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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CCNY |
 Gene summary |
| Gene information | Gene symbol | CCNY | Gene ID | 219771 |
| Gene name | cyclin Y | |
| Synonyms | C10orf9|CBCP1|CCNX|CFP1 | |
| Cytomap | 10p11.21 | |
| Type of gene | protein-coding | |
| Description | cyclin-Ycyc-Ycyclin box protein 1cyclin fold protein 1cyclin-Xcyclin-box carrying protein 1 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context | - 28241067(Cyclin Y-mediated transcript profiling reveals several important functional pathways regulated by Cyclin Y in hippocampal neurons) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CCNY | GO:0000086 | G2/M transition of mitotic cell cycle | 20059949 |
| CCNY | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity | 19524571|20059949 |
| CCNY | GO:0060828 | regulation of canonical Wnt signaling pathway | 20059949 |
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Gene structures and expression levels for CCNY |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000108100
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CCNY |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_149388 | chr10 | 35525964:35525999:35529973:35530030:35530124:35530243 | 35529973:35530030 |
| exon_skip_158945 | chr10 | 35525964:35525999:35530124:35530243:35553019:35553183 | 35530124:35530243 |
| exon_skip_166125 | chr10 | 35337052:35337207:35501501:35501535:35516523:35516575 | 35501501:35501535 |
| exon_skip_218388 | chr10 | 35337052:35337207:35394816:35394878:35483404:35483478 | 35394816:35394878 |
| exon_skip_219198 | chr10 | 35525961:35525999:35529973:35530030:35530124:35530243 | 35529973:35530030 |
| exon_skip_24719 | chr10 | 35483404:35483478:35501501:35501535:35516523:35516575 | 35501501:35501535 |
| exon_skip_266606 | chr10 | 35337194:35337207:35483404:35483478:35501501:35501535 | 35483404:35483478 |
| exon_skip_27480 | chr10 | 35525961:35525999:35529973:35530030:35530124:35530179 | 35529973:35530030 |
| exon_skip_285807 | chr10 | 35516523:35516623:35525964:35525999:35529973:35530030 | 35525964:35525999 |
| exon_skip_41288 | chr10 | 35337052:35337207:35483404:35483478:35501501:35501535 | 35483404:35483478 |
| exon_skip_53614 | chr10 | 35501501:35501535:35516523:35516623:35525964:35525999 | 35516523:35516623 |
| exon_skip_56228 | chr10 | 35530196:35530243:35553019:35553185:35566023:35566128 | 35553019:35553185 |
| exon_skip_60226 | chr10 | 35337194:35337207:35501501:35501535:35516523:35516575 | 35501501:35501535 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CCNY |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374704 | 35501501 | 35501535 | Frame-shift |
| ENST00000374704 | 35516523 | 35516623 | Frame-shift |
| ENST00000374704 | 35529973 | 35530030 | Frame-shift |
| ENST00000374704 | 35553019 | 35553185 | Frame-shift |
| ENST00000374704 | 35483404 | 35483478 | In-frame |
| ENST00000374704 | 35525964 | 35525999 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374704 | 35501501 | 35501535 | Frame-shift |
| ENST00000374704 | 35516523 | 35516623 | Frame-shift |
| ENST00000374704 | 35529973 | 35530030 | Frame-shift |
| ENST00000374704 | 35483404 | 35483478 | In-frame |
| ENST00000374704 | 35525964 | 35525999 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374704 | 35501501 | 35501535 | Frame-shift |
| ENST00000374704 | 35516523 | 35516623 | Frame-shift |
| ENST00000374704 | 35529973 | 35530030 | Frame-shift |
| ENST00000374704 | 35553019 | 35553185 | Frame-shift |
| ENST00000374704 | 35483404 | 35483478 | In-frame |
| ENST00000374704 | 35525964 | 35525999 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CCNY |
p-ENSG00000108100_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000374704 | 3977 | 341 | 35483404 | 35483478 | 336 | 409 | 52 | 76 |
| ENST00000374704 | 3977 | 341 | 35525964 | 35525999 | 547 | 581 | 122 | 133 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000374704 | 3977 | 341 | 35483404 | 35483478 | 336 | 409 | 52 | 76 |
| ENST00000374704 | 3977 | 341 | 35525964 | 35525999 | 547 | 581 | 122 | 133 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000374704 | 3977 | 341 | 35483404 | 35483478 | 336 | 409 | 52 | 76 |
| ENST00000374704 | 3977 | 341 | 35525964 | 35525999 | 547 | 581 | 122 | 133 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8ND76 | 52 | 76 | 1 | 54 | Alternative sequence | ID=VSP_014833;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:18060517;Dbxref=PMID:14702039,PMID:15489334,PMID:18060517 |
| Q8ND76 | 52 | 76 | 52 | 76 | Alternative sequence | ID=VSP_014834;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4 |
| Q8ND76 | 52 | 76 | 2 | 341 | Chain | ID=PRO_0000080514;Note=Cyclin-Y |
| Q8ND76 | 52 | 76 | 67 | 67 | Modified residue | Note=Phosphothreonine%3B by CDK14;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24794231;Dbxref=PMID:24794231 |
| Q8ND76 | 52 | 76 | 71 | 71 | Modified residue | Note=Phosphoserine%3B by CDK14;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24794231;Dbxref=PMID:24794231 |
| Q8ND76 | 52 | 76 | 73 | 73 | Modified residue | Note=Phosphoserine%3B by CDK14;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24794231;Dbxref=PMID:24794231 |
| Q8ND76 | 52 | 76 | 75 | 75 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24794231;Dbxref=PMID:24794231 |
| Q8ND76 | 122 | 133 | 2 | 341 | Chain | ID=PRO_0000080514;Note=Cyclin-Y |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8ND76 | 52 | 76 | 1 | 54 | Alternative sequence | ID=VSP_014833;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:18060517;Dbxref=PMID:14702039,PMID:15489334,PMID:18060517 |
| Q8ND76 | 52 | 76 | 52 | 76 | Alternative sequence | ID=VSP_014834;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4 |
| Q8ND76 | 52 | 76 | 2 | 341 | Chain | ID=PRO_0000080514;Note=Cyclin-Y |
| Q8ND76 | 52 | 76 | 67 | 67 | Modified residue | Note=Phosphothreonine%3B by CDK14;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24794231;Dbxref=PMID:24794231 |
| Q8ND76 | 52 | 76 | 71 | 71 | Modified residue | Note=Phosphoserine%3B by CDK14;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24794231;Dbxref=PMID:24794231 |
| Q8ND76 | 52 | 76 | 73 | 73 | Modified residue | Note=Phosphoserine%3B by CDK14;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24794231;Dbxref=PMID:24794231 |
| Q8ND76 | 52 | 76 | 75 | 75 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24794231;Dbxref=PMID:24794231 |
| Q8ND76 | 122 | 133 | 2 | 341 | Chain | ID=PRO_0000080514;Note=Cyclin-Y |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8ND76 | 52 | 76 | 1 | 54 | Alternative sequence | ID=VSP_014833;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:18060517;Dbxref=PMID:14702039,PMID:15489334,PMID:18060517 |
| Q8ND76 | 52 | 76 | 52 | 76 | Alternative sequence | ID=VSP_014834;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4 |
| Q8ND76 | 52 | 76 | 2 | 341 | Chain | ID=PRO_0000080514;Note=Cyclin-Y |
| Q8ND76 | 52 | 76 | 67 | 67 | Modified residue | Note=Phosphothreonine%3B by CDK14;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24794231;Dbxref=PMID:24794231 |
| Q8ND76 | 52 | 76 | 71 | 71 | Modified residue | Note=Phosphoserine%3B by CDK14;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24794231;Dbxref=PMID:24794231 |
| Q8ND76 | 52 | 76 | 73 | 73 | Modified residue | Note=Phosphoserine%3B by CDK14;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24794231;Dbxref=PMID:24794231 |
| Q8ND76 | 52 | 76 | 75 | 75 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24794231;Dbxref=PMID:24794231 |
| Q8ND76 | 122 | 133 | 2 | 341 | Chain | ID=PRO_0000080514;Note=Cyclin-Y |
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3'-UTR located exon skipping events that lost miRNA binding sites in CCNY |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CCNY |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CCNY |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| CDR | MSBB | IFG | exon_skip_285807 | 4.117920e-01 | 2.945836e-02 | chr10 | + | 35516523 | 35516623 | 35525964 | 35525999 | 35529973 | 35530030 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CCNY |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| CB | exon_skip_41288 | rs10827506 | chr10:35462969 | 4.799271e-08 | 2.540374e-05 |
| CB | exon_skip_41288 | rs4934753 | chr10:35466417 | 1.018005e-07 | 4.843644e-05 |
| CB | exon_skip_41288 | rs12770412 | chr10:35581786 | 3.938705e-07 | 1.609339e-04 |
| CB | exon_skip_41288 | rs3003981 | chr10:35429284 | 4.007665e-07 | 1.633777e-04 |
| CB | exon_skip_41288 | rs7902346 | chr10:35494128 | 4.583362e-05 | 9.144266e-03 |
| HCC | exon_skip_41288 | rs10508817 | chr10:35447387 | 5.680287e-24 | 1.311896e-20 |
| HCC | exon_skip_41288 | rs4934753 | chr10:35466417 | 5.680287e-24 | 1.311896e-20 |
| HCC | exon_skip_41288 | rs1345561 | chr10:35481694 | 5.680287e-24 | 1.311896e-20 |
| HCC | exon_skip_41288 | rs10827509 | chr10:35504335 | 5.680287e-24 | 1.311896e-20 |
| HCC | exon_skip_41288 | rs11595699 | chr10:35507426 | 5.680287e-24 | 1.311896e-20 |
| HCC | exon_skip_41288 | rs4934551 | chr10:35555662 | 1.652410e-23 | 3.505142e-20 |
| HCC | exon_skip_41288 | rs10827514 | chr10:35575457 | 1.652410e-23 | 3.505142e-20 |
| HCC | exon_skip_41288 | rs4244998 | chr10:35579619 | 1.652410e-23 | 3.505142e-20 |
| HCC | exon_skip_41288 | rs12770412 | chr10:35581786 | 5.169865e-23 | 9.909058e-20 |
| HCC | exon_skip_41288 | rs7072266 | chr10:35522976 | 2.040893e-22 | 3.579639e-19 |
| HCC | exon_skip_41288 | rs10827506 | chr10:35462969 | 4.391569e-22 | 7.355661e-19 |
| HCC | exon_skip_41288 | rs11010213 | chr10:35509263 | 4.391569e-22 | 7.355661e-19 |
| HCC | exon_skip_41288 | rs3003981 | chr10:35429284 | 1.514532e-21 | 2.437931e-18 |
| HCC | exon_skip_41288 | rs4934549 | chr10:35493809 | 2.396170e-21 | 3.685370e-18 |
| HCC | exon_skip_41288 | rs7902346 | chr10:35494128 | 7.962507e-21 | 1.184308e-17 |
| HCC | exon_skip_41288 | rs10508818 | chr10:35484381 | 9.233785e-15 | 6.164239e-12 |
| DLPFC | exon_skip_41288 | rs4934753 | chr10:35466417 | 3.720298e-18 | 3.491290e-15 |
| DLPFC | exon_skip_41288 | rs12770412 | chr10:35581786 | 7.692861e-18 | 7.060651e-15 |
| DLPFC | exon_skip_41288 | rs10508817 | chr10:35447387 | 1.054006e-17 | 9.415202e-15 |
| DLPFC | exon_skip_41288 | rs1345561 | chr10:35481694 | 1.054006e-17 | 9.415202e-15 |
| DLPFC | exon_skip_41288 | rs10827509 | chr10:35504335 | 1.054006e-17 | 9.415202e-15 |
| DLPFC | exon_skip_41288 | rs11595699 | chr10:35507426 | 1.054006e-17 | 9.415202e-15 |
| DLPFC | exon_skip_41288 | rs4934551 | chr10:35555662 | 2.660120e-17 | 2.244215e-14 |
| DLPFC | exon_skip_41288 | rs10827514 | chr10:35575457 | 2.660120e-17 | 2.244215e-14 |
| DLPFC | exon_skip_41288 | rs4244998 | chr10:35579619 | 2.660120e-17 | 2.244215e-14 |
| DLPFC | exon_skip_41288 | rs7072266 | chr10:35522976 | 3.551535e-17 | 2.936926e-14 |
| DLPFC | exon_skip_41288 | rs3003981 | chr10:35429284 | 1.888894e-16 | 1.427722e-13 |
| DLPFC | exon_skip_41288 | rs10827506 | chr10:35462969 | 7.203624e-16 | 4.951913e-13 |
| DLPFC | exon_skip_41288 | rs11010213 | chr10:35509263 | 7.203624e-16 | 4.951913e-13 |
| DLPFC | exon_skip_41288 | rs4934549 | chr10:35493809 | 2.592170e-15 | 1.684840e-12 |
| DLPFC | exon_skip_41288 | rs7902346 | chr10:35494128 | 3.175782e-11 | 1.112143e-08 |
| DLPFC | exon_skip_41288 | rs10508818 | chr10:35484381 | 1.489041e-10 | 4.737788e-08 |
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Correlation with RNA binding proteins (RBPs) for CCNY |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CCNY |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CCNY |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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