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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for CERS3 |
Gene summary |
Gene information | Gene symbol | CERS3 | Gene ID | 204219 |
Gene name | ceramide synthase 3 | |
Synonyms | ARCI9|LASS3 | |
Cytomap | 15q26.3 | |
Type of gene | protein-coding | |
Description | ceramide synthase 3LAG1 homolog, ceramide synthase 3LAG1 longevity assurance homolog 3dihydroceramide synthase 3sphingosine N-acyltransferase CERS3 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
CERS3 | GO:0046513 | ceramide biosynthetic process | 17977534|22038835 |
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Gene structures and expression levels for CERS3 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CERS3 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_41888 | chr15 | 100501804:100501850:100503710:100503848:100521667:100521756 | 100503710:100503848 |
exon_skip_73694 | chr15 | 100501677:100501850:100503710:100503848:100521667:100521756 | 100503710:100503848 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CERS3 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000394113 | 100503710 | 100503848 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000394113 | 100503710 | 100503848 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for CERS3 |
p-ENSG00000154227_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in CERS3 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000394113 | 100503710 | 100503848 | hsa-miR-6728-3p | chr15:100503797-100503804 | 8mer-1a | chr15:100503786-100503809 | 158.00 | -19.56 |
Mayo | ENST00000394113 | 100503710 | 100503848 | hsa-miR-7152-3p | chr15:100503827-100503834 | 8mer-1a | chr15:100503819-100503840 | 160.00 | -29.58 |
Mayo | ENST00000394113 | 100503710 | 100503848 | hsa-miR-3160-3p | chr15:100503772-100503779 | 8mer-1a | chr15:100503767-100503796 | 154.00 | -21.25 |
Mayo | ENST00000394113 | 100503710 | 100503848 | hsa-miR-2276-5p | chr15:100503831-100503838 | 8mer-1a | chr15:100503819-100503840 | 160.00 | -29.58 |
Mayo | ENST00000394113 | 100503710 | 100503848 | hsa-miR-6766-3p | chr15:100503767-100503774 | 8mer-1a | chr15:100503767-100503796 | 154.00 | -21.25 |
Mayo | ENST00000394113 | 100503710 | 100503848 | hsa-miR-642a-5p | chr15:100503832-100503839 | 8mer-1a | chr15:100503819-100503840 | 160.00 | -29.58 |
Mayo | ENST00000394113 | 100503710 | 100503848 | hsa-miR-3190-5p | chr15:100503812-100503819 | 8mer-1a | chr15:100503803-100503822 | 145.00 | -28.05 |
Mayo | ENST00000394113 | 100503710 | 100503848 | hsa-miR-4782-3p | chr15:100503767-100503774 | 8mer-1a | chr15:100503767-100503796 | 154.00 | -21.25 |
Mayo | ENST00000394113 | 100503710 | 100503848 | hsa-miR-6817-3p | chr15:100503799-100503806 | 8mer-1a | chr15:100503786-100503809 | 158.00 | -19.56 |
Mayo | ENST00000394113 | 100503710 | 100503848 | hsa-miR-3909 | chr15:100503763-100503770 | 8mer-1a | chr15:100503749-100503770 | 158.00 | -25.51 |
Mayo | ENST00000394113 | 100503710 | 100503848 | hsa-miR-3938 | chr15:100503834-100503841 | 8mer-1a | chr15:100503820-100503841 | 141.00 | -17.34 |
Mayo | ENST00000394113 | 100503710 | 100503848 | hsa-miR-544b | chr15:100503743-100503750 | 8mer-1a | chr15:100503730-100503751 | 159.00 | -22.67 |
Mayo | ENST00000394113 | 100503710 | 100503848 | hsa-miR-219a-5p | chr15:100503767-100503774 | 8mer-1a | chr15:100503767-100503796 | 154.00 | -21.25 |
Mayo | ENST00000394113 | 100503710 | 100503848 | hsa-miR-6873-3p | chr15:100503800-100503807 | 8mer-1a | chr15:100503786-100503809 | 158.00 | -19.56 |
Mayo | ENST00000394113 | 100503710 | 100503848 | hsa-miR-93-3p | chr15:100503795-100503802 | 8mer-1a | chr15:100503786-100503809 | 158.00 | -19.56 |
