|
||||||
|
 | |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| 3'-UTR located exon skipping events lost miRNA binding sites |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| |
| |
|
Gene summary for ETFA |
 Gene summary |
| Gene information | Gene symbol | ETFA | Gene ID | 2108 |
| Gene name | electron transfer flavoprotein subunit alpha | |
| Synonyms | EMA|GA2|MADD | |
| Cytomap | 15q24.2-q24.3 | |
| Type of gene | protein-coding | |
| Description | electron transfer flavoprotein subunit alpha, mitochondrialalpha-ETFelectron transfer flavoprotein alpha subunitelectron transfer flavoprotein, alpha polypeptideepididymis secretory sperm binding proteinglutaric aciduria II | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ETFA | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase | 25416781 |
Top |
Gene structures and expression levels for ETFA |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
ENSG00000140374
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000560179.1 | ETFA-212:retained_intron:ETFA | 2.480526e+01 | -1.094400e+00 | 1.557372e-09 | 6.280118e-08 |
| CB | DOWN | ENST00000565910.5 | ETFA-220:nonsense_mediated_decay:ETFA | 2.112231e+01 | -2.278919e+00 | 4.567109e-06 | 5.426730e-05 |
| CB | UP | ENST00000559602.5 | ETFA-208:protein_coding:ETFA | 2.825496e+01 | 1.165916e+00 | 7.124749e-03 | 2.632208e-02 |
| TC | UP | ENST00000559602.5 | ETFA-208:protein_coding:ETFA | 5.212661e+01 | 1.121062e+00 | 9.572572e-04 | 9.572990e-03 |
| TC | DOWN | ENST00000565910.5 | ETFA-220:nonsense_mediated_decay:ETFA | 1.292049e+01 | -1.656332e+00 | 1.348181e-03 | 1.240056e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
 |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ETFA |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_106452 | chr15 | 76287846:76287945:76292431:76292513:76311350:76311396 | 76292431:76292513 |
| exon_skip_108901 | chr15 | 76283757:76283825:76284365:76284460:76285637:76285738 | 76284365:76284460 |
| exon_skip_110859 | chr15 | 76292431:76292513:76292619:76292700:76311350:76311396 | 76292619:76292700 |
| exon_skip_111205 | chr15 | 76295708:76295737:76309932:76310064:76311350:76311396 | 76309932:76310064 |
| exon_skip_136607 | chr15 | 76292431:76292513:76292619:76292700:76295591:76295737 | 76292619:76292700 |
| exon_skip_194443 | chr15 | 76292619:76292700:76295591:76295737:76309932:76310064 | 76295591:76295737 |
| exon_skip_199964 | chr15 | 76287934:76287945:76292431:76292513:76311350:76311414 | 76292431:76292513 |
| exon_skip_202213 | chr15 | 76292496:76292513:76292619:76292700:76295591:76295737 | 76292619:76292700 |
| exon_skip_203652 | chr15 | 76292431:76292513:76295591:76295737:76309932:76310064 | 76295591:76295737 |
| exon_skip_216334 | chr15 | 76274483:76274494:76283757:76283825:76285637:76285738 | 76283757:76283825 |
| exon_skip_22194 | chr15 | 76216559:76216597:76217586:76217677:76225849:76225929 | 76217586:76217677 |
| exon_skip_233918 | chr15 | 76274483:76274494:76283757:76283825:76285637:76285665 | 76283757:76283825 |
| exon_skip_238693 | chr15 | 76292499:76292513:76292619:76292700:76295591:76295737 | 76292619:76292700 |
| exon_skip_247569 | chr15 | 76292431:76292513:76295591:76295737:76311350:76311396 | 76295591:76295737 |
| exon_skip_255879 | chr15 | 76285637:76285738:76286371:76286481:76287846:76287945 | 76286371:76286481 |
| exon_skip_256733 | chr15 | 76225849:76225929:76227713:76227897:76231333:76231398 | 76227713:76227897 |
| exon_skip_263 | chr15 | 76283757:76283825:76284805:76284927:76285637:76285738 | 76284805:76284927 |
| exon_skip_268871 | chr15 | 76292619:76292700:76295591:76295737:76311350:76311396 | 76295591:76295737 |
| exon_skip_268954 | chr15 | 76295591:76295737:76309932:76310064:76311350:76311396 | 76309932:76310064 |
| exon_skip_281279 | chr15 | 76216583:76216597:76217586:76217677:76225849:76225929 | 76217586:76217677 |
| exon_skip_35680 | chr15 | 76286406:76286481:76287846:76287945:76292431:76292491 | 76287846:76287945 |
| exon_skip_48346 | chr15 | 76287846:76287945:76292431:76292513:76295591:76295737 | 76292431:76292513 |
| exon_skip_50556 | chr15 | 76292496:76292513:76295591:76295737:76311350:76311414 | 76295591:76295737 |
| exon_skip_50916 | chr15 | 76292496:76292513:76292619:76292700:76311350:76311414 | 76292619:76292700 |
| exon_skip_58413 | chr15 | 76292499:76292513:76292619:76292700:76311350:76311414 | 76292619:76292700 |
| exon_skip_93219 | chr15 | 76292499:76292513:76295591:76295737:76311350:76311414 | 76295591:76295737 |
| exon_skip_95626 | chr15 | 76225849:76225929:76227713:76227918:76231333:76231398 | 76227713:76227918 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for ETFA |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000557943 | 76287846 | 76287945 | Frame-shift |
| ENST00000557943 | 76292619 | 76292700 | Frame-shift |
| ENST00000557943 | 76283757 | 76283825 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000557943 | 76292619 | 76292700 | Frame-shift |
| ENST00000557943 | 76283757 | 76283825 | In-frame |
| ENST00000557943 | 76286371 | 76286481 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000557943 | 76292619 | 76292700 | Frame-shift |
| ENST00000557943 | 76283757 | 76283825 | In-frame |
| ENST00000557943 | 76286371 | 76286481 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for ETFA |
p-ENSG00000140374_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000557943 | 2304 | 333 | 76283757 | 76283825 | 746 | 813 | 221 | 244 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000557943 | 2304 | 333 | 76286371 | 76286481 | 533 | 642 | 150 | 187 |
| ENST00000557943 | 2304 | 333 | 76283757 | 76283825 | 746 | 813 | 221 | 244 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000557943 | 2304 | 333 | 76286371 | 76286481 | 533 | 642 | 150 | 187 |
| ENST00000557943 | 2304 | 333 | 76283757 | 76283825 | 746 | 813 | 221 | 244 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P13804 | 221 | 244 | 216 | 221 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 221 | 244 | 244 | 247 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 221 | 244 | 223 | 223 | Binding site | Note=FAD;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1EFV,ECO:0000244|PDB:2A1T,ECO:0000269|PubMed:15975918,ECO:0000269|PubMed:8962055;Dbxref=PMID:15975918,PMID:8962055 |
| P13804 | 221 | 244 | 20 | 333 | Chain | ID=PRO_0000008650;Note=Electron transfer flavoprotein subunit alpha%2C mitochondrial |
| P13804 | 221 | 244 | 223 | 225 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 221 | 244 | 229 | 231 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 221 | 244 | 232 | 241 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 221 | 244 | 226 | 226 | Modified residue | Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5 |
| P13804 | 221 | 244 | 226 | 226 | Modified residue | Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5 |
| P13804 | 221 | 244 | 232 | 232 | Modified residue | Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5 |
| P13804 | 221 | 244 | 232 | 232 | Modified residue | Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5 |
| P13804 | 221 | 244 | 205 | 333 | Region | Note=Domain II;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8962055;Dbxref=PMID:8962055 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P13804 | 150 | 187 | 153 | 159 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 150 | 187 | 162 | 168 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 150 | 187 | 178 | 180 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 150 | 187 | 184 | 187 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 150 | 187 | 20 | 333 | Chain | ID=PRO_0000008650;Note=Electron transfer flavoprotein subunit alpha%2C mitochondrial |
| P13804 | 150 | 187 | 170 | 172 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 150 | 187 | 158 | 158 | Modified residue | Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5 |
| P13804 | 150 | 187 | 158 | 158 | Modified residue | Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5 |
| P13804 | 150 | 187 | 164 | 164 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5 |
| P13804 | 150 | 187 | 187 | 187 | Modified residue | Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5 |
| P13804 | 150 | 187 | 157 | 157 | Natural variant | ID=VAR_002367;Note=In GA2A. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1882842;Dbxref=dbSNP:rs119458969,PMID:1882842 |
| P13804 | 150 | 187 | 171 | 171 | Natural variant | ID=VAR_008547;Note=Decreased protein stability. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10356313;Dbxref=dbSNP:rs1801591,PMID:10356313 |
| P13804 | 150 | 187 | 20 | 204 | Region | Note=Domain I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8962055;Dbxref=PMID:8962055 |
| P13804 | 150 | 187 | 149 | 152 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 221 | 244 | 216 | 221 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 221 | 244 | 244 | 247 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 221 | 244 | 223 | 223 | Binding site | Note=FAD;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1EFV,ECO:0000244|PDB:2A1T,ECO:0000269|PubMed:15975918,ECO:0000269|PubMed:8962055;Dbxref=PMID:15975918,PMID:8962055 |
| P13804 | 221 | 244 | 20 | 333 | Chain | ID=PRO_0000008650;Note=Electron transfer flavoprotein subunit alpha%2C mitochondrial |
| P13804 | 221 | 244 | 223 | 225 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 221 | 244 | 229 | 231 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 221 | 244 | 232 | 241 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 221 | 244 | 226 | 226 | Modified residue | Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5 |
| P13804 | 221 | 244 | 226 | 226 | Modified residue | Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5 |
| P13804 | 221 | 244 | 232 | 232 | Modified residue | Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5 |
| P13804 | 221 | 244 | 232 | 232 | Modified residue | Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5 |
| P13804 | 221 | 244 | 205 | 333 | Region | Note=Domain II;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8962055;Dbxref=PMID:8962055 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P13804 | 150 | 187 | 153 | 159 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 150 | 187 | 162 | 168 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 150 | 187 | 178 | 180 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 150 | 187 | 184 | 187 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 150 | 187 | 20 | 333 | Chain | ID=PRO_0000008650;Note=Electron transfer flavoprotein subunit alpha%2C mitochondrial |
| P13804 | 150 | 187 | 170 | 172 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 150 | 187 | 158 | 158 | Modified residue | Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5 |
| P13804 | 150 | 187 | 158 | 158 | Modified residue | Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5 |
| P13804 | 150 | 187 | 164 | 164 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5 |
| P13804 | 150 | 187 | 187 | 187 | Modified residue | Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5 |
| P13804 | 150 | 187 | 157 | 157 | Natural variant | ID=VAR_002367;Note=In GA2A. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1882842;Dbxref=dbSNP:rs119458969,PMID:1882842 |
| P13804 | 150 | 187 | 171 | 171 | Natural variant | ID=VAR_008547;Note=Decreased protein stability. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10356313;Dbxref=dbSNP:rs1801591,PMID:10356313 |
| P13804 | 150 | 187 | 20 | 204 | Region | Note=Domain I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8962055;Dbxref=PMID:8962055 |
| P13804 | 150 | 187 | 149 | 152 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 221 | 244 | 216 | 221 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 221 | 244 | 244 | 247 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 221 | 244 | 223 | 223 | Binding site | Note=FAD;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:1EFV,ECO:0000244|PDB:2A1T,ECO:0000269|PubMed:15975918,ECO:0000269|PubMed:8962055;Dbxref=PMID:15975918,PMID:8962055 |
| P13804 | 221 | 244 | 20 | 333 | Chain | ID=PRO_0000008650;Note=Electron transfer flavoprotein subunit alpha%2C mitochondrial |
| P13804 | 221 | 244 | 223 | 225 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 221 | 244 | 229 | 231 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 221 | 244 | 232 | 241 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1EFV |
| P13804 | 221 | 244 | 226 | 226 | Modified residue | Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5 |
| P13804 | 221 | 244 | 226 | 226 | Modified residue | Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5 |
| P13804 | 221 | 244 | 232 | 232 | Modified residue | Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5 |
| P13804 | 221 | 244 | 232 | 232 | Modified residue | Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99LC5 |
| P13804 | 221 | 244 | 205 | 333 | Region | Note=Domain II;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8962055;Dbxref=PMID:8962055 |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in ETFA |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for ETFA |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for ETFA |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ETFA |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| CB | exon_skip_268954 | rs11634019 | chr15:76342339 | 9.970039e-14 | 1.897489e-10 |
| CB | exon_skip_268954 | rs17361504 | chr15:76309530 | 4.316592e-13 | 7.203562e-10 |
| CB | exon_skip_268954 | rs11072591 | chr15:76357221 | 9.297121e-13 | 1.406057e-09 |
| CB | exon_skip_268954 | rs12913096 | chr15:76259511 | 4.872409e-12 | 6.414226e-09 |
| CB | exon_skip_268954 | rs12437866 | chr15:76316021 | 2.767371e-10 | 2.575540e-07 |
| CB | exon_skip_268954 | rs1568083 | chr15:76378575 | 3.647135e-08 | 1.980020e-05 |
| HCC | exon_skip_268871 | rs4886791 | chr15:76303909 | 1.547834e-04 | 1.317640e-02 |
| HCC | exon_skip_268871 | rs4886789 | chr15:76273262 | 1.833234e-04 | 1.510454e-02 |
| HCC | exon_skip_268871 | rs8029637 | chr15:76295146 | 1.833234e-04 | 1.510454e-02 |
| HCC | exon_skip_268871 | rs883993 | chr15:76222779 | 2.323471e-04 | 1.834304e-02 |
| HCC | exon_skip_268871 | rs4886779 | chr15:76198206 | 4.107476e-04 | 2.903650e-02 |
| HCC | exon_skip_268871 | rs11636851 | chr15:76258632 | 7.978750e-04 | 4.899770e-02 |
| DLPFC | exon_skip_268954 | rs12595211 | chr15:76236490 | 1.319632e-18 | 1.304351e-15 |
| DLPFC | exon_skip_268954 | rs12913096 | chr15:76259511 | 1.319632e-18 | 1.304351e-15 |
| DLPFC | exon_skip_268954 | rs17361504 | chr15:76309530 | 3.264240e-17 | 2.726342e-14 |
| DLPFC | exon_skip_268954 | rs4886789 | chr15:76273262 | 3.756259e-16 | 2.728073e-13 |
| DLPFC | exon_skip_268954 | rs8029637 | chr15:76295146 | 3.756259e-16 | 2.728073e-13 |
| DLPFC | exon_skip_268954 | rs883993 | chr15:76222779 | 1.473444e-15 | 9.884680e-13 |
| DLPFC | exon_skip_268954 | rs11636851 | chr15:76258632 | 3.169452e-15 | 2.028486e-12 |
| DLPFC | exon_skip_268954 | rs4886791 | chr15:76303909 | 1.145020e-14 | 6.711145e-12 |
| DLPFC | exon_skip_268954 | rs8030411 | chr15:76407514 | 1.553495e-12 | 6.681035e-10 |
| DLPFC | exon_skip_268954 | rs17362383 | chr15:76358361 | 1.751587e-12 | 7.464039e-10 |
| DLPFC | exon_skip_268954 | rs17460201 | chr15:76381286 | 1.751587e-12 | 7.464039e-10 |
| DLPFC | exon_skip_268954 | rs12907805 | chr15:76398265 | 1.751587e-12 | 7.464039e-10 |
| DLPFC | exon_skip_268954 | rs4886798 | chr15:76380885 | 9.484299e-12 | 3.625368e-09 |
| DLPFC | exon_skip_268954 | rs8028504 | chr15:76294978 | 1.998365e-11 | 7.134611e-09 |
| DLPFC | exon_skip_268954 | rs11072591 | chr15:76357221 | 2.245955e-11 | 7.982363e-09 |
| DLPFC | exon_skip_268954 | rs2957614 | chr15:76404294 | 2.245955e-11 | 7.982363e-09 |
| DLPFC | exon_skip_268954 | rs12437866 | chr15:76316021 | 5.256749e-09 | 1.279803e-06 |
| DLPFC | exon_skip_268954 | rs1568083 | chr15:76378575 | 4.373632e-08 | 8.964227e-06 |
| DLPFC | exon_skip_268954 | rs4886801 | chr15:76409012 | 2.914905e-04 | 2.103433e-02 |
| DLPFC | exon_skip_268954 | rs2469208 | chr15:76298745 | 4.844425e-04 | 3.151197e-02 |
| DLPFC | exon_skip_268954 | rs8042654 | chr15:76270397 | 7.478356e-04 | 4.437680e-02 |
| DLPFC | exon_skip_268954 | rs3743175 | chr15:76404427 | 7.787258e-04 | 4.565094e-02 |
Top |
Correlation with RNA binding proteins (RBPs) for ETFA |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM3 | exon_skip_268871 | -4.313008e-01 | 1.536236e-08 |
| CB | RBM4 | exon_skip_268871 | 5.653244e-01 | 1.006346e-14 |
| DLPFC | RBM3 | exon_skip_268871 | -5.382597e-01 | 7.400277e-27 |
| HCC | RBM3 | exon_skip_268871 | -6.743093e-01 | 1.476303e-37 |
| HCC | HNRNPD | exon_skip_268871 | -4.121830e-01 | 1.273640e-12 |
| IFG | RBM3 | exon_skip_268871 | -6.264255e-01 | 3.621140e-04 |
| IFG | ILF2 | exon_skip_268954 | 4.040785e-01 | 3.295805e-02 |
| IFG | HNRNPC | exon_skip_268954 | 4.077013e-01 | 3.127486e-02 |
| PCC | RBM3 | exon_skip_268871 | -5.363806e-01 | 2.431643e-17 |
| PG | RBM3 | exon_skip_268871 | -4.013063e-01 | 5.844006e-08 |
| TC | RBM3 | exon_skip_268871 | -5.149628e-01 | 3.242716e-12 |
| TC | RBM4 | exon_skip_268871 | 4.612998e-01 | 8.303200e-10 |
Top |
RelatedDrugs for ETFA |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ETFA |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|