ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for FES

Gene summary

Gene information	Gene symbol	FES
	Gene ID	2242
	Gene name	FES proto-oncogene, tyrosine kinase
	Synonyms	FPS
	Cytomap	15q26.1
	Type of gene	protein-coding
	Description	tyrosine-protein kinase Fes/FpsOncogene FES, feline sarcoma virusfeline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homologfeline sarcoma oncogenefeline sarcoma/Fujinami avian sarcoma oncogene homologp
	Modification date	20200313
	UniProtAcc	A0A024RC92, C9J3W6, E7EMJ7, E7ENM8, E9PGC7, E9PIJ7, H0YNN8, H0YNT6, P07332, Q4JFK7, Q4JFK8,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
FES	GO:0018108	peptidyl-tyrosine phosphorylation	11509660\|15485904
FES	GO:0046777	protein autophosphorylation	7687763

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Gene structures and expression levels for FES

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000182511

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
PG	UP	ENST00000481665.5	FES-213:retained_intron:FES	1.673507e+00	1.346836e+00	5.453462e-04	9.381716e-03
CB	UP	ENST00000444422.2	FES-207:protein_coding:FES	2.865469e+00	2.850524e+00	2.361925e-03	1.057405e-02
CB	UP	ENST00000470152.6	FES-212:nonsense_mediated_decay:FES	5.358151e+00	1.024985e+00	6.394889e-03	2.408522e-02

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FES

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_14683	chr15	90892707:90892825:90893100:90893194:90893291:90893414	90893100:90893194
exon_skip_157746	chr15	90890407:90890484:90890982:90891191:90891554:90891676	90890982:90891191
exon_skip_199981	chr15	90889306:90889443:90889517:90889636:90889840:90889939	90889517:90889636
exon_skip_253103	chr15	90885046:90885258:90885412:90885585:90886961:90887015	90885412:90885585
exon_skip_256444	chr15	90885046:90885258:90885412:90885585:90886961:90887057	90885412:90885585
exon_skip_288964	chr15	90890401:90890484:90891554:90891676:90892058:90892111	90891554:90891676
exon_skip_55919	chr15	90890401:90890484:90890982:90891191:90891554:90891676	90890982:90891191
exon_skip_67878	chr15	90893654:90893811:90893936:90894058:90895416:90895598	90893936:90894058

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for FES

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000328850	90893100	90893194	Frame-shift
ENST00000328850	90885412	90885585	In-frame
ENST00000328850	90889517	90889636	In-frame
ENST00000328850	90890982	90891191	In-frame
ENST00000328850	90893936	90894058	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000328850	90893100	90893194	Frame-shift
ENST00000328850	90885412	90885585	In-frame
ENST00000328850	90890982	90891191	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000328850	90893100	90893194	Frame-shift
ENST00000328850	90885412	90885585	In-frame
ENST00000328850	90889517	90889636	In-frame
ENST00000328850	90890982	90891191	In-frame

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Infer the effects of exon skipping event on protein functional features for FES

p-ENSG00000182511_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000328850	2846	822	90885412	90885585	357	529	71	129
ENST00000328850	2846	822	90889517	90889636	950	1068	269	308
ENST00000328850	2846	822	90890982	90891191	1464	1672	440	510
ENST00000328850	2846	822	90893936	90894058	2347	2468	735	775

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000328850	2846	822	90885412	90885585	357	529	71	129
ENST00000328850	2846	822	90890982	90891191	1464	1672	440	510

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000328850	2846	822	90885412	90885585	357	529	71	129
ENST00000328850	2846	822	90889517	90889636	950	1068	269	308
ENST00000328850	2846	822	90890982	90891191	1464	1672	440	510

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P07332	71	129	72	129	Alternative sequence	ID=VSP_041748;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|Ref.3;Dbxref=PMID:14702039
P07332	71	129	1	822	Chain	ID=PRO_0000088088;Note=Tyrosine-protein kinase Fes/Fps
P07332	71	129	125	169	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
P07332	71	129	1	260	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01077
P07332	71	129	68	96	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4DYL
P07332	71	129	98	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4DYL
P07332	71	129	113	114	Mutagenesis	Note=Reduced binding to membranes containing phosphoinositides. RK->EE;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19001085;Dbxref=PMID:19001085
P07332	71	129	113	114	Mutagenesis	Note=Reduced binding to membranes containing phosphoinositides. RK->QQ;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19001085;Dbxref=PMID:19001085
P07332	71	129	85	85	Natural variant	ID=VAR_041697;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs56041861,PMID:17344846
P07332	71	129	1	300	Region	Note=Important for interaction with membranes containing phosphoinositides
P07332	269	308	1	822	Chain	ID=PRO_0000088088;Note=Tyrosine-protein kinase Fes/Fps
P07332	269	308	303	344	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4DYL
P07332	269	308	1	300	Region	Note=Important for interaction with membranes containing phosphoinositides
P07332	269	308	300	302	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4DYL
P07332	440	510	441	510	Alternative sequence	ID=VSP_041749;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|Ref.3;Dbxref=PMID:14702039
P07332	440	510	461	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WQU
P07332	440	510	479	484	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CBL
P07332	440	510	491	494	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CBL
P07332	440	510	503	506	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CBL
P07332	440	510	507	509	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3BKB
P07332	440	510	1	822	Chain	ID=PRO_0000088088;Note=Tyrosine-protein kinase Fes/Fps
P07332	440	510	460	549	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00191
P07332	440	510	450	452	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CBL
P07332	440	510	455	457	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CBL
P07332	440	510	467	473	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CBL
P07332	440	510	463	463	Mutagenesis	Note=Abolishes kinase activity. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18775312;Dbxref=PMID:18775312
P07332	440	510	483	483	Mutagenesis	Note=Abolishes pTyr binding. Abolishes association with microtubules. Abolishes autophosphorylation. Reduced kinase activity. R->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:15485904,ECO:0000269\|PubMed:18775312;Dbxref=PMID:15485904,
P07332	440	510	486	489	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3BKB
P07332	735	775	736	738	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CBL
P07332	735	775	1	822	Chain	ID=PRO_0000088088;Note=Tyrosine-protein kinase Fes/Fps
P07332	735	775	561	822	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P07332	735	775	739	754	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CBL
P07332	735	775	766	774	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CBL
P07332	735	775	743	743	Mutagenesis	Note=Strongly reduced autophosphorylation and kinase activity. V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:15867340,ECO:0000269\|PubMed:16455651;Dbxref=PMID:15867340,PMID:16455651
P07332	735	775	759	759	Mutagenesis	Note=Reduced autophosphorylation and strongly reduced kinase activity. S->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:15867340,ECO:0000269\|PubMed:16455651;Dbxref=PMID:15867340,PMID:16455651
P07332	735	775	755	757	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4E93

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P07332	71	129	72	129	Alternative sequence	ID=VSP_041748;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|Ref.3;Dbxref=PMID:14702039
P07332	71	129	1	822	Chain	ID=PRO_0000088088;Note=Tyrosine-protein kinase Fes/Fps
P07332	71	129	125	169	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
P07332	71	129	1	260	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01077
P07332	71	129	68	96	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4DYL
P07332	71	129	98	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4DYL
P07332	71	129	113	114	Mutagenesis	Note=Reduced binding to membranes containing phosphoinositides. RK->EE;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19001085;Dbxref=PMID:19001085
P07332	71	129	113	114	Mutagenesis	Note=Reduced binding to membranes containing phosphoinositides. RK->QQ;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19001085;Dbxref=PMID:19001085
P07332	71	129	85	85	Natural variant	ID=VAR_041697;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs56041861,PMID:17344846
P07332	71	129	1	300	Region	Note=Important for interaction with membranes containing phosphoinositides
P07332	440	510	441	510	Alternative sequence	ID=VSP_041749;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|Ref.3;Dbxref=PMID:14702039
P07332	440	510	461	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WQU
P07332	440	510	479	484	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CBL
P07332	440	510	491	494	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CBL
P07332	440	510	503	506	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CBL
P07332	440	510	507	509	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3BKB
P07332	440	510	1	822	Chain	ID=PRO_0000088088;Note=Tyrosine-protein kinase Fes/Fps
P07332	440	510	460	549	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00191
P07332	440	510	450	452	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CBL
P07332	440	510	455	457	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CBL
P07332	440	510	467	473	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CBL
P07332	440	510	463	463	Mutagenesis	Note=Abolishes kinase activity. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18775312;Dbxref=PMID:18775312
P07332	440	510	483	483	Mutagenesis	Note=Abolishes pTyr binding. Abolishes association with microtubules. Abolishes autophosphorylation. Reduced kinase activity. R->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:15485904,ECO:0000269\|PubMed:18775312;Dbxref=PMID:15485904,
P07332	440	510	486	489	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3BKB

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P07332	71	129	72	129	Alternative sequence	ID=VSP_041748;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|Ref.3;Dbxref=PMID:14702039
P07332	71	129	1	822	Chain	ID=PRO_0000088088;Note=Tyrosine-protein kinase Fes/Fps
P07332	71	129	125	169	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
P07332	71	129	1	260	Domain	Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01077
P07332	71	129	68	96	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4DYL
P07332	71	129	98	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4DYL
P07332	71	129	113	114	Mutagenesis	Note=Reduced binding to membranes containing phosphoinositides. RK->EE;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19001085;Dbxref=PMID:19001085
P07332	71	129	113	114	Mutagenesis	Note=Reduced binding to membranes containing phosphoinositides. RK->QQ;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19001085;Dbxref=PMID:19001085
P07332	71	129	85	85	Natural variant	ID=VAR_041697;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs56041861,PMID:17344846
P07332	71	129	1	300	Region	Note=Important for interaction with membranes containing phosphoinositides
P07332	269	308	1	822	Chain	ID=PRO_0000088088;Note=Tyrosine-protein kinase Fes/Fps
P07332	269	308	303	344	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4DYL
P07332	269	308	1	300	Region	Note=Important for interaction with membranes containing phosphoinositides
P07332	269	308	300	302	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4DYL
P07332	440	510	441	510	Alternative sequence	ID=VSP_041749;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|Ref.3;Dbxref=PMID:14702039
P07332	440	510	461	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WQU
P07332	440	510	479	484	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CBL
P07332	440	510	491	494	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CBL
P07332	440	510	503	506	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CBL
P07332	440	510	507	509	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3BKB
P07332	440	510	1	822	Chain	ID=PRO_0000088088;Note=Tyrosine-protein kinase Fes/Fps
P07332	440	510	460	549	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00191
P07332	440	510	450	452	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CBL
P07332	440	510	455	457	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CBL
P07332	440	510	467	473	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CBL
P07332	440	510	463	463	Mutagenesis	Note=Abolishes kinase activity. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18775312;Dbxref=PMID:18775312
P07332	440	510	483	483	Mutagenesis	Note=Abolishes pTyr binding. Abolishes association with microtubules. Abolishes autophosphorylation. Reduced kinase activity. R->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:15485904,ECO:0000269\|PubMed:18775312;Dbxref=PMID:15485904,
P07332	440	510	486	489	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3BKB

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3'-UTR located exon skipping events that lost miRNA binding sites in FES

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for FES

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for FES

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FES

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for FES

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
TC	RBM4B	exon_skip_157746	-4.206151e-01	9.249436e-08
TC	HNRNPH2	exon_skip_14683	-4.480285e-01	1.268918e-08
TC	ESRP1	exon_skip_14683	-4.211463e-01	1.086058e-07

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RelatedDrugs for FES

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P07332	approved\|investigational	DB12010	Fostamatinib	small molecule	P07332

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RelatedDiseases for FES

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for FES

Gene structures and expression levels for FES

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FES

Open reading frame (ORF) annotation in the exon skipping event for FES

Infer the effects of exon skipping event on protein functional features for FES

3'-UTR located exon skipping events that lost miRNA binding sites in FES

SNVs in the skipped exons for FES

AD stage-associated exon skippint events for FES

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FES

Correlation with RNA binding proteins (RBPs) for FES

RelatedDrugs for FES

RelatedDiseases for FES