Mayo | ENST00000394113 | 100503710 | 100503848 | hsa-miR-4286 | chr15:100503822-100503829 | 8mer-1a | chr15:100503819-100503840 | 160.00 | -29.58 |
Mayo | ENST00000394113 | 100503710 | 100503848 | hsa-miR-3926 | chr15:100503810-100503817 | 8mer-1a | chr15:100503803-100503822 | 145.00 | -28.05 |
Mayo | ENST00000394113 | 100503710 | 100503848 | hsa-miR-6852-3p | chr15:100503763-100503770 | 8mer-1a | chr15:100503749-100503770 | 158.00 | -25.51 |
ROSMAP | ENST00000394113 | 100503710 | 100503848 | hsa-miR-6728-3p | chr15:100503797-100503804 | 8mer-1a | chr15:100503786-100503809 | 158.00 | -19.56 |
ROSMAP | ENST00000394113 | 100503710 | 100503848 | hsa-miR-7152-3p | chr15:100503827-100503834 | 8mer-1a | chr15:100503819-100503840 | 160.00 | -29.58 |
ROSMAP | ENST00000394113 | 100503710 | 100503848 | hsa-miR-3160-3p | chr15:100503772-100503779 | 8mer-1a | chr15:100503767-100503796 | 154.00 | -21.25 |
ROSMAP | ENST00000394113 | 100503710 | 100503848 | hsa-miR-2276-5p | chr15:100503831-100503838 | 8mer-1a | chr15:100503819-100503840 | 160.00 | -29.58 |
ROSMAP | ENST00000394113 | 100503710 | 100503848 | hsa-miR-6766-3p | chr15:100503767-100503774 | 8mer-1a | chr15:100503767-100503796 | 154.00 | -21.25 |
ROSMAP | ENST00000394113 | 100503710 | 100503848 | hsa-miR-642a-5p | chr15:100503832-100503839 | 8mer-1a | chr15:100503819-100503840 | 160.00 | -29.58 |
ROSMAP | ENST00000394113 | 100503710 | 100503848 | hsa-miR-3190-5p | chr15:100503812-100503819 | 8mer-1a | chr15:100503803-100503822 | 145.00 | -28.05 |
ROSMAP | ENST00000394113 | 100503710 | 100503848 | hsa-miR-4782-3p | chr15:100503767-100503774 | 8mer-1a | chr15:100503767-100503796 | 154.00 | -21.25 |
ROSMAP | ENST00000394113 | 100503710 | 100503848 | hsa-miR-6817-3p | chr15:100503799-100503806 | 8mer-1a | chr15:100503786-100503809 | 158.00 | -19.56 |
ROSMAP | ENST00000394113 | 100503710 | 100503848 | hsa-miR-3909 | chr15:100503763-100503770 | 8mer-1a | chr15:100503749-100503770 | 158.00 | -25.51 |
ROSMAP | ENST00000394113 | 100503710 | 100503848 | hsa-miR-3938 | chr15:100503834-100503841 | 8mer-1a | chr15:100503820-100503841 | 141.00 | -17.34 |
ROSMAP | ENST00000394113 | 100503710 | 100503848 | hsa-miR-544b | chr15:100503743-100503750 | 8mer-1a | chr15:100503730-100503751 | 159.00 | -22.67 |
ROSMAP | ENST00000394113 | 100503710 | 100503848 | hsa-miR-219a-5p | chr15:100503767-100503774 | 8mer-1a | chr15:100503767-100503796 | 154.00 | -21.25 |
ROSMAP | ENST00000394113 | 100503710 | 100503848 | hsa-miR-6873-3p | chr15:100503800-100503807 | 8mer-1a | chr15:100503786-100503809 | 158.00 | -19.56 |
ROSMAP | ENST00000394113 | 100503710 | 100503848 | hsa-miR-93-3p | chr15:100503795-100503802 | 8mer-1a | chr15:100503786-100503809 | 158.00 | -19.56 |
ROSMAP | ENST00000394113 | 100503710 | 100503848 | hsa-miR-4286 | chr15:100503822-100503829 | 8mer-1a | chr15:100503819-100503840 | 160.00 | -29.58 |
ROSMAP | ENST00000394113 | 100503710 | 100503848 | hsa-miR-3926 | chr15:100503810-100503817 | 8mer-1a | chr15:100503803-100503822 | 145.00 | -28.05 |
ROSMAP | ENST00000394113 | 100503710 | 100503848 | hsa-miR-6852-3p | chr15:100503763-100503770 | 8mer-1a | chr15:100503749-100503770 | 158.00 | -25.51 |
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SNVs in the skipped exons for CERS3 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CERS3 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CERS3 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CERS3 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CERS3 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CERS3 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |