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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for EPHA7 |
Gene summary |
Gene information | Gene symbol | EPHA7 | Gene ID | 2045 |
Gene name | EPH receptor A7 | |
Synonyms | EHK-3|EHK3|EK11|HEK11 | |
Cytomap | 6q16.1 | |
Type of gene | protein-coding | |
Description | ephrin type-A receptor 7EPH homology kinase 3EPH-like kinase 11Eph homology kinase-3receptor protein-tyrosine kinase HEK11tyrosine-protein kinase receptor EHK-3 | |
Modification date | 20200313 | |
UniProtAcc | L8EAA4, Q15375, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
EPHA7 | GO:0048013 | ephrin receptor signaling pathway | 17726105 |
EPHA7 | GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 17726105 |
EPHA7 | GO:0070372 | regulation of ERK1 and ERK2 cascade | 17726105 |
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Gene structures and expression levels for EPHA7 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for EPHA7 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_203313 | chr6 | 93240020:93243540:93245298:93245453:93246792:93246985 | 93245298:93245453 |
exon_skip_8398 | chr6 | 93258099:93258284:93259354:93259479:93263860:93263915 | 93259354:93259479 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for EPHA7 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000369303 | 93245298 | 93245453 | In-frame |
ENST00000369303 | 93259354 | 93259479 | In-frame |
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Infer the effects of exon skipping event on protein functional features for EPHA7 |
p-ENSG00000135333_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000369303 | 6605 | 998 | 93259354 | 93259479 | 1984 | 2108 | 599 | 641 |
ENST00000369303 | 6605 | 998 | 93245298 | 93245453 | 2912 | 3066 | 909 | 960 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q15375 | 599 | 641 | 280 | 998 | Alternative sequence | ID=VSP_014381;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
Q15375 | 599 | 641 | 451 | 998 | Alternative sequence | ID=VSP_041944;Note=In isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q15375 | 599 | 641 | 600 | 604 | Alternative sequence | ID=VSP_041945;Note=In isoform 4. FKFPG->C;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
Q15375 | 599 | 641 | 614 | 616 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2REI |
Q15375 | 599 | 641 | 633 | 641 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2REI |
Q15375 | 599 | 641 | 28 | 998 | Chain | ID=PRO_0000016818;Note=Ephrin type-A receptor 7 |
Q15375 | 599 | 641 | 633 | 894 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
Q15375 | 599 | 641 | 611 | 613 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2REI |
Q15375 | 599 | 641 | 617 | 624 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2REI |
Q15375 | 599 | 641 | 630 | 632 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2REI |
Q15375 | 599 | 641 | 608 | 608 | Modified residue | Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q15375 | 599 | 641 | 614 | 614 | Modified residue | Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q15375 | 599 | 641 | 639 | 647 | Nucleotide binding | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
Q15375 | 599 | 641 | 577 | 998 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q15375 | 909 | 960 | 280 | 998 | Alternative sequence | ID=VSP_014381;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
Q15375 | 909 | 960 | 451 | 998 | Alternative sequence | ID=VSP_041944;Note=In isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q15375 | 909 | 960 | 28 | 998 | Chain | ID=PRO_0000016818;Note=Ephrin type-A receptor 7 |
Q15375 | 909 | 960 | 923 | 987 | Domain | Note=SAM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00184 |
Q15375 | 909 | 960 | 928 | 934 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H8M |
Q15375 | 909 | 960 | 938 | 940 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H8M |
Q15375 | 909 | 960 | 941 | 946 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H8M |
Q15375 | 909 | 960 | 952 | 956 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H8M |
Q15375 | 909 | 960 | 960 | 965 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H8M |
Q15375 | 909 | 960 | 940 | 940 | Modified residue | Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q15375 | 909 | 960 | 577 | 998 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in EPHA7 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for EPHA7 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for EPHA7 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for EPHA7 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for EPHA7 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for EPHA7 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Q15375 | approved|investigational | DB12010 | Fostamatinib | small molecule | Q15375 |
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RelatedDiseases for EPHA7 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |