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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for DPP6 |
Gene summary |
Gene information | Gene symbol | DPP6 | Gene ID | 1804 |
Gene name | dipeptidyl peptidase like 6 | |
Synonyms | DPL1|DPPX|MRD33|VF2 | |
Cytomap | 7q36.2 | |
Type of gene | protein-coding | |
Description | dipeptidyl aminopeptidase-like protein 6DPP VIdipeptidyl aminopeptidase IV-related proteindipeptidyl peptidase IV-related proteindipeptidyl peptidase VIdipeptidyl-peptidase 6 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context | - 30874922(Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
DPP6 | GO:1901379 | regulation of potassium ion transmembrane transport | 18364354 |
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Gene structures and expression levels for DPP6 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PG | DOWN | ENST00000427557.1 | DPP6-205:protein_coding:DPP6 | 7.202009e+01 | -1.198289e+00 | 7.382248e-04 | 1.168555e-02 |
CB | DOWN | ENST00000496611.1 | DPP6-215:lncRNA:DPP6 | 3.975599e+00 | -1.291462e+00 | 3.752326e-04 | 2.261937e-03 |
TC | DOWN | ENST00000406326.5 | DPP6-204:protein_coding:DPP6 | 1.000309e+00 | -1.328493e+00 | 5.523950e-05 | 1.011114e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DPP6 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_131203 | chr7 | 154889272:154889344:154889457:154889530:154892334:154892538 | 154889457:154889530 |
exon_skip_132386 | chr7 | 154868056:154868093:154872624:154872693:154875906:154876100 | 154872624:154872693 |
exon_skip_133444 | chr7 | 154795845:154795883:154801355:154801462:154803864:154803955 | 154801355:154801462 |
exon_skip_180362 | chr7 | 154801355:154801462:154803864:154803955:154804917:154804964 | 154803864:154803955 |
exon_skip_185420 | chr7 | 154806994:154807112:154853780:154853827:154867995:154868093 | 154853780:154853827 |
exon_skip_192991 | chr7 | 154446214:154446328:154474939:154475037:154540532:154540626 | 154474939:154475037 |
exon_skip_221707 | chr7 | 154637821:154637873:154669360:154669441:154727767:154727887 | 154669360:154669441 |
exon_skip_246531 | chr7 | 154669360:154669441:154727767:154727887:154769417:154769571 | 154727767:154727887 |
exon_skip_291461 | chr7 | 154566842:154566916:154637821:154637873:154669360:154669441 | 154637821:154637873 |
exon_skip_295361 | chr7 | 154727767:154727887:154769417:154769571:154772845:154772942 | 154769417:154769571 |
exon_skip_56973 | chr7 | 154853780:154853827:154867995:154868093:154872624:154872693 | 154867995:154868093 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for DPP6 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for DPP6 |
p-ENSG00000130226_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in DPP6 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for DPP6 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for DPP6 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DPP6 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for DPP6 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for DPP6 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DPP6 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |