|
||||||
|
 | |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| 3'-UTR located exon skipping events lost miRNA binding sites |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| |
| |
|
Gene summary for TMEM218 |
 Gene summary |
| Gene information | Gene symbol | TMEM218 | Gene ID | 219854 |
| Gene name | transmembrane protein 218 | |
| Synonyms | - | |
| Cytomap | 11q24.2 | |
| Type of gene | protein-coding | |
| Description | transmembrane protein 218 | |
| Modification date | 20200327 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
Gene structures and expression levels for TMEM218 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
ENSG00000150433
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000531262.5 | TMEM218-211:lncRNA:TMEM218 | 1.060551e+01 | 9.277037e-01 | 1.235544e-03 | 1.701773e-02 |
| CB | DOWN | ENST00000528724.5 | TMEM218-207:protein_coding:TMEM218 | 8.102711e+00 | -1.886554e+00 | 3.612992e-04 | 2.191370e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
 |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TMEM218 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_173434 | chr11 | 125102734:125102809:125110644:125110746:125111585:125111611 | 125110644:125110746 |
| exon_skip_19784 | chr11 | 125102734:125102809:125110491:125110549:125111539:125111589 | 125110491:125110549 |
| exon_skip_202237 | chr11 | 125101201:125101303:125101444:125101521:125102132:125102317 | 125101444:125101521 |
| exon_skip_216895 | chr11 | 125101256:125101303:125101444:125101521:125102132:125102302 | 125101444:125101521 |
| exon_skip_221462 | chr11 | 125101201:125101303:125102132:125102317:125102734:125102809 | 125102132:125102317 |
| exon_skip_246678 | chr11 | 125102734:125102809:125110491:125110549:125111539:125111579 | 125110491:125110549 |
| exon_skip_247437 | chr11 | 125101256:125101303:125102132:125102809:125111539:125111579 | 125102132:125102809 |
| exon_skip_268359 | chr11 | 125102734:125102809:125110491:125110549:125110644:125110746 | 125110491:125110549 |
| exon_skip_269946 | chr11 | 125101256:125101303:125101444:125101521:125102132:125102297 | 125101444:125101521 |
| exon_skip_271554 | chr11 | 125101256:125101303:125102132:125102351:125102637:125102809 | 125102132:125102351 |
| exon_skip_289948 | chr11 | 125101201:125101303:125102132:125102302:125102734:125102809 | 125102132:125102302 |
| exon_skip_3370 | chr11 | 125101201:125101303:125102734:125102809:125111539:125111579 | 125102734:125102809 |
| exon_skip_33719 | chr11 | 125101256:125101303:125102734:125102809:125111539:125111579 | 125102734:125102809 |
| exon_skip_39803 | chr11 | 125102734:125102809:125110644:125110746:125111587:125111613 | 125110644:125110746 |
| exon_skip_56238 | chr11 | 125101201:125101303:125101444:125101521:125102132:125102302 | 125101444:125101521 |
| exon_skip_57817 | chr11 | 125101256:125101303:125102132:125102302:125102734:125102809 | 125102132:125102302 |
| exon_skip_63189 | chr11 | 125102734:125102809:125110644:125110746:125111539:125111579 | 125110644:125110746 |
| exon_skip_6993 | chr11 | 125110491:125110549:125110644:125110746:125111539:125111579 | 125110644:125110746 |
| exon_skip_85630 | chr11 | 125101256:125101303:125102132:125102317:125102734:125102809 | 125102132:125102317 |
| exon_skip_97407 | chr11 | 125101256:125101303:125102132:125102317:125102637:125102809 | 125102132:125102317 |
| exon_skip_9920 | chr11 | 125101201:125101256:125102132:125102351:125102734:125102809 | 125102132:125102351 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for TMEM218 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000279968 | 125102132 | 125102351 | 3UTR-3CDS |
| ENST00000526175 | 125102132 | 125102317 | 3UTR-3CDS |
| ENST00000527271 | 125102132 | 125102317 | 3UTR-3CDS |
| ENST00000527766 | 125102132 | 125102302 | 3UTR-3CDS |
| ENST00000529583 | 125102132 | 125102317 | 3UTR-3CDS |
| ENST00000531909 | 125102132 | 125102317 | 3UTR-3CDS |
| ENST00000532407 | 125102132 | 125102317 | 3UTR-3CDS |
| ENST00000526175 | 125110491 | 125110549 | 3UTR-3UTR |
| ENST00000529583 | 125110491 | 125110549 | 3UTR-3UTR |
| ENST00000527271 | 125110644 | 125110746 | 3UTR-3UTR |
| ENST00000529583 | 125110644 | 125110746 | 3UTR-3UTR |
| ENST00000532407 | 125110644 | 125110746 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000279968 | 125102132 | 125102351 | 3UTR-3CDS |
| ENST00000526175 | 125102132 | 125102317 | 3UTR-3CDS |
| ENST00000527271 | 125102132 | 125102317 | 3UTR-3CDS |
| ENST00000529583 | 125102132 | 125102317 | 3UTR-3CDS |
| ENST00000531909 | 125102132 | 125102317 | 3UTR-3CDS |
| ENST00000532407 | 125102132 | 125102317 | 3UTR-3CDS |
| ENST00000526175 | 125110491 | 125110549 | 3UTR-3UTR |
| ENST00000529583 | 125110491 | 125110549 | 3UTR-3UTR |
| ENST00000532407 | 125110644 | 125110746 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000279968 | 125102132 | 125102351 | 3UTR-3CDS |
| ENST00000526175 | 125102132 | 125102317 | 3UTR-3CDS |
| ENST00000527271 | 125102132 | 125102317 | 3UTR-3CDS |
| ENST00000527766 | 125102132 | 125102302 | 3UTR-3CDS |
| ENST00000529583 | 125102132 | 125102317 | 3UTR-3CDS |
| ENST00000531909 | 125102132 | 125102317 | 3UTR-3CDS |
| ENST00000532407 | 125102132 | 125102317 | 3UTR-3CDS |
| ENST00000526175 | 125110491 | 125110549 | 3UTR-3UTR |
| ENST00000529583 | 125110491 | 125110549 | 3UTR-3UTR |
| ENST00000527271 | 125110644 | 125110746 | 3UTR-3UTR |
| ENST00000529583 | 125110644 | 125110746 | 3UTR-3UTR |
| ENST00000532407 | 125110644 | 125110746 | 3UTR-3UTR |
Top |
Infer the effects of exon skipping event on protein functional features for TMEM218 |
p-ENSG00000150433_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in TMEM218 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000532407 | 125110644 | 125110746 | hsa-miR-4302 | chr11:125110731-125110738 | 8mer-1a | chr11:125110724-125110743 | 162.00 | -20.21 |
| Mayo | ENST00000532407 | 125110644 | 125110746 | hsa-miR-4717-5p | chr11:125110679-125110686 | 8mer-1a | chr11:125110678-125110699 | 157.00 | -24.19 |
| Mayo | ENST00000532407 | 125110644 | 125110746 | hsa-miR-4530 | chr11:125110694-125110701 | 8mer-1a | chr11:125110685-125110707 | 158.00 | -24.52 |
| Mayo | ENST00000532407 | 125110644 | 125110746 | hsa-miR-5702 | chr11:125110735-125110742 | 8mer-1a | chr11:125110724-125110743 | 162.00 | -20.21 |
| Mayo | ENST00000532407 | 125110644 | 125110746 | hsa-miR-5704 | chr11:125110680-125110687 | 8mer-1a | chr11:125110678-125110699 | 157.00 | -24.19 |
| Mayo | ENST00000532407 | 125110644 | 125110746 | hsa-miR-4469 | chr11:125110700-125110707 | 8mer-1a | chr11:125110685-125110707 | 158.00 | -24.52 |
| Mayo | ENST00000532407 | 125110644 | 125110746 | hsa-miR-7848-3p | chr11:125110670-125110677 | 8mer-1a | chr11:125110666-125110686 | 150.00 | -25.82 |
| Mayo | ENST00000532407 | 125110644 | 125110746 | hsa-miR-937-5p | chr11:125110736-125110743 | 8mer-1a | chr11:125110724-125110743 | 162.00 | -20.21 |
| Mayo | ENST00000529583 | 125110491 | 125110549 | hsa-miR-455-3p | chr11:125110526-125110533 | 8mer-1a | chr11:125110525-125110546 | 156.00 | -17.79 |
| MSBB | ENST00000532407 | 125110644 | 125110746 | hsa-miR-4302 | chr11:125110731-125110738 | 8mer-1a | chr11:125110724-125110743 | 162.00 | -20.21 |
| MSBB | ENST00000532407 | 125110644 | 125110746 | hsa-miR-4717-5p | chr11:125110679-125110686 | 8mer-1a | chr11:125110678-125110699 | 157.00 | -24.19 |
| MSBB | ENST00000532407 | 125110644 | 125110746 | hsa-miR-4530 | chr11:125110694-125110701 | 8mer-1a | chr11:125110685-125110707 | 158.00 | -24.52 |
| MSBB | ENST00000532407 | 125110644 | 125110746 | hsa-miR-5702 | chr11:125110735-125110742 | 8mer-1a | chr11:125110724-125110743 | 162.00 | -20.21 |
| MSBB | ENST00000532407 | 125110644 | 125110746 | hsa-miR-5704 | chr11:125110680-125110687 | 8mer-1a | chr11:125110678-125110699 | 157.00 | -24.19 |
| MSBB | ENST00000532407 | 125110644 | 125110746 | hsa-miR-4469 | chr11:125110700-125110707 | 8mer-1a | chr11:125110685-125110707 | 158.00 | -24.52 |
| MSBB | ENST00000532407 | 125110644 | 125110746 | hsa-miR-7848-3p | chr11:125110670-125110677 | 8mer-1a | chr11:125110666-125110686 | 150.00 | -25.82 |
| MSBB | ENST00000532407 | 125110644 | 125110746 | hsa-miR-937-5p | chr11:125110736-125110743 | 8mer-1a | chr11:125110724-125110743 | 162.00 | -20.21 |
| MSBB | ENST00000529583 | 125110491 | 125110549 | hsa-miR-455-3p | chr11:125110526-125110533 | 8mer-1a | chr11:125110525-125110546 | 156.00 | -17.79 |
| ROSMAP | ENST00000532407 | 125110644 | 125110746 | hsa-miR-4302 | chr11:125110731-125110738 | 8mer-1a | chr11:125110724-125110743 | 162.00 | -20.21 |
| ROSMAP | ENST00000532407 | 125110644 | 125110746 | hsa-miR-4717-5p | chr11:125110679-125110686 | 8mer-1a | chr11:125110678-125110699 | 157.00 | -24.19 |
| ROSMAP | ENST00000532407 | 125110644 | 125110746 | hsa-miR-4530 | chr11:125110694-125110701 | 8mer-1a | chr11:125110685-125110707 | 158.00 | -24.52 |
| ROSMAP | ENST00000532407 | 125110644 | 125110746 | hsa-miR-5702 | chr11:125110735-125110742 | 8mer-1a | chr11:125110724-125110743 | 162.00 | -20.21 |
| ROSMAP | ENST00000532407 | 125110644 | 125110746 | hsa-miR-5704 | chr11:125110680-125110687 | 8mer-1a | chr11:125110678-125110699 | 157.00 | -24.19 |
| ROSMAP | ENST00000532407 | 125110644 | 125110746 | hsa-miR-4469 | chr11:125110700-125110707 | 8mer-1a | chr11:125110685-125110707 | 158.00 | -24.52 |
| ROSMAP | ENST00000532407 | 125110644 | 125110746 | hsa-miR-7848-3p | chr11:125110670-125110677 | 8mer-1a | chr11:125110666-125110686 | 150.00 | -25.82 |
| ROSMAP | ENST00000532407 | 125110644 | 125110746 | hsa-miR-937-5p | chr11:125110736-125110743 | 8mer-1a | chr11:125110724-125110743 | 162.00 | -20.21 |
| ROSMAP | ENST00000529583 | 125110491 | 125110549 | hsa-miR-455-3p | chr11:125110526-125110533 | 8mer-1a | chr11:125110525-125110546 | 156.00 | -17.79 |
Top |
SNVs in the skipped exons for TMEM218 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for TMEM218 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TMEM218 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for TMEM218 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Top |
RelatedDrugs for TMEM218 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TMEM218 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|