ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for MYCBP2

Gene summary

Gene information	Gene symbol	MYCBP2
	Gene ID	23077
	Gene name	MYC binding protein 2
	Synonyms	Myc-bp2\|PAM\|PHR1\|Phr
	Cytomap	13q22.3
	Type of gene	protein-coding
	Description	E3 ubiquitin-protein ligase MYCBP2HighwireMYC binding protein 2, E3 ubiquitin protein ligasePAM/Highwire/RPM-1 protein 1RING-type E3 ubiquitin transferase MYCBP2myc-binding protein 2pam/highwire/rpm-1 proteinprotein associated with Myc
	Modification date	20200313
	UniProtAcc	A0A087WY34, A0A0C4DGY7, A0A499FJI4, H7C3U4,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
MYCBP2	GO:0016567	protein ubiquitination	29643511
MYCBP2	GO:0031398	positive regulation of protein ubiquitination	20534529

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Gene structures and expression levels for MYCBP2

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000005810

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
PCC	DOWN	ENST00000596342.1	MYCBP2-AS1-205:lncRNA:MYCBP2	1.643412e+00	-8.372332e-01	2.085939e-03	4.018951e-02
PG	DOWN	ENST00000485061.2	MYCBP2-207:lncRNA:MYCBP2	3.530083e+01	-9.255918e-01	6.584670e-04	1.076606e-02
CB	DOWN	ENST00000491491.1	MYCBP2-209:lncRNA:MYCBP2	1.087555e+00	-3.675733e+00	1.295125e-02	4.288488e-02

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MYCBP2

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_107471	chr13	77061169:77061301:77061662:77061790:77062596:77062697	77061662:77061790
exon_skip_124061	chr13	77180127:77180318:77181701:77181922:77185103:77185371	77181701:77181922
exon_skip_130300	chr13	77125336:77125468:77126318:77126542:77139196:77139336	77126318:77126542
exon_skip_137057	chr13	77157937:77158109:77161906:77161955:77164454:77164541	77161906:77161955
exon_skip_14754	chr13	77070631:77070711:77076760:77076849:77077148:77077387	77076760:77076849
exon_skip_167020	chr13	77098885:77099013:77103209:77103310:77118340:77118462	77103209:77103310
exon_skip_17287	chr13	77056986:77057093:77058218:77058406:77059523:77059626	77058218:77058406
exon_skip_176965	chr13	77288161:77288376:77296599:77296674:77326474:77326540	77296599:77296674
exon_skip_191829	chr13	77098885:77099013:77103209:77103310:77118340:77118396	77103209:77103310
exon_skip_211813	chr13	77270031:77270063:77270296:77270538:77273472:77273511	77270296:77270538
exon_skip_21425	chr13	77288161:77288376:77296599:77296674:77326474:77326679	77296599:77296674
exon_skip_219067	chr13	77225435:77225554:77233156:77233263:77243059:77243160	77233156:77233263
exon_skip_242586	chr13	77096312:77096481:77097370:77099013:77121373:77121495	77097370:77099013
exon_skip_243579	chr13	77140047:77140163:77140846:77140943:77144445:77144560	77140846:77140943
exon_skip_243636	chr13	77070631:77070711:77076751:77076849:77077148:77077387	77076751:77076849
exon_skip_251993	chr13	77126452:77126542:77129156:77129230:77139196:77139336	77129156:77129230
exon_skip_264899	chr13	77098885:77099013:77118340:77118519:77121373:77121392	77118340:77118519
exon_skip_272991	chr13	77098885:77099013:77118340:77118519:77121373:77121495	77118340:77118519
exon_skip_30648	chr13	77270296:77270538:77272323:77272399:77273472:77273511	77272323:77272399
exon_skip_31819	chr13	77211956:77212160:77217840:77217957:77224451:77224532	77217840:77217957
exon_skip_32556	chr13	77273472:77273668:77278758:77278911:77288161:77288376	77278758:77278911
exon_skip_48320	chr13	77087484:77087633:77088832:77089031:77090106:77090263	77088832:77089031
exon_skip_66489	chr13	77051811:77051918:77055558:77055767:77056986:77057093	77055558:77055767
exon_skip_7719	chr13	77126318:77126542:77129156:77129230:77139196:77139336	77129156:77129230
exon_skip_79940	chr13	77270398:77270538:77272323:77272399:77273472:77273511	77272323:77272399
exon_skip_9502	chr13	77087535:77087633:77088832:77089031:77090106:77090263	77088832:77089031

