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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for USP33 |
 Gene summary |
| Gene information | Gene symbol | USP33 | Gene ID | 23032 |
| Gene name | ubiquitin specific peptidase 33 | |
| Synonyms | VDU1 | |
| Cytomap | 1p31.1 | |
| Type of gene | protein-coding | |
| Description | ubiquitin carboxyl-terminal hydrolase 33VHL-interacting deubiquitinating enzyme 1deubiquitinating enzyme 33pVHL-interacting deubiquitinating enzyme 1ubiquitin thioesterase 33ubiquitin thiolesterase 33ubiquitin-specific-processing protease 33 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| USP33 | GO:0009267 | cellular response to starvation | 24056301 |
| USP33 | GO:0016579 | protein deubiquitination | 11739384|19363159|19424180|23486064 |
| USP33 | GO:0070536 | protein K63-linked deubiquitination | 19363159 |
| USP33 | GO:0071108 | protein K48-linked deubiquitination | 19363159 |
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Gene structures and expression levels for USP33 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000077254
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| HCC | UP | ENST00000481579.5 | USP33-209:protein_coding:USP33 | 7.052766e+01 | 1.031496e+00 | 1.171223e-05 | 1.581722e-03 |
| CB | DOWN | ENST00000481579.5 | USP33-209:protein_coding:USP33 | 1.793327e+03 | -8.058169e-01 | 1.342645e-09 | 5.551412e-08 |
| CB | UP | ENST00000370792.7 | USP33-202:protein_coding:USP33 | 1.170426e+02 | 8.410888e-01 | 1.579853e-05 | 1.553348e-04 |
| CB | UP | ENST00000524536.5 | USP33-211:protein_coding:USP33 | 1.989378e+00 | 9.825210e-01 | 9.382007e-03 | 3.299677e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for USP33 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_101875 | chr1 | 77741617:77741748:77745421:77745599:77759643:77759689 | 77745421:77745599 |
| exon_skip_124909 | chr1 | 77713200:77713281:77714614:77714783:77715742:77715853 | 77714614:77714783 |
| exon_skip_131406 | chr1 | 77697863:77697931:77701369:77701471:77711747:77711855 | 77701369:77701471 |
| exon_skip_139122 | chr1 | 77745421:77745599:77746399:77746556:77759643:77759689 | 77746399:77746556 |
| exon_skip_148490 | chr1 | 77713200:77713281:77715742:77715868:77717867:77717988 | 77715742:77715868 |
| exon_skip_152518 | chr1 | 77713200:77713281:77714614:77714783:77715742:77715868 | 77714614:77714783 |
| exon_skip_157119 | chr1 | 77711785:77711855:77713200:77713281:77714614:77714783 | 77713200:77713281 |
| exon_skip_166266 | chr1 | 77739398:77739417:77740877:77740939:77741376:77741429 | 77740877:77740939 |
| exon_skip_168835 | chr1 | 77713240:77713281:77715742:77715868:77717867:77718047 | 77715742:77715868 |
| exon_skip_176918 | chr1 | 77730618:77730731:77734347:77734416:77736056:77736158 | 77734347:77734416 |
| exon_skip_184737 | chr1 | 77713200:77713281:77715742:77715868:77717867:77718047 | 77715742:77715868 |
| exon_skip_199149 | chr1 | 77721172:77721205:77721831:77721925:77722024:77722196 | 77721831:77721925 |
| exon_skip_203404 | chr1 | 77695991:77697474:77697863:77697931:77701369:77701471 | 77697863:77697931 |
| exon_skip_213295 | chr1 | 77725622:77725762:77728295:77728712:77729860:77729938 | 77728295:77728712 |
| exon_skip_2227 | chr1 | 77714614:77714783:77715742:77715868:77717867:77718047 | 77715742:77715868 |
| exon_skip_227910 | chr1 | 77721172:77721205:77721831:77721901:77722024:77722196 | 77721831:77721901 |
| exon_skip_243846 | chr1 | 77734357:77734416:77736056:77736158:77739265:77739417 | 77736056:77736158 |
| exon_skip_245700 | chr1 | 77728295:77728712:77729860:77729938:77730618:77730731 | 77729860:77729938 |
| exon_skip_246458 | chr1 | 77713240:77713281:77714614:77714783:77715742:77715868 | 77714614:77714783 |
| exon_skip_287288 | chr1 | 77714614:77714783:77715742:77715868:77717867:77717988 | 77715742:77715868 |
| exon_skip_67247 | chr1 | 77739398:77739417:77740877:77740934:77741376:77741429 | 77740877:77740934 |
| exon_skip_93686 | chr1 | 77736056:77736158:77739265:77739417:77740877:77740934 | 77739265:77739417 |
| exon_skip_95347 | chr1 | 77701369:77701471:77711747:77711855:77713200:77713281 | 77711747:77711855 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for USP33 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370793 | 77745421 | 77745599 | 3UTR-3CDS |
| ENST00000357428 | 77701369 | 77701471 | Frame-shift |
| ENST00000370793 | 77701369 | 77701471 | Frame-shift |
| ENST00000357428 | 77714614 | 77714783 | Frame-shift |
| ENST00000370793 | 77714614 | 77714783 | Frame-shift |
| ENST00000357428 | 77715742 | 77715868 | Frame-shift |
| ENST00000370793 | 77715742 | 77715868 | Frame-shift |
| ENST00000357428 | 77729860 | 77729938 | Frame-shift |
| ENST00000370793 | 77729860 | 77729938 | Frame-shift |
| ENST00000357428 | 77734347 | 77734416 | Frame-shift |
| ENST00000370793 | 77734347 | 77734416 | Frame-shift |
| ENST00000357428 | 77697863 | 77697931 | In-frame |
| ENST00000370793 | 77697863 | 77697931 | In-frame |
| ENST00000357428 | 77739265 | 77739417 | In-frame |
| ENST00000370793 | 77739265 | 77739417 | In-frame |
| ENST00000357428 | 77740877 | 77740939 | In-frame |
| ENST00000370793 | 77740877 | 77740939 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370793 | 77745421 | 77745599 | 3UTR-3CDS |
| ENST00000357428 | 77701369 | 77701471 | Frame-shift |
| ENST00000370793 | 77701369 | 77701471 | Frame-shift |
| ENST00000357428 | 77714614 | 77714783 | Frame-shift |
| ENST00000370793 | 77714614 | 77714783 | Frame-shift |
| ENST00000357428 | 77715742 | 77715868 | Frame-shift |
| ENST00000370793 | 77715742 | 77715868 | Frame-shift |
| ENST00000357428 | 77721831 | 77721925 | Frame-shift |
| ENST00000370793 | 77721831 | 77721925 | Frame-shift |
| ENST00000357428 | 77729860 | 77729938 | Frame-shift |
| ENST00000370793 | 77729860 | 77729938 | Frame-shift |
| ENST00000357428 | 77734347 | 77734416 | Frame-shift |
| ENST00000370793 | 77734347 | 77734416 | Frame-shift |
| ENST00000357428 | 77740877 | 77740939 | In-frame |
| ENST00000370793 | 77740877 | 77740939 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370793 | 77745421 | 77745599 | 3UTR-3CDS |
| ENST00000357428 | 77701369 | 77701471 | Frame-shift |
| ENST00000370793 | 77701369 | 77701471 | Frame-shift |
| ENST00000357428 | 77711747 | 77711855 | Frame-shift |
| ENST00000370793 | 77711747 | 77711855 | Frame-shift |
| ENST00000357428 | 77713200 | 77713281 | Frame-shift |
| ENST00000370793 | 77713200 | 77713281 | Frame-shift |
| ENST00000357428 | 77714614 | 77714783 | Frame-shift |
| ENST00000370793 | 77714614 | 77714783 | Frame-shift |
| ENST00000357428 | 77715742 | 77715868 | Frame-shift |
| ENST00000370793 | 77715742 | 77715868 | Frame-shift |
| ENST00000357428 | 77721831 | 77721925 | Frame-shift |
| ENST00000370793 | 77721831 | 77721925 | Frame-shift |
| ENST00000357428 | 77728295 | 77728712 | Frame-shift |
| ENST00000370793 | 77728295 | 77728712 | Frame-shift |
| ENST00000357428 | 77729860 | 77729938 | Frame-shift |
| ENST00000370793 | 77729860 | 77729938 | Frame-shift |
| ENST00000357428 | 77734347 | 77734416 | Frame-shift |
| ENST00000370793 | 77734347 | 77734416 | Frame-shift |
| ENST00000357428 | 77736056 | 77736158 | Frame-shift |
| ENST00000370793 | 77736056 | 77736158 | Frame-shift |
| ENST00000357428 | 77697863 | 77697931 | In-frame |
| ENST00000370793 | 77697863 | 77697931 | In-frame |
| ENST00000357428 | 77739265 | 77739417 | In-frame |
| ENST00000370793 | 77739265 | 77739417 | In-frame |
| ENST00000357428 | 77740877 | 77740939 | In-frame |
| ENST00000370793 | 77740877 | 77740939 | In-frame |
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Infer the effects of exon skipping event on protein functional features for USP33 |
p-ENSG00000077254_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000357428 | 4172 | 942 | 77740877 | 77740939 | 229 | 290 | 76 | 96 |
| ENST00000370793 | 4519 | 942 | 77740877 | 77740939 | 576 | 637 | 76 | 96 |
| ENST00000357428 | 4172 | 942 | 77739265 | 77739417 | 292 | 443 | 97 | 147 |
| ENST00000370793 | 4519 | 942 | 77739265 | 77739417 | 639 | 790 | 97 | 147 |
| ENST00000357428 | 4172 | 942 | 77697863 | 77697931 | 2603 | 2670 | 867 | 890 |
| ENST00000370793 | 4519 | 942 | 77697863 | 77697931 | 2950 | 3017 | 867 | 890 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000357428 | 4172 | 942 | 77740877 | 77740939 | 229 | 290 | 76 | 96 |
