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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for EIF4A2 |
 Gene summary |
| Gene information | Gene symbol | EIF4A2 | Gene ID | 1974 |
| Gene name | eukaryotic translation initiation factor 4A2 | |
| Synonyms | BM-010|DDX2B|EIF4A|EIF4F|eIF-4A-II|eIF4A-II | |
| Cytomap | 3q27.3 | |
| Type of gene | protein-coding | |
| Description | eukaryotic initiation factor 4A-IIATP-dependent RNA helicase eIF4A-2 | |
| Modification date | 20200322 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| EIF4A2 | GO:1900260 | negative regulation of RNA-directed 5'-3' RNA polymerase activity | 11922617 |
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Gene structures and expression levels for EIF4A2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000156976
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PCC | DOWN | ENST00000475409.1 | EIF4A2-217:retained_intron:EIF4A2 | 5.985736e+00 | -8.659389e-01 | 5.866232e-05 | 4.232385e-03 |
| PG | DOWN | ENST00000445596.5 | EIF4A2-208:protein_coding:EIF4A2 | 1.066063e+00 | -1.561185e+00 | 7.168982e-04 | 1.143107e-02 |
| CB | DOWN | ENST00000443963.5 | EIF4A2-207:nonsense_mediated_decay:EIF4A2 | 2.793441e+03 | -2.294189e+00 | 6.812164e-13 | 1.082751e-10 |
| CB | UP | ENST00000465792.1 | EIF4A2-213:retained_intron:EIF4A2 | 3.449666e+01 | 1.077945e+00 | 5.614093e-09 | 1.852827e-07 |
| CB | UP | ENST00000465222.1 | EIF4A2-211:retained_intron:EIF4A2 | 3.992495e+01 | 1.088360e+00 | 1.133421e-08 | 3.342544e-07 |
| CB | UP | ENST00000498746.1 | EIF4A2-227:protein_coding:EIF4A2 | 2.773913e+01 | 8.174280e-01 | 8.572838e-07 | 1.315750e-05 |
| CB | UP | ENST00000466362.1 | EIF4A2-214:retained_intron:EIF4A2 | 1.289531e+00 | 1.498501e+00 | 1.072054e-02 | 3.679938e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for EIF4A2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_113338 | chr3 | 186787803:186787882:186788310:186788416:186789125:186789140 | 186788310:186788416 |
| exon_skip_136235 | chr3 | 186787803:186787882:186788310:186788420:186789125:186789140 | 186788310:186788420 |
| exon_skip_193782 | chr3 | 186783597:186783639:186784429:186784477:186784564:186784659 | 186784429:186784477 |
| exon_skip_212027 | chr3 | 186783597:186783639:186784432:186784477:186784564:186784659 | 186784432:186784477 |
| exon_skip_239255 | chr3 | 186784564:186784696:186784962:186785101:186785883:186785953 | 186784962:186785101 |
| exon_skip_254100 | chr3 | 186784564:186784696:186784962:186785101:186785883:186785929 | 186784962:186785101 |
| exon_skip_292000 | chr3 | 186784564:186784696:186784962:186785101:186785883:186785987 | 186784962:186785101 |
| exon_skip_31488 | chr3 | 186784564:186784696:186784962:186785101:186785883:186785956 | 186784962:186785101 |
| exon_skip_31697 | chr3 | 186784564:186784696:186784962:186785101:186785883:186786044 | 186784962:186785101 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for EIF4A2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000323963 | 186784432 | 186784477 | Frame-shift |
| ENST00000323963 | 186784962 | 186785101 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000323963 | 186784432 | 186784477 | Frame-shift |
| ENST00000323963 | 186784962 | 186785101 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000323963 | 186784432 | 186784477 | Frame-shift |
| ENST00000323963 | 186784962 | 186785101 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for EIF4A2 |
p-ENSG00000156976_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in EIF4A2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for EIF4A2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for EIF4A2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for EIF4A2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for EIF4A2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | DAZAP1 | exon_skip_31697 | 4.632338e-01 | 7.821279e-10 |
| CB | TARDBP | exon_skip_31697 | 5.580702e-01 | 2.133434e-14 |
| CB | CNOT4 | exon_skip_31697 | 6.399027e-01 | 1.085200e-19 |
| CB | HNRNPA2B1 | exon_skip_31697 | 6.689401e-01 | 5.608703e-22 |
| DLPFC | DAZAP1 | exon_skip_292000 | 4.387717e-01 | 6.653929e-13 |
| DLPFC | TARDBP | exon_skip_292000 | 4.909728e-01 | 3.300550e-16 |
| DLPFC | CNOT4 | exon_skip_292000 | 5.786904e-01 | 3.268626e-23 |
| DLPFC | RBM5 | exon_skip_292000 | 4.654822e-01 | 1.594164e-14 |
| DLPFC | MBNL1 | exon_skip_292000 | 5.647366e-01 | 5.894026e-22 |
| DLPFC | UNK | exon_skip_292000 | 4.030958e-01 | 5.990555e-11 |
| DLPFC | PCBP2 | exon_skip_292000 | 6.219772e-01 | 1.614813e-27 |
| DLPFC | RC3H1 | exon_skip_292000 | 4.567061e-01 | 5.631889e-14 |
| DLPFC | SNRPA | exon_skip_292000 | 4.794436e-01 | 1.984207e-15 |
| DLPFC | HNRNPA1 | exon_skip_292000 | 4.488004e-01 | 1.702740e-13 |
| DLPFC | ENOX1 | exon_skip_292000 | 6.772210e-01 | 4.263254e-34 |
| DLPFC | HNRNPA1L2 | exon_skip_292000 | 4.692069e-01 | 9.228258e-15 |
| DLPFC | HNRNPA2B1 | exon_skip_292000 | 5.466062e-01 | 2.071679e-20 |
| DLPFC | HNRNPDL | exon_skip_292000 | 5.408015e-01 | 6.190843e-20 |
| DLPFC | RALYL | exon_skip_292000 | 6.703881e-01 | 3.314050e-33 |
| DLPFC | SRSF9 | exon_skip_292000 | 5.781297e-01 | 3.681323e-23 |
| DLPFC | SRSF5 | exon_skip_292000 | 4.781230e-01 | 2.426371e-15 |
| HCC | DAZAP1 | exon_skip_31488 | -4.094135e-01 | 1.857564e-12 |
| HCC | RBM5 | exon_skip_31488 | -4.684997e-01 | 2.666813e-16 |
| HCC | UNK | exon_skip_31488 | -5.486427e-01 | 7.380019e-23 |
| HCC | SNRNP70 | exon_skip_31488 | -4.810295e-01 | 3.243142e-17 |
| HCC | SRSF5 | exon_skip_31488 | -6.007471e-01 | 3.617726e-28 |
| PG | RALYL | exon_skip_31697 | 4.698055e-01 | 7.159772e-13 |
| STG | RALYL | exon_skip_254100 | 4.214145e-01 | 2.591572e-05 |
| TC | CNOT4 | exon_skip_31697 | 4.404950e-01 | 5.575643e-09 |
| TC | MBNL1 | exon_skip_31697 | 4.497223e-01 | 2.434043e-09 |
| TC | RALYL | exon_skip_31697 | 6.832507e-01 | 2.435515e-23 |
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RelatedDrugs for EIF4A2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EIF4A2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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