC | SRSF2 | exon_skip_93746 | 4.035888e-01 | 8.372590e-07 |
| TC | SRSF5 | exon_skip_93746 | 4.338912e-01 | 9.502508e-08 |
| TC | HNRNPH2 | exon_skip_93746 | 4.011909e-01 | 9.857177e-07 |
| TC | RBM6 | exon_skip_102382 | -4.306564e-01 | 7.927102e-08 |
| TC | PTBP1 | exon_skip_102382 | -4.752234e-01 | 2.006676e-09 |
| TC | ESRP1 | exon_skip_102382 | 4.807091e-01 | 1.229328e-09 |
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RelatedDrugs for TNRC6B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TNRC6B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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