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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for FHL2 |
Gene summary |
Gene information | Gene symbol | FHL2 | Gene ID | 2274 |
Gene name | four and a half LIM domains 2 | |
Synonyms | AAG11|DRAL|FHL-2|SLIM-3|SLIM3 | |
Cytomap | 2q12.2 | |
Type of gene | protein-coding | |
Description | four and a half LIM domains protein 2LIM domain protein DRALaging-associated gene 11down-regulated in rhabdomyosarcoma LIM proteinskeletal muscle LIM-protein 3 | |
Modification date | 20200327 | |
UniProtAcc | ||
Context | - 28725932(DNA Methylation in ELOVL2 and C1orf132 Correctly Predicted Chronological Age of Individuals From Three Disease Groups) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
FHL2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 15692560 |
FHL2 | GO:0043066 | negative regulation of apoptotic process | 15692560 |
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Gene structures and expression levels for FHL2 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FHL2 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_142374 | chr2 | 105386458:105386540:105396647:105396697:105398842:105399051 | 105396647:105396697 |
exon_skip_171601 | chr2 | 105373559:105373733:105377996:105378117:105386361:105386540 | 105377996:105378117 |
exon_skip_238043 | chr2 | 105386458:105386540:105396647:105396697:105398970:105399061 | 105396647:105396697 |
exon_skip_63287 | chr2 | 105367570:105367739:105373559:105373733:105386361:105386540 | 105373559:105373733 |
exon_skip_89095 | chr2 | 105386458:105386540:105396647:105396697:105398970:105399050 | 105396647:105396697 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for FHL2 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000322142 | 105396647 | 105396697 | 3UTR-3UTR |
ENST00000322142 | 105373559 | 105373733 | Frame-shift |
ENST00000393352 | 105373559 | 105373733 | Frame-shift |
ENST00000393353 | 105373559 | 105373733 | Frame-shift |
ENST00000408995 | 105373559 | 105373733 | Frame-shift |
ENST00000409807 | 105373559 | 105373733 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000322142 | 105396647 | 105396697 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000322142 | 105396647 | 105396697 | 3UTR-3UTR |
ENST00000322142 | 105373559 | 105373733 | Frame-shift |
ENST00000393352 | 105373559 | 105373733 | Frame-shift |
ENST00000393353 | 105373559 | 105373733 | Frame-shift |
ENST00000408995 | 105373559 | 105373733 | Frame-shift |
ENST00000409807 | 105373559 | 105373733 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for FHL2 |
p-ENSG00000115641_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in FHL2 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000322142 | 105396647 | 105396697 | hsa-miR-4254 | chr2:105396672-105396679 | 8mer-1a | chr2:105396670-105396689 | 162.00 | -20.80 |
Mayo | ENST00000322142 | 105396647 | 105396697 | hsa-miR-4711-3p | chr2:105396679-105396686 | 8mer-1a | chr2:105396670-105396689 | 162.00 | -20.80 |
Mayo | ENST00000322142 | 105396647 | 105396697 | hsa-miR-146b-5p | chr2:105396686-105396693 | 8mer-1a | chr2:105396671-105396693 | 155.00 | -24.69 |
Mayo | ENST00000322142 | 105396647 | 105396697 | hsa-miR-7153-5p | chr2:105396686-105396693 | 8mer-1a | chr2:105396671-105396693 | 155.00 | -24.69 |
Mayo | ENST00000322142 | 105396647 | 105396697 | hsa-miR-146a-5p | chr2:105396686-105396693 | 8mer-1a | chr2:105396671-105396693 | 155.00 | -24.69 |
MSBB | ENST00000322142 | 105396647 | 105396697 | hsa-miR-4254 | chr2:105396672-105396679 | 8mer-1a | chr2:105396670-105396689 | 162.00 | -20.80 |
MSBB | ENST00000322142 | 105396647 | 105396697 | hsa-miR-4711-3p | chr2:105396679-105396686 | 8mer-1a | chr2:105396670-105396689 | 162.00 | -20.80 |
MSBB | ENST00000322142 | 105396647 | 105396697 | hsa-miR-146b-5p | chr2:105396686-105396693 | 8mer-1a | chr2:105396671-105396693 | 155.00 | -24.69 |
MSBB | ENST00000322142 | 105396647 | 105396697 | hsa-miR-7153-5p | chr2:105396686-105396693 | 8mer-1a | chr2:105396671-105396693 | 155.00 | -24.69 |
MSBB | ENST00000322142 | 105396647 | 105396697 | hsa-miR-146a-5p | chr2:105396686-105396693 | 8mer-1a | chr2:105396671-105396693 | 155.00 | -24.69 |
ROSMAP | ENST00000322142 | 105396647 | 105396697 | hsa-miR-4254 | chr2:105396672-105396679 | 8mer-1a | chr2:105396670-105396689 | 162.00 | -20.80 |
ROSMAP | ENST00000322142 | 105396647 | 105396697 | hsa-miR-4711-3p | chr2:105396679-105396686 | 8mer-1a | chr2:105396670-105396689 | 162.00 | -20.80 |
ROSMAP | ENST00000322142 | 105396647 | 105396697 | hsa-miR-146b-5p | chr2:105396686-105396693 | 8mer-1a | chr2:105396671-105396693 | 155.00 | -24.69 |
ROSMAP | ENST00000322142 | 105396647 | 105396697 | hsa-miR-7153-5p | chr2:105396686-105396693 | 8mer-1a | chr2:105396671-105396693 | 155.00 | -24.69 |
ROSMAP | ENST00000322142 | 105396647 | 105396697 | hsa-miR-146a-5p | chr2:105396686-105396693 | 8mer-1a | chr2:105396671-105396693 | 155.00 | -24.69 |
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SNVs in the skipped exons for FHL2 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for FHL2 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FHL2 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for FHL2 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
PCC | RBM3 | exon_skip_142374 | 4.465734e-01 | 6.555276e-10 |
TC | RBM3 | exon_skip_142374 | 4.777630e-01 | 1.539793e-08 |
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RelatedDrugs for FHL2 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FHL2 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |