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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ENO1 |
 Gene summary |
| Gene information | Gene symbol | ENO1 | Gene ID | 2023 |
| Gene name | enolase 1 | |
| Synonyms | ENO1L1|HEL-S-17|MPB1|NNE|PPH | |
| Cytomap | 1p36.23 | |
| Type of gene | protein-coding | |
| Description | alpha-enolasec-myc promoter-binding protein-12-phospho-D-glycerate hydro-lyaseMYC promoter-binding protein 1alpha enolase like 1enolase 1, (alpha)enolase-alphaepididymis secretory protein Li 17non-neural enolasephosphopyruvate hydrataseplasminog | |
| Modification date | 20200320 | |
| UniProtAcc | ||
| Context | - 25890254(Redox proteomics identification of specifically carbonylated proteins in the hippocampi of triple transgenic Alzheimer's disease mice at its earliest pathological stage) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ENO1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 2005901 |
| ENO1 | GO:0030308 | negative regulation of cell growth | 10082554 |
| ENO1 | GO:0045892 | negative regulation of transcription, DNA-templated | 10082554 |
| ENO1 | GO:0061621 | canonical glycolysis | 29775581 |
| ENO1 | GO:1903298 | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway | 15459207 |
| ENO1 | GO:2001171 | positive regulation of ATP biosynthetic process | 15459207 |
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Gene structures and expression levels for ENO1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000074800
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000646906.1 | ENO1-215:protein_coding:ENO1 | 1.682294e+01 | 1.123765e+00 | 8.441958e-07 | 7.753352e-05 |
| PG | UP | ENST00000646660.1 | ENO1-213:protein_coding:ENO1 | 6.261494e+00 | 5.841420e+00 | 1.961694e-03 | 2.353000e-02 |
| PG | UP | ENST00000645600.1 | ENO1-209:lncRNA:ENO1 | 2.540432e+00 | 3.104456e+00 | 4.342036e-03 | 4.138955e-02 |
| CB | DOWN | ENST00000442636.1 | ENO1-AS1-201:lncRNA:ENO1 | 1.504756e+00 | -9.607763e-01 | 3.970026e-05 | 3.382965e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ENO1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_100990 | chr1 | 8867988:8868057:8870825:8870883:8871891:8871944 | 8870825:8870883 |
| exon_skip_106141 | chr1 | 8870452:8870510:8870825:8870883:8871891:8871944 | 8870825:8870883 |
| exon_skip_120330 | chr1 | 8868049:8868057:8870452:8870510:8871891:8871944 | 8870452:8870510 |
| exon_skip_120647 | chr1 | 8870461:8870510:8870825:8870883:8871891:8871944 | 8870825:8870883 |
| exon_skip_127891 | chr1 | 8871891:8871986:8874824:8874917:8878580:8878622 | 8874824:8874917 |
| exon_skip_127926 | chr1 | 8867184:8867250:8867988:8868057:8871891:8871944 | 8867988:8868057 |
| exon_skip_138702 | chr1 | 8868049:8868057:8870452:8870510:8870825:8870883 | 8870452:8870510 |
| exon_skip_149396 | chr1 | 8867184:8867250:8867988:8868057:8870452:8870510 | 8867988:8868057 |
| exon_skip_18973 | chr1 | 8867988:8868057:8870452:8870510:8870825:8870883 | 8870452:8870510 |
| exon_skip_242279 | chr1 | 8870452:8870510:8870825:8870883:8871891:8871986 | 8870825:8870883 |
| exon_skip_252614 | chr1 | 8871891:8871986:8874824:8874917:8878580:8878600 | 8874824:8874917 |
| exon_skip_259392 | chr1 | 8868049:8868057:8870825:8870883:8871891:8871944 | 8870825:8870883 |
| exon_skip_267416 | chr1 | 8861007:8861429:8862887:8862945:8863235:8863343 | 8862887:8862945 |
| exon_skip_83430 | chr1 | 8871891:8871986:8874824:8874917:8878580:8878646 | 8874824:8874917 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ENO1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000234590 | 8870452 | 8870510 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000234590 | 8870452 | 8870510 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000234590 | 8862887 | 8862945 | Frame-shift |
| ENST00000234590 | 8867988 | 8868057 | Frame-shift |
| ENST00000234590 | 8870452 | 8870510 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for ENO1 |
p-ENSG00000074800_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ENO1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ENO1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ENO1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | MSBB | IFG | exon_skip_242021 | 4.119081e-01 | 2.940809e-02 | chr1 | - | 8871891 | 8871986 | 8874824 | 8874914 | 8878580 | 8878646 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ENO1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| HCC | exon_skip_138702 | rs6684149 | chr1:8943119 | 7.987533e-04 | 4.901925e-02 |
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Correlation with RNA binding proteins (RBPs) for ENO1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| DLPFC | HNRNPK | exon_skip_18973 | 4.160631e-01 | 1.559217e-14 |
| DLPFC | TRA2A | exon_skip_18973 | 4.292269e-01 | 1.840291e-15 |
| DLPFC | PCBP2 | exon_skip_18973 | 4.142184e-01 | 2.088058e-14 |
| DLPFC | HNRNPH2 | exon_skip_18973 | 4.075678e-01 | 5.896503e-14 |
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RelatedDrugs for ENO1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P06733 | approved|investigational | DB01593 | Zinc | small molecule | P06733 |
| P06733 | approved|investigational | DB14487 | Zinc acetate | small molecule | P06733 |
| P06733 | approved|investigational | DB14533 | Zinc chloride | small molecule | P06733 |
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RelatedDiseases for ENO1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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