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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for SENP5 |
 Gene summary |
| Gene information | Gene symbol | SENP5 | Gene ID | 205564 |
| Gene name | SUMO specific peptidase 5 | |
| Synonyms | - | |
| Cytomap | 3q29 | |
| Type of gene | protein-coding | |
| Description | sentrin-specific protease 5SUMO1/sentrin specific peptidase 5SUMO1/sentrin specific protease 5sentrin/SUMO-specific protease SENP5 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for SENP5 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000119231
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000448068.5 | SENP5-205:protein_coding:SENP5 | 2.109606e+01 | 1.278261e+00 | 7.000898e-13 | 1.107423e-10 |
| CB | UP | ENST00000445299.6 | SENP5-204:protein_coding:SENP5 | 1.228309e+01 | 8.605475e-01 | 1.830908e-04 | 1.234650e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SENP5 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_123497 | chr3 | 196923418:196923551:196927796:196927879:196929633:196929683 | 196927796:196927879 |
| exon_skip_180943 | chr3 | 196900039:196900062:196900365:196900412:196903533:196903610 | 196900365:196900412 |
| exon_skip_187513 | chr3 | 196903550:196903610:196923414:196923551:196927796:196927879 | 196923414:196923551 |
| exon_skip_189772 | chr3 | 196903533:196903610:196923414:196923551:196927796:196927879 | 196923414:196923551 |
| exon_skip_212791 | chr3 | 196867945:196868073:196885151:196886694:196899666:196899771 | 196885151:196886694 |
| exon_skip_245683 | chr3 | 196868042:196868073:196885151:196886694:196899666:196899771 | 196885151:196886694 |
| exon_skip_43256 | chr3 | 196923502:196923551:196927796:196927879:196929633:196929683 | 196927796:196927879 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_123497 | Mayo_CB | 4.316049e-01 | 6.378462e-01 | -2.062412e-01 | 7.846903e-09 |
| exon_skip_123497 | Mayo_TC | 6.973171e-01 | 8.002941e-01 | -1.029770e-01 | 3.981081e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for SENP5 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000323460 | 196885151 | 196886694 | 5CDS-5UTR |
| ENST00000323460 | 196923414 | 196923551 | In-frame |
| ENST00000323460 | 196927796 | 196927879 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000323460 | 196885151 | 196886694 | 5CDS-5UTR |
| ENST00000323460 | 196923414 | 196923551 | In-frame |
| ENST00000323460 | 196927796 | 196927879 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000323460 | 196885151 | 196886694 | 5CDS-5UTR |
| ENST00000323460 | 196900365 | 196900412 | In-frame |
| ENST00000323460 | 196923414 | 196923551 | In-frame |
| ENST00000323460 | 196927796 | 196927879 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SENP5 |
p-ENSG00000119231_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000323460 | 6325 | 755 | 196923414 | 196923551 | 2135 | 2271 | 628 | 674 |
| ENST00000323460 | 6325 | 755 | 196927796 | 196927879 | 2273 | 2355 | 674 | 702 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000323460 | 6325 | 755 | 196923414 | 196923551 | 2135 | 2271 | 628 | 674 |
| ENST00000323460 | 6325 | 755 | 196927796 | 196927879 | 2273 | 2355 | 674 | 702 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000323460 | 6325 | 755 | 196900365 | 196900412 | 2009 | 2055 | 586 | 602 |
| ENST00000323460 | 6325 | 755 | 196923414 | 196923551 | 2135 | 2271 | 628 | 674 |
| ENST00000323460 | 6325 | 755 | 196927796 | 196927879 | 2273 | 2355 | 674 | 702 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96HI0 | 628 | 674 | 646 | 646 | Active site | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q96HI0 | 628 | 674 | 663 | 663 | Active site | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q96HI0 | 628 | 674 | 629 | 674 | Alternative sequence | ID=VSP_056415;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q96HI0 | 628 | 674 | 1 | 755 | Chain | ID=PRO_0000101723;Note=Sentrin-specific protease 5 |
| Q96HI0 | 628 | 674 | 567 | 724 | Region | Note=Protease |
| Q96HI0 | 674 | 702 | 629 | 674 | Alternative sequence | ID=VSP_056415;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q96HI0 | 674 | 702 | 1 | 755 | Chain | ID=PRO_0000101723;Note=Sentrin-specific protease 5 |
| Q96HI0 | 674 | 702 | 567 | 724 | Region | Note=Protease |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96HI0 | 628 | 674 | 646 | 646 | Active site | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q96HI0 | 628 | 674 | 663 | 663 | Active site | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q96HI0 | 628 | 674 | 629 | 674 | Alternative sequence | ID=VSP_056415;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q96HI0 | 628 | 674 | 1 | 755 | Chain | ID=PRO_0000101723;Note=Sentrin-specific protease 5 |
| Q96HI0 | 628 | 674 | 567 | 724 | Region | Note=Protease |
| Q96HI0 | 674 | 702 | 629 | 674 | Alternative sequence | ID=VSP_056415;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q96HI0 | 674 | 702 | 1 | 755 | Chain | ID=PRO_0000101723;Note=Sentrin-specific protease 5 |
| Q96HI0 | 674 | 702 | 567 | 724 | Region | Note=Protease |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96HI0 | 586 | 602 | 1 | 755 | Chain | ID=PRO_0000101723;Note=Sentrin-specific protease 5 |
| Q96HI0 | 586 | 602 | 567 | 724 | Region | Note=Protease |
| Q96HI0 | 628 | 674 | 646 | 646 | Active site | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q96HI0 | 628 | 674 | 663 | 663 | Active site | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q96HI0 | 628 | 674 | 629 | 674 | Alternative sequence | ID=VSP_056415;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q96HI0 | 628 | 674 | 1 | 755 | Chain | ID=PRO_0000101723;Note=Sentrin-specific protease 5 |
| Q96HI0 | 628 | 674 | 567 | 724 | Region | Note=Protease |
| Q96HI0 | 674 | 702 | 629 | 674 | Alternative sequence | ID=VSP_056415;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q96HI0 | 674 | 702 | 1 | 755 | Chain | ID=PRO_0000101723;Note=Sentrin-specific protease 5 |
| Q96HI0 | 674 | 702 | 567 | 724 | Region | Note=Protease |
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3'-UTR located exon skipping events that lost miRNA binding sites in SENP5 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for SENP5 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for SENP5 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SENP5 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for SENP5 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TRA2A | exon_skip_123497 | -4.684982e-01 | 2.468982e-09 |
| CB | NUP42 | exon_skip_123497 | 4.031776e-01 | 4.521580e-07 |
| IFG | RBMS3 | exon_skip_212791 | 4.523205e-01 | 1.784343e-02 |
| IFG | RBM25 | exon_skip_212791 | 4.444461e-01 | 2.019802e-02 |
| IFG | ELAVL1 | exon_skip_212791 | 4.483407e-01 | 1.900356e-02 |
| IFG | ZNF638 | exon_skip_212791 | 4.569959e-01 | 1.655554e-02 |
| IFG | SRSF11 | exon_skip_212791 | 4.998489e-01 | 7.934600e-03 |
| IFG | CNOT4 | exon_skip_212791 | 4.550617e-01 | 1.707874e-02 |
| IFG | TRA2A | exon_skip_212791 | 5.292337e-01 | 4.531518e-03 |
| IFG | KHDRBS2 | exon_skip_212791 | 4.120003e-01 | 3.272869e-02 |
| IFG | SF1 | exon_skip_212791 | 4.132247e-01 | 3.216326e-02 |
| IFG | FUBP1 | exon_skip_212791 | 4.041036e-01 | 3.657010e-02 |
| IFG | PTBP1 | exon_skip_212791 | 4.044098e-01 | 3.641475e-02 |
| IFG | PABPC4 | exon_skip_212791 | 4.104699e-01 | 3.344668e-02 |
| PCC | RBM3 | exon_skip_123497 | 4.285273e-01 | 2.204551e-10 |
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RelatedDrugs for SENP5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SENP5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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