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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for DAAM1 |
Gene summary |
Gene information | Gene symbol | DAAM1 | Gene ID | 23002 |
Gene name | dishevelled associated activator of morphogenesis 1 | |
Synonyms | - | |
Cytomap | 14q23.1 | |
Type of gene | protein-coding | |
Description | disheveled-associated activator of morphogenesis 1 | |
Modification date | 20200313 | |
UniProtAcc | G3V275, Q9Y4D1, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for DAAM1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PG | UP | ENST00000554459.5 | DAAM1-206:lncRNA:DAAM1 | 1.238619e+01 | 8.402667e-01 | 3.126213e-03 | 3.274649e-02 |
CB | UP | ENST00000553966.5 | DAAM1-205:lncRNA:DAAM1 | 2.488045e+01 | 1.838883e+00 | 4.605213e-10 | 2.306753e-08 |
TC | UP | ENST00000554459.5 | DAAM1-206:lncRNA:DAAM1 | 3.119136e+01 | 8.059562e-01 | 2.226389e-08 | 1.752020e-06 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DAAM1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_237278 | chr14 | 59326933:59326991:59330501:59330688:59331209:59331508 | 59330501:59330688 |
exon_skip_261259 | chr14 | 59291217:59291306:59315280:59315351:59320490:59320584 | 59315280:59315351 |
exon_skip_33352 | chr14 | 59331813:59331920:59338385:59338414:59340074:59340180 | 59338385:59338414 |
exon_skip_67902 | chr14 | 59359397:59359504:59360802:59360862:59363651:59363782 | 59360802:59360862 |
exon_skip_82077 | chr14 | 59331813:59331920:59340074:59340180:59347539:59347623 | 59340074:59340180 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_67902 | Mayo_CB | 7.685000e-01 | 9.039063e-01 | -1.354062e-01 | 2.203220e-08 |
exon_skip_33352 | Mayo_TC | 1.330000e-01 | 2.519672e-01 | -1.189672e-01 | 2.431632e-07 |
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Open reading frame (ORF) annotation in the exon skipping event for DAAM1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000395125 | 59360802 | 59360862 | Frame-shift |
ENST00000395125 | 59315280 | 59315351 | In-frame |
ENST00000395125 | 59338385 | 59338414 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000395125 | 59360802 | 59360862 | Frame-shift |
ENST00000395125 | 59338385 | 59338414 | In-frame |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000395125 | 59330501 | 59330688 | Frame-shift |
ENST00000395125 | 59360802 | 59360862 | Frame-shift |
ENST00000395125 | 59338385 | 59338414 | In-frame |
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Infer the effects of exon skipping event on protein functional features for DAAM1 |
p-ENSG00000100592_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000395125 | 5823 | 1078 | 59315280 | 59315351 | 298 | 368 | 91 | 115 |
ENST00000395125 | 5823 | 1078 | 59338385 | 59338414 | 1993 | 2021 | 656 | 666 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000395125 | 5823 | 1078 | 59338385 | 59338414 | 1993 | 2021 | 656 | 666 |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000395125 | 5823 | 1078 | 59338385 | 59338414 | 1993 | 2021 | 656 | 666 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9Y4D1 | 91 | 115 | 1 | 1078 | Chain | ID=PRO_0000194907;Note=Disheveled-associated activator of morphogenesis 1 |
Q9Y4D1 | 91 | 115 | 45 | 420 | Domain | Note=GBD/FH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00579 |
Q9Y4D1 | 656 | 666 | 656 | 665 | Alternative sequence | ID=VSP_008000;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
Q9Y4D1 | 656 | 666 | 1 | 1078 | Chain | ID=PRO_0000194907;Note=Disheveled-associated activator of morphogenesis 1 |
Q9Y4D1 | 656 | 666 | 600 | 1009 | Domain | Note=FH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00774 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9Y4D1 | 656 | 666 | 656 | 665 | Alternative sequence | ID=VSP_008000;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
Q9Y4D1 | 656 | 666 | 1 | 1078 | Chain | ID=PRO_0000194907;Note=Disheveled-associated activator of morphogenesis 1 |
Q9Y4D1 | 656 | 666 | 600 | 1009 | Domain | Note=FH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00774 |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9Y4D1 | 656 | 666 | 656 | 665 | Alternative sequence | ID=VSP_008000;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
Q9Y4D1 | 656 | 666 | 1 | 1078 | Chain | ID=PRO_0000194907;Note=Disheveled-associated activator of morphogenesis 1 |
Q9Y4D1 | 656 | 666 | 600 | 1009 | Domain | Note=FH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00774 |
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3'-UTR located exon skipping events that lost miRNA binding sites in DAAM1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for DAAM1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for DAAM1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DAAM1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for DAAM1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | DAZAP1 | exon_skip_67902 | -4.315703e-01 | 6.643834e-08 |
CB | SAMD4A | exon_skip_67902 | -5.279861e-01 | 1.042779e-11 |
CB | CNOT4 | exon_skip_67902 | -5.022748e-01 | 1.415905e-10 |
CB | RBM45 | exon_skip_67902 | 6.375416e-01 | 8.535071e-18 |
CB | NUP42 | exon_skip_67902 | 5.397655e-01 | 2.927987e-12 |
CB | SRSF4 | exon_skip_67902 | -4.755817e-01 | 1.704308e-09 |
IFG | RBM5 | exon_skip_33352 | -4.330611e-01 | 4.409038e-02 |
PCC | ELAVL4 | exon_skip_33352 | 5.008702e-01 | 6.600265e-14 |
PCC | RALYL | exon_skip_33352 | 4.708766e-01 | 2.894160e-12 |
TC | ELAVL4 | exon_skip_33352 | 7.402416e-01 | 9.833958e-26 |
TC | HNRNPD | exon_skip_33352 | 5.176989e-01 | 4.903962e-11 |
TC | RALYL | exon_skip_33352 | 7.324858e-01 | 5.628373e-25 |
TC | CELF1 | exon_skip_33352 | 4.063009e-01 | 5.763835e-07 |
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RelatedDrugs for DAAM1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DAAM1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |