ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for CPEB3

Gene summary

Gene information	Gene symbol	CPEB3
	Gene ID	22849
	Gene name	cytoplasmic polyadenylation element binding protein 3
	Synonyms	-
	Cytomap	10q23.32
	Type of gene	protein-coding
	Description	cytoplasmic polyadenylation element-binding protein 3CPE-BP3CPE-binding protein 3hCPEB-3
	Modification date	20200322
	UniProtAcc	B3KXC1, Q5QP71, Q8NE35,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CPEB3	GO:0000122	negative regulation of transcription by RNA polymerase II	20639532
CPEB3	GO:0017148	negative regulation of translation	21336257\|22711986
CPEB3	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	21336257
CPEB3	GO:0061158	3'-UTR-mediated mRNA destabilization	21336257
CPEB3	GO:0071230	cellular response to amino acid stimulus	20639532\|22730302
CPEB3	GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	21336257

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Gene structures and expression levels for CPEB3

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000107864

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

ENST

Transcript info.

Base mean exp.

log2FC(AD/control)

P-value

Adjc. p-value

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CPEB3

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_148510	chr10	92144945:92145085:92180963:92181019:92192477:92192636	92180963:92181019
exon_skip_181188	chr10	92144945:92145112:92180963:92181019:92192546:92192636	92180963:92181019
exon_skip_231582	chr10	92143029:92143118:92144945:92145085:92180963:92181019	92144945:92145085
exon_skip_28063	chr10	92111076:92111194:92143029:92143118:92144945:92145085	92143029:92143118
exon_skip_68005	chr10	92048642:92052439:92081320:92081501:92091830:92091944	92081320:92081501
exon_skip_71042	chr10	92143029:92143118:92144945:92145112:92180963:92181019	92144945:92145112
exon_skip_84038	chr10	92081320:92081501:92091830:92091944:92111076:92111194	92091830:92091944

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information	Tissue type	Avg(PSIs) in AD	Avg(PSIs) in control	Difference (PSI)	Adj. p-value
exon_skip_71188	Mayo_TC	2.715385e-01	3.892857e-01	-1.177473e-01	2.247781e-06

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Open reading frame (ORF) annotation in the exon skipping event for CPEB3

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000265997	92081320	92081501	Frame-shift
ENST00000614585	92081320	92081501	Frame-shift
ENST00000265997	92091830	92091944	Frame-shift
ENST00000614585	92091830	92091944	Frame-shift
ENST00000265997	92143029	92143118	In-frame
ENST00000614585	92143029	92143118	In-frame
ENST00000265997	92144945	92145085	In-frame
ENST00000614585	92144945	92145085	In-frame
ENST00000265997	92180963	92181019	In-frame
ENST00000614585	92180963	92181019	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000265997	92091830	92091944	Frame-shift
ENST00000614585	92091830	92091944	Frame-shift
ENST00000265997	92143029	92143118	In-frame
ENST00000614585	92143029	92143118	In-frame
ENST00000265997	92144945	92145085	In-frame
ENST00000614585	92144945	92145085	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000265997	92091830	92091944	Frame-shift
ENST00000614585	92091830	92091944	Frame-shift
ENST00000265997	92144945	92145085	In-frame
ENST00000614585	92144945	92145085	In-frame
ENST00000265997	92180963	92181019	In-frame
ENST00000614585	92180963	92181019	In-frame

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Infer the effects of exon skipping event on protein functional features for CPEB3

p-ENSG00000107864_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000265997	4868	698	92180963	92181019	1339	1394	388	407
ENST00000614585	5806	698	92180963	92181019	1288	1343	388	407
ENST00000265997	4868	698	92144945	92145085	1396	1535	407	454
ENST00000614585	5806	698	92144945	92145085	1345	1484	407	454
ENST00000265997	4868	698	92143029	92143118	1537	1625	454	484
ENST00000614585	5806	698	92143029	92143118	1486	1574	454	484

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000265997	4868	698	92144945	92145085	1396	1535	407	454
ENST00000614585	5806	698	92144945	92145085	1345	1484	407	454
ENST00000265997	4868	698	92143029	92143118	1537	1625	454	484
ENST00000614585	5806	698	92143029	92143118	1486	1574	454	484

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000265997	4868	698	92180963	92181019	1339	1394	388	407
ENST00000614585	5806	698	92180963	92181019	1288	1343	388	407
ENST00000265997	4868	698	92144945	92145085	1396	1535	407	454
ENST00000614585	5806	698	92144945	92145085	1345	1484	407	454

