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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for ERG |
Gene summary |
Gene information | Gene symbol | ERG | Gene ID | 2078 |
Gene name | ETS transcription factor ERG | |
Synonyms | erg-3|p55 | |
Cytomap | 21q22.2 | |
Type of gene | protein-coding | |
Description | transcriptional regulator ERGERG, ETS transcription factorFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian | |
Modification date | 20200320 | |
UniProtAcc | A0A088AWP2, | |
Context | - 15068237(Aberrant Protein Expression of Transcription Factors BACH1 and ERG, Both Encoded on Chromosome 21, in Brains of Patients With Down Syndrome and Alzheimer's Disease) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
ERG | GO:0045944 | positive regulation of transcription by RNA polymerase II | 18195090|23913826 |
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Gene structures and expression levels for ERG |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PCC | UP | ENST00000538313.5 | RERG-207:protein_coding:RERG | 9.838265e+00 | 4.272060e+00 | 1.179961e-03 | 2.814378e-02 |
PG | UP | ENST00000473107.1 | ERG-213:lncRNA:ERG | 2.269434e+00 | 1.434116e+00 | 4.792773e-03 | 4.436771e-02 |
CB | DOWN | ENST00000492088.3 | CATSPERG-215:retained_intron:CATSPERG | 1.411061e+02 | -1.068169e+00 | 4.746975e-14 | 1.283904e-11 |
CB | DOWN | ENST00000471517.5 | CATSPERG-209:nonsense_mediated_decay:CATSPERG | 3.574494e+01 | -9.667267e-01 | 4.349309e-12 | 5.036398e-10 |
CB | DOWN | ENST00000410018.5 | CATSPERG-204:protein_coding:CATSPERG | 3.316795e+01 | -1.565896e+00 | 3.382182e-08 | 8.483701e-07 |
CB | UP | ENST00000453032.6 | ERG-211:protein_coding:ERG | 7.428866e+00 | 1.266405e+00 | 1.862580e-03 | 8.690896e-03 |
CB | DOWN | ENST00000466060.5 | CATSPERG-206:lncRNA:CATSPERG | 1.273456e+00 | -1.047512e+00 | 3.050407e-03 | 1.308244e-02 |
CB | DOWN | ENST00000412458.6 | CATSPERG-205:nonsense_mediated_decay:CATSPERG | 2.854827e+00 | -1.384069e+00 | 3.109540e-03 | 1.329373e-02 |
CB | UP | ENST00000546331.5 | RERG-209:protein_coding:RERG | 3.354744e+00 | 1.228157e+00 | 6.436287e-03 | 2.421816e-02 |
TC | DOWN | ENST00000398897.5 | ERG-202:protein_coding:ERG | 5.851087e+00 | -6.131132e+00 | 5.174355e-05 | 9.571860e-04 |
TC | UP | ENST00000453032.6 | ERG-211:protein_coding:ERG | 2.737798e+01 | 1.143268e+00 | 7.295945e-04 | 7.740849e-03 |
TC | UP | ENST00000473107.1 | ERG-213:lncRNA:ERG | 1.989284e+00 | 1.272566e+00 | 2.703083e-03 | 2.106778e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ERG |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_136229 | chr21 | 38392376:38392444:38400574:38400645:38402557:38402637 | 38400574:38400645 |
exon_skip_14092 | chr21 | 38403604:38403709:38423410:38423561:38445404:38445621 | 38423410:38423561 |
exon_skip_179976 | chr21 | 38392376:38392444:38402557:38402637:38403506:38403709 | 38402557:38402637 |
exon_skip_22533 | chr21 | 38445584:38445621:38474027:38474121:38498363:38498442 | 38474027:38474121 |
exon_skip_266687 | chr21 | 38423410:38423561:38445404:38445621:38498363:38498476 | 38445404:38445621 |
exon_skip_270961 | chr21 | 38395370:38395580:38400574:38400645:38402557:38402637 | 38400574:38400645 |
exon_skip_284389 | chr21 | 38400574:38400645:38402557:38402637:38403506:38403709 | 38402557:38402637 |
exon_skip_55149 | chr21 | 38423410:38423561:38445404:38445621:38498363:38498442 | 38445404:38445621 |
exon_skip_70648 | chr21 | 38445404:38445621:38474027:38474121:38498363:38498456 | 38474027:38474121 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ERG |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000398911 | 38402557 | 38402637 | In-frame |
ENST00000442448 | 38402557 | 38402637 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000398911 | 38423410 | 38423561 | Frame-shift |
ENST00000442448 | 38423410 | 38423561 | Frame-shift |
ENST00000398911 | 38402557 | 38402637 | In-frame |
ENST00000442448 | 38402557 | 38402637 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ERG |
p-ENSG00000157554_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ERG |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ERG |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ERG |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ERG |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ERG |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ERG |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ERG |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |