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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for KIF21B |
 Gene summary |
| Gene information | Gene symbol | KIF21B | Gene ID | 23046 |
| Gene name | kinesin family member 21B | |
| Synonyms | - | |
| Cytomap | 1q32.1 | |
| Type of gene | protein-coding | |
| Description | kinesin-like protein KIF21B | |
| Modification date | 20200313 | |
| UniProtAcc | O75037, Q2UVF0, | |
| Context | - 29060936(Overexpression of Kinesin Superfamily Motor Proteins in Alzheimer's Disease) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for KIF21B |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000116852
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for KIF21B |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_210122 | chr1 | 201004340:201004455:201004766:201004933:201005308:201005442 | 201004766:201004933 |
| exon_skip_54075 | chr1 | 201004340:201004455:201004541:201004933:201005308:201005442 | 201004541:201004933 |
| exon_skip_68774 | chr1 | 200980960:200981096:200983056:200983094:200984859:200984972 | 200983056:200983094 |
| exon_skip_98862 | chr1 | 201003586:201003781:201004340:201004455:201004766:201004933 | 201004340:201004455 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_241856 | ROSMAP_DLPFC | 3.933333e-01 | 4.964356e-01 | -1.031023e-01 | 1.125684e-02 |
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Open reading frame (ORF) annotation in the exon skipping event for KIF21B |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000422435 | 201004340 | 201004455 | Frame-shift |
| ENST00000422435 | 200983056 | 200983094 | In-frame |
| ENST00000422435 | 201004766 | 201004933 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000422435 | 200983056 | 200983094 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000422435 | 200983056 | 200983094 | In-frame |
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Infer the effects of exon skipping event on protein functional features for KIF21B |
p-ENSG00000116852_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000422435 | 5536 | 1637 | 201004766 | 201004933 | 1050 | 1216 | 244 | 299 |
| ENST00000422435 | 5536 | 1637 | 200983056 | 200983094 | 4121 | 4158 | 1268 | 1280 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000422435 | 5536 | 1637 | 200983056 | 200983094 | 4121 | 4158 | 1268 | 1280 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000422435 | 5536 | 1637 | 200983056 | 200983094 | 4121 | 4158 | 1268 | 1280 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O75037 | 244 | 299 | 1 | 1637 | Chain | ID=PRO_0000125464;Note=Kinesin-like protein KIF21B |
| O75037 | 244 | 299 | 8 | 370 | Domain | Note=Kinesin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00283 |
| O75037 | 1268 | 1280 | 1269 | 1281 | Alternative sequence | ID=VSP_016217;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9455484;Dbxref=PMID:15489334,PMID:9455484 |
| O75037 | 1268 | 1280 | 1 | 1637 | Chain | ID=PRO_0000125464;Note=Kinesin-like protein KIF21B |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O75037 | 1268 | 1280 | 1269 | 1281 | Alternative sequence | ID=VSP_016217;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9455484;Dbxref=PMID:15489334,PMID:9455484 |
| O75037 | 1268 | 1280 | 1 | 1637 | Chain | ID=PRO_0000125464;Note=Kinesin-like protein KIF21B |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O75037 | 1268 | 1280 | 1269 | 1281 | Alternative sequence | ID=VSP_016217;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9455484;Dbxref=PMID:15489334,PMID:9455484 |
| O75037 | 1268 | 1280 | 1 | 1637 | Chain | ID=PRO_0000125464;Note=Kinesin-like protein KIF21B |
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3'-UTR located exon skipping events that lost miRNA binding sites in KIF21B |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for KIF21B |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for KIF21B |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for KIF21B |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for KIF21B |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | HNRNPK | exon_skip_241856 | 4.708484e-01 | 1.245318e-07 |
| CB | KHDRBS2 | exon_skip_241856 | 4.195710e-01 | 3.372790e-06 |
| CB | RALYL | exon_skip_241856 | 4.442263e-01 | 7.383963e-07 |
| CB | PTBP3 | exon_skip_241856 | 4.340784e-01 | 1.399962e-06 |
| CB | FXR2 | exon_skip_68774 | 4.175581e-01 | 6.978560e-07 |
| CB | RALYL | exon_skip_68774 | 4.881471e-01 | 3.332321e-09 |
| CB | SRSF9 | exon_skip_68774 | 5.616592e-01 | 2.968866e-12 |
| DLPFC | KHDRBS2 | exon_skip_241856 | 5.778427e-01 | 5.801256e-27 |
| HCC | RBM6 | exon_skip_241856 | -5.187908e-01 | 9.936017e-20 |
| HCC | KHDRBS3 | exon_skip_241856 | -4.107831e-01 | 2.981883e-12 |
| HCC | EIF4G2 | exon_skip_241856 | -5.132557e-01 | 2.805971e-19 |
| HCC | PTBP1 | exon_skip_241856 | -5.785360e-01 | 3.657493e-25 |
| HCC | ZC3H10 | exon_skip_241856 | -5.193888e-01 | 8.871835e-20 |
| PCC | RBM6 | exon_skip_241856 | -4.712865e-01 | 8.705877e-13 |
| PCC | PTBP1 | exon_skip_241856 | -6.287928e-01 | 4.530113e-24 |
| PCC | ZC3H10 | exon_skip_241856 | -4.228038e-01 | 2.438028e-10 |
| TC | HNRNPK | exon_skip_176434 | 4.051179e-01 | 2.053850e-07 |
| TC | KHDRBS2 | exon_skip_176434 | 7.395792e-01 | 9.494628e-28 |
| TC | KHDRBS3 | exon_skip_176434 | 6.781912e-01 | 5.974141e-22 |
| TC | RBM24 | exon_skip_176434 | 6.568501e-01 | 2.988952e-20 |
| TC | RALYL | exon_skip_176434 | 7.478548e-01 | 1.173526e-28 |
| TC | PTBP1 | exon_skip_176434 | -4.338742e-01 | 2.110543e-08 |
| TC | PTBP3 | exon_skip_176434 | 4.233658e-01 | 4.968661e-08 |
| TC | NOVA1 | exon_skip_176434 | 6.300064e-01 | 2.673794e-18 |
| TC | FXR2 | exon_skip_68774 | 4.802874e-01 | 2.911777e-10 |
| TC | ILF2 | exon_skip_68774 | 5.007396e-01 | 3.755803e-11 |
| TC | RALYL | exon_skip_68774 | 7.122254e-01 | 3.922928e-25 |
| TC | PTBP3 | exon_skip_68774 | 4.624024e-01 | 1.567842e-09 |
| TC | CELF1 | exon_skip_68774 | 5.856540e-01 | 1.488866e-15 |
| TC | EWSR1 | exon_skip_68774 | 4.020441e-01 | 2.361555e-07 |
| TC | SRSF9 | exon_skip_68774 | 4.023493e-01 | 2.307942e-07 |
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RelatedDrugs for KIF21B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KIF21B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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