ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for NCOA6

Gene summary

Gene information	Gene symbol	NCOA6
	Gene ID	23054
	Gene name	nuclear receptor coactivator 6
	Synonyms	AIB3\|ASC2\|NRC\|PRIP\|RAP250\|TRBP
	Cytomap	20q11.22
	Type of gene	protein-coding
	Description	nuclear receptor coactivator 6NRC RAP250PPAR-interacting proteinactivating signal cointegrator-2amplified in breast cancer protein 3amplified in breast cancer-3 proteincancer-amplified transcriptional coactivator ASC-2nuclear receptor coactivator R
	Modification date	20200313
	UniProtAcc	A0A0D9SFT8, F6M2K2, F6M2K3, F6M2K4, Q14686, Q1RMZ3,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
NCOA6	GO:0006352	DNA-templated transcription, initiation	10567404
NCOA6	GO:0006974	cellular response to DNA damage stimulus	17500065
NCOA6	GO:0030099	myeloid cell differentiation	11302752
NCOA6	GO:0045944	positive regulation of transcription by RNA polymerase II	11443112

Top

Gene structures and expression levels for NCOA6

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000198646

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
STG	UP	ENST00000359003.7	NCOA6-201:protein_coding:NCOA6	1.879149e+02	1.339799e+00	8.549526e-08	7.228755e-05
CB	DOWN	ENST00000593786.1	NCOA6-205:lncRNA:NCOA6	3.798874e+01	-3.035556e+00	1.040131e-07	2.195743e-06
CB	DOWN	ENST00000471897.1	NCOA6-204:retained_intron:NCOA6	1.094997e+02	-1.438472e+00	1.858888e-07	3.586020e-06
TC	DOWN	ENST00000593786.1	NCOA6-205:lncRNA:NCOA6	2.785696e+01	-2.442049e+00	8.032955e-05	1.356637e-03

Landscape of isoform expressions across multiple brain tissues between AD and control.

Top

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NCOA6

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_11098	chr20	34715067:34715365:34727259:34727407:34732559:34732593	34727259:34727407
exon_skip_113087	chr20	34768464:34768586:34776293:34776448:34782121:34782401	34776293:34776448
exon_skip_136915	chr20	34715067:34715365:34727259:34727407:34732559:34732595	34727259:34727407
exon_skip_137580	chr20	34749403:34750519:34754722:34754868:34757220:34757436	34754722:34754868
exon_skip_190276	chr20	34732559:34732595:34736690:34736758:34740363:34743341	34736690:34736758
exon_skip_242217	chr20	34757674:34758104:34758805:34758933:34768464:34768586	34758805:34758933
exon_skip_268317	chr20	34782121:34782404:34792450:34792563:34825472:34825630	34792450:34792563
exon_skip_289966	chr20	34736690:34736758:34740363:34743341:34746807:34746928	34740363:34743341
exon_skip_33451	chr20	34749403:34750519:34754722:34754868:34757220:34758104	34754722:34754868
exon_skip_43024	chr20	34727259:34727407:34732559:34732595:34736690:34736758	34732559:34732595
exon_skip_57056	chr20	34792450:34792563:34809453:34809522:34819302:34821639	34809453:34809522
exon_skip_58504	chr20	34768464:34768586:34776293:34776448:34782121:34782404	34776293:34776448
exon_skip_74615	chr20	34757887:34758104:34758805:34758933:34768464:34768586	34758805:34758933
exon_skip_91862	chr20	34732559:34732595:34736690:34736758:34740363:34740517	34736690:34736758

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

Top

Open reading frame (ORF) annotation in the exon skipping event for NCOA6

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000359003	34792450	34792563	3UTR-3UTR
ENST00000359003	34727259	34727407	Frame-shift
ENST00000374796	34727259	34727407	Frame-shift
ENST00000359003	34732559	34732595	Frame-shift
ENST00000374796	34732559	34732595	Frame-shift
ENST00000359003	34740363	34743341	In-frame
ENST00000374796	34740363	34743341	In-frame
ENST00000359003	34754722	34754868	In-frame
ENST00000374796	34754722	34754868	In-frame
ENST00000359003	34776293	34776448	In-frame
ENST00000374796	34776293	34776448	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000359003	34727259	34727407	Frame-shift
ENST00000374796	34727259	34727407	Frame-shift
ENST00000359003	34740363	34743341	In-frame
ENST00000374796	34740363	34743341	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000359003	34792450	34792563	3UTR-3UTR
ENST00000374796	34809453	34809522	3UTR-3UTR
ENST00000359003	34727259	34727407	Frame-shift
ENST00000374796	34727259	34727407	Frame-shift
ENST00000359003	34732559	34732595	Frame-shift
ENST00000374796	34732559	34732595	Frame-shift
ENST00000359003	34736690	34736758	In-frame
ENST00000374796	34736690	34736758	In-frame
ENST00000359003	34740363	34743341	In-frame
ENST00000374796	34740363	34743341	In-frame
ENST00000359003	34754722	34754868	In-frame
ENST00000374796	34754722	34754868	In-frame
ENST00000359003	34758805	34758933	In-frame
ENST00000374796	34758805	34758933	In-frame
ENST00000359003	34776293	34776448	In-frame
ENST00000374796	34776293	34776448	In-frame

Top

Infer the effects of exon skipping event on protein functional features for NCOA6

p-ENSG00000198646_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000359003	7098	2063	34776293	34776448	577	731	78	130
ENST00000374796	9328	2063	34776293	34776448	2807	2961	78	130
ENST00000359003	7098	2063	34754722	34754868	1870	2015	509	558
ENST00000374796	9328	2063	34754722	34754868	4100	4245	509	558
ENST00000359003	7098	2063	34740363	34743341	3256	6233	971	1964
ENST00000374796	9328	2063	34740363	34743341	5486	8463	971	1964

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000359003	7098	2063	34740363	34743341	3256	6233	971	1964
ENST00000374796	9328	2063	34740363	34743341	5486	8463	971	1964

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000359003	7098	2063	34776293	34776448	577	731	78	130
ENST00000374796	9328	2063	34776293	34776448	2807	2961	78	130
ENST00000359003	7098	2063	34758805	34758933	856	983	171	214
ENST00000374796	9328	2063	34758805	34758933	3086	3213	171	214
ENST00000359003	7098	2063	34754722	34754868	1870	2015	509	558
ENST00000374796	9328	2063	34754722	34754868	4100	4245	509	558
ENST00000359003	7098	2063	34740363	34743341	3256	6233	971	1964
ENST00000374796	9328	2063	34740363	34743341	5486	8463	971	1964
ENST00000359003	7098	2063	34736690	34736758	6235	6302	1964	1987
ENST00000374796	9328	2063	34736690	34736758	8465	8532	1964	1987

