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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ACSL4 |
 Gene summary |
| Gene information | Gene symbol | ACSL4 | Gene ID | 2182 |
| Gene name | acyl-CoA synthetase long chain family member 4 | |
| Synonyms | ACS4|FACL4|LACS4|MRX63|MRX68 | |
| Cytomap | Xq23 | |
| Type of gene | protein-coding | |
| Description | long-chain-fatty-acid--CoA ligase 4acyl-CoA synthetase 4arachidonate--CoA ligasefatty-acid-Coenzyme A ligase, long-chain 4lignoceroyl-CoA synthaselong-chain acyl-CoA synthetase 4long-chain fatty-acid-Coenzyme A ligase 4 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ACSL4 | GO:0001676 | long-chain fatty acid metabolic process | 24269233 |
| ACSL4 | GO:0006629 | lipid metabolic process | 9598324 |
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Gene structures and expression levels for ACSL4 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000068366
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000502391.6 | ACSL4-206:protein_coding:ACSL4 | 1.186991e+02 | 1.494697e+00 | 7.966406e-06 | 8.724019e-05 |
| CB | UP | ENST00000514500.1 | ACSL4-211:nonsense_mediated_decay:ACSL4 | 9.698877e+00 | 8.371248e-01 | 4.500192e-04 | 2.634948e-03 |
| CB | UP | ENST00000672282.1 | ACSL4-213:protein_coding:ACSL4 | 5.428039e+01 | 1.586052e+00 | 4.652377e-03 | 1.855140e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ACSL4 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_121979 | chrX | 109683136:109683375:109691003:109691131:109696144:109696196 | 109691003:109691131 |
| exon_skip_167371 | chrX | 109683136:109683375:109696144:109696196:109733139:109733198 | 109696144:109696196 |
| exon_skip_168281 | chrX | 109659354:109659511:109661531:109661645:109663211:109663402 | 109661531:109661645 |
| exon_skip_185349 | chrX | 109683638:109683666:109696144:109696196:109733139:109733198 | 109696144:109696196 |
| exon_skip_20260 | chrX | 109682864:109682896:109683136:109683372:109696144:109696196 | 109683136:109683372 |
| exon_skip_206047 | chrX | 109683136:109683552:109696144:109696196:109733139:109733198 | 109696144:109696196 |
| exon_skip_274564 | chrX | 109682864:109682896:109683136:109683552:109696144:109696196 | 109683136:109683552 |
| exon_skip_280995 | chrX | 109682864:109682896:109683136:109683375:109696144:109696196 | 109683136:109683375 |
| exon_skip_291332 | chrX | 109682864:109682896:109683136:109683666:109696144:109696196 | 109683136:109683666 |
| exon_skip_296089 | chrX | 109683136:109683372:109696144:109696196:109733139:109733198 | 109696144:109696196 |
| exon_skip_86521 | chrX | 109683325:109683666:109696144:109696196:109733139:109733198 | 109696144:109696196 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ACSL4 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000469796 | 109696144 | 109696196 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000469796 | 109696144 | 109696196 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000469796 | 109683136 | 109683666 | 3UTR-3CDS |
| ENST00000469796 | 109696144 | 109696196 | 3UTR-3UTR |
| ENST00000340800 | 109661531 | 109661645 | Frame-shift |
| ENST00000469796 | 109661531 | 109661645 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for ACSL4 |
p-ENSG00000068366_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ACSL4 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000469796 | 109696144 | 109696196 | hsa-miR-22-5p | chrX:109696166-109696173 | 8mer-1a | chrX:109696150-109696173 | 144.00 | -9.87 |
| MSBB | ENST00000469796 | 109696144 | 109696196 | hsa-miR-22-5p | chrX:109696166-109696173 | 8mer-1a | chrX:109696150-109696173 | 144.00 | -9.87 |
| ROSMAP | ENST00000469796 | 109696144 | 109696196 | hsa-miR-22-5p | chrX:109696166-109696173 | 8mer-1a | chrX:109696150-109696173 | 144.00 | -9.87 |
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SNVs in the skipped exons for ACSL4 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ACSL4 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ACSL4 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ACSL4 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| IFG | PABPN1 | exon_skip_86521 | -4.349360e-01 | 2.337456e-02 |
| IFG | RBM47 | exon_skip_86521 | -4.905564e-01 | 9.379614e-03 |
| IFG | TRA2A | exon_skip_86521 | -4.423026e-01 | 2.088120e-02 |
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RelatedDrugs for ACSL4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| O60488 | approved|investigational | DB00412 | Rosiglitazone | small molecule | O60488 |
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RelatedDiseases for ACSL4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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