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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for DDX5 |
Gene summary |
Gene information | Gene symbol | DDX5 | Gene ID | 1655 |
Gene name | DEAD-box helicase 5 | |
Synonyms | G17P1|HLR1|HUMP68|p68 | |
Cytomap | 17q23.3 | |
Type of gene | protein-coding | |
Description | probable ATP-dependent RNA helicase DDX5ATP-dependent RNA helicase DDX5DEAD (Asp-Glu-Ala-Asp) box helicase 5DEAD (Asp-Glu-Ala-Asp) box polypeptide 5DEAD box protein 5DEAD box-5DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD)RNA h | |
Modification date | 20200313 | |
UniProtAcc | A0A0G2JLI4, B5BUE6, J3KRX8, J3KRZ1, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
DDX5 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 15298701 |
DDX5 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | 21343338 |
DDX5 | GO:0000956 | nuclear-transcribed mRNA catabolic process | 23788676 |
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Gene structures and expression levels for DDX5 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | UP | ENST00000583562.1 | DDX5-225:retained_intron:DDX5 | 2.449449e+01 | 9.709704e-01 | 4.759715e-08 | 1.130587e-06 |
CB | DOWN | ENST00000450599.6 | DDX5-202:protein_coding:DDX5 | 1.461852e+02 | -1.478838e+00 | 9.255839e-05 | 6.937935e-04 |
CB | UP | ENST00000581551.1 | DDX5-217:retained_intron:DDX5 | 9.184179e+00 | 1.111331e+00 | 1.062903e-04 | 7.797698e-04 |
CB | UP | ENST00000582326.1 | DDX5-221:retained_intron:DDX5 | 2.061771e+01 | 8.862927e-01 | 1.276100e-03 | 6.337094e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DDX5 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_136891 | chr17 | 64504222:64504318:64504677:64504842:64506076:64506289 | 64504677:64504842 |
exon_skip_153443 | chr17 | 64504755:64504842:64506076:64506262:64506755:64506903 | 64506076:64506262 |
exon_skip_162924 | chr17 | 64504222:64504318:64504677:64504880:64506076:64506289 | 64504677:64504880 |
exon_skip_166697 | chr17 | 64504677:64504842:64506076:64506262:64506755:64506903 | 64506076:64506262 |
exon_skip_181639 | chr17 | 64503983:64504116:64504222:64504318:64504677:64504842 | 64504222:64504318 |
exon_skip_191920 | chr17 | 64502010:64502069:64502162:64502223:64502439:64502549 | 64502162:64502223 |
exon_skip_20457 | chr17 | 64504677:64504842:64506076:64506262:64506514:64506626 | 64506076:64506262 |
exon_skip_221648 | chr17 | 64502439:64502549:64502926:64503098:64503188:64503246 | 64502926:64503098 |
exon_skip_230127 | chr17 | 64503188:64503348:64503430:64503571:64503803:64503816 | 64503430:64503571 |
exon_skip_274070 | chr17 | 64503856:64503868:64503983:64504116:64504222:64504289 | 64503983:64504116 |
exon_skip_280781 | chr17 | 64504273:64504318:64504677:64504842:64506076:64506259 | 64504677:64504842 |
exon_skip_285766 | chr17 | 64504677:64504842:64506076:64506259:64506514:64506626 | 64506076:64506259 |
exon_skip_68036 | chr17 | 64504273:64504318:64504677:64504880:64506076:64506259 | 64504677:64504880 |
exon_skip_81549 | chr17 | 64503095:64503098:64503188:64503348:64503430:64503435 | 64503188:64503348 |
exon_skip_8329 | chr17 | 64502162:64502223:64502439:64502549:64502926:64503096 | 64502439:64502549 |
exon_skip_99952 | chr17 | 64503983:64504116:64504222:64504318:64504677:64504692 | 64504222:64504318 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for DDX5 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000225792 | 64502162 | 64502223 | Frame-shift |
ENST00000225792 | 64502926 | 64503098 | Frame-shift |
ENST00000225792 | 64504222 | 64504318 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000225792 | 64502439 | 64502549 | In-frame |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000225792 | 64502162 | 64502223 | Frame-shift |
ENST00000225792 | 64503188 | 64503348 | Frame-shift |
ENST00000225792 | 64503430 | 64503571 | Frame-shift |
ENST00000225792 | 64503983 | 64504116 | Frame-shift |
ENST00000225792 | 64504222 | 64504318 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for DDX5 |
p-ENSG00000108654_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000225792 | 2571 | 614 | 64502439 | 64502549 | 1386 | 1495 | 328 | 364 |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
P17844 | 328 | 364 | 1 | 614 | Chain | ID=PRO_0000054991;Note=Probable ATP-dependent RNA helicase DDX5 |
P17844 | 328 | 364 | 340 | 340 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
P17844 | 328 | 364 | 343 | 343 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
P17844 | 328 | 364 | 328 | 475 | Domain | Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542 |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in DDX5 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for DDX5 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for DDX5 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DDX5 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for DDX5 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for DDX5 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DDX5 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |