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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for FCGR1A |
 Gene summary |
| Gene information | Gene symbol | FCGR1A | Gene ID | 2209 |
| Gene name | Fc fragment of IgG receptor Ia | |
| Synonyms | CD64|CD64A|FCRI|IGFR1 | |
| Cytomap | 1q21.2 | |
| Type of gene | protein-coding | |
| Description | high affinity immunoglobulin gamma Fc receptor IFc fragment of IgG, high affinity Ia, receptor (CD64)Fc fragment of IgG, high affinity Ia, receptor for (CD64)Fc gamma receptor IaFc-gamma RIFc-gamma receptor I A1IgG Fc receptor Ifc-gamma RIAfcgamma | |
| Modification date | 20200329 | |
| UniProtAcc | C9JSN8, P12314, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for FCGR1A |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000150337
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FCGR1A |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_34133 | chr1 | 149782728:149782774:149783170:149783190:149784003:149784257 | 149783170:149783190 |
| exon_skip_83498 | chr1 | 149783170:149783190:149784003:149784257:149788366:149788617 | 149784003:149784257 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for FCGR1A |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000369168 | 149783170 | 149783190 | In-frame |
| ENST00000369168 | 149784003 | 149784257 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000369168 | 149784003 | 149784257 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000369168 | 149784003 | 149784257 | In-frame |
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Infer the effects of exon skipping event on protein functional features for FCGR1A |
p-ENSG00000150337_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000369168 | 2197 | 374 | 149784003 | 149784257 | 108 | 361 | 18 | 102 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000369168 | 2197 | 374 | 149784003 | 149784257 | 108 | 361 | 18 | 102 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000369168 | 2197 | 374 | 149784003 | 149784257 | 108 | 361 | 18 | 102 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P12314 | 18 | 102 | 23 | 28 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 31 | 34 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 39 | 44 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 54 | 62 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 67 | 74 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 81 | 87 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 88 | 91 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X4M |
| P12314 | 18 | 102 | 96 | 101 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 16 | 374 | Chain | ID=PRO_0000015139;Note=High affinity immunoglobulin gamma Fc receptor I |
| P12314 | 18 | 102 | 43 | 85 | Disulfide bond | Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:21965667;Dbxref=PMID:21965667 |
| P12314 | 18 | 102 | 22 | 101 | Domain | Note=Ig-like C2-type 1 |
| P12314 | 18 | 102 | 95 | 184 | Domain | Note=Ig-like C2-type 2 |
| P12314 | 18 | 102 | 59 | 59 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21965667;Dbxref=PMID:21965667 |
| P12314 | 18 | 102 | 78 | 78 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:21965667;Dbxref=PMID:19159218,PMID:21965667 |
| P12314 | 18 | 102 | 77 | 79 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 25 | 25 | Sequence conflict | Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P12314 | 18 | 102 | 16 | 292 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P12314 | 18 | 102 | 23 | 28 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 31 | 34 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 39 | 44 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 54 | 62 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 67 | 74 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 81 | 87 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 88 | 91 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X4M |
| P12314 | 18 | 102 | 96 | 101 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 16 | 374 | Chain | ID=PRO_0000015139;Note=High affinity immunoglobulin gamma Fc receptor I |
| P12314 | 18 | 102 | 43 | 85 | Disulfide bond | Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:21965667;Dbxref=PMID:21965667 |
| P12314 | 18 | 102 | 22 | 101 | Domain | Note=Ig-like C2-type 1 |
| P12314 | 18 | 102 | 95 | 184 | Domain | Note=Ig-like C2-type 2 |
| P12314 | 18 | 102 | 59 | 59 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21965667;Dbxref=PMID:21965667 |
| P12314 | 18 | 102 | 78 | 78 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:21965667;Dbxref=PMID:19159218,PMID:21965667 |
| P12314 | 18 | 102 | 77 | 79 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 25 | 25 | Sequence conflict | Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P12314 | 18 | 102 | 16 | 292 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P12314 | 18 | 102 | 23 | 28 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 31 | 34 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 39 | 44 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 54 | 62 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 67 | 74 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 81 | 87 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 88 | 91 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X4M |
| P12314 | 18 | 102 | 96 | 101 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 16 | 374 | Chain | ID=PRO_0000015139;Note=High affinity immunoglobulin gamma Fc receptor I |
| P12314 | 18 | 102 | 43 | 85 | Disulfide bond | Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:21965667;Dbxref=PMID:21965667 |
| P12314 | 18 | 102 | 22 | 101 | Domain | Note=Ig-like C2-type 1 |
| P12314 | 18 | 102 | 95 | 184 | Domain | Note=Ig-like C2-type 2 |
| P12314 | 18 | 102 | 59 | 59 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21965667;Dbxref=PMID:21965667 |
| P12314 | 18 | 102 | 78 | 78 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:21965667;Dbxref=PMID:19159218,PMID:21965667 |
| P12314 | 18 | 102 | 77 | 79 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W4O |
| P12314 | 18 | 102 | 25 | 25 | Sequence conflict | Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P12314 | 18 | 102 | 16 | 292 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in FCGR1A |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for FCGR1A |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for FCGR1A |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FCGR1A |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for FCGR1A |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| HCC | SAMD4A | exon_skip_226331 | -4.073847e-01 | 1.179037e-11 |
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RelatedDrugs for FCGR1A |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P12314 | approved | DB00002 | Cetuximab | biotech | P12314 |
| P12314 | approved|investigational | DB00005 | Etanercept | biotech | P12314 |
| P12314 | approved | DB00054 | Abciximab | biotech | P12314 |
| P12314 | approved|investigational | DB00056 | Gemtuzumab ozogamicin | biotech | P12314 |
| P12314 | approved|investigational | DB00072 | Trastuzumab | biotech | P12314 |
| P12314 | approved|investigational | DB00074 | Basiliximab | biotech | P12314 |
| P12314 | approved|investigational | DB00075 | Muromonab | biotech | P12314 |
| P12314 | approved|investigational | DB00078 | Ibritumomab tiuxetan | biotech | P12314 |
| P12314 | approved|investigational | DB00081 | Tositumomab | biotech | P12314 |
| P12314 | approved|investigational | DB00087 | Alemtuzumab | biotech | P12314 |
| P12314 | approved|investigational|withdrawn | DB00092 | Alefacept | biotech | P12314 |
| P12314 | approved|investigational | DB00095 | Efalizumab | biotech | P12314 |
| P12314 | approved|investigational | DB00108 | Natalizumab | biotech | P12314 |
| P12314 | approved|investigational | DB00110 | Palivizumab | biotech | P12314 |
| P12314 | approved|investigational | DB00112 | Bevacizumab | biotech | P12314 |
| P12314 | approved|investigational | DB00707 | Porfimer sodium | small molecule | P12314 |
| P12314 | approved|investigational | DB00992 | Methyl aminolevulinate | small molecule | P12314 |
| P12314 | approved|investigational|withdrawn | DB06607 | Catumaxomab | biotech | P12314 |
| P12314 | approved|investigational | DB11767 | Sarilumab | biotech | P12314 |
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RelatedDiseases for FCGR1A |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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