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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TSNARE1 |
 Gene summary |
| Gene information | Gene symbol | TSNARE1 | Gene ID | 203062 |
| Gene name | t-SNARE domain containing 1 | |
| Synonyms | - | |
| Cytomap | 8q24.3 | |
| Type of gene | protein-coding | |
| Description | t-SNARE domain-containing protein 1 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TSNARE1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000171045
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TSNARE1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_106938 | chr8 | 142274781:142274863:142279860:142280324:142284413:142284430 | 142279860:142280324 |
| exon_skip_112753 | chr8 | 142271567:142271691:142274781:142274863:142284413:142284485 | 142274781:142274863 |
| exon_skip_119972 | chr8 | 142274781:142274863:142279860:142280324:142284413:142284485 | 142279860:142280324 |
| exon_skip_161647 | chr8 | 142315003:142315089:142318544:142318634:142330901:142330970 | 142318544:142318634 |
| exon_skip_168214 | chr8 | 142354637:142354763:142365911:142366017:142403104:142403168 | 142365911:142366017 |
| exon_skip_171335 | chr8 | 142344353:142344472:142345743:142345892:142354637:142354724 | 142345743:142345892 |
| exon_skip_18716 | chr8 | 142271567:142271691:142274781:142274863:142279860:142279997 | 142274781:142274863 |
| exon_skip_205554 | chr8 | 142331754:142331831:142354637:142354763:142403104:142403168 | 142354637:142354763 |
| exon_skip_260455 | chr8 | 142345743:142345892:142354637:142354763:142365911:142366017 | 142354637:142354763 |
| exon_skip_277706 | chr8 | 142314384:142314440:142315003:142315092:142318544:142318634 | 142315003:142315092 |
| exon_skip_283155 | chr8 | 142314384:142314440:142315003:142315089:142318544:142318634 | 142315003:142315089 |
| exon_skip_286128 | chr8 | 142315003:142315092:142318544:142318634:142330901:142330970 | 142318544:142318634 |
| exon_skip_296711 | chr8 | 142345743:142345892:142354637:142354763:142403104:142403168 | 142354637:142354763 |
| exon_skip_44363 | chr8 | 142271567:142271691:142274781:142274863:142279860:142279994 | 142274781:142274863 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_18716 | Mayo_TC | 7.234375e-01 | 8.284211e-01 | -1.049836e-01 | 7.843697e-03 |
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Open reading frame (ORF) annotation in the exon skipping event for TSNARE1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000524325 | 142318544 | 142318634 | Frame-shift |
| ENST00000524325 | 142315003 | 142315092 | In-frame |
| ENST00000524325 | 142345743 | 142345892 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000524325 | 142318544 | 142318634 | Frame-shift |
| ENST00000524325 | 142345743 | 142345892 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000524325 | 142318544 | 142318634 | Frame-shift |
| ENST00000524325 | 142315003 | 142315092 | In-frame |
| ENST00000524325 | 142345743 | 142345892 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TSNARE1 |
p-ENSG00000171045_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000524325 | 1980 | 513 | 142345743 | 142345892 | 265 | 413 | 29 | 79 |
| ENST00000524325 | 1980 | 513 | 142315003 | 142315092 | 1161 | 1249 | 328 | 357 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000524325 | 1980 | 513 | 142345743 | 142345892 | 265 | 413 | 29 | 79 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000524325 | 1980 | 513 | 142345743 | 142345892 | 265 | 413 | 29 | 79 |
| ENST00000524325 | 1980 | 513 | 142315003 | 142315092 | 1161 | 1249 | 328 | 357 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96NA8 | 29 | 79 | 1 | 513 | Chain | ID=PRO_0000065668;Note=t-SNARE domain-containing protein 1 |
| Q96NA8 | 29 | 79 | 55 | 55 | Natural variant | ID=VAR_051461;Note=R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs33970858,PMID:14702039 |
| Q96NA8 | 328 | 357 | 329 | 329 | Alternative sequence | ID=VSP_056304;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q96NA8 | 328 | 357 | 1 | 513 | Chain | ID=PRO_0000065668;Note=t-SNARE domain-containing protein 1 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96NA8 | 29 | 79 | 1 | 513 | Chain | ID=PRO_0000065668;Note=t-SNARE domain-containing protein 1 |
| Q96NA8 | 29 | 79 | 55 | 55 | Natural variant | ID=VAR_051461;Note=R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs33970858,PMID:14702039 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96NA8 | 29 | 79 | 1 | 513 | Chain | ID=PRO_0000065668;Note=t-SNARE domain-containing protein 1 |
| Q96NA8 | 29 | 79 | 55 | 55 | Natural variant | ID=VAR_051461;Note=R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs33970858,PMID:14702039 |
| Q96NA8 | 328 | 357 | 329 | 329 | Alternative sequence | ID=VSP_056304;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q96NA8 | 328 | 357 | 1 | 513 | Chain | ID=PRO_0000065668;Note=t-SNARE domain-containing protein 1 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TSNARE1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TSNARE1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TSNARE1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TSNARE1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| TC | exon_skip_171335 | rs6583612 | chr8:142265882 | 7.137807e-06 | 1.858942e-03 |
| TC | exon_skip_18716 | rs12676425 | chr8:142332496 | 6.389218e-05 | 1.149333e-02 |
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Correlation with RNA binding proteins (RBPs) for TSNARE1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| IFG | PTBP3 | exon_skip_171335 | 4.725253e-01 | 3.053607e-02 |
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RelatedDrugs for TSNARE1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TSNARE1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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