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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for FCGR2B |
 Gene summary |
| Gene information | Gene symbol | FCGR2B | Gene ID | 2213 |
| Gene name | Fc fragment of IgG receptor IIb | |
| Synonyms | CD32|CD32B|FCG2|FCGR2|FCGR2C|FcRII-c|IGFR2 | |
| Cytomap | 1q23.3 | |
| Type of gene | protein-coding | |
| Description | low affinity immunoglobulin gamma Fc region receptor II-bCDw32Fc fragment of IgG, low affinity II, receptor for (CD32)Fc fragment of IgG, low affinity IIb, receptor (CD32)Fc fragment of IgG, low affinity IIb, receptor for (CD32)Fc gamma RIIbFc gamma | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| FCGR2B | GO:0006898 | receptor-mediated endocytosis | 2142460 |
| FCGR2B | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 2142460 |
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Gene structures and expression levels for FCGR2B |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000072694
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| DLPFC | UP | ENST00000358671.9 | FCGR2B-202:protein_coding:FCGR2B | 1.482886e+00 | 1.345185e+00 | 3.180187e-04 | 1.546088e-02 |
| PG | UP | ENST00000480308.5 | FCGR2B-204:retained_intron:FCGR2B | 3.799094e+00 | 1.320740e+00 | 2.428847e-06 | 1.749845e-04 |
| PG | UP | ENST00000358671.9 | FCGR2B-202:protein_coding:FCGR2B | 2.254554e+00 | 1.510323e+00 | 4.164499e-04 | 7.747653e-03 |
| PG | UP | ENST00000485778.1 | FCGR2B-205:retained_intron:FCGR2B | 2.973332e+00 | 1.184762e+00 | 9.828883e-04 | 1.441482e-02 |
| TC | UP | ENST00000236937.13 | FCGR2B-201:protein_coding:FCGR2B | 2.504469e+01 | 8.497768e-01 | 1.004644e-03 | 9.937785e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FCGR2B |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_246638 | chr1 | 161673960:161674073:161675257:161675313:161677328:161677365 | 161675257:161675313 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for FCGR2B |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000358671 | 161675257 | 161675313 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000358671 | 161675257 | 161675313 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000358671 | 161675257 | 161675313 | In-frame |
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Infer the effects of exon skipping event on protein functional features for FCGR2B |
p-ENSG00000072694_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000358671 | 2132 | 310 | 161675257 | 161675313 | 843 | 898 | 254 | 272 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000358671 | 2132 | 310 | 161675257 | 161675313 | 843 | 898 | 254 | 272 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000358671 | 2132 | 310 | 161675257 | 161675313 | 843 | 898 | 254 | 272 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P31994 | 254 | 272 | 254 | 272 | Alternative sequence | ID=VSP_002643;Note=In isoform IIB2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2142460,ECO:0000303|PubMed:2529342,ECO:0000303|PubMed:2 |
| P31994 | 254 | 272 | 43 | 310 | Chain | ID=PRO_0000015147;Note=Low affinity immunoglobulin gamma Fc region receptor II-b |
| P31994 | 254 | 272 | 258 | 258 | Natural variant | ID=VAR_008798;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8466861;Dbxref=dbSNP:rs148534844,PMID:8466861 |
| P31994 | 254 | 272 | 241 | 310 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P31994 | 254 | 272 | 254 | 272 | Alternative sequence | ID=VSP_002643;Note=In isoform IIB2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2142460,ECO:0000303|PubMed:2529342,ECO:0000303|PubMed:2 |
| P31994 | 254 | 272 | 43 | 310 | Chain | ID=PRO_0000015147;Note=Low affinity immunoglobulin gamma Fc region receptor II-b |
| P31994 | 254 | 272 | 258 | 258 | Natural variant | ID=VAR_008798;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8466861;Dbxref=dbSNP:rs148534844,PMID:8466861 |
| P31994 | 254 | 272 | 241 | 310 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P31994 | 254 | 272 | 254 | 272 | Alternative sequence | ID=VSP_002643;Note=In isoform IIB2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2142460,ECO:0000303|PubMed:2529342,ECO:0000303|PubMed:2 |
| P31994 | 254 | 272 | 43 | 310 | Chain | ID=PRO_0000015147;Note=Low affinity immunoglobulin gamma Fc region receptor II-b |
| P31994 | 254 | 272 | 258 | 258 | Natural variant | ID=VAR_008798;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8466861;Dbxref=dbSNP:rs148534844,PMID:8466861 |
| P31994 | 254 | 272 | 241 | 310 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in FCGR2B |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for FCGR2B |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for FCGR2B |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FCGR2B |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for FCGR2B |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for FCGR2B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P31994 | approved | DB00002 | Cetuximab | biotech | P31994 |
| P31994 | approved|investigational | DB00005 | Etanercept | biotech | P31994 |
| P31994 | approved | DB00054 | Abciximab | biotech | P31994 |
| P31994 | approved|investigational | DB00056 | Gemtuzumab ozogamicin | biotech | P31994 |
| P31994 | approved|investigational | DB00072 | Trastuzumab | biotech | P31994 |
| P31994 | approved|investigational | DB00074 | Basiliximab | biotech | P31994 |
| P31994 | approved|investigational | DB00075 | Muromonab | biotech | P31994 |
| P31994 | approved|investigational | DB00078 | Ibritumomab tiuxetan | biotech | P31994 |
| P31994 | approved|investigational | DB00081 | Tositumomab | biotech | P31994 |
| P31994 | approved|investigational | DB00087 | Alemtuzumab | biotech | P31994 |
| P31994 | approved|investigational|withdrawn | DB00092 | Alefacept | biotech | P31994 |
| P31994 | approved|investigational | DB00095 | Efalizumab | biotech | P31994 |
| P31994 | approved | DB00098 | Antithymocyte immunoglobulin (rabbit) | biotech | P31994 |
| P31994 | approved|investigational | DB00108 | Natalizumab | biotech | P31994 |
| P31994 | approved|investigational | DB00110 | Palivizumab | biotech | P31994 |
| P31994 | approved|investigational | DB00112 | Bevacizumab | biotech | P31994 |
| P31994 | approved|investigational | DB11767 | Sarilumab | biotech | P31994 |
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RelatedDiseases for FCGR2B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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