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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for NBPF11 |
 Gene summary |
| Gene information | Gene symbol | NBPF11 | Gene ID | 200030 |
| Gene name | NBPF member 11 | |
| Synonyms | NBPF24 | |
| Cytomap | 1q21.2 | |
| Type of gene | protein-coding | |
| Description | neuroblastoma breakpoint family member 11neuroblastoma breakpoint family, member 24 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for NBPF11 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000263956
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NBPF11 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_14947 | chr1 | 148135672:148135813:148137711:148137809:148143415:148143686 | 148137711:148137809 |
| exon_skip_158179 | chr1 | 148115793:148115998:148116463:148116535:148117572:148117786 | 148116463:148116535 |
| exon_skip_167721 | chr1 | 148120501:148120710:148122055:148122266:148122729:148122801 | 148122055:148122266 |
| exon_skip_171452 | chr1 | 148124899:148125001:148126829:148127038:148135672:148135813 | 148126829:148127038 |
| exon_skip_189297 | chr1 | 148109284:148109335:148110378:148110541:148114437:148114488 | 148110378:148110541 |
| exon_skip_201647 | chr1 | 148123924:148124067:148124899:148125001:148126829:148126884 | 148124899:148125001 |
| exon_skip_244364 | chr1 | 148126829:148127038:148127141:148127288:148135672:148135813 | 148127141:148127288 |
| exon_skip_37948 | chr1 | 148127141:148127288:148135124:148135247:148135672:148135813 | 148135124:148135247 |
| exon_skip_45668 | chr1 | 148122055:148122266:148122729:148122801:148123853:148124067 | 148122729:148122801 |
| exon_skip_48639 | chr1 | 148123853:148124067:148124899:148125001:148126829:148126884 | 148124899:148125001 |
| exon_skip_59862 | chr1 | 148127141:148127288:148135672:148135813:148143415:148143686 | 148135672:148135813 |
| exon_skip_85223 | chr1 | 148114437:148114488:148115793:148115998:148116463:148116535 | 148115793:148115998 |
| exon_skip_90708 | chr1 | 148109284:148109411:148110378:148110541:148114437:148114488 | 148110378:148110541 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for NBPF11 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000615281 | 148126829 | 148127038 | 3UTR-3CDS |
| ENST00000615281 | 148137711 | 148137809 | 3UTR-3UTR |
| ENST00000614015 | 148110378 | 148110541 | Frame-shift |
| ENST00000615281 | 148110378 | 148110541 | Frame-shift |
| ENST00000614015 | 148122055 | 148122266 | Frame-shift |
| ENST00000615281 | 148122055 | 148122266 | Frame-shift |
| ENST00000614015 | 148122729 | 148122801 | Frame-shift |
| ENST00000615281 | 148122729 | 148122801 | Frame-shift |
| ENST00000614015 | 148124899 | 148125001 | Frame-shift |
| ENST00000615281 | 148124899 | 148125001 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000615281 | 148126829 | 148127038 | 3UTR-3CDS |
| ENST00000615281 | 148137711 | 148137809 | 3UTR-3UTR |
| ENST00000614015 | 148110378 | 148110541 | Frame-shift |
| ENST00000615281 | 148110378 | 148110541 | Frame-shift |
| ENST00000614015 | 148115793 | 148115998 | Frame-shift |
| ENST00000615281 | 148115793 | 148115998 | Frame-shift |
| ENST00000614015 | 148124899 | 148125001 | Frame-shift |
| ENST00000615281 | 148124899 | 148125001 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000615281 | 148126829 | 148127038 | 3UTR-3CDS |
| ENST00000615281 | 148137711 | 148137809 | 3UTR-3UTR |
| ENST00000614015 | 148110378 | 148110541 | Frame-shift |
| ENST00000615281 | 148110378 | 148110541 | Frame-shift |
| ENST00000614015 | 148116463 | 148116535 | Frame-shift |
| ENST00000615281 | 148116463 | 148116535 | Frame-shift |
| ENST00000614015 | 148122729 | 148122801 | Frame-shift |
| ENST00000615281 | 148122729 | 148122801 | Frame-shift |
| ENST00000614015 | 148124899 | 148125001 | Frame-shift |
| ENST00000615281 | 148124899 | 148125001 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for NBPF11 |
p-ENSG00000263956_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in NBPF11 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000615281 | 148137711 | 148137809 | hsa-miR-6740-3p | chr1:148137746-148137753 | 8mer-1a | chr1:148137741-148137762 | 150.00 | -26.70 |
| Mayo | ENST00000615281 | 148137711 | 148137809 | hsa-miR-4778-3p | chr1:148137744-148137751 | 8mer-1a | chr1:148137741-148137762 | 150.00 | -26.70 |
| Mayo | ENST00000615281 | 148137711 | 148137809 | hsa-miR-6809-5p | chr1:148137733-148137740 | 8mer-1a | chr1:148137719-148137744 | 154.00 | -29.20 |
| MSBB | ENST00000615281 | 148137711 | 148137809 | hsa-miR-6740-3p | chr1:148137746-148137753 | 8mer-1a | chr1:148137741-148137762 | 150.00 | -26.70 |
| MSBB | ENST00000615281 | 148137711 | 148137809 | hsa-miR-4778-3p | chr1:148137744-148137751 | 8mer-1a | chr1:148137741-148137762 | 150.00 | -26.70 |
| MSBB | ENST00000615281 | 148137711 | 148137809 | hsa-miR-6809-5p | chr1:148137733-148137740 | 8mer-1a | chr1:148137719-148137744 | 154.00 | -29.20 |
| ROSMAP | ENST00000615281 | 148137711 | 148137809 | hsa-miR-6740-3p | chr1:148137746-148137753 | 8mer-1a | chr1:148137741-148137762 | 150.00 | -26.70 |
| ROSMAP | ENST00000615281 | 148137711 | 148137809 | hsa-miR-4778-3p | chr1:148137744-148137751 | 8mer-1a | chr1:148137741-148137762 | 150.00 | -26.70 |
| ROSMAP | ENST00000615281 | 148137711 | 148137809 | hsa-miR-6809-5p | chr1:148137733-148137740 | 8mer-1a | chr1:148137719-148137744 | 154.00 | -29.20 |
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SNVs in the skipped exons for NBPF11 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for NBPF11 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NBPF11 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for NBPF11 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | U2AF2 | exon_skip_244364 | -4.741063e-01 | 1.130386e-07 |
| CB | TIA1 | exon_skip_244364 | 4.833376e-01 | 5.875350e-08 |
| CB | HNRNPC | exon_skip_244364 | -4.145955e-01 | 4.985263e-06 |
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RelatedDrugs for NBPF11 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NBPF11 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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