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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MTIF3 |
 Gene summary |
| Gene information | Gene symbol | MTIF3 | Gene ID | 219402 |
| Gene name | mitochondrial translational initiation factor 3 | |
| Synonyms | IF3mt | |
| Cytomap | 13q12.2 | |
| Type of gene | protein-coding | |
| Description | translation initiation factor IF-3, mitochondrialIF-3(Mt) | |
| Modification date | 20200320 | |
| UniProtAcc | A0A024RDQ7, Q9H2K0, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MTIF3 | GO:0032790 | ribosome disassembly | 12095986 |
| MTIF3 | GO:0070124 | mitochondrial translational initiation | 12095986 |
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Gene structures and expression levels for MTIF3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000122033
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000471771.5 | MTIF3-207:lncRNA:MTIF3 | 1.610554e+01 | 9.444511e-01 | 9.156345e-10 | 4.067567e-08 |
| CB | DOWN | ENST00000405591.3 | MTIF3-203:protein_coding:MTIF3 | 4.752580e+02 | -8.492582e-01 | 1.100467e-07 | 2.303906e-06 |
| CB | UP | ENST00000485959.5 | MTIF3-211:lncRNA:MTIF3 | 5.515142e+00 | 8.726308e-01 | 9.250608e-03 | 3.263103e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MTIF3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_111157 | chr13 | 27435684:27435893:27437116:27437273:27439989:27440051 | 27437116:27437273 |
| exon_skip_120168 | chr13 | 27440281:27440449:27441017:27441077:27445088:27445137 | 27441017:27441077 |
| exon_skip_145894 | chr13 | 27435684:27435893:27437116:27437273:27439989:27440169 | 27437116:27437273 |
| exon_skip_186717 | chr13 | 27437269:27437273:27439989:27440449:27445088:27445134 | 27439989:27440449 |
| exon_skip_193172 | chr13 | 27440281:27440449:27445088:27445156:27450509:27450564 | 27445088:27445156 |
| exon_skip_211088 | chr13 | 27437269:27437273:27439989:27440449:27445088:27445137 | 27439989:27440449 |
| exon_skip_229103 | chr13 | 27445088:27445156:27449852:27449918:27450064:27450143 | 27449852:27449918 |
| exon_skip_238816 | chr13 | 27440281:27440449:27445088:27445156:27450064:27450131 | 27445088:27445156 |
| exon_skip_243452 | chr13 | 27440402:27440449:27441017:27441077:27445088:27445137 | 27441017:27441077 |
| exon_skip_256452 | chr13 | 27437269:27437273:27439989:27440449:27441017:27441077 | 27439989:27440449 |
| exon_skip_25799 | chr13 | 27435684:27435893:27437116:27437273:27439989:27440449 | 27437116:27437273 |
| exon_skip_265487 | chr13 | 27445088:27445156:27449852:27449918:27450064:27450131 | 27449852:27449918 |
| exon_skip_57550 | chr13 | 27440281:27440449:27445088:27445137:27450064:27450131 | 27445088:27445137 |
| exon_skip_7950 | chr13 | 27435684:27435893:27437116:27437273:27439989:27440147 | 27437116:27437273 |
| exon_skip_84871 | chr13 | 27440281:27440449:27441017:27441077:27445088:27445134 | 27441017:27441077 |
| exon_skip_90106 | chr13 | 27440281:27440449:27445088:27445137:27450509:27450564 | 27445088:27445137 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for MTIF3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000381116 | 27439989 | 27440449 | 3UTR-3CDS |
| ENST00000381120 | 27439989 | 27440449 | 3UTR-3CDS |
| ENST00000381116 | 27441017 | 27441077 | 3UTR-3UTR |
| ENST00000381120 | 27445088 | 27445156 | 3UTR-3UTR |
| ENST00000381116 | 27437116 | 27437273 | Frame-shift |
| ENST00000381120 | 27437116 | 27437273 | Frame-shift |
| ENST00000405591 | 27437116 | 27437273 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000381120 | 27439989 | 27440449 | 3UTR-3CDS |
| ENST00000381116 | 27441017 | 27441077 | 3UTR-3UTR |
| ENST00000381116 | 27437116 | 27437273 | Frame-shift |
| ENST00000381120 | 27437116 | 27437273 | Frame-shift |
| ENST00000405591 | 27437116 | 27437273 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000381120 | 27439989 | 27440449 | 3UTR-3CDS |
| ENST00000381116 | 27441017 | 27441077 | 3UTR-3UTR |
| ENST00000381116 | 27437116 | 27437273 | Frame-shift |
| ENST00000381120 | 27437116 | 27437273 | Frame-shift |
| ENST00000405591 | 27437116 | 27437273 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for MTIF3 |
p-ENSG00000122033_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in MTIF3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000381116 | 27441017 | 27441077 | hsa-miR-3605-5p | chr13:27441050-27441057 | 8mer-1a | chr13:27441038-27441062 | 178.00 | -27.19 |
| MSBB | ENST00000381116 | 27441017 | 27441077 | hsa-miR-3605-5p | chr13:27441050-27441057 | 8mer-1a | chr13:27441038-27441062 | 178.00 | -27.19 |
| ROSMAP | ENST00000381120 | 27445088 | 27445156 | hsa-miR-4684-5p | chr13:27445140-27445147 | 8mer-1a | chr13:27445133-27445156 | 158.00 | -14.95 |
| ROSMAP | ENST00000381116 | 27441017 | 27441077 | hsa-miR-3605-5p | chr13:27441050-27441057 | 8mer-1a | chr13:27441038-27441062 | 178.00 | -27.19 |
| ROSMAP | ENST00000381120 | 27445088 | 27445156 | hsa-miR-942-5p | chr13:27445142-27445149 | 8mer-1a | chr13:27445133-27445156 | 158.00 | -14.95 |
| ROSMAP | ENST00000381120 | 27445088 | 27445156 | hsa-miR-6072 | chr13:27445121-27445128 | 8mer-1a | chr13:27445108-27445128 | 156.00 | -20.10 |
| ROSMAP | ENST00000381120 | 27445088 | 27445156 | hsa-miR-520b-5p | chr13:27445139-27445146 | 8mer-1a | chr13:27445128-27445146 | 164.00 | -20.32 |
| ROSMAP | ENST00000381120 | 27445088 | 27445156 | hsa-miR-519a-2-5p | chr13:27445139-27445146 | 8mer-1a | chr13:27445128-27445146 | 164.00 | -20.32 |
| ROSMAP | ENST00000381120 | 27445088 | 27445156 | hsa-miR-4279 | chr13:27445124-27445131 | 8mer-1a | chr13:27445117-27445140 | 152.00 | -18.28 |
| ROSMAP | ENST00000381120 | 27445088 | 27445156 | hsa-miR-6891-3p | chr13:27445121-27445128 | 8mer-1a | chr13:27445108-27445128 | 156.00 | -20.10 |
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SNVs in the skipped exons for MTIF3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MTIF3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| CDR | MSBB | IFG | exon_skip_120168 | -4.519215e-01 | 1.576643e-02 | chr13 | - | 27440281 | 27440449 | 27441017 | 27441077 | 27445088 | 27445137 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MTIF3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MTIF3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for MTIF3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MTIF3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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