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q8NE35	388	407	366	388	Alternative sequence	ID=VSP_022034;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10231032;Dbxref=PMID:10231032
Q8NE35	388	407	366	388	Alternative sequence	ID=VSP_022034;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10231032;Dbxref=PMID:10231032
Q8NE35	388	407	1	698	Chain	ID=PRO_0000269261;Note=Cytoplasmic polyadenylation element-binding protein 3
Q8NE35	388	407	1	698	Chain	ID=PRO_0000269261;Note=Cytoplasmic polyadenylation element-binding protein 3
Q8NE35	407	454	408	408	Alternative sequence	ID=VSP_022035;Note=In isoform 2. N->SRSSLFPFED;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10231032;Dbxref=PMID:10231032
Q8NE35	407	454	408	408	Alternative sequence	ID=VSP_022035;Note=In isoform 2. N->SRSSLFPFED;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10231032;Dbxref=PMID:10231032
Q8NE35	407	454	443	446	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	407	454	443	446	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	407	454	1	698	Chain	ID=PRO_0000269261;Note=Cytoplasmic polyadenylation element-binding protein 3
Q8NE35	407	454	1	698	Chain	ID=PRO_0000269261;Note=Cytoplasmic polyadenylation element-binding protein 3
Q8NE35	407	454	441	532	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00176
Q8NE35	407	454	441	532	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00176
Q8NE35	407	454	454	460	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	407	454	454	460	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	407	454	441	441	Mutagenesis	Note=Does not impair RNA binding. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	441	441	Mutagenesis	Note=Does not impair RNA binding. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	444	444	Mutagenesis	Note=Abolishes RNA binding. F->A%2CN;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	444	444	Mutagenesis	Note=Abolishes RNA binding. F->A%2CN;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	444	444	Mutagenesis	Note=Does not impair RNA binding. F->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	444	444	Mutagenesis	Note=Does not impair RNA binding. F->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	446	446	Mutagenesis	Note=Does not impair RNA binding. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	446	446	Mutagenesis	Note=Does not impair RNA binding. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	441	442	Site	Note=Cleavage%3B by CAPN2;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q7TN99
Q8NE35	407	454	441	442	Site	Note=Cleavage%3B by CAPN2;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q7TN99
Q8NE35	407	454	444	444	Site	Note=Required for RNA-binding activity;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	444	444	Site	Note=Required for RNA-binding activity;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	467	470	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RUG
Q8NE35	454	484	467	470	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RUG
Q8NE35	454	484	474	477	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	454	484	474	477	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	454	484	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RUG
Q8NE35	454	484	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RUG
Q8NE35	454	484	1	698	Chain	ID=PRO_0000269261;Note=Cytoplasmic polyadenylation element-binding protein 3
Q8NE35	454	484	1	698	Chain	ID=PRO_0000269261;Note=Cytoplasmic polyadenylation element-binding protein 3
Q8NE35	454	484	441	532	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00176
Q8NE35	454	484	441	532	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00176
Q8NE35	454	484	454	460	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	454	484	454	460	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	454	484	463	463	Mutagenesis	Note=Does not impair RNA binding. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	463	463	Mutagenesis	Note=Does not impair RNA binding. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	470	470	Mutagenesis	Note=Does not impair RNA binding. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	470	470	Mutagenesis	Note=Does not impair RNA binding. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	474	474	Mutagenesis	Note=Does not impair RNA binding. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	474	474	Mutagenesis	Note=Does not impair RNA binding. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	479	479	Mutagenesis	Note=Does not impair RNA binding. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	479	479	Mutagenesis	Note=Does not impair RNA binding. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	461	464	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	454	484	461	464	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q8NE35	407	454	408	408	Alternative sequence	ID=VSP_022035;Note=In isoform 2. N->SRSSLFPFED;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10231032;Dbxref=PMID:10231032
Q8NE35	407	454	408	408	Alternative sequence	ID=VSP_022035;Note=In isoform 2. N->SRSSLFPFED;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10231032;Dbxref=PMID:10231032
Q8NE35	407	454	443	446	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	407	454	443	446	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	407	454	1	698	Chain	ID=PRO_0000269261;Note=Cytoplasmic polyadenylation element-binding protein 3
Q8NE35	407	454	1	698	Chain	ID=PRO_0000269261;Note=Cytoplasmic polyadenylation element-binding protein 3
Q8NE35	407	454	441	532	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00176
Q8NE35	407	454	441	532	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00176
Q8NE35	407	454	454	460	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	407	454	454	460	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	407	454	441	441	Mutagenesis	Note=Does not impair RNA binding. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	441	441	Mutagenesis	Note=Does not impair RNA binding. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	444	444	Mutagenesis	Note=Abolishes RNA binding. F->A%2CN;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	444	444	Mutagenesis	Note=Abolishes RNA binding. F->A%2CN;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	444	444	Mutagenesis	Note=Does not impair RNA binding. F->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	444	444	Mutagenesis	Note=Does not impair RNA binding. F->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	446	446	Mutagenesis	Note=Does not impair RNA binding. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	446	446	Mutagenesis	Note=Does not impair RNA binding. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	441	442	Site	Note=Cleavage%3B by CAPN2;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q7TN99
Q8NE35	407	454	441	442	Site	Note=Cleavage%3B by CAPN2;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q7TN99
Q8NE35	407	454	444	444	Site	Note=Required for RNA-binding activity;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	444	444	Site	Note=Required for RNA-binding activity;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	467	470	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RUG
Q8NE35	454	484	467	470	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RUG
Q8NE35	454	484	474	477	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	454	484	474	477	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	454	484	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RUG
Q8NE35	454	484	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RUG
Q8NE35	454	484	1	698	Chain	ID=PRO_0000269261;Note=Cytoplasmic polyadenylation element-binding protein 3
Q8NE35	454	484	1	698	Chain	ID=PRO_0000269261;Note=Cytoplasmic polyadenylation element-binding protein 3
Q8NE35	454	484	441	532	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00176
Q8NE35	454	484	441	532	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00176
Q8NE35	454	484	454	460	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	454	484	454	460	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	454	484	463	463	Mutagenesis	Note=Does not impair RNA binding. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	463	463	Mutagenesis	Note=Does not impair RNA binding. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	470	470	Mutagenesis	Note=Does not impair RNA binding. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	470	470	Mutagenesis	Note=Does not impair RNA binding. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	474	474	Mutagenesis	Note=Does not impair RNA binding. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	474	474	Mutagenesis	Note=Does not impair RNA binding. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	479	479	Mutagenesis	Note=Does not impair RNA binding. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	479	479	Mutagenesis	Note=Does not impair RNA binding. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	454	484	461	464	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	454	484	461	464	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q8NE35	388	407	366	388	Alternative sequence	ID=VSP_022034;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10231032;Dbxref=PMID:10231032
Q8NE35	388	407	366	388	Alternative sequence	ID=VSP_022034;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10231032;Dbxref=PMID:10231032
Q8NE35	388	407	1	698	Chain	ID=PRO_0000269261;Note=Cytoplasmic polyadenylation element-binding protein 3
Q8NE35	388	407	1	698	Chain	ID=PRO_0000269261;Note=Cytoplasmic polyadenylation element-binding protein 3
Q8NE35	407	454	408	408	Alternative sequence	ID=VSP_022035;Note=In isoform 2. N->SRSSLFPFED;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10231032;Dbxref=PMID:10231032
Q8NE35	407	454	408	408	Alternative sequence	ID=VSP_022035;Note=In isoform 2. N->SRSSLFPFED;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10231032;Dbxref=PMID:10231032
Q8NE35	407	454	443	446	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	407	454	443	446	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	407	454	1	698	Chain	ID=PRO_0000269261;Note=Cytoplasmic polyadenylation element-binding protein 3
Q8NE35	407	454	1	698	Chain	ID=PRO_0000269261;Note=Cytoplasmic polyadenylation element-binding protein 3
Q8NE35	407	454	441	532	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00176
Q8NE35	407	454	441	532	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00176
Q8NE35	407	454	454	460	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	407	454	454	460	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2DNL
Q8NE35	407	454	441	441	Mutagenesis	Note=Does not impair RNA binding. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	441	441	Mutagenesis	Note=Does not impair RNA binding. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	444	444	Mutagenesis	Note=Abolishes RNA binding. F->A%2CN;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	444	444	Mutagenesis	Note=Abolishes RNA binding. F->A%2CN;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	444	444	Mutagenesis	Note=Does not impair RNA binding. F->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	444	444	Mutagenesis	Note=Does not impair RNA binding. F->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	446	446	Mutagenesis	Note=Does not impair RNA binding. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	446	446	Mutagenesis	Note=Does not impair RNA binding. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	441	442	Site	Note=Cleavage%3B by CAPN2;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q7TN99
Q8NE35	407	454	441	442	Site	Note=Cleavage%3B by CAPN2;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q7TN99
Q8NE35	407	454	444	444	Site	Note=Required for RNA-binding activity;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026
Q8NE35	407	454	444	444	Site	Note=Required for RNA-binding activity;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24343026;Dbxref=PMID:24343026

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3'-UTR located exon skipping events that lost miRNA binding sites in CPEB3

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for CPEB3

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for CPEB3

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CPEB3

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for CPEB3

Correlated RBP and related information.

Tissue type

RBP name

Exon skip ID

Correlation coeifficient

P-value

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RelatedDrugs for CPEB3

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CPEB3

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for CPEB3

Gene structures and expression levels for CPEB3

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CPEB3

Open reading frame (ORF) annotation in the exon skipping event for CPEB3

Infer the effects of exon skipping event on protein functional features for CPEB3

3'-UTR located exon skipping events that lost miRNA binding sites in CPEB3

SNVs in the skipped exons for CPEB3

AD stage-associated exon skippint events for CPEB3

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CPEB3

Correlation with RNA binding proteins (RBPs) for CPEB3

RelatedDrugs for CPEB3

RelatedDiseases for CPEB3