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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for FGL1 |
Gene summary |
Gene information | Gene symbol | FGL1 | Gene ID | 2267 |
Gene name | fibrinogen like 1 | |
Synonyms | HFREP1|HP-041|HPS|LFIRE-1|LFIRE1 | |
Cytomap | 8p22 | |
Type of gene | protein-coding | |
Description | fibrinogen-like protein 1hepassocinhepatocellular carcinoma-related sequencehepatocyte-derived fibrinogen-related protein 1liver fibrinogen-related protein 1 | |
Modification date | 20200313 | |
UniProtAcc | D3DSP9, Q08830, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
FGL1 | GO:0072574 | hepatocyte proliferation | 19880967 |
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Gene structures and expression levels for FGL1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | DOWN | ENST00000427924.5 | FGL1-205:protein_coding:FGL1 | 2.024809e+00 | -1.160897e+00 | 1.485265e-02 | 4.788426e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FGL1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_100435 | chr8 | 17885520:17885571:17891681:17891807:17895447:17895517 | 17891681:17891807 |
exon_skip_124269 | chr8 | 17881999:17882179:17885492:17885571:17895447:17895517 | 17885492:17885571 |
exon_skip_95356 | chr8 | 17885492:17885571:17891681:17891807:17895447:17895517 | 17891681:17891807 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for FGL1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000381841 | 17891681 | 17891807 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000381841 | 17891681 | 17891807 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000398056 | 17885492 | 17885571 | 3UTR-3CDS |
ENST00000427924 | 17885492 | 17885571 | 3UTR-3CDS |
ENST00000381841 | 17891681 | 17891807 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for FGL1 |
p-ENSG00000104760_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in FGL1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000381841 | 17891681 | 17891807 | hsa-miR-2116-3p | chr8:17891737-17891744 | 8mer-1a | chr8:17891731-17891756 | 150.00 | -16.09 |
Mayo | ENST00000381841 | 17891681 | 17891807 | hsa-miR-6797-5p | chr8:17891792-17891799 | 8mer-1a | chr8:17891775-17891799 | 162.00 | -22.55 |
Mayo | ENST00000381841 | 17891681 | 17891807 | hsa-miR-1249-5p | chr8:17891792-17891799 | 8mer-1a | chr8:17891775-17891799 | 162.00 | -22.55 |
Mayo | ENST00000381841 | 17891681 | 17891807 | hsa-miR-421 | chr8:17891761-17891768 | 8mer-1a | chr8:17891746-17891768 | 163.00 | -17.87 |
MSBB | ENST00000381841 | 17891681 | 17891807 | hsa-miR-2116-3p | chr8:17891737-17891744 | 8mer-1a | chr8:17891731-17891756 | 150.00 | -16.09 |
MSBB | ENST00000381841 | 17891681 | 17891807 | hsa-miR-6797-5p | chr8:17891792-17891799 | 8mer-1a | chr8:17891775-17891799 | 162.00 | -22.55 |
MSBB | ENST00000381841 | 17891681 | 17891807 | hsa-miR-1249-5p | chr8:17891792-17891799 | 8mer-1a | chr8:17891775-17891799 | 162.00 | -22.55 |
MSBB | ENST00000381841 | 17891681 | 17891807 | hsa-miR-421 | chr8:17891761-17891768 | 8mer-1a | chr8:17891746-17891768 | 163.00 | -17.87 |
ROSMAP | ENST00000381841 | 17891681 | 17891807 | hsa-miR-2116-3p | chr8:17891737-17891744 | 8mer-1a | chr8:17891731-17891756 | 150.00 | -16.09 |
ROSMAP | ENST00000381841 | 17891681 | 17891807 | hsa-miR-6797-5p | chr8:17891792-17891799 | 8mer-1a | chr8:17891775-17891799 | 162.00 | -22.55 |
ROSMAP | ENST00000381841 | 17891681 | 17891807 | hsa-miR-1249-5p | chr8:17891792-17891799 | 8mer-1a | chr8:17891775-17891799 | 162.00 | -22.55 |
ROSMAP | ENST00000381841 | 17891681 | 17891807 | hsa-miR-421 | chr8:17891761-17891768 | 8mer-1a | chr8:17891746-17891768 | 163.00 | -17.87 |
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SNVs in the skipped exons for FGL1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for FGL1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FGL1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for FGL1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for FGL1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FGL1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |