ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for SEC31A

Gene summary

Gene information	Gene symbol	SEC31A
	Gene ID	22872
	Gene name	SEC31 homolog A, COPII coat complex component
	Synonyms	ABP125\|ABP130\|HSPC275\|HSPC334\|NEDSOSB\|SEC31L1
	Cytomap	4q21.22
	Type of gene	protein-coding
	Description	protein transport protein Sec31ASEC31 homolog A, COPII coating complex componentSEC31-like protein 1SEC31-related protein Aweb1-like proteinyeast Sec31p homolog
	Modification date	20200313
	UniProtAcc	A0A024A2P5, A0A1S5UZ19, D6RAB3, D6RBT0, D6RCQ9, D6RE64, D6REA9, D6REC0, D6REX3, D6RHE8, D6RHZ5, H0Y8V7, H0Y8W8, H0Y9K1, H0Y9T9, H0Y9V3, H0YAB3, H0YAF5, H7BXG7, O94979, U3KQC9, U3KQR3,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
SEC31A	GO:0051592	response to calcium ion	17196169
SEC31A	GO:0090110	cargo loading into COPII-coated vesicle	17499046\|18843296

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Gene structures and expression levels for SEC31A

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000138674

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
PG	UP	ENST00000511975.5	SEC31A-233:lncRNA:SEC31A	2.642146e+00	4.585436e+00	8.693147e-06	4.531817e-04
PG	UP	ENST00000505984.5	SEC31A-217:protein_coding:SEC31A	8.059240e+00	5.944246e+00	1.648438e-05	7.289241e-04
CB	UP	ENST00000510167.1	SEC31A-230:protein_coding:SEC31A	4.188727e+01	1.436990e+00	2.400056e-11	1.976904e-09
CB	UP	ENST00000505984.5	SEC31A-217:protein_coding:SEC31A	1.806487e+01	6.807222e+00	2.490266e-08	6.537082e-07
CB	UP	ENST00000348405.8	SEC31A-203:protein_coding:SEC31A	3.244874e+02	1.184927e+00	8.274548e-08	1.808643e-06
CB	UP	ENST00000264405.9	SEC31A-201:protein_coding:SEC31A	8.469778e+00	8.640674e-01	9.312266e-04	4.863918e-03
CB	UP	ENST00000511975.5	SEC31A-233:lncRNA:SEC31A	2.793368e+00	1.790196e+00	1.907498e-03	8.863877e-03
TC	UP	ENST00000348405.8	SEC31A-203:protein_coding:SEC31A	3.331226e+02	8.747352e-01	7.715327e-05	1.314453e-03

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SEC31A

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_121138	chr4	82861631:82861708:82862534:82862572:82863318:82863392	82862534:82862572
exon_skip_130121	chr4	82819044:82819253:82821037:82821108:82824555:82824674	82821037:82821108
exon_skip_131099	chr4	82821037:82821108:82824555:82824674:82827369:82827612	82824555:82824674
exon_skip_135390	chr4	82829000:82829058:82830937:82830975:82842140:82842166	82830937:82830975
exon_skip_137748	chr4	82880799:82880922:82881858:82881940:82891088:82891178	82881858:82881940
exon_skip_145385	chr4	82857689:82857764:82861631:82861708:82862534:82862572	82861631:82861708
exon_skip_159234	chr4	82844386:82844509:82848804:82848977:82851431:82851604	82848804:82848977
exon_skip_16459	chr4	82829000:82829058:82830937:82830975:82842140:82842341	82830937:82830975
exon_skip_165971	chr4	82819044:82819253:82824555:82824674:82827369:82827612	82824555:82824674
exon_skip_174759	chr4	82880807:82880922:82881858:82881937:82891088:82891120	82881858:82881937
exon_skip_187656	chr4	82875785:82875822:82878858:82878928:82880799:82880922	82878858:82878928
exon_skip_222780	chr4	82880799:82880922:82881858:82881937:82891088:82891178	82881858:82881937
exon_skip_233001	chr4	82844386:82844509:82845201:82845293:82848804:82848843	82845201:82845293
exon_skip_246696	chr4	82874698:82874751:82875727:82875822:82878730:82878918	82875727:82875822
exon_skip_269325	chr4	82829000:82829058:82830937:82830975:82842140:82842481	82830937:82830975
exon_skip_279179	chr4	82829000:82829058:82842185:82842481:82844386:82844460	82842185:82842481
exon_skip_294204	chr4	82819044:82819253:82821037:82821108:82824555:82824587	82821037:82821108
exon_skip_29614	chr4	82857689:82857764:82862534:82862572:82863318:82863392	82862534:82862572
exon_skip_34043	chr4	82874698:82874751:82875727:82875822:82878730:82878809	82875727:82875822
exon_skip_41009	chr4	82867155:82867316:82870325:82870424:82871944:82872086	82870325:82870424
exon_skip_4378	chr4	82857689:82857764:82861631:82861708:82863318:82863392	82861631:82861708
exon_skip_52971	chr4	82880807:82880922:82881858:82881940:82891088:82891120	82881858:82881940
exon_skip_53927	chr4	82827556:82827632:82829000:82829058:82842185:82842481	82829000:82829058
exon_skip_55826	chr4	82829000:82829058:82842140:82842481:82844386:82844460	82842140:82842481
exon_skip_64392	chr4	82875785:82875822:82878730:82878928:82880799:82880922	82878730:82878928
exon_skip_76232	chr4	82829000:82829058:82844386:82844509:82848804:82848843	82844386:82844509
exon_skip_76288	chr4	82830937:82830975:82842140:82842481:82844386:82844460	82842140:82842481
exon_skip_88903	chr4	82875785:82875822:82878730:82878918:82880799:82880922	82878730:82878918

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information	Tissue type	Avg(PSIs) in AD	Avg(PSIs) in control	Difference (PSI)	Adj. p-value
exon_skip_121138	Mayo_CB	6.640244e-01	8.091045e-01	-1.450801e-01	1.548928e-07
exon_skip_29614	Mayo_TC	5.791463e-01	6.822388e-01	-1.030925e-01	3.981081e-06

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Open reading frame (ORF) annotation in the exon skipping event for SEC31A

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000448323	82881858	82881937	3UTR-3CDS
ENST00000355196	82870325	82870424	Frame-shift
ENST00000395310	82870325	82870424	Frame-shift
ENST00000448323	82870325	82870424	Frame-shift
ENST00000355196	82821037	82821108	In-frame
ENST00000395310	82821037	82821108	In-frame
ENST00000448323	82821037	82821108	In-frame
ENST00000355196	82824555	82824674	In-frame
ENST00000395310	82824555	82824674	In-frame
ENST00000448323	82824555	82824674	In-frame
ENST00000355196	82842140	82842481	In-frame
ENST00000395310	82842140	82842481	In-frame
ENST00000448323	82842140	82842481	In-frame
ENST00000355196	82848804	82848977	In-frame
ENST00000395310	82848804	82848977	In-frame
ENST00000448323	82848804	82848977	In-frame
ENST00000355196	82861631	82861708	In-frame
ENST00000395310	82861631	82861708	In-frame
ENST00000448323	82861631	82861708	In-frame
ENST00000355196	82862534	82862572	In-frame
ENST00000395310	82862534	82862572	In-frame
ENST00000448323	82862534	82862572	In-frame
ENST00000355196	82875727	82875822	In-frame
ENST00000395310	82875727	82875822	In-frame
ENST00000448323	82875727	82875822	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000448323	82881858	82881937	3UTR-3CDS
ENST00000355196	82870325	82870424	Frame-shift
ENST00000395310	82870325	82870424	Frame-shift
ENST00000448323	82870325	82870424	Frame-shift
ENST00000355196	82821037	82821108	In-frame
ENST00000395310	82821037	82821108	In-frame
ENST00000448323	82821037	82821108	In-frame
ENST00000355196	82824555	82824674	In-frame
ENST00000395310	82824555	82824674	In-frame
ENST00000448323	82824555	82824674	In-frame
ENST00000355196	82842140	82842481	In-frame
ENST00000395310	82842140	82842481	In-frame
ENST00000448323	82842140	82842481	In-frame
ENST00000355196	82861631	82861708	In-frame
ENST00000395310	82861631	82861708	In-frame
ENST00000448323	82861631	82861708	In-frame
ENST00000355196	82862534	82862572	In-frame
ENST00000395310	82862534	82862572	In-frame
ENST00000448323	82862534	82862572	In-frame
ENST00000355196	82875727	82875822	In-frame
ENST00000395310	82875727	82875822	In-frame
ENST00000448323	82875727	82875822	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000448323	82881858	82881937	3UTR-3CDS
ENST00000355196	82870325	82870424	Frame-shift
ENST00000395310	82870325	82870424	Frame-shift
ENST00000448323	82870325	82870424	Frame-shift
ENST00000355196	82878730	82878928	Frame-shift
ENST00000395310	82878730	82878928	Frame-shift
ENST00000448323	82878730	82878928	Frame-shift
ENST00000355196	82821037	82821108	In-frame
ENST00000395310	82821037	82821108	In-frame
ENST00000448323	82821037	82821108	In-frame
ENST00000355196	82824555	82824674	In-frame
ENST00000395310	82824555	82824674	In-frame
ENST00000448323	82824555	82824674	In-frame
ENST00000355196	82842140	82842481	In-frame
ENST00000395310	82842140	82842481	In-frame
ENST00000448323	82842140	82842481	In-frame
ENST00000355196	82848804	82848977	In-frame
ENST00000395310	82848804	82848977	In-frame
ENST00000448323	82848804	82848977	In-frame
ENST00000355196	82861631	82861708	In-frame
ENST00000395310	82861631	82861708	In-frame
ENST00000448323	82861631	82861708	In-frame
ENST00000355196	82862534	82862572	In-frame
ENST00000395310	82862534	82862572	In-frame
ENST00000448323	82862534	82862572	In-frame
ENST00000355196	82875727	82875822	In-frame
ENST00000395310	82875727	82875822	In-frame
ENST00000448323	82875727	82875822	In-frame

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Infer the effects of exon skipping event on protein functional features for SEC31A

p-ENSG00000138674_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000355196	4121	1220	82875727	82875822	781	875	134	165
ENST00000395310	4276	1220	82875727	82875822	586	680	134	165
ENST00000448323	4272	1220	82875727	82875822	583	677	134	165
ENST00000355196	4121	1220	82862534	82862572	1888	1925	503	515
ENST00000395310	4276	1220	82862534	82862572	1693	1730	503	515
ENST00000448323	4272	1220	82862534	82862572	1690	1727	503	515
ENST00000355196	4121	1220	82861631	82861708	1927	2003	516	541
ENST00000395310	4276	1220	82861631	82861708	1732	1808	516	541
ENST00000448323	4272	1220	82861631	82861708	1729	1805	516	541
ENST00000355196	4121	1220	82848804	82848977	2707	2879	776	833
ENST00000395310	4276	1220	82848804	82848977	2512	2684	776	833
ENST00000448323	4272	1220	82848804	82848977	2509	2681	776	833
ENST00000355196	4121	1220	82842140	82842481	3005	3345	875	989
ENST00000395310	4276	1220	82842140	82842481	2810	3150	875	989
ENST00000448323	4272	1220	82842140	82842481	2807	3147	875	989
ENST00000355196	4121	1220	82824555	82824674	3670	3788	1097	1136
ENST00000395310	4276	1220	82824555	82824674	3475	3593	1097	1136
ENST00000448323	4272	1220	82824555	82824674	3472	3590	1097	1136
ENST00000355196	4121	1220	82821037	82821108	3790	3860	1137	1160
ENST00000395310	4276	1220	82821037	82821108	3595	3665	1137	1160
ENST00000448323	4272	1220	82821037	82821108	3592	3662	1137	1160

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000355196	4121	1220	82875727	82875822	781	875	134	165
ENST00000395310	4276	1220	82875727	82875822	586	680	134	165
ENST00000448323	4272	1220	82875727	82875822	583	677	134	165
ENST00000355196	4121	1220	82862534	82862572	1888	1925	503	515
ENST00000395310	4276	1220	82862534	82862572	1693	1730	503	515
ENST00000448323	4272	1220	82862534	82862572	1690	1727	503	515
ENST00000355196	4121	1220	82861631	82861708	1927	2003	516	541
ENST00000395310	4276	1220	82861631	82861708	1732	1808	516	541
ENST00000448323	4272	1220	82861631	82861708	1729	1805	516	541
ENST00000355196	4121	1220	82842140	82842481	3005	3345	875	989
ENST00000395310	4276	1220	82842140	82842481	2810	3150	875	989
ENST00000448323	4272	1220	82842140	82842481	2807	3147	875	989
ENST00000355196	4121	1220	82824555	82824674	3670	3788	1097	1136
ENST00000395310	4276	1220	82824555	82824674	3475	3593	1097	1136
ENST00000448323	4272	1220	82824555	82824674	3472	3590	1097	1136
ENST00000355196	4121	1220	82821037	82821108	3790	3860	1137	1160
ENST00000395310	4276	1220	82821037	82821108	3595	3665	1137	1160
ENST00000448323	4272	1220	82821037	82821108	3592	3662	1137	1160

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000355196	4121	1220	82875727	82875822	781	875	134	165
ENST00000395310	4276	1220	82875727	82875822	586	680	134	165
ENST00000448323	4272	1220	82875727	82875822	583	677	134	165
ENST00000355196	4121	1220	82862534	82862572	1888	1925	503	515
ENST00000395310	4276	1220	82862534	82862572	1693	1730	503	515
ENST00000448323	4272	1220	82862534	82862572	1690	1727	503	515
ENST00000355196	4121	1220	82861631	82861708	1927	2003	516	541
ENST00000395310	4276	1220	82861631	82861708	1732	1808	516	541
ENST00000448323	4272	1220	82861631	82861708	1729	1805	516	541
ENST00000355196	4121	1220	82848804	82848977	2707	2879	776	833
ENST00000395310	4276	1220	82848804	82848977	2512	2684	776	833
ENST00000448323	4272	1220	82848804	82848977	2509	2681	776	833
ENST00000355196	4121	1220	82842140	82842481	3005	3345	875	989
ENST00000395310	4276	1220	82842140	82842481	2810	3150	875	989
ENST00000448323	4272	1220	82842140	82842481	2807	3147	875	989
ENST00000355196	4121	1220	82824555	82824674	3670	3788	1097	1136
ENST00000395310	4276	1220	82824555	82824674	3475	3593	1097	1136
ENST00000448323	4272	1220	82824555	82824674	3472	3590	1097	1136
ENST00000355196	4121	1220	82821037	82821108	3790	3860	1137	1160
ENST00000395310	4276	1220	82821037	82821108	3595	3665	1137	1160
ENST00000448323	4272	1220	82821037	82821108	3592	3662	1137	1160

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O94979	134	165	1	228	Alternative sequence	ID=VSP_026742;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O94979	134	165	1	228	Alternative sequence	ID=VSP_026742;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O94979	134	165	1	228	Alternative sequence	ID=VSP_026742;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O94979	134	165	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	134	165	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	134	165	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	134	165	161	471	Region	Note=Interaction with SEC13;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	134	165	161	471	Region	Note=Interaction with SEC13;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	134	165	161	471	Region	Note=Interaction with SEC13;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	134	165	120	160	Repeat	Note=WD 3
O94979	134	165	120	160	Repeat	Note=WD 3
O94979	134	165	120	160	Repeat	Note=WD 3
O94979	503	515	504	542	Alternative sequence	ID=VSP_026744;Note=In isoform 4%2C isoform 6%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|Ref.2;
O94979	503	515	504	542	Alternative sequence	ID=VSP_026744;Note=In isoform 4%2C isoform 6%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|Ref.2;
O94979	503	515	504	542	Alternative sequence	ID=VSP_026744;Note=In isoform 4%2C isoform 6%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|Ref.2;
O94979	503	515	504	509	Alternative sequence	ID=VSP_026745;Note=In isoform 5. IALALN->VNFWES;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	503	515	504	509	Alternative sequence	ID=VSP_026745;Note=In isoform 5. IALALN->VNFWES;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	503	515	504	509	Alternative sequence	ID=VSP_026745;Note=In isoform 5. IALALN->VNFWES;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	503	515	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	503	515	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	503	515	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	503	515	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	503	515	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	503	515	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	516	541	504	542	Alternative sequence	ID=VSP_026744;Note=In isoform 4%2C isoform 6%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|Ref.2;
O94979	516	541	504	542	Alternative sequence	ID=VSP_026744;Note=In isoform 4%2C isoform 6%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|Ref.2;
O94979	516	541	504	542	Alternative sequence	ID=VSP_026744;Note=In isoform 4%2C isoform 6%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|Ref.2;
O94979	516	541	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	516	541	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	516	541	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	516	541	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	516	541	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	516	541	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	516	541	527	527	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:17081983,PMID:21406692,PMID:23186163,PMID
O94979	516	541	527	527	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:17081983,PMID:21406692,PMID:23186163,PMID
O94979	516	541	527	527	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:17081983,PMID:21406692,PMID:23186163,PMID
O94979	516	541	532	532	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:17081983;Dbxref=PMID:17081983
O94979	516	541	532	532	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:17081983;Dbxref=PMID:17081983
O94979	516	541	532	532	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:17081983;Dbxref=PMID:17081983
O94979	776	833	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	776	833	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	776	833	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	776	833	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	776	833	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	776	833	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	776	833	800	1091	Compositional bias	Note=Pro-rich
O94979	776	833	800	1091	Compositional bias	Note=Pro-rich
O94979	776	833	800	1091	Compositional bias	Note=Pro-rich
O94979	776	833	799	799	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:1
O94979	776	833	799	799	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:1
O94979	776	833	799	799	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:1
O94979	776	833	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	776	833	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	776	833	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	875	989	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	875	989	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	875	989	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	875	989	876	876	Alternative sequence	ID=VSP_026748;Note=In isoform 3 and isoform 6. P->R;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
O94979	875	989	876	876	Alternative sequence	ID=VSP_026748;Note=In isoform 3 and isoform 6. P->R;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
O94979	875	989	876	876	Alternative sequence	ID=VSP_026748;Note=In isoform 3 and isoform 6. P->R;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
O94979	875	989	877	990	Alternative sequence	ID=VSP_026749;Note=In isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
O94979	875	989	877	990	Alternative sequence	ID=VSP_026749;Note=In isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
O94979	875	989	877	990	Alternative sequence	ID=VSP_026749;Note=In isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
O94979	875	989	974	988	Alternative sequence	ID=VSP_026750;Note=In isoform 2%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
O94979	875	989	974	988	Alternative sequence	ID=VSP_026750;Note=In isoform 2%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
O94979	875	989	974	988	Alternative sequence	ID=VSP_026750;Note=In isoform 2%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
O94979	875	989	989	989	Alternative sequence	ID=VSP_026751;Note=In isoform 8. T->TENQSIQDQAPMLE;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.11
O94979	875	989	989	989	Alternative sequence	ID=VSP_026751;Note=In isoform 8. T->TENQSIQDQAPMLE;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.11
O94979	875	989	989	989	Alternative sequence	ID=VSP_026751;Note=In isoform 8. T->TENQSIQDQAPMLE;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.11
O94979	875	989	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	875	989	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	875	989	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	875	989	800	1091	Compositional bias	Note=Pro-rich
O94979	875	989	800	1091	Compositional bias	Note=Pro-rich
O94979	875	989	800	1091	Compositional bias	Note=Pro-rich
O94979	875	989	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	875	989	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	875	989	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	1097	1136	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	1097	1136	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	1097	1136	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	1097	1136	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	1097	1136	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	1097	1136	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	1097	1136	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	1097	1136	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	1097	1136	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	1137	1160	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	1137	1160	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	1137	1160	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	1137	1160	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	1137	1160	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	1137	1160	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O94979	134	165	1	228	Alternative sequence	ID=VSP_026742;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O94979	134	165	1	228	Alternative sequence	ID=VSP_026742;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O94979	134	165	1	228	Alternative sequence	ID=VSP_026742;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O94979	134	165	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	134	165	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	134	165	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	134	165	161	471	Region	Note=Interaction with SEC13;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	134	165	161	471	Region	Note=Interaction with SEC13;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	134	165	161	471	Region	Note=Interaction with SEC13;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	134	165	120	160	Repeat	Note=WD 3
O94979	134	165	120	160	Repeat	Note=WD 3
O94979	134	165	120	160	Repeat	Note=WD 3
O94979	503	515	504	542	Alternative sequence	ID=VSP_026744;Note=In isoform 4%2C isoform 6%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|Ref.2;
O94979	503	515	504	542	Alternative sequence	ID=VSP_026744;Note=In isoform 4%2C isoform 6%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|Ref.2;
O94979	503	515	504	542	Alternative sequence	ID=VSP_026744;Note=In isoform 4%2C isoform 6%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|Ref.2;
O94979	503	515	504	509	Alternative sequence	ID=VSP_026745;Note=In isoform 5. IALALN->VNFWES;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	503	515	504	509	Alternative sequence	ID=VSP_026745;Note=In isoform 5. IALALN->VNFWES;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	503	515	504	509	Alternative sequence	ID=VSP_026745;Note=In isoform 5. IALALN->VNFWES;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	503	515	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	503	515	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	503	515	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	503	515	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	503	515	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	503	515	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	516	541	504	542	Alternative sequence	ID=VSP_026744;Note=In isoform 4%2C isoform 6%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|Ref.2;
O94979	516	541	504	542	Alternative sequence	ID=VSP_026744;Note=In isoform 4%2C isoform 6%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|Ref.2;
O94979	516	541	504	542	Alternative sequence	ID=VSP_026744;Note=In isoform 4%2C isoform 6%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|Ref.2;
O94979	516	541	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	516	541	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	516	541	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	516	541	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	516	541	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	516	541	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	516	541	527	527	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:17081983,PMID:21406692,PMID:23186163,PMID
O94979	516	541	527	527	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:17081983,PMID:21406692,PMID:23186163,PMID
O94979	516	541	527	527	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:17081983,PMID:21406692,PMID:23186163,PMID
O94979	516	541	532	532	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:17081983;Dbxref=PMID:17081983
O94979	516	541	532	532	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:17081983;Dbxref=PMID:17081983
O94979	516	541	532	532	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:17081983;Dbxref=PMID:17081983
O94979	875	989	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	875	989	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	875	989	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	875	989	876	876	Alternative sequence	ID=VSP_026748;Note=In isoform 3 and isoform 6. P->R;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
O94979	875	989	876	876	Alternative sequence	ID=VSP_026748;Note=In isoform 3 and isoform 6. P->R;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
O94979	875	989	876	876	Alternative sequence	ID=VSP_026748;Note=In isoform 3 and isoform 6. P->R;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
O94979	875	989	877	990	Alternative sequence	ID=VSP_026749;Note=In isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
O94979	875	989	877	990	Alternative sequence	ID=VSP_026749;Note=In isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
O94979	875	989	877	990	Alternative sequence	ID=VSP_026749;Note=In isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
O94979	875	989	974	988	Alternative sequence	ID=VSP_026750;Note=In isoform 2%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
O94979	875	989	974	988	Alternative sequence	ID=VSP_026750;Note=In isoform 2%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
O94979	875	989	974	988	Alternative sequence	ID=VSP_026750;Note=In isoform 2%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
O94979	875	989	989	989	Alternative sequence	ID=VSP_026751;Note=In isoform 8. T->TENQSIQDQAPMLE;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.11
O94979	875	989	989	989	Alternative sequence	ID=VSP_026751;Note=In isoform 8. T->TENQSIQDQAPMLE;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.11
O94979	875	989	989	989	Alternative sequence	ID=VSP_026751;Note=In isoform 8. T->TENQSIQDQAPMLE;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.11
O94979	875	989	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	875	989	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	875	989	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	875	989	800	1091	Compositional bias	Note=Pro-rich
O94979	875	989	800	1091	Compositional bias	Note=Pro-rich
O94979	875	989	800	1091	Compositional bias	Note=Pro-rich
O94979	875	989	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	875	989	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	875	989	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	1097	1136	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	1097	1136	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	1097	1136	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	1097	1136	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	1097	1136	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	1097	1136	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	1097	1136	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	1097	1136	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	1097	1136	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	1137	1160	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	1137	1160	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	1137	1160	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	1137	1160	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	1137	1160	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	1137	1160	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O94979	134	165	1	228	Alternative sequence	ID=VSP_026742;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O94979	134	165	1	228	Alternative sequence	ID=VSP_026742;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O94979	134	165	1	228	Alternative sequence	ID=VSP_026742;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O94979	134	165	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	134	165	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	134	165	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	134	165	161	471	Region	Note=Interaction with SEC13;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	134	165	161	471	Region	Note=Interaction with SEC13;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	134	165	161	471	Region	Note=Interaction with SEC13;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	134	165	120	160	Repeat	Note=WD 3
