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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ZNF438 |
 Gene summary |
| Gene information | Gene symbol | ZNF438 | Gene ID | 220929 |
| Gene name | zinc finger protein 438 | |
| Synonyms | bA330O11.1 | |
| Cytomap | 10p11.23 | |
| Type of gene | protein-coding | |
| Description | zinc finger protein 438 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ZNF438 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000183621
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000413025.5 | ZNF438-204:protein_coding:ZNF438 | 7.336544e+01 | 8.690503e-01 | 8.687704e-03 | 3.097548e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZNF438 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_144868 | chr10 | 30835567:30835640:30850222:30850367:30876998:30877065 | 30850222:30850367 |
| exon_skip_196262 | chr10 | 30908933:30909015:30910360:30910440:30941575:30941651 | 30910360:30910440 |
| exon_skip_259192 | chr10 | 30850222:30850367:30857680:30857778:30876998:30877065 | 30857680:30857778 |
| exon_skip_282584 | chr10 | 30848531:30850367:30875331:30875509:30876998:30877065 | 30875331:30875509 |
| exon_skip_289442 | chr10 | 30848531:30850367:30857680:30857778:30876998:30877065 | 30857680:30857778 |
| exon_skip_53733 | chr10 | 30850222:30850367:30875331:30875509:30876998:30877065 | 30875331:30875509 |
| exon_skip_81765 | chr10 | 30844781:30845573:30848531:30849443:30850222:30850367 | 30848531:30849443 |
| exon_skip_90047 | chr10 | 30941575:30941651:30984369:30984426:31031833:31031925 | 30984369:30984426 |
| exon_skip_98755 | chr10 | 30850222:30850367:30876998:30877065:30908933:30909015 | 30876998:30877065 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF438 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000361310 | 30910360 | 30910440 | 3UTR-3UTR |
| ENST00000442986 | 30910360 | 30910440 | 3UTR-3UTR |
| ENST00000436087 | 30984369 | 30984426 | 3UTR-3UTR |
| ENST00000442986 | 30984369 | 30984426 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000361310 | 30910360 | 30910440 | 3UTR-3UTR |
| ENST00000442986 | 30910360 | 30910440 | 3UTR-3UTR |
| ENST00000436087 | 30984369 | 30984426 | 3UTR-3UTR |
| ENST00000442986 | 30984369 | 30984426 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000361310 | 30876998 | 30877065 | 3UTR-3CDS |
| ENST00000413025 | 30876998 | 30877065 | 3UTR-3CDS |
| ENST00000436087 | 30876998 | 30877065 | 3UTR-3CDS |
| ENST00000442986 | 30876998 | 30877065 | 3UTR-3CDS |
| ENST00000361310 | 30910360 | 30910440 | 3UTR-3UTR |
| ENST00000442986 | 30910360 | 30910440 | 3UTR-3UTR |
| ENST00000436087 | 30984369 | 30984426 | 3UTR-3UTR |
| ENST00000442986 | 30984369 | 30984426 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for ZNF438 |
p-ENSG00000183621_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZNF438 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000442986 | 30910360 | 30910440 | hsa-miR-215-3p | chr10:30910401-30910408 | 8mer-1a | chr10:30910401-30910423 | 159.00 | -20.35 |
| Mayo | ENST00000442986 | 30910360 | 30910440 | hsa-miR-616-3p | chr10:30910399-30910406 | 8mer-1a | chr10:30910386-30910408 | 151.00 | -15.93 |
| Mayo | ENST00000442986 | 30910360 | 30910440 | hsa-miR-3064-3p | chr10:30910394-30910401 | 8mer-1a | chr10:30910386-30910408 | 151.00 | -15.93 |
| Mayo | ENST00000442986 | 30910360 | 30910440 | hsa-miR-4317 | chr10:30910397-30910404 | 8mer-1a | chr10:30910386-30910408 | 151.00 | -15.93 |
| Mayo | ENST00000442986 | 30910360 | 30910440 | hsa-miR-4793-5p | chr10:30910428-30910435 | 8mer-1a | chr10:30910420-30910440 | 149.00 | -19.02 |
| Mayo | ENST00000442986 | 30910360 | 30910440 | hsa-miR-4638-3p | chr10:30910382-30910389 | 8mer-1a | chr10:30910374-30910394 | 155.00 | -16.44 |
| Mayo | ENST00000442986 | 30910360 | 30910440 | hsa-miR-766-5p | chr10:30910416-30910423 | 8mer-1a | chr10:30910401-30910423 | 159.00 | -20.35 |
| MSBB | ENST00000442986 | 30910360 | 30910440 | hsa-miR-215-3p | chr10:30910401-30910408 | 8mer-1a | chr10:30910401-30910423 | 159.00 | -20.35 |
| MSBB | ENST00000442986 | 30910360 | 30910440 | hsa-miR-616-3p | chr10:30910399-30910406 | 8mer-1a | chr10:30910386-30910408 | 151.00 | -15.93 |
| MSBB | ENST00000442986 | 30910360 | 30910440 | hsa-miR-3064-3p | chr10:30910394-30910401 | 8mer-1a | chr10:30910386-30910408 | 151.00 | -15.93 |
| MSBB | ENST00000442986 | 30910360 | 30910440 | hsa-miR-4317 | chr10:30910397-30910404 | 8mer-1a | chr10:30910386-30910408 | 151.00 | -15.93 |
| MSBB | ENST00000442986 | 30910360 | 30910440 | hsa-miR-4793-5p | chr10:30910428-30910435 | 8mer-1a | chr10:30910420-30910440 | 149.00 | -19.02 |
| MSBB | ENST00000442986 | 30910360 | 30910440 | hsa-miR-4638-3p | chr10:30910382-30910389 | 8mer-1a | chr10:30910374-30910394 | 155.00 | -16.44 |
| MSBB | ENST00000442986 | 30910360 | 30910440 | hsa-miR-766-5p | chr10:30910416-30910423 | 8mer-1a | chr10:30910401-30910423 | 159.00 | -20.35 |
| ROSMAP | ENST00000442986 | 30910360 | 30910440 | hsa-miR-215-3p | chr10:30910401-30910408 | 8mer-1a | chr10:30910401-30910423 | 159.00 | -20.35 |
| ROSMAP | ENST00000442986 | 30910360 | 30910440 | hsa-miR-616-3p | chr10:30910399-30910406 | 8mer-1a | chr10:30910386-30910408 | 151.00 | -15.93 |
| ROSMAP | ENST00000442986 | 30910360 | 30910440 | hsa-miR-3064-3p | chr10:30910394-30910401 | 8mer-1a | chr10:30910386-30910408 | 151.00 | -15.93 |
| ROSMAP | ENST00000442986 | 30910360 | 30910440 | hsa-miR-4317 | chr10:30910397-30910404 | 8mer-1a | chr10:30910386-30910408 | 151.00 | -15.93 |
| ROSMAP | ENST00000442986 | 30910360 | 30910440 | hsa-miR-4793-5p | chr10:30910428-30910435 | 8mer-1a | chr10:30910420-30910440 | 149.00 | -19.02 |
| ROSMAP | ENST00000442986 | 30910360 | 30910440 | hsa-miR-4638-3p | chr10:30910382-30910389 | 8mer-1a | chr10:30910374-30910394 | 155.00 | -16.44 |
| ROSMAP | ENST00000442986 | 30910360 | 30910440 | hsa-miR-766-5p | chr10:30910416-30910423 | 8mer-1a | chr10:30910401-30910423 | 159.00 | -20.35 |
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SNVs in the skipped exons for ZNF438 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZNF438 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF438 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ZNF438 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ZNF438 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF438 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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