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information	Tissue type	Avg(PSIs) in AD	Avg(PSIs) in control	Difference (PSI)	Adj. p-value
exon_skip_130300	MSBB_PG	5.017600e-01	3.751852e-01	1.265748e-01	2.007674e-06
exon_skip_251993	MSBB_PG	5.094400e-01	6.251923e-01	-1.157523e-01	1.225577e-02

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Open reading frame (ORF) annotation in the exon skipping event for MYCBP2

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000357337	77140846	77140943	Frame-shift
ENST00000544440	77140846	77140943	Frame-shift
ENST00000357337	77217840	77217957	Frame-shift
ENST00000544440	77217840	77217957	Frame-shift
ENST00000357337	77278758	77278911	Frame-shift
ENST00000544440	77278758	77278911	Frame-shift
ENST00000357337	77296599	77296674	Frame-shift
ENST00000357337	77058218	77058406	In-frame
ENST00000544440	77058218	77058406	In-frame
ENST00000357337	77076751	77076849	In-frame
ENST00000544440	77076751	77076849	In-frame
ENST00000357337	77097370	77099013	In-frame
ENST00000544440	77097370	77099013	In-frame
ENST00000357337	77126318	77126542	In-frame
ENST00000544440	77126318	77126542	In-frame
ENST00000357337	77181701	77181922	In-frame
ENST00000544440	77181701	77181922	In-frame
ENST00000357337	77233156	77233263	In-frame
ENST00000544440	77233156	77233263	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000357337	77140846	77140943	Frame-shift
ENST00000544440	77140846	77140943	Frame-shift
ENST00000357337	77217840	77217957	Frame-shift
ENST00000544440	77217840	77217957	Frame-shift
ENST00000357337	77278758	77278911	Frame-shift
ENST00000544440	77278758	77278911	Frame-shift
ENST00000357337	77296599	77296674	Frame-shift
ENST00000357337	77058218	77058406	In-frame
ENST00000544440	77058218	77058406	In-frame
ENST00000357337	77076751	77076849	In-frame
ENST00000544440	77076751	77076849	In-frame
ENST00000357337	77097370	77099013	In-frame
ENST00000544440	77097370	77099013	In-frame
ENST00000357337	77126318	77126542	In-frame
ENST00000544440	77126318	77126542	In-frame
ENST00000357337	77233156	77233263	In-frame
ENST00000544440	77233156	77233263	In-frame
ENST00000357337	77270296	77270538	In-frame
ENST00000544440	77270296	77270538	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000357337	77088832	77089031	Frame-shift
ENST00000544440	77088832	77089031	Frame-shift
ENST00000357337	77140846	77140943	Frame-shift
ENST00000544440	77140846	77140943	Frame-shift
ENST00000357337	77161906	77161955	Frame-shift
ENST00000544440	77161906	77161955	Frame-shift
ENST00000357337	77217840	77217957	Frame-shift
ENST00000544440	77217840	77217957	Frame-shift
ENST00000357337	77278758	77278911	Frame-shift
ENST00000544440	77278758	77278911	Frame-shift
ENST00000357337	77296599	77296674	Frame-shift
ENST00000357337	77055558	77055767	In-frame
ENST00000544440	77055558	77055767	In-frame
ENST00000357337	77058218	77058406	In-frame
ENST00000544440	77058218	77058406	In-frame
ENST00000357337	77061662	77061790	In-frame
ENST00000544440	77061662	77061790	In-frame
ENST00000357337	77076751	77076849	In-frame
ENST00000544440	77076751	77076849	In-frame
ENST00000357337	77097370	77099013	In-frame
ENST00000544440	77097370	77099013	In-frame
ENST00000357337	77126318	77126542	In-frame
ENST00000544440	77126318	77126542	In-frame
ENST00000357337	77233156	77233263	In-frame
ENST00000544440	77233156	77233263	In-frame

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Infer the effects of exon skipping event on protein functional features for MYCBP2

p-ENSG00000005810_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST

Length of mRNA

Length of AA seq.

Genomic start

Genomic end

mRNA start

mRNA end

AA start

AA end

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST

Length of mRNA

Length of AA seq.

Genomic start

Genomic end

mRNA start

mRNA end

AA start

AA end

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST

Length of mRNA

Length of AA seq.

Genomic start

Genomic end

mRNA start

mRNA end

AA start

AA end

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

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3'-UTR located exon skipping events that lost miRNA binding sites in MYCBP2

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for MYCBP2

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for MYCBP2

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

ADstage

MSBB

IFG

exon_skip_190924

3.844553e-01

4.338491e-02

chr13

77098885

77099013

77118340

77118495

77121373

77121495

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MYCBP2

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for MYCBP2

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	TARDBP	exon_skip_190924	-4.522755e-01	1.264701e-08
CB	ZNF638	exon_skip_190924	-5.793801e-01	2.786244e-14
CB	RBM6	exon_skip_190924	-4.797216e-01	1.174890e-09
CB	CNOT4	exon_skip_190924	-4.585918e-01	7.455742e-09
CB	PCBP4	exon_skip_190924	4.642012e-01	4.620969e-09
CB	PTBP1	exon_skip_190924	-4.464532e-01	2.039137e-08
CB	ZNF638	exon_skip_272991	-5.408499e-01	8.939136e-12
CB	RBM6	exon_skip_130300	4.135461e-01	5.092629e-07
CB	HNRNPDL	exon_skip_130300	-4.119093e-01	5.705284e-07
CB	NUP42	exon_skip_130300	-4.907939e-01	1.139187e-09
CB	PTBP1	exon_skip_130300	5.165398e-01	1.038794e-10
CB	TIA1	exon_skip_7719	5.486855e-01	4.664190e-12
CB	NUP42	exon_skip_7719	6.613742e-01	1.886603e-18
CB	SRSF9	exon_skip_7719	4.009500e-01	1.316736e-06
FL	HNRNPH2	exon_skip_130300	-4.275858e-01	6.181335e-10
FL	ILF2	exon_skip_7719	4.206357e-01	2.048044e-09
FL	RALYL	exon_skip_7719	4.017275e-01	1.207941e-08
FL	PTBP1	exon_skip_7719	-4.114563e-01	4.914453e-09
FL	HNRNPH2	exon_skip_7719	4.750112e-01	6.469489e-12
FL	ELAVL4	exon_skip_219067	-5.697987e-01	1.939212e-18
FL	KHDRBS3	exon_skip_219067	-5.107569e-01	1.498051e-14
FL	RALYL	exon_skip_219067	-5.044734e-01	3.519316e-14
FL	NOVA1	exon_skip_219067	-4.053864e-01	3.132307e-09
HCC	MSI1	exon_skip_130300	5.922505e-01	3.397351e-26
HCC	SFPQ	exon_skip_130300	4.853535e-01	6.867588e-17
HCC	RBM6	exon_skip_130300	5.284972e-01	2.979741e-20
HCC	SRSF11	exon_skip_130300	4.024646e-01	1.271554e-11
HCC	KHDRBS2	exon_skip_130300	-4.521452e-01	1.319306e-14
HCC	KHDRBS3	exon_skip_130300	4.021113e-01	1.329993e-11
HCC	EIF4G2	exon_skip_130300	4.814058e-01	1.322551e-16
HCC	PTBP1	exon_skip_130300	6.141560e-01	1.477436e-28
HCC	SRSF4	exon_skip_130300	4.554304e-01	8.041229e-15
HCC	HNRNPF	exon_skip_130300	5.340718e-01	1.008746e-20
HCC	ZNF326	exon_skip_7719	-5.364603e-01	7.483137e-21
HCC	U2AF2	exon_skip_7719	-4.216789e-01	1.125102e-12
HCC	TIA1	exon_skip_7719	-4.549383e-01	9.746457e-15
HCC	RBM5	exon_skip_7719	-5.746451e-01	2.458236e-24
HCC	KHDRBS3	exon_skip_7719	-4.113994e-01	4.407965e-12
HCC	FUBP1	exon_skip_7719	-4.399438e-01	8.841735e-14
HCC	RALY	exon_skip_7719	-4.965654e-01	1.176173e-17
HCC	PTBP1	exon_skip_7719	-6.286395e-01	4.109974e-30
HCC	HNRNPF	exon_skip_7719	-5.320945e-01	1.756798e-20
HCC	RBMS2	exon_skip_219067	5.638780e-01	3.181391e-23
HCC	RBM6	exon_skip_219067	4.638190e-01	2.834716e-15
HCC	SAMD4A	exon_skip_219067	4.899813e-01	4.162243e-17
HCC	RALYL	exon_skip_219067	-4.389610e-01	1.134940e-13
IFG	RBM24	exon_skip_190924	4.849678e-01	8.905454e-03
IFG	RBM6	exon_skip_130300	4.085060e-01	3.091055e-02
IFG	IGF2BP2	exon_skip_130300	4.492914e-01	1.646216e-02
IFG	FXR2	exon_skip_130300	-5.078900e-01	5.795303e-03
IFG	ILF2	exon_skip_130300	-5.415654e-01	2.916855e-03
IFG	KHDRBS3	exon_skip_130300	-6.186576e-01	4.493890e-04
IFG	PTBP1	exon_skip_130300	5.844439e-01	1.091313e-03
IFG	HNRNPL	exon_skip_130300	-4.186570e-01	2.660240e-02
IFG	HNRNPH2	exon_skip_130300	-6.049401e-01	6.491559e-04
IFG	ESRP1	exon_skip_130300	-4.276671e-01	2.319954e-02
IFG	TIA1	exon_skip_7719	-4.744018e-01	1.075363e-02
IFG	PTBP1	exon_skip_7719	-4.810566e-01	9.555764e-03
IFG	ESRP2	exon_skip_7719	-4.486605e-01	1.663277e-02
IFG	ELAVL4	exon_skip_219067	-6.674007e-01	1.046532e-04
IFG	FXR2	exon_skip_219067	-5.438670e-01	2.775938e-03
IFG	KHDRBS3	exon_skip_219067	-5.328083e-01	3.510565e-03
IFG	RALYL	exon_skip_219067	-6.123402e-01	5.334486e-04
IFG	NOVA1	exon_skip_219067	-4.689132e-01	1.183375e-02
PCC	MSI1	exon_skip_130300	5.029721e-01	1.216071e-13
PCC	PTBP1	exon_skip_130300	5.209182e-01	1.117311e-14
PCC	ESRP2	exon_skip_130300	4.056852e-01	5.808521e-09
PCC	HNRNPF	exon_skip_130300	4.159601e-01	2.172477e-09
PCC	RALYL	exon_skip_7719	5.197367e-01	1.313173e-14
PCC	PTBP1	exon_skip_7719	-5.667162e-01	1.278419e-17
PCC	RBMS2	exon_skip_219067	5.975642e-01	2.334638e-20
PCC	ELAVL4	exon_skip_219067	-6.262793e-01	9.557545e-23
PCC	SAMD4A	exon_skip_219067	4.439915e-01	7.114970e-11
PCC	FXR2	exon_skip_219067	-4.033190e-01	4.594626e-09
PCC	RALYL	exon_skip_219067	-6.458202e-01	1.614830e-24
PCC	CPEB1	exon_skip_219067	-5.160858e-01	9.808308e-15
PCC	NOVA1	exon_skip_219067	-4.463419e-01	5.495917e-11
PG	FXR2	exon_skip_130300	-4.415759e-01	6.113343e-10
PG	KHDRBS2	exon_skip_130300	-4.784211e-01	1.257952e-11
PG	KHDRBS3	exon_skip_130300	-5.019525e-01	8.171128e-13
PG	PTBP1	exon_skip_130300	4.068645e-01	1.588034e-08
PG	HNRNPH2	exon_skip_130300	-4.840078e-01	6.697425e-12
PG	NOVA1	exon_skip_130300	-4.091975e-01	1.290422e-08
PG	ELAVL4	exon_skip_219067	-7.215844e-01	9.735201e-35
PG	FXR2	exon_skip_219067	-4.805087e-01	2.055749e-13
PG	PCBP1	exon_skip_219067	-4.508265e-01	8.300708e-12
PG	KHDRBS3	exon_skip_219067	-5.978435e-01	1.516824e-21
PG	RALYL	exon_skip_219067	-6.199571e-01	1.780142e-23
PG	CPEB1	exon_skip_219067	-4.434127e-01	1.980030e-11
PG	NOVA1	exon_skip_219067	-4.399984e-01	2.934303e-11
STG	MSI1	exon_skip_130300	4.548655e-01	1.223118e-05
STG	IGF2BP2	exon_skip_130300	4.002798e-01	1.472006e-04
STG	PCBP1	exon_skip_130300	-4.267809e-01	4.639563e-05
STG	KHDRBS3	exon_skip_130300	-4.183414e-01	6.772146e-05
STG	HNRNPH2	exon_skip_130300	-4.508103e-01	1.493676e-05
STG	ESRP2	exon_skip_130300	4.037335e-01	1.273245e-04
STG	NOVA1	exon_skip_130300	-4.458926e-01	1.896858e-05
STG	ILF2	exon_skip_7719	4.534946e-01	1.476891e-05
STG	KHDRBS3	exon_skip_7719	5.152258e-01	5.310011e-07
