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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ZHX3 |
 Gene summary |
| Gene information | Gene symbol | ZHX3 | Gene ID | 23051 |
| Gene name | zinc fingers and homeoboxes 3 | |
| Synonyms | TIX1 | |
| Cytomap | 20q12 | |
| Type of gene | protein-coding | |
| Description | zinc fingers and homeoboxes protein 3triple homeobox 1triple homeobox protein 1zinc finger and homeodomain protein 3 | |
| Modification date | 20200313 | |
| UniProtAcc | A0A0A0MST6, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ZHX3 | GO:0045892 | negative regulation of transcription, DNA-templated | 12659632 |
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Gene structures and expression levels for ZHX3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000174306
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000487057.5 | ZHX3-210:lncRNA:ZHX3 | 3.686034e+00 | 8.315668e-01 | 1.238905e-03 | 1.704341e-02 |
| PG | UP | ENST00000373261.5 | ZHX3-202:protein_coding:ZHX3 | 3.824052e+00 | 1.399121e+00 | 3.769014e-03 | 3.756098e-02 |
| CB | UP | ENST00000559234.5 | ZHX3-214:protein_coding:ZHX3 | 1.001178e+02 | 9.677990e-01 | 6.791291e-03 | 2.529408e-02 |
| TC | UP | ENST00000544979.6 | ZHX3-211:protein_coding:ZHX3 | 3.830894e+01 | 8.064279e-01 | 3.028452e-04 | 3.876621e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZHX3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_101440 | chr20 | 41204778:41205066:41213734:41213899:41268990:41269083 | 41213734:41213899 |
| exon_skip_129731 | chr20 | 41205022:41205066:41213734:41213899:41238688:41238796 | 41213734:41213899 |
| exon_skip_189582 | chr20 | 41239598:41239704:41267463:41267612:41268990:41269083 | 41267463:41267612 |
| exon_skip_267095 | chr20 | 41204778:41205066:41213734:41213899:41238688:41238796 | 41213734:41213899 |
| exon_skip_290591 | chr20 | 41205022:41205066:41213734:41213899:41268990:41269083 | 41213734:41213899 |
| exon_skip_3192 | chr20 | 41213758:41213899:41267463:41267612:41268979:41269083 | 41267463:41267612 |
| exon_skip_51397 | chr20 | 41238727:41238796:41239598:41239704:41267463:41267612 | 41239598:41239704 |
| exon_skip_61751 | chr20 | 41238727:41238796:41239598:41239704:41268990:41269083 | 41239598:41239704 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ZHX3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000560361 | 41213734 | 41213899 | 3UTR-3UTR |
| ENST00000560361 | 41239598 | 41239704 | 3UTR-3UTR |
| ENST00000560361 | 41267463 | 41267612 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000560361 | 41213734 | 41213899 | 3UTR-3UTR |
| ENST00000560361 | 41239598 | 41239704 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000560361 | 41213734 | 41213899 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for ZHX3 |
p-ENSG00000174306_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZHX3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000560361 | 41213734 | 41213899 | hsa-miR-186-3p | chr20:41213847-41213854 | 8mer-1a | chr20:41213839-41213863 | 166.00 | -23.48 |
| Mayo | ENST00000560361 | 41213734 | 41213899 | hsa-miR-558 | chr20:41213822-41213829 | 8mer-1a | chr20:41213811-41213829 | 162.00 | -24.13 |
| Mayo | ENST00000560361 | 41213734 | 41213899 | hsa-miR-4775 | chr20:41213798-41213805 | 8mer-1a | chr20:41213786-41213811 | 158.00 | -17.21 |
| Mayo | ENST00000560361 | 41213734 | 41213899 | hsa-miR-6813-3p | chr20:41213857-41213864 | 8mer-1a | chr20:41213844-41213869 | 158.00 | -22.49 |
| Mayo | ENST00000560361 | 41213734 | 41213899 | hsa-miR-1271-3p | chr20:41213814-41213821 | 8mer-1a | chr20:41213811-41213829 | 162.00 | -24.13 |
| Mayo | ENST00000560361 | 41213734 | 41213899 | hsa-miR-550a-3-5p | chr20:41213814-41213821 | 8mer-1a | chr20:41213811-41213829 | 162.00 | -24.13 |
| Mayo | ENST00000560361 | 41213734 | 41213899 | hsa-miR-550a-5p | chr20:41213814-41213821 | 8mer-1a | chr20:41213811-41213829 | 162.00 | -24.13 |
| MSBB | ENST00000560361 | 41213734 | 41213899 | hsa-miR-186-3p | chr20:41213847-41213854 | 8mer-1a | chr20:41213839-41213863 | 166.00 | -23.48 |
| MSBB | ENST00000560361 | 41239598 | 41239704 | hsa-miR-6740-3p | chr20:41239664-41239671 | 8mer-1a | chr20:41239657-41239675 | 162.00 | -21.16 |
| MSBB | ENST00000560361 | 41239598 | 41239704 | hsa-miR-8068 | chr20:41239674-41239681 | 8mer-1a | chr20:41239668-41239686 | 156.00 | -12.18 |
| MSBB | ENST00000560361 | 41239598 | 41239704 | hsa-miR-7113-5p | chr20:41239626-41239633 | 8mer-1a | chr20:41239613-41239642 | 146.00 | -24.63 |
| MSBB | ENST00000560361 | 41239598 | 41239704 | hsa-miR-4496 | chr20:41239688-41239695 | 8mer-1a | chr20:41239681-41239701 | 157.00 | -16.81 |
| MSBB | ENST00000560361 | 41239598 | 41239704 | hsa-miR-4743-3p | chr20:41239668-41239675 | 8mer-1a | chr20:41239657-41239675 | 162.00 | -21.16 |
| MSBB | ENST00000560361 | 41213734 | 41213899 | hsa-miR-558 | chr20:41213822-41213829 | 8mer-1a | chr20:41213811-41213829 | 162.00 | -24.13 |
| MSBB | ENST00000560361 | 41239598 | 41239704 | hsa-miR-6888-3p | chr20:41239667-41239674 | 8mer-1a | chr20:41239657-41239675 | 162.00 | -21.16 |
| MSBB | ENST00000560361 | 41213734 | 41213899 | hsa-miR-4775 | chr20:41213798-41213805 | 8mer-1a | chr20:41213786-41213811 | 158.00 | -17.21 |
| MSBB | ENST00000560361 | 41213734 | 41213899 | hsa-miR-6813-3p | chr20:41213857-41213864 | 8mer-1a | chr20:41213844-41213869 | 158.00 | -22.49 |
| MSBB | ENST00000560361 | 41213734 | 41213899 | hsa-miR-1271-3p | chr20:41213814-41213821 | 8mer-1a | chr20:41213811-41213829 | 162.00 | -24.13 |
| MSBB | ENST00000560361 | 41213734 | 41213899 | hsa-miR-550a-3-5p | chr20:41213814-41213821 | 8mer-1a | chr20:41213811-41213829 | 162.00 | -24.13 |
| MSBB | ENST00000560361 | 41213734 | 41213899 | hsa-miR-550a-5p | chr20:41213814-41213821 | 8mer-1a | chr20:41213811-41213829 | 162.00 | -24.13 |
| ROSMAP | ENST00000560361 | 41267463 | 41267612 | hsa-miR-5581-5p | chr20:41267556-41267563 | 8mer-1a | chr20:41267545-41267566 | 170.00 | -31.97 |
| ROSMAP | ENST00000560361 | 41213734 | 41213899 | hsa-miR-186-3p | chr20:41213847-41213854 | 8mer-1a | chr20:41213839-41213863 | 166.00 | -23.48 |
| ROSMAP | ENST00000560361 | 41239598 | 41239704 | hsa-miR-6740-3p | chr20:41239664-41239671 | 8mer-1a | chr20:41239657-41239675 | 162.00 | -21.16 |
| ROSMAP | ENST00000560361 | 41267463 | 41267612 | hsa-miR-4297 | chr20:41267556-41267563 | 8mer-1a | chr20:41267545-41267566 | 170.00 | -31.97 |
| ROSMAP | ENST00000560361 | 41239598 | 41239704 | hsa-miR-8068 | chr20:41239674-41239681 | 8mer-1a | chr20:41239668-41239686 | 156.00 | -12.18 |
| ROSMAP | ENST00000560361 | 41267463 | 41267612 | hsa-miR-6752-3p | chr20:41267560-41267567 | 8mer-1a | chr20:41267547-41267569 | 162.00 | -28.34 |
| ROSMAP | ENST00000560361 | 41239598 | 41239704 | hsa-miR-7113-5p | chr20:41239626-41239633 | 8mer-1a | chr20:41239613-41239642 | 146.00 | -24.63 |
| ROSMAP | ENST00000560361 | 41267463 | 41267612 | hsa-miR-7113-3p | chr20:41267562-41267569 | 8mer-1a | chr20:41267547-41267569 | 162.00 | -28.34 |
| ROSMAP | ENST00000560361 | 41239598 | 41239704 | hsa-miR-4496 | chr20:41239688-41239695 | 8mer-1a | chr20:41239681-41239701 | 157.00 | -16.81 |
| ROSMAP | ENST00000560361 | 41267463 | 41267612 | hsa-miR-3935 | chr20:41267584-41267591 | 8mer-1a | chr20:41267570-41267594 | 161.00 | -27.09 |
| ROSMAP | ENST00000560361 | 41239598 | 41239704 | hsa-miR-4743-3p | chr20:41239668-41239675 | 8mer-1a | chr20:41239657-41239675 | 162.00 | -21.16 |
| ROSMAP | ENST00000560361 | 41213734 | 41213899 | hsa-miR-558 | chr20:41213822-41213829 | 8mer-1a | chr20:41213811-41213829 | 162.00 | -24.13 |
| ROSMAP | ENST00000560361 | 41239598 | 41239704 | hsa-miR-6888-3p | chr20:41239667-41239674 | 8mer-1a | chr20:41239657-41239675 | 162.00 | -21.16 |
| ROSMAP | ENST00000560361 | 41213734 | 41213899 | hsa-miR-4775 | chr20:41213798-41213805 | 8mer-1a | chr20:41213786-41213811 | 158.00 | -17.21 |
| ROSMAP | ENST00000560361 | 41267463 | 41267612 | hsa-miR-3616-3p | chr20:41267511-41267518 | 8mer-1a | chr20:41267497-41267519 | 150.00 | -18.85 |
| ROSMAP | ENST00000560361 | 41213734 | 41213899 | hsa-miR-6813-3p | chr20:41213857-41213864 | 8mer-1a | chr20:41213844-41213869 | 158.00 | -22.49 |
| ROSMAP | ENST00000560361 | 41267463 | 41267612 | hsa-miR-1226-5p | chr20:41267512-41267519 | 8mer-1a | chr20:41267497-41267519 | 150.00 | -18.85 |
| ROSMAP | ENST00000560361 | 41267463 | 41267612 | hsa-miR-577 | chr20:41267582-41267589 | 8mer-1a | chr20:41267570-41267594 | 161.00 | -27.09 |
| ROSMAP | ENST00000560361 | 41213734 | 41213899 | hsa-miR-1271-3p | chr20:41213814-41213821 | 8mer-1a | chr20:41213811-41213829 | 162.00 | -24.13 |
| ROSMAP | ENST00000560361 | 41213734 | 41213899 | hsa-miR-550a-3-5p | chr20:41213814-41213821 | 8mer-1a | chr20:41213811-41213829 | 162.00 | -24.13 |
| ROSMAP | ENST00000560361 | 41213734 | 41213899 | hsa-miR-550a-5p | chr20:41213814-41213821 | 8mer-1a | chr20:41213811-41213829 | 162.00 | -24.13 |
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SNVs in the skipped exons for ZHX3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZHX3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZHX3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ZHX3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | PABPC1 | exon_skip_186960 | -4.003496e-01 | 1.706581e-07 |
| IFG | ZNF326 | exon_skip_210126 | 4.187124e-01 | 2.658028e-02 |
| IFG | PABPC1 | exon_skip_210126 | 4.031127e-01 | 3.341887e-02 |
| TC | SRSF2 | exon_skip_159364 | -4.033237e-01 | 1.236233e-07 |
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RelatedDrugs for ZHX3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZHX3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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