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q14686	78	130	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
Q14686	78	130	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
Q14686	78	130	95	95	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
Q14686	78	130	95	95	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
Q14686	78	130	1	1310	Region	Note=NCOA1-binding region
Q14686	78	130	1	1310	Region	Note=NCOA1-binding region
Q14686	78	130	1	1057	Region	Note=CREBBP-binding region
Q14686	78	130	1	1057	Region	Note=CREBBP-binding region
Q14686	78	130	1	928	Region	Note=TBP/GTF2A-binding region
Q14686	78	130	1	928	Region	Note=TBP/GTF2A-binding region
Q14686	509	558	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
Q14686	509	558	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
Q14686	509	558	227	1041	Compositional bias	Note=Gln-rich
Q14686	509	558	227	1041	Compositional bias	Note=Gln-rich
Q14686	509	558	512	512	Natural variant	ID=VAR_027874;Note=P->L;Dbxref=dbSNP:rs6060031
Q14686	509	558	512	512	Natural variant	ID=VAR_027874;Note=P->L;Dbxref=dbSNP:rs6060031
Q14686	509	558	1	1310	Region	Note=NCOA1-binding region
Q14686	509	558	1	1310	Region	Note=NCOA1-binding region
Q14686	509	558	1	1057	Region	Note=CREBBP-binding region
Q14686	509	558	1	1057	Region	Note=CREBBP-binding region
Q14686	509	558	1	928	Region	Note=TBP/GTF2A-binding region
Q14686	509	558	1	928	Region	Note=TBP/GTF2A-binding region
Q14686	971	1964	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
Q14686	971	1964	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
Q14686	971	1964	227	1041	Compositional bias	Note=Gln-rich
Q14686	971	1964	227	1041	Compositional bias	Note=Gln-rich
Q14686	971	1964	1047	1047	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1047	1047	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1058	1058	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1058	1058	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1096	1096	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1096	1096	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1819	1819	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1819	1819	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1822	1822	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1822	1822	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1491	1495	Motif	Note=LXXLL motif 2
Q14686	971	1964	1491	1495	Motif	Note=LXXLL motif 2
Q14686	971	1964	1060	1060	Natural variant	ID=VAR_036551;Note=In a breast cancer sample%3B somatic mutation. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q14686	971	1964	1060	1060	Natural variant	ID=VAR_036551;Note=In a breast cancer sample%3B somatic mutation. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q14686	971	1964	1191	1191	Natural variant	ID=VAR_036552;Note=In a breast cancer sample%3B somatic mutation. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q14686	971	1964	1191	1191	Natural variant	ID=VAR_036552;Note=In a breast cancer sample%3B somatic mutation. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q14686	971	1964	1	1310	Region	Note=NCOA1-binding region
Q14686	971	1964	1	1310	Region	Note=NCOA1-binding region
Q14686	971	1964	1	1057	Region	Note=CREBBP-binding region
Q14686	971	1964	1	1057	Region	Note=CREBBP-binding region
Q14686	971	1964	1641	2063	Region	Note=EP300/CRSP3-binding region
Q14686	971	1964	1641	2063	Region	Note=EP300/CRSP3-binding region

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q14686	971	1964	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
Q14686	971	1964	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
Q14686	971	1964	227	1041	Compositional bias	Note=Gln-rich
Q14686	971	1964	227	1041	Compositional bias	Note=Gln-rich
Q14686	971	1964	1047	1047	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1047	1047	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1058	1058	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1058	1058	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1096	1096	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1096	1096	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1819	1819	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1819	1819	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1822	1822	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1822	1822	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1491	1495	Motif	Note=LXXLL motif 2
Q14686	971	1964	1491	1495	Motif	Note=LXXLL motif 2
Q14686	971	1964	1060	1060	Natural variant	ID=VAR_036551;Note=In a breast cancer sample%3B somatic mutation. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q14686	971	1964	1060	1060	Natural variant	ID=VAR_036551;Note=In a breast cancer sample%3B somatic mutation. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q14686	971	1964	1191	1191	Natural variant	ID=VAR_036552;Note=In a breast cancer sample%3B somatic mutation. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q14686	971	1964	1191	1191	Natural variant	ID=VAR_036552;Note=In a breast cancer sample%3B somatic mutation. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q14686	971	1964	1	1310	Region	Note=NCOA1-binding region
Q14686	971	1964	1	1310	Region	Note=NCOA1-binding region
Q14686	971	1964	1	1057	Region	Note=CREBBP-binding region
Q14686	971	1964	1	1057	Region	Note=CREBBP-binding region
Q14686	971	1964	1641	2063	Region	Note=EP300/CRSP3-binding region
Q14686	971	1964	1641	2063	Region	Note=EP300/CRSP3-binding region

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q14686	78	130	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
Q14686	78	130	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
Q14686	78	130	95	95	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
Q14686	78	130	95	95	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
Q14686	78	130	1	1310	Region	Note=NCOA1-binding region
Q14686	78	130	1	1310	Region	Note=NCOA1-binding region
Q14686	78	130	1	1057	Region	Note=CREBBP-binding region
Q14686	78	130	1	1057	Region	Note=CREBBP-binding region
Q14686	78	130	1	928	Region	Note=TBP/GTF2A-binding region
Q14686	78	130	1	928	Region	Note=TBP/GTF2A-binding region
Q14686	171	214	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
Q14686	171	214	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
Q14686	171	214	1	1310	Region	Note=NCOA1-binding region
Q14686	171	214	1	1310	Region	Note=NCOA1-binding region
Q14686	171	214	1	1057	Region	Note=CREBBP-binding region
Q14686	171	214	1	1057	Region	Note=CREBBP-binding region
Q14686	171	214	1	928	Region	Note=TBP/GTF2A-binding region
Q14686	171	214	1	928	Region	Note=TBP/GTF2A-binding region
Q14686	509	558	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
Q14686	509	558	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
Q14686	509	558	227	1041	Compositional bias	Note=Gln-rich
Q14686	509	558	227	1041	Compositional bias	Note=Gln-rich
Q14686	509	558	512	512	Natural variant	ID=VAR_027874;Note=P->L;Dbxref=dbSNP:rs6060031
Q14686	509	558	512	512	Natural variant	ID=VAR_027874;Note=P->L;Dbxref=dbSNP:rs6060031
Q14686	509	558	1	1310	Region	Note=NCOA1-binding region
Q14686	509	558	1	1310	Region	Note=NCOA1-binding region
Q14686	509	558	1	1057	Region	Note=CREBBP-binding region
Q14686	509	558	1	1057	Region	Note=CREBBP-binding region
Q14686	509	558	1	928	Region	Note=TBP/GTF2A-binding region
Q14686	509	558	1	928	Region	Note=TBP/GTF2A-binding region
Q14686	971	1964	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
Q14686	971	1964	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
Q14686	971	1964	227	1041	Compositional bias	Note=Gln-rich
Q14686	971	1964	227	1041	Compositional bias	Note=Gln-rich
Q14686	971	1964	1047	1047	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1047	1047	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1058	1058	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1058	1058	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1096	1096	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1096	1096	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1819	1819	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1819	1819	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1822	1822	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1822	1822	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9JL19
Q14686	971	1964	1491	1495	Motif	Note=LXXLL motif 2
Q14686	971	1964	1491	1495	Motif	Note=LXXLL motif 2
Q14686	971	1964	1060	1060	Natural variant	ID=VAR_036551;Note=In a breast cancer sample%3B somatic mutation. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q14686	971	1964	1060	1060	Natural variant	ID=VAR_036551;Note=In a breast cancer sample%3B somatic mutation. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q14686	971	1964	1191	1191	Natural variant	ID=VAR_036552;Note=In a breast cancer sample%3B somatic mutation. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q14686	971	1964	1191	1191	Natural variant	ID=VAR_036552;Note=In a breast cancer sample%3B somatic mutation. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q14686	971	1964	1	1310	Region	Note=NCOA1-binding region
Q14686	971	1964	1	1310	Region	Note=NCOA1-binding region
Q14686	971	1964	1	1057	Region	Note=CREBBP-binding region
Q14686	971	1964	1	1057	Region	Note=CREBBP-binding region
Q14686	971	1964	1641	2063	Region	Note=EP300/CRSP3-binding region
Q14686	971	1964	1641	2063	Region	Note=EP300/CRSP3-binding region
Q14686	1964	1987	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
Q14686	1964	1987	1	2063	Chain	ID=PRO_0000094413;Note=Nuclear receptor coactivator 6
Q14686	1964	1987	1641	2063	Region	Note=EP300/CRSP3-binding region
Q14686	1964	1987	1641	2063	Region	Note=EP300/CRSP3-binding region

Top

3'-UTR located exon skipping events that lost miRNA binding sites in NCOA6

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type	ENST	Exon skip start	Exon skip end	microRNA	Binding site by TargetScan	Binding type by TargetScan	Bdinding site by miRanda	Score of miRanda	Energy by miRanda
Mayo	ENST00000374796	34809453	34809522	hsa-miR-4693-3p	chr20:34809473-34809480	8mer-1a	chr20:34809466-34809488	161.00	-17.61
Mayo	ENST00000374796	34809453	34809522	hsa-miR-6761-5p	chr20:34809475-34809482	8mer-1a	chr20:34809466-34809488	161.00	-17.61
Mayo	ENST00000374796	34809453	34809522	hsa-miR-7106-5p	chr20:34809511-34809518	8mer-1a	chr20:34809498-34809520	158.00	-26.09
Mayo	ENST00000359003	34792450	34792563	hsa-miR-6762-3p	chr20:34792546-34792553	8mer-1a	chr20:34792535-34792557	152.00	-18.47
Mayo	ENST00000359003	34792450	34792563	hsa-miR-631	chr20:34792481-34792488	8mer-1a	chr20:34792481-34792503	157.00	-21.48
Mayo	ENST00000359003	34792450	34792563	hsa-miR-5009-5p	chr20:34792495-34792502	8mer-1a	chr20:34792494-34792514	157.00	-22.23
Mayo	ENST00000359003	34792450	34792563	hsa-miR-8058	chr20:34792495-34792502	8mer-1a	chr20:34792494-34792514	157.00	-22.23
Mayo	ENST00000359003	34792450	34792563	hsa-miR-4529-3p	chr20:34792496-34792503	8mer-1a	chr20:34792494-34792514	157.00	-22.23
Mayo	ENST00000359003	34792450	34792563	hsa-miR-647	chr20:34792547-34792554	8mer-1a	chr20:34792535-34792557	152.00	-18.47
Mayo	ENST00000359003	34792450	34792563	hsa-miR-6829-5p	chr20:34792539-34792546	8mer-1a	chr20:34792535-34792557	152.00	-18.47
Mayo	ENST00000359003	34792450	34792563	hsa-miR-3661	chr20:34792481-34792488	8mer-1a	chr20:34792481-34792503	157.00	-21.48
Mayo	ENST00000374796	34809453	34809522	hsa-miR-6831-3p	chr20:34809486-34809493	8mer-1a	chr20:34809483-34809506	165.00	-32.33
ROSMAP	ENST00000359003	34792450	34792563	hsa-miR-6762-3p	chr20:34792546-34792553	8mer-1a	chr20:34792535-34792557	152.00	-18.47
ROSMAP	ENST00000359003	34792450	34792563	hsa-miR-631	chr20:34792481-34792488	8mer-1a	chr20:34792481-34792503	157.00	-21.48
ROSMAP	ENST00000359003	34792450	34792563	hsa-miR-5009-5p	chr20:34792495-34792502	8mer-1a	chr20:34792494-34792514	157.00	-22.23
ROSMAP	ENST00000359003	34792450	34792563	hsa-miR-8058	chr20:34792495-34792502	8mer-1a	chr20:34792494-34792514	157.00	-22.23
ROSMAP	ENST00000359003	34792450	34792563	hsa-miR-4529-3p	chr20:34792496-34792503	8mer-1a	chr20:34792494-34792514	157.00	-22.23
ROSMAP	ENST00000359003	34792450	34792563	hsa-miR-647	chr20:34792547-34792554	8mer-1a	chr20:34792535-34792557	152.00	-18.47
ROSMAP	ENST00000359003	34792450	34792563	hsa-miR-6829-5p	chr20:34792539-34792546	8mer-1a	chr20:34792535-34792557	152.00	-18.47
ROSMAP	ENST00000359003	34792450	34792563	hsa-miR-3661	chr20:34792481-34792488	8mer-1a	chr20:34792481-34792503	157.00	-21.48

Top

SNVs in the skipped exons for NCOA6

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

Top

AD stage-associated exon skippint events for NCOA6

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

Top

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NCOA6

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

Top

Correlation with RNA binding proteins (RBPs) for NCOA6

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	TRA2A	exon_skip_145078	-4.794208e-01	1.854888e-10
CB	SRSF4	exon_skip_145078	-4.041076e-01	1.397672e-07
CB	PCBP4	exon_skip_242217	4.230268e-01	6.257347e-08
CB	FUBP1	exon_skip_242217	-4.332674e-01	2.749451e-08
TC	RBFOX2	exon_skip_289966	4.112177e-01	7.265738e-08

Top

RelatedDrugs for NCOA6

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for NCOA6

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

Home

Download

Statistics

Landscape

Help

Contact

Gene summary for NCOA6

Gene structures and expression levels for NCOA6

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NCOA6

Open reading frame (ORF) annotation in the exon skipping event for NCOA6

Infer the effects of exon skipping event on protein functional features for NCOA6

3'-UTR located exon skipping events that lost miRNA binding sites in NCOA6

SNVs in the skipped exons for NCOA6

AD stage-associated exon skippint events for NCOA6

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NCOA6

Correlation with RNA binding proteins (RBPs) for NCOA6

RelatedDrugs for NCOA6

RelatedDiseases for NCOA6