STG	HNRNPC	exon_skip_7719	4.463291e-01	2.087097e-05
STG	RALYL	exon_skip_7719	5.375666e-01	1.344515e-07
STG	HNRNPL	exon_skip_7719	4.195100e-01	7.122994e-05
STG	HNRNPH2	exon_skip_7719	4.848403e-01	2.958867e-06
STG	EIF4B	exon_skip_7719	4.156367e-01	8.433641e-05
STG	ZCRB1	exon_skip_7719	4.116864e-01	9.997916e-05
STG	ELAVL4	exon_skip_219067	-6.382298e-01	1.009940e-11
STG	KHDRBS3	exon_skip_219067	-4.758506e-01	1.869242e-06
STG	RALYL	exon_skip_219067	-5.812879e-01	1.527411e-09
STG	NOVA1	exon_skip_219067	-4.830770e-01	1.235249e-06
TC	RALYL	exon_skip_190924	4.021651e-01	6.396469e-07
TC	RBM24	exon_skip_272991	4.178775e-01	4.152453e-07
TC	MSI1	exon_skip_130300	4.993230e-01	6.100935e-10
TC	IGF2BP2	exon_skip_130300	4.044602e-01	1.041881e-06
TC	KHDRBS2	exon_skip_130300	-7.247360e-01	1.986920e-23
TC	KHDRBS3	exon_skip_130300	-6.049761e-01	6.174932e-15
TC	NUP42	exon_skip_130300	-5.441860e-01	7.519488e-12
TC	PTBP1	exon_skip_130300	5.892996e-01	4.450398e-14
TC	CELF1	exon_skip_130300	-4.100874e-01	7.118299e-07
TC	HNRNPH2	exon_skip_130300	-5.643750e-01	8.333364e-13
TC	ESRP1	exon_skip_130300	-5.410604e-01	1.043436e-11
TC	HNRNPF	exon_skip_130300	4.522887e-01	3.243608e-08
TC	NOVA1	exon_skip_130300	-6.006220e-01	1.080370e-14
TC	RBM25	exon_skip_7719	4.394120e-01	1.356208e-07
TC	MBNL1	exon_skip_7719	4.214932e-01	4.827325e-07
TC	ILF2	exon_skip_7719	5.017701e-01	8.841003e-10
TC	KHDRBS3	exon_skip_7719	6.265475e-01	9.329703e-16
TC	RBM24	exon_skip_7719	6.102042e-01	8.034350e-15
TC	HNRNPA0	exon_skip_7719	6.538445e-01	1.901704e-17
TC	NUP42	exon_skip_7719	6.458944e-01	6.155317e-17
TC	RALYL	exon_skip_7719	6.765637e-01	5.414773e-19
TC	PTBP1	exon_skip_7719	-4.878771e-01	2.965092e-09
TC	CPEB4	exon_skip_7719	4.212925e-01	4.894467e-07
TC	HNRNPH2	exon_skip_7719	6.934771e-01	3.092894e-20
TC	ESRP1	exon_skip_7719	5.686803e-01	1.133248e-12
TC	RBMS2	exon_skip_219067	5.540374e-01	7.079190e-13
TC	ELAVL4	exon_skip_219067	-6.739157e-01	2.866495e-20
TC	FXR2	exon_skip_219067	-4.660129e-01	4.481859e-09
TC	KHDRBS3	exon_skip_219067	-5.989594e-01	2.749209e-15
TC	RALYL	exon_skip_219067	-6.906780e-01	1.368572e-21
TC	CPEB1	exon_skip_219067	-4.092964e-01	3.861599e-07
TC	NOVA1	exon_skip_219067	-5.749637e-01	5.923527e-14

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RelatedDrugs for MYCBP2

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for MYCBP2

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for MYCBP2

Gene structures and expression levels for MYCBP2

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MYCBP2

Open reading frame (ORF) annotation in the exon skipping event for MYCBP2

Infer the effects of exon skipping event on protein functional features for MYCBP2

3'-UTR located exon skipping events that lost miRNA binding sites in MYCBP2

SNVs in the skipped exons for MYCBP2

AD stage-associated exon skippint events for MYCBP2

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MYCBP2

Correlation with RNA binding proteins (RBPs) for MYCBP2

RelatedDrugs for MYCBP2

RelatedDiseases for MYCBP2