O94979	134	165	120	160	Repeat	Note=WD 3
O94979	134	165	120	160	Repeat	Note=WD 3
O94979	503	515	504	542	Alternative sequence	ID=VSP_026744;Note=In isoform 4%2C isoform 6%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|Ref.2;
O94979	503	515	504	542	Alternative sequence	ID=VSP_026744;Note=In isoform 4%2C isoform 6%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|Ref.2;
O94979	503	515	504	542	Alternative sequence	ID=VSP_026744;Note=In isoform 4%2C isoform 6%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|Ref.2;
O94979	503	515	504	509	Alternative sequence	ID=VSP_026745;Note=In isoform 5. IALALN->VNFWES;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	503	515	504	509	Alternative sequence	ID=VSP_026745;Note=In isoform 5. IALALN->VNFWES;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	503	515	504	509	Alternative sequence	ID=VSP_026745;Note=In isoform 5. IALALN->VNFWES;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	503	515	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	503	515	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	503	515	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	503	515	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	503	515	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	503	515	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	516	541	504	542	Alternative sequence	ID=VSP_026744;Note=In isoform 4%2C isoform 6%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|Ref.2;
O94979	516	541	504	542	Alternative sequence	ID=VSP_026744;Note=In isoform 4%2C isoform 6%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|Ref.2;
O94979	516	541	504	542	Alternative sequence	ID=VSP_026744;Note=In isoform 4%2C isoform 6%2C isoform 7 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005,ECO:0000303\|Ref.2;
O94979	516	541	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	516	541	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	516	541	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	516	541	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	516	541	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	516	541	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	516	541	527	527	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:17081983,PMID:21406692,PMID:23186163,PMID
O94979	516	541	527	527	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:17081983,PMID:21406692,PMID:23186163,PMID
O94979	516	541	527	527	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:17081983,PMID:21406692,PMID:23186163,PMID
O94979	516	541	532	532	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:17081983;Dbxref=PMID:17081983
O94979	516	541	532	532	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:17081983;Dbxref=PMID:17081983
O94979	516	541	532	532	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:17081983;Dbxref=PMID:17081983
O94979	776	833	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	776	833	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	776	833	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	776	833	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	776	833	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	776	833	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	776	833	800	1091	Compositional bias	Note=Pro-rich
O94979	776	833	800	1091	Compositional bias	Note=Pro-rich
O94979	776	833	800	1091	Compositional bias	Note=Pro-rich
O94979	776	833	799	799	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:1
O94979	776	833	799	799	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:1
O94979	776	833	799	799	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:1
O94979	776	833	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	776	833	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	776	833	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	875	989	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	875	989	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	875	989	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	875	989	876	876	Alternative sequence	ID=VSP_026748;Note=In isoform 3 and isoform 6. P->R;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
O94979	875	989	876	876	Alternative sequence	ID=VSP_026748;Note=In isoform 3 and isoform 6. P->R;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
O94979	875	989	876	876	Alternative sequence	ID=VSP_026748;Note=In isoform 3 and isoform 6. P->R;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
O94979	875	989	877	990	Alternative sequence	ID=VSP_026749;Note=In isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
O94979	875	989	877	990	Alternative sequence	ID=VSP_026749;Note=In isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
O94979	875	989	877	990	Alternative sequence	ID=VSP_026749;Note=In isoform 3 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005
O94979	875	989	974	988	Alternative sequence	ID=VSP_026750;Note=In isoform 2%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
O94979	875	989	974	988	Alternative sequence	ID=VSP_026750;Note=In isoform 2%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
O94979	875	989	974	988	Alternative sequence	ID=VSP_026750;Note=In isoform 2%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
O94979	875	989	989	989	Alternative sequence	ID=VSP_026751;Note=In isoform 8. T->TENQSIQDQAPMLE;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.11
O94979	875	989	989	989	Alternative sequence	ID=VSP_026751;Note=In isoform 8. T->TENQSIQDQAPMLE;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.11
O94979	875	989	989	989	Alternative sequence	ID=VSP_026751;Note=In isoform 8. T->TENQSIQDQAPMLE;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.11
O94979	875	989	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	875	989	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	875	989	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	875	989	800	1091	Compositional bias	Note=Pro-rich
O94979	875	989	800	1091	Compositional bias	Note=Pro-rich
O94979	875	989	800	1091	Compositional bias	Note=Pro-rich
O94979	875	989	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	875	989	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	875	989	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	1097	1136	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	1097	1136	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	1097	1136	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	1097	1136	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	1097	1136	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	1097	1136	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	1097	1136	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	1097	1136	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	1097	1136	800	1113	Region	Note=Interaction with PDCD6;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16957052;Dbxref=PMID:16957052
O94979	1137	1160	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	1137	1160	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	1137	1160	510	1220	Alternative sequence	ID=VSP_026746;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O94979	1137	1160	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	1137	1160	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A
O94979	1137	1160	1	1220	Chain	ID=PRO_0000295147;Note=Protein transport protein Sec31A

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3'-UTR located exon skipping events that lost miRNA binding sites in SEC31A

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for SEC31A

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for SEC31A

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SEC31A

sQTL information located at the skipped exons.

Tissue type	Exon skip ID	SNP id	Location	P-value	FDR
HCC	exon_skip_279179	rs17354078	chr4:82747477	1.812286e-05	2.119782e-03
HCC	exon_skip_279179	rs17354064	chr4:82745368	2.003030e-05	2.315216e-03
HCC	exon_skip_4378	rs4693060	chr4:82933211	7.073146e-04	4.457749e-02

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Correlation with RNA binding proteins (RBPs) for SEC31A

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	PABPN1	exon_skip_29614	-5.148159e-01	2.100175e-09
CB	TRA2A	exon_skip_29614	-5.098616e-01	3.170272e-09
CB	SNRPA	exon_skip_29614	-5.162247e-01	1.865841e-09
CB	PABPN1	exon_skip_121138	-4.545622e-01	5.767568e-09
CB	TRA2A	exon_skip_121138	-5.623400e-01	8.462840e-14
CB	SNRPA	exon_skip_121138	-4.928648e-01	1.711030e-10
FL	KHDRBS3	exon_skip_145385	4.273482e-01	1.448119e-09
HCC	RBM6	exon_skip_279179	-4.170903e-01	7.860746e-13
HCC	HNRNPF	exon_skip_279179	-4.521517e-01	4.632023e-15
HCC	SRSF11	exon_skip_145385	-4.251804e-01	2.532749e-13
HCC	KHDRBS3	exon_skip_145385	-4.452062e-01	1.343084e-14
HCC	SRSF4	exon_skip_145385	-4.007980e-01	7.028063e-12
HCC	HNRNPF	exon_skip_145385	-4.948933e-01	3.779574e-18
HCC	HNRNPF	exon_skip_4378	-4.119571e-01	1.138548e-10
IFG	RBM24	exon_skip_145385	4.226487e-01	2.806905e-02
PCC	HNRNPF	exon_skip_55826	-4.183565e-01	2.639855e-10
PCC	RBM6	exon_skip_279179	-4.153627e-01	4.418176e-10
PCC	HNRNPF	exon_skip_279179	-5.137136e-01	2.101387e-15
PCC	HNRNPF	exon_skip_145385	-5.151926e-01	1.980332e-15
STG	KHDRBS3	exon_skip_145385	4.600648e-01	1.370436e-05
TC	NOVA1	exon_skip_55826	4.944629e-01	4.027228e-11
TC	SRSF2	exon_skip_279179	4.174504e-01	3.978393e-08
TC	HNRNPA0	exon_skip_279179	4.687706e-01	4.059311e-10
TC	NUP42	exon_skip_279179	4.249208e-01	2.138018e-08
TC	RALYL	exon_skip_279179	5.602214e-01	1.333596e-14
TC	HNRNPH2	exon_skip_279179	5.135176e-01	3.814210e-12
TC	ESRP1	exon_skip_279179	4.063687e-01	9.724727e-08
TC	NOVA1	exon_skip_279179	6.843944e-01	1.927875e-23
TC	KHDRBS3	exon_skip_145385	5.719862e-01	9.293755e-15
TC	RBM24	exon_skip_145385	5.802909e-01	3.085743e-15
TC	HNRNPH2	exon_skip_145385	4.908664e-01	1.026652e-10
TC	ESRP1	exon_skip_145385	5.285686e-01	1.843600e-12

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RelatedDrugs for SEC31A

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SEC31A

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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