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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for DCLK2 |
 Gene summary |
| Gene information | Gene symbol | DCLK2 | Gene ID | 166614 |
| Gene name | doublecortin like kinase 2 | |
| Synonyms | CL2|CLICK-II|CLICK2|CLIK2|DCAMKL2|DCDC3|DCDC3B|DCK2 | |
| Cytomap | 4q31.23-q31.3 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase DCLK2CaMK-like CREB regulatory kinase 2doublecortin and CaM kinase-like 2doublecortin domain-containing protein 3Bdoublecortin-like and CAM kinase-like 2 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for DCLK2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000170390
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| STG | UP | ENST00000411937.6 | DCLK2-203:nonsense_mediated_decay:DCLK2 | 1.310343e+01 | 2.233191e+01 | 2.083220e-35 | 9.488487e-32 |
| PG | UP | ENST00000506325.5 | DCLK2-204:protein_coding:DCLK2 | 2.626953e+01 | 5.963260e+00 | 5.610968e-09 | 1.619317e-06 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DCLK2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_102673 | chr4 | 150247603:150247699:150248305:150248385:150249568:150249587 | 150248305:150248385 |
| exon_skip_107919 | chr4 | 150249652:150249684:150254426:150254438:150256020:150256036 | 150254426:150254438 |
| exon_skip_127364 | chr4 | 150079028:150079448:150102478:150102812:150193138:150193240 | 150102478:150102812 |
| exon_skip_129974 | chr4 | 150102567:150102812:150193138:150193240:150198002:150198103 | 150193138:150193240 |
| exon_skip_144433 | chr4 | 150239742:150239875:150240399:150240476:150247603:150247699 | 150240399:150240476 |
| exon_skip_173349 | chr4 | 150249630:150249684:150253474:150253556:150256020:150256036 | 150253474:150253556 |
| exon_skip_179657 | chr4 | 150198002:150198103:150199028:150199078:150203795:150203889 | 150199028:150199078 |
| exon_skip_195435 | chr4 | 150249568:150249684:150253474:150253556:150256020:150256119 | 150253474:150253556 |
| exon_skip_212965 | chr4 | 150193138:150193240:150198002:150198103:150203795:150203889 | 150198002:150198103 |
| exon_skip_259784 | chr4 | 150249630:150249684:150254426:150254438:150256020:150256036 | 150254426:150254438 |
| exon_skip_277778 | chr4 | 150249568:150249684:150253474:150253556:150256020:150256036 | 150253474:150253556 |
| exon_skip_288308 | chr4 | 150102478:150102812:150193138:150193240:150198002:150198103 | 150193138:150193240 |
| exon_skip_31283 | chr4 | 150247603:150247699:150248305:150248385:150249568:150249684 | 150248305:150248385 |
| exon_skip_56375 | chr4 | 150249568:150249684:150254426:150254438:150256020:150256036 | 150254426:150254438 |
| exon_skip_83878 | chr4 | 150248305:150248385:150249568:150249684:150256020:150256036 | 150249568:150249684 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_179657 | MSBB_STG | 4.796923e-01 | 6.125000e-01 | -1.328077e-01 | 2.143122e-02 |
| exon_skip_179657 | MSBB_PG | 4.008219e-01 | 5.726786e-01 | -1.718567e-01 | 5.101957e-07 |
| exon_skip_179657 | Mayo_TC | 3.215854e-01 | 4.237662e-01 | -1.021809e-01 | 2.722029e-03 |
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Open reading frame (ORF) annotation in the exon skipping event for DCLK2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000296550 | 150193138 | 150193240 | Frame-shift |
| ENST00000296550 | 150198002 | 150198103 | In-frame |
| ENST00000296550 | 150240399 | 150240476 | In-frame |
| ENST00000296550 | 150248305 | 150248385 | In-frame |
| ENST00000296550 | 150249568 | 150249684 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000296550 | 150193138 | 150193240 | Frame-shift |
| ENST00000296550 | 150248305 | 150248385 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000296550 | 150193138 | 150193240 | Frame-shift |
| ENST00000296550 | 150198002 | 150198103 | In-frame |
| ENST00000296550 | 150240399 | 150240476 | In-frame |
| ENST00000296550 | 150248305 | 150248385 | In-frame |
| ENST00000296550 | 150249568 | 150249684 | In-frame |
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Infer the effects of exon skipping event on protein functional features for DCLK2 |
p-ENSG00000170390_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000296550 | 4282 | 766 | 150198002 | 150198103 | 1615 | 1715 | 287 | 320 |
| ENST00000296550 | 4282 | 766 | 150240399 | 150240476 | 2456 | 2532 | 567 | 592 |
| ENST00000296550 | 4282 | 766 | 150248305 | 150248385 | 2631 | 2710 | 625 | 652 |
| ENST00000296550 | 4282 | 766 | 150249568 | 150249684 | 2712 | 2827 | 652 | 691 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000296550 | 4282 | 766 | 150248305 | 150248385 | 2631 | 2710 | 625 | 652 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000296550 | 4282 | 766 | 150198002 | 150198103 | 1615 | 1715 | 287 | 320 |
| ENST00000296550 | 4282 | 766 | 150240399 | 150240476 | 2456 | 2532 | 567 | 592 |
| ENST00000296550 | 4282 | 766 | 150248305 | 150248385 | 2631 | 2710 | 625 | 652 |
| ENST00000296550 | 4282 | 766 | 150249568 | 150249684 | 2712 | 2827 | 652 | 691 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8N568 | 287 | 320 | 1 | 766 | Chain | ID=PRO_0000085922;Note=Serine/threonine-protein kinase DCLK2 |
| Q8N568 | 287 | 320 | 293 | 362 | Compositional bias | Note=Ser-rich |
| Q8N568 | 567 | 592 | 1 | 766 | Chain | ID=PRO_0000085922;Note=Serine/threonine-protein kinase DCLK2 |
| Q8N568 | 567 | 592 | 394 | 651 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q8N568 | 567 | 592 | 583 | 583 | Natural variant | ID=VAR_040443;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35745104,PMID:17344846 |
| Q8N568 | 625 | 652 | 1 | 766 | Chain | ID=PRO_0000085922;Note=Serine/threonine-protein kinase DCLK2 |
| Q8N568 | 625 | 652 | 394 | 651 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q8N568 | 625 | 652 | 647 | 647 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5MPA9 |
| Q8N568 | 652 | 691 | 1 | 766 | Chain | ID=PRO_0000085922;Note=Serine/threonine-protein kinase DCLK2 |
| Q8N568 | 652 | 691 | 666 | 666 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5MPA9 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8N568 | 625 | 652 | 1 | 766 | Chain | ID=PRO_0000085922;Note=Serine/threonine-protein kinase DCLK2 |
| Q8N568 | 625 | 652 | 394 | 651 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q8N568 | 625 | 652 | 647 | 647 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5MPA9 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8N568 | 287 | 320 | 1 | 766 | Chain | ID=PRO_0000085922;Note=Serine/threonine-protein kinase DCLK2 |
| Q8N568 | 287 | 320 | 293 | 362 | Compositional bias | Note=Ser-rich |
| Q8N568 | 567 | 592 | 1 | 766 | Chain | ID=PRO_0000085922;Note=Serine/threonine-protein kinase DCLK2 |
| Q8N568 | 567 | 592 | 394 | 651 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q8N568 | 567 | 592 | 583 | 583 | Natural variant | ID=VAR_040443;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35745104,PMID:17344846 |
| Q8N568 | 625 | 652 | 1 | 766 | Chain | ID=PRO_0000085922;Note=Serine/threonine-protein kinase DCLK2 |
| Q8N568 | 625 | 652 | 394 | 651 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q8N568 | 625 | 652 | 647 | 647 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5MPA9 |
| Q8N568 | 652 | 691 | 1 | 766 | Chain | ID=PRO_0000085922;Note=Serine/threonine-protein kinase DCLK2 |
| Q8N568 | 652 | 691 | 666 | 666 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5MPA9 |
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3'-UTR located exon skipping events that lost miRNA binding sites in DCLK2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for DCLK2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for DCLK2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DCLK2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for DCLK2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | PCBP1 | exon_skip_179657 | 4.333134e-01 | 1.294382e-08 |
| CB | EWSR1 | exon_skip_179657 | 4.018323e-01 | 1.666680e-07 |
| CB | SRSF9 | exon_skip_179657 | 4.326611e-01 | 1.368446e-08 |
| CB | HNRNPH2 | exon_skip_179657 | 4.627586e-01 | 9.256564e-10 |
| FL | ILF2 | exon_skip_179657 | 5.705552e-01 | 2.085769e-18 |
| FL | SRSF9 | exon_skip_179657 | 4.873722e-01 | 3.787211e-13 |
| FL | HNRNPH2 | exon_skip_179657 | 5.336500e-01 | 6.783642e-16 |
| FL | ESRP1 | exon_skip_179657 | 4.213209e-01 | 7.034688e-10 |
| HCC | RBM25 | exon_skip_179657 | -4.340031e-01 | 6.395796e-14 |
| HCC | PCBP1 | exon_skip_179657 | -4.706545e-01 | 2.120522e-16 |
| HCC | PCBP4 | exon_skip_179657 | -4.806855e-01 | 3.930307e-17 |
| HCC | HNRNPA2B1 | exon_skip_179657 | -5.227520e-01 | 1.773407e-20 |
| HCC | HNRNPF | exon_skip_179657 | -7.176267e-01 | 2.541169e-44 |
| HCC | RBM4B | exon_skip_179657 | -6.369490e-01 | 2.343225e-32 |
| PCC | PCBP4 | exon_skip_179657 | -4.336918e-01 | 3.522614e-11 |
| PCC | HNRNPF | exon_skip_179657 | -5.638851e-01 | 2.820566e-19 |
| PG | PCBP1 | exon_skip_179657 | 5.432421e-01 | 6.651291e-17 |
| PG | HNRNPH2 | exon_skip_179657 | 4.527738e-01 | 1.328963e-11 |
| STG | ILF2 | exon_skip_179657 | 4.813013e-01 | 1.800481e-06 |
| STG | SRSF9 | exon_skip_179657 | 4.214285e-01 | 3.908553e-05 |
| STG | HNRNPH2 | exon_skip_179657 | 6.199858e-01 | 9.248693e-11 |
| TC | ILF2 | exon_skip_179657 | 4.709219e-01 | 3.743926e-10 |
| TC | HNRNPH2 | exon_skip_179657 | 6.497839e-01 | 1.928768e-20 |
| TC | ESRP1 | exon_skip_179657 | 6.054955e-01 | 2.798848e-17 |
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RelatedDrugs for DCLK2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q8N568 | approved|investigational | DB12010 | Fostamatinib | small molecule | Q8N568 |
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RelatedDiseases for DCLK2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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