| ENST00000370793 | 4519 | 942 | 77740877 | 77740939 | 576 | 637 | 76 | 96 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000357428 | 4172 | 942 | 77740877 | 77740939 | 229 | 290 | 76 | 96 |
| ENST00000370793 | 4519 | 942 | 77740877 | 77740939 | 576 | 637 | 76 | 96 |
| ENST00000357428 | 4172 | 942 | 77739265 | 77739417 | 292 | 443 | 97 | 147 |
| ENST00000370793 | 4519 | 942 | 77739265 | 77739417 | 639 | 790 | 97 | 147 |
| ENST00000357428 | 4172 | 942 | 77697863 | 77697931 | 2603 | 2670 | 867 | 890 |
| ENST00000370793 | 4519 | 942 | 77697863 | 77697931 | 2950 | 3017 | 867 | 890 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8TEY7 | 76 | 96 | 1 | 942 | Chain | ID=PRO_0000080664;Note=Ubiquitin carboxyl-terminal hydrolase 33 |
| Q8TEY7 | 76 | 96 | 1 | 942 | Chain | ID=PRO_0000080664;Note=Ubiquitin carboxyl-terminal hydrolase 33 |
| Q8TEY7 | 76 | 96 | 91 | 98 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 76 | 96 | 91 | 98 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 76 | 96 | 86 | 89 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 76 | 96 | 86 | 89 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 76 | 96 | 59 | 123 | Zinc finger | Note=UBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502 |
| Q8TEY7 | 76 | 96 | 59 | 123 | Zinc finger | Note=UBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502 |
| Q8TEY7 | 97 | 147 | 103 | 106 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 103 | 106 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 111 | 114 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 111 | 114 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 119 | 121 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 119 | 121 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 1 | 942 | Chain | ID=PRO_0000080664;Note=Ubiquitin carboxyl-terminal hydrolase 33 |
| Q8TEY7 | 97 | 147 | 1 | 942 | Chain | ID=PRO_0000080664;Note=Ubiquitin carboxyl-terminal hydrolase 33 |
| Q8TEY7 | 97 | 147 | 91 | 98 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 91 | 98 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 107 | 110 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 107 | 110 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 115 | 118 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 115 | 118 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 59 | 123 | Zinc finger | Note=UBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502 |
| Q8TEY7 | 97 | 147 | 59 | 123 | Zinc finger | Note=UBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502 |
| Q8TEY7 | 867 | 890 | 837 | 942 | Alternative sequence | ID=VSP_008594;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q8TEY7 | 867 | 890 | 837 | 942 | Alternative sequence | ID=VSP_008594;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q8TEY7 | 867 | 890 | 1 | 942 | Chain | ID=PRO_0000080664;Note=Ubiquitin carboxyl-terminal hydrolase 33 |
| Q8TEY7 | 867 | 890 | 1 | 942 | Chain | ID=PRO_0000080664;Note=Ubiquitin carboxyl-terminal hydrolase 33 |
| Q8TEY7 | 867 | 890 | 818 | 921 | Domain | Note=DUSP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00613 |
| Q8TEY7 | 867 | 890 | 818 | 921 | Domain | Note=DUSP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00613 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8TEY7 | 76 | 96 | 1 | 942 | Chain | ID=PRO_0000080664;Note=Ubiquitin carboxyl-terminal hydrolase 33 |
| Q8TEY7 | 76 | 96 | 1 | 942 | Chain | ID=PRO_0000080664;Note=Ubiquitin carboxyl-terminal hydrolase 33 |
| Q8TEY7 | 76 | 96 | 91 | 98 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 76 | 96 | 91 | 98 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 76 | 96 | 86 | 89 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 76 | 96 | 86 | 89 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 76 | 96 | 59 | 123 | Zinc finger | Note=UBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502 |
| Q8TEY7 | 76 | 96 | 59 | 123 | Zinc finger | Note=UBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8TEY7 | 76 | 96 | 1 | 942 | Chain | ID=PRO_0000080664;Note=Ubiquitin carboxyl-terminal hydrolase 33 |
| Q8TEY7 | 76 | 96 | 1 | 942 | Chain | ID=PRO_0000080664;Note=Ubiquitin carboxyl-terminal hydrolase 33 |
| Q8TEY7 | 76 | 96 | 91 | 98 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 76 | 96 | 91 | 98 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 76 | 96 | 86 | 89 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 76 | 96 | 86 | 89 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 76 | 96 | 59 | 123 | Zinc finger | Note=UBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502 |
| Q8TEY7 | 76 | 96 | 59 | 123 | Zinc finger | Note=UBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502 |
| Q8TEY7 | 97 | 147 | 103 | 106 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 103 | 106 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 111 | 114 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 111 | 114 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 119 | 121 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 119 | 121 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 1 | 942 | Chain | ID=PRO_0000080664;Note=Ubiquitin carboxyl-terminal hydrolase 33 |
| Q8TEY7 | 97 | 147 | 1 | 942 | Chain | ID=PRO_0000080664;Note=Ubiquitin carboxyl-terminal hydrolase 33 |
| Q8TEY7 | 97 | 147 | 91 | 98 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 91 | 98 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 107 | 110 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 107 | 110 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 115 | 118 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 115 | 118 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UZG |
| Q8TEY7 | 97 | 147 | 59 | 123 | Zinc finger | Note=UBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502 |
| Q8TEY7 | 97 | 147 | 59 | 123 | Zinc finger | Note=UBP-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502 |
| Q8TEY7 | 867 | 890 | 837 | 942 | Alternative sequence | ID=VSP_008594;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q8TEY7 | 867 | 890 | 837 | 942 | Alternative sequence | ID=VSP_008594;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q8TEY7 | 867 | 890 | 1 | 942 | Chain | ID=PRO_0000080664;Note=Ubiquitin carboxyl-terminal hydrolase 33 |
| Q8TEY7 | 867 | 890 | 1 | 942 | Chain | ID=PRO_0000080664;Note=Ubiquitin carboxyl-terminal hydrolase 33 |
| Q8TEY7 | 867 | 890 | 818 | 921 | Domain | Note=DUSP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00613 |
| Q8TEY7 | 867 | 890 | 818 | 921 | Domain | Note=DUSP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00613 |
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3'-UTR located exon skipping events that lost miRNA binding sites in USP33 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for USP33 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for USP33 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| CDR | MSBB | IFG | exon_skip_131406 | 5.155992e-01 | 4.982458e-03 | chr1 | - | 77697863 | 77697931 | 77701369 | 77701471 | 77711747 | 77711855 |
| CDR | MSBB | IFG | exon_skip_176918 | -5.010203e-01 | 6.611721e-03 | chr1 | - | 77730618 | 77730731 | 77734347 | 77734416 | 77736056 | 77736158 |
| CDR | MSBB | IFG | exon_skip_245700 | -3.771718e-01 | 4.786349e-02 | chr1 | - | 77728295 | 77728712 | 77729860 | 77729938 | 77730618 | 77730731 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for USP33 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for USP33 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | PTBP1 | exon_skip_265676 | 4.261348e-01 | 1.376011e-07 |
| CB | DAZAP1 | exon_skip_2227 | -5.238374e-01 | 1.921419e-12 |
| CB | TARDBP | exon_skip_2227 | -5.041762e-01 | 1.675874e-11 |
| CB | ZNF638 | exon_skip_2227 | -6.286187e-01 | 1.203943e-18 |
| CB | TRA2A | exon_skip_2227 | -6.029418e-01 | 6.507374e-17 |
| CB | NUP42 | exon_skip_2227 | 4.500918e-01 | 3.335247e-09 |
| CB | PTBP1 | exon_skip_2227 | -5.424602e-01 | 2.163345e-13 |
| IFG | TRA2A | exon_skip_101875 | -4.434724e-01 | 1.809186e-02 |
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RelatedDrugs for USP33 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